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GoldHamster

Id Subject Object Predicate Lexical cue
T1 2-13 D005959 denotes Glucosidase
T10 18-49 P20417 denotes Protein Tyrosine Phosphatase 1B
T11 18-49 P35821 denotes Protein Tyrosine Phosphatase 1B
T12 18-49 P18031 denotes Protein Tyrosine Phosphatase 1B
T14 18-49 O13016 denotes Protein Tyrosine Phosphatase 1B
T15 18-49 PR:000013448 denotes Protein Tyrosine Phosphatase 1B
T13 18-49 D054562 denotes Protein Tyrosine Phosphatase 1B
T17 26-34 10962 denotes Tyrosine
T21 26-34 SO:0001446 denotes Tyrosine
T23 35-46 GO:0016791 denotes Phosphatase
T26 111-134 127450 denotes Sargassum serratifolium
T27 171-183 D000459 denotes Phaeophyceae
T28 460-471 CHEBI:22586 denotes antioxidant
T33 630-637 SO:0000104 denotes protein
T29 630-637 GO:0003675 denotes protein
T41 630-661 P20417 denotes protein tyrosine phosphatase 1B
T42 630-661 P35821 denotes protein tyrosine phosphatase 1B
T43 630-661 P18031 denotes protein tyrosine phosphatase 1B
T45 630-661 O13016 denotes protein tyrosine phosphatase 1B
T46 630-661 PR:000013448 denotes protein tyrosine phosphatase 1B
T44 630-661 D054562 denotes protein tyrosine phosphatase 1B
T48 638-646 10962 denotes tyrosine
T52 638-646 SO:0001446 denotes tyrosine
T54 647-658 GO:0016791 denotes phosphatase
T79 663-666 CHEBI:52242 denotes PTP
T93 663-668 P20417 denotes PTP1B
T94 663-668 P35821 denotes PTP1B
T95 663-668 PR:O13016 denotes PTP1B
T96 663-668 P18031 denotes PTP1B
T97 663-668 O13016 denotes PTP1B
T98 663-668 PR:000013448 denotes PTP1B
T99 663-668 PR:P18031 denotes PTP1B
T100 673-684 D005959 denotes glucosidase
T101 690-694 CHEBI:29330 denotes ONOO
T102 713-722 MOP:0000556 denotes nitration
T126 789-792 CHEBI:52242 denotes PTP
T140 789-794 P20417 denotes PTP1B
T141 789-794 P35821 denotes PTP1B
T142 789-794 PR:O13016 denotes PTP1B
T143 789-794 P18031 denotes PTP1B
T144 789-794 O13016 denotes PTP1B
T145 789-794 PR:000013448 denotes PTP1B
T146 789-794 PR:P18031 denotes PTP1B
T147 801-812 D005959 denotes glucosidase
T172 875-878 CHEBI:52242 denotes PTP
T186 875-880 P20417 denotes PTP1B
T187 875-880 P35821 denotes PTP1B
T188 875-880 PR:O13016 denotes PTP1B
T189 875-880 P18031 denotes PTP1B
T190 875-880 O13016 denotes PTP1B
T191 875-880 PR:000013448 denotes PTP1B
T192 875-880 PR:P18031 denotes PTP1B
T193 887-898 D005959 denotes glucosidase
T194 984-1006 C528847 denotes sargahydroquinoic acid
T195 984-1006 C528847 denotes sargahydroquinoic acid
T197 1008-1022 C503204 denotes sargachromenol
T198 1008-1022 C503204 denotes sargachromenol
T199 1027-1044 C477718 denotes sargaquinoic acid
T200 1027-1044 C477718 denotes sargaquinoic acid
T202 1076-1084 CHEBI:29021 denotes n-hexane
T203 1076-1084 C026385 denotes n-hexane
T204 1076-1084 C026385 denotes n-hexane
T229 1193-1196 CHEBI:52242 denotes PTP
T243 1193-1198 P20417 denotes PTP1B
T244 1193-1198 P35821 denotes PTP1B
T245 1193-1198 PR:O13016 denotes PTP1B
T246 1193-1198 P18031 denotes PTP1B
T247 1193-1198 O13016 denotes PTP1B
T248 1193-1198 PR:000013448 denotes PTP1B
T249 1193-1198 PR:P18031 denotes PTP1B
T250 1241-1255 C503204 denotes sargachromenol
T251 1241-1255 C503204 denotes sargachromenol
T252 1260-1277 C477718 denotes sargaquinoic acid
T253 1260-1277 C477718 denotes sargaquinoic acid
T255 1330-1341 D005959 denotes glucosidase
T279 1421-1424 CHEBI:52242 denotes PTP
T293 1421-1426 P20417 denotes PTP1B
T294 1421-1426 P35821 denotes PTP1B
T295 1421-1426 PR:O13016 denotes PTP1B
T296 1421-1426 P18031 denotes PTP1B
T297 1421-1426 O13016 denotes PTP1B
T298 1421-1426 PR:000013448 denotes PTP1B
T299 1421-1426 PR:P18031 denotes PTP1B
T300 1425-1433 P10773 denotes B enzyme
T301 1446-1468 C528847 denotes sargahydroquinoic acid
T302 1446-1468 C528847 denotes sargahydroquinoic acid
T304 1473-1490 C477718 denotes sargaquinoic acid
T305 1473-1490 C477718 denotes sargaquinoic acid
T307 1529-1543 C503204 denotes sargachromenol
T308 1529-1543 C503204 denotes sargachromenol
T309 1638-1642 CHEBI:29330 denotes ONOO
T310 1661-1670 MOP:0000556 denotes nitration
T311 1738-1745 SO:0100018 denotes binding
T312 1738-1745 SO:0001091 denotes binding
T313 1738-1745 GO:0005488 denotes binding
T314 1794-1801 SO:0100018 denotes binding
T315 1794-1801 SO:0001091 denotes binding
T316 1794-1801 GO:0005488 denotes binding
T340 1812-1815 CHEBI:52242 denotes PTP
T354 1812-1817 P20417 denotes PTP1B
T355 1812-1817 P35821 denotes PTP1B
T356 1812-1817 PR:O13016 denotes PTP1B
T357 1812-1817 P18031 denotes PTP1B
T358 1812-1817 O13016 denotes PTP1B
T359 1812-1817 PR:000013448 denotes PTP1B
T360 1812-1817 PR:P18031 denotes PTP1B
T361 1824-1835 D005959 denotes glucosidase
T362 1903-1910 SO:0100018 denotes binding
T363 1903-1910 SO:0001091 denotes binding
T364 1903-1910 GO:0005488 denotes binding
T365 2074-2090 D000074385 denotes food ingredients
T366 2074-2090 D000074385 denotes food ingredients
T367 2127-2142 D003924 denotes type 2 diabetes
T368 2127-2142 D003924 denotes type 2 diabetes

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 136-257 DRI_Background denotes Sargassum serratifolium C. Agardh (Phaeophyceae, Fucales) is a marine brown alga that belongs to the family Sargassaceae.
T2 258-327 DRI_Background denotes It is widely distributed throughout coastal areas of Korea and Japan.
T3 328-502 DRI_Background denotes S. serratifolium has been found to contain high concentrations of plastoquinones, which have strong anti-cancer, anti-inflammatory, antioxidant, and neuroprotective activity.
T4 503-723 DRI_Background denotes This study aims to investigate the anti-diabetic activity of S. serratifolium and its major constituents through inhibition of protein tyrosine phosphatase 1B (PTP1B), α-glucosidase, and ONOO--mediated albumin nitration.
T5 724-726 DRI_Background denotes S.
T6 751-853 DRI_Background denotes extract and fractions exhibited broad PTP1B and α-glucosidase inhibitory activity (IC50, 1.83~7.04 and
T7 871-914 DRI_Background denotes for PTP1B and α-glucosidase, respectively).
T8 915-1114 DRI_Background denotes In an attempt to identify bioactive compounds, three plastoquinones (sargahydroquinoic acid, sargachromenol and sargaquinoic acid) were isolated from the active n-hexane fraction of S. serratifolium.
T9 1115-1219 DRI_Outcome denotes All three plastoquinones exhibited dose-dependent inhibitory activity against PTP1B in the IC50 range of
T10 1233-1396 DRI_Outcome denotes , while sargachromenol and sargaquinoic acid showed dose-dependent inhibitory activity against α-glucosidase (IC50 42.41 ± 3.09 and 96.17 ± 3.48 µM, respectively).
T11 1397-1585 DRI_Background denotes In the kinetic study of PTP1B enzyme inhibition, sargahydroquinoic acid and sargaquinoic acid led to mixed-type inhibition, whereas sargachromenol displayed noncompetitive-type inhibition.
T12 1672-1959 DRI_Approach denotes Docking simulations of these plastoquinones demonstrated negative binding energies and close proximity to residues in the binding pocket of PTP1B and α-glucosidase, indicating that these plastoquinones have high affinity and tight binding capacity towards the active site of the enzymes.
T13 1960-2143 DRI_Background denotes These results demonstrate that S. serratifolium and its major plastoquinones may have the potential as functional food ingredients for the prevention and treatment of type 2 diabetes.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 61-69 CVCL_C410|Hybridoma|Mus musculus denotes Activity
T2 160-161 CVCL_S361|Finite_cell_line|Mus musculus denotes C
T3 197-198 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T4 345-348 CVCL_6758|Undefined_cell_line_type|Cricetulus griseus denotes has
T5 345-348 CVCL_E689|Transformed_cell_line|Homo sapiens denotes has
T6 433-439 CVCL_E025|Induced_pluripotent_stem_cell|Homo sapiens denotes cancer
T7 493-501 CVCL_C410|Hybridoma|Mus musculus denotes activity
T8 552-560 CVCL_C410|Hybridoma|Mus musculus denotes activity
T9 824-832 CVCL_C410|Hybridoma|Mus musculus denotes activity
T10 868-870 CVCL_F566|Transformed_cell_line|Homo sapiens denotes mL
T11 868-870 CVCL_W799|Cancer_cell_line|Homo sapiens denotes mL
T12 918-920 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T13 918-920 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T14 1069-1075 CVCL_C410|Hybridoma|Mus musculus denotes active
T15 1176-1184 CVCL_C410|Hybridoma|Mus musculus denotes activity
T16 1311-1319 CVCL_C410|Hybridoma|Mus musculus denotes activity
T17 1932-1938 CVCL_C410|Hybridoma|Mus musculus denotes active
T18 2037-2040 CVCL_E773|Transformed_cell_line|Homo sapiens denotes may