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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 152-229 DRI_Approach denotes pheral antigen plays a crucial role in Echinococcus granulosus pathogenicity.
T2 230-418 DRI_Outcome denotes Considering the diversity of antigen among different EG95 isolates, it seems to be an ideal antigen for designing a universal multivalent minigene vaccine, so-called multi-epitope vaccine.
T3 419-576 DRI_Approach denotes This is the first in silico study to design a construct for the development of global EG95-based hydatid vaccine against E. granulosus in intermediate hosts.
T4 577-692 DRI_Approach denotes After antigen sequence selection, the three-dimensional structure of EG95 was modeled and multilaterally validated.
T5 693-876 DRI_Outcome denotes The preliminary parameters for B-cell epitope prediction were implemented such as the possible transmembrane helix, signal peptide, post-translational modifications and allergenicity.
T6 877-990 DRI_Background denotes The high ranked linear and conformational B-cell epitopes derived from several online web-servers (e.g., ElliPro,
T7 1004-1049 DRI_Background denotes , BcePred, ABCpred, SVMTrip, IEDB algorithms,
T8 1061-1064 DRI_Background denotes and
T9 1079-1174 DRI_Background denotes ) were utilized for multiple sequence alignment and then for engineering the vaccine construct.
T10 1175-1345 DRI_Approach denotes T-helper based epitopes were predicted by molecular docking between the high frequent ovar class II allele (Ovar-DRB1*1202) and hexadecamer fragments of the EG95 protein.
T11 1346-1411 DRI_Approach denotes Having used the immune-informatics tools, we formulated the first
T12 1432-1516 DRI_Approach denotes vaccine based on T-helper epitope with high-binding affinity to the ovar MHC allele.
T13 1517-1595 DRI_Approach denotes This designed construct was analyzed for different physicochemical properties.
T14 1596-1674 DRI_Background denotes It was also codon-optimized for high-level expression in Escherichia coli k12.
T15 1675-1893 DRI_Outcome denotes Taken all, we propose the present in silico vaccine constructs as a promising platform for the generation of broadly protective vaccines for species and genus-specific immunization of the natural hosts of the parasite.

GoldHamster

Id Subject Object Predicate Lexical cue
T1 44-47 PR:000001004 denotes CD4
T2 44-47 PR:P06332 denotes CD4
T3 44-47 PR:P05540 denotes CD4
T4 44-47 PR:P01730 denotes CD4
T5 62-68 CL:0000236 denotes B-cell
T6 62-77 D018985 denotes B-cell epitopes
T7 62-77 D018985 denotes B-cell epitopes
T10 119-140 D004443 denotes cystic echinococcosis
T11 119-140 D004443 denotes cystic echinococcosis
T14 159-166 D000941 denotes antigen
T15 159-166 CHEBI:59132 denotes antigen
T16 159-166 D000941 denotes antigen
T18 191-214 6210 denotes Echinococcus granulosus
T19 191-214 D048209 denotes Echinococcus granulosus
T20 259-266 D000941 denotes antigen
T21 259-266 CHEBI:59132 denotes antigen
T22 259-266 D000941 denotes antigen
T23 322-329 D000941 denotes antigen
T24 322-329 CHEBI:59132 denotes antigen
T25 322-329 D000941 denotes antigen
T27 402-409 SO:0001018 denotes epitope
T26 402-409 CHEBI:53000 denotes epitope
T28 465-474 SO:0000804 denotes construct
T29 516-523 D004443 denotes hydatid
T30 516-523 D004443 denotes hydatid
T31 557-569 SO:0000933 denotes intermediate
T32 583-590 D000941 denotes antigen
T33 583-590 CHEBI:59132 denotes antigen
T34 583-590 D000941 denotes antigen
T35 591-599 SO:0000001 denotes sequence
T36 682-691 SO:0000789 denotes validated
T37 724-730 CL:0000236 denotes B-cell
T38 724-738 D018985 denotes B-cell epitope
T39 724-738 D018985 denotes B-cell epitope
T41 731-738 SO:0001018 denotes epitope
T43 788-801 GO:0044214 denotes transmembrane
T44 788-801 GO:0016021 denotes transmembrane
T45 788-807 SO:0001812 denotes transmembrane helix
T50 802-807 6535 denotes helix
T51 802-807 145123 denotes helix
T47 802-807 UBERON:0002488 denotes helix
T56 809-823 SO:0000418 denotes signal peptide
T55 809-823 PR:000021936 denotes signal peptide
T54 809-823 D021382 denotes signal peptide
T61 893-899 SO:0000987 denotes linear
T62 919-925 CL:0000236 denotes B-cell
T63 919-934 D018985 denotes B-cell epitopes
T64 919-934 D018985 denotes B-cell epitopes
T67 963-966 UBERON:0006015 denotes web
T68 1108-1116 SO:0000001 denotes sequence
T69 1164-1173 SO:0000804 denotes construct
T70 1190-1198 D000939 denotes epitopes
T71 1190-1198 D000939 denotes epitopes
T72 1204-1213 SO:0000732 denotes predicted
T73 1266-1274 SO:0000182 denotes class II
T74 1275-1281 SO:0001023 denotes allele
T75 1288-1291 D004004 denotes DRB
T76 1288-1291 D004004 denotes DRB
T77 1288-1292 PR:O04492 denotes DRB1
T78 1288-1292 PR:Q8CFD1 denotes DRB1
T79 1288-1292 PR:Q8IUH3 denotes DRB1
T80 1288-1292 PR:000013803 denotes DRB1
T81 1288-1292 PR:Q8BHN5 denotes DRB1
T85 1337-1344 PR:000000001 denotes protein
T86 1337-1344 SO:0000104 denotes protein
T82 1337-1344 GO:0003675 denotes protein
T83 1337-1344 CHEBI:36080 denotes protein
T84 1337-1344 CHEBI:11122 denotes protein
T88 1458-1465 SO:0001018 denotes epitope
T87 1458-1465 CHEBI:53000 denotes epitope
T89 1476-1483 SO:0100018 denotes binding
T90 1476-1483 SO:0001091 denotes binding
T91 1476-1483 GO:0005488 denotes binding
T92 1505-1508 PR:P05661 denotes MHC
T93 1509-1515 SO:0001023 denotes allele
T94 1531-1540 SO:0000804 denotes construct
T96 1608-1613 D003062 denotes codon
T95 1608-1613 SO:0000360 denotes codon
T100 1653-1673 D048168 denotes Escherichia coli k12
T101 1670-1673 PR:000030941 denotes k12
T103 1670-1673 PR:Q8WVN6 denotes k12
T104 1670-1673 Q64291 denotes k12
T106 1670-1673 PR:000032844 denotes k12
T107 1670-1673 PR:000009452 denotes k12
T108 1670-1673 PR:Q9JL59 denotes k12
T109 1670-1673 Q28706 denotes k12
T110 1670-1673 Q99456 denotes k12
T111 1670-1673 Q6IFW5 denotes k12
T102 1670-1673 CVCL_W625 denotes k12
T105 1670-1673 CVCL_IX41 denotes k12
T112 1803-1811 D014612 denotes vaccines
T113 1803-1811 D014612 denotes vaccines
T114 1884-1892 D010271 denotes parasite

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 0-1 CVCL_6479|Finite_cell_line|Mus musculus denotes A
T2 62-63 CVCL_6480|Finite_cell_line|Mus musculus denotes B
T3 173-174 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T4 313-315 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T5 313-315 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T6 344-345 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T7 463-464 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T8 724-725 CVCL_6480|Finite_cell_line|Mus musculus denotes B
T9 919-920 CVCL_6480|Finite_cell_line|Mus musculus denotes B
T10 1388-1390 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes we
T11 1670-1673 CVCL_IX41|Cancer_cell_line|Felis catus denotes k12
T12 1670-1673 CVCL_W625|Cancer_cell_line|Mus musculus denotes k12
T13 1686-1688 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes we
T14 1741-1742 CVCL_6479|Finite_cell_line|Mus musculus denotes a