> top > docs > PubMed:29146903 > annotations

PubMed:29146903 JSONTXT

Annnotations TAB JSON ListView MergeView

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-102 Sentence denotes Wiskott-Aldrich syndrome protein regulates autophagy and inflammasome activity in innate immune cells.
T2 103-217 Sentence denotes Dysregulation of autophagy and inflammasome activity contributes to the development of auto-inflammatory diseases.
T3 218-325 Sentence denotes Emerging evidence highlights the importance of the actin cytoskeleton in modulating inflammatory responses.
T4 326-486 Sentence denotes Here we show that deficiency of Wiskott-Aldrich syndrome protein (WASp), which signals to the actin cytoskeleton, modulates autophagy and inflammasome function.
T5 487-695 Sentence denotes In a model of sterile inflammation utilizing TLR4 ligation followed by ATP or nigericin treatment, inflammasome activation is enhanced in monocytes from WAS patients and in WAS-knockout mouse dendritic cells.
T6 696-1050 Sentence denotes In ex vivo models of enteropathogenic Escherichia coli and Shigella flexneri infection, WASp deficiency causes defective bacterial clearance, excessive inflammasome activation and host cell death that are associated with dysregulated septin cage-like formation, impaired autophagic p62/LC3 recruitment and defective formation of canonical autophagosomes.
T7 1051-1263 Sentence denotes Taken together, we propose that dysregulation of autophagy and inflammasome activities contribute to the autoinflammatory manifestations of WAS, thereby identifying potential targets for therapeutic intervention.
T1 0-102 Sentence denotes Wiskott-Aldrich syndrome protein regulates autophagy and inflammasome activity in innate immune cells.
T2 103-217 Sentence denotes Dysregulation of autophagy and inflammasome activity contributes to the development of auto-inflammatory diseases.
T3 218-325 Sentence denotes Emerging evidence highlights the importance of the actin cytoskeleton in modulating inflammatory responses.
T4 326-486 Sentence denotes Here we show that deficiency of Wiskott-Aldrich syndrome protein (WASp), which signals to the actin cytoskeleton, modulates autophagy and inflammasome function.
T5 487-695 Sentence denotes In a model of sterile inflammation utilizing TLR4 ligation followed by ATP or nigericin treatment, inflammasome activation is enhanced in monocytes from WAS patients and in WAS-knockout mouse dendritic cells.
T6 696-1050 Sentence denotes In ex vivo models of enteropathogenic Escherichia coli and Shigella flexneri infection, WASp deficiency causes defective bacterial clearance, excessive inflammasome activation and host cell death that are associated with dysregulated septin cage-like formation, impaired autophagic p62/LC3 recruitment and defective formation of canonical autophagosomes.
T7 1051-1263 Sentence denotes Taken together, we propose that dysregulation of autophagy and inflammasome activities contribute to the autoinflammatory manifestations of WAS, thereby identifying potential targets for therapeutic intervention.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 982-985 Glycan denotes LC3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G06239NA

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 0-24 Disease denotes Wiskott-Aldrich syndrome http://purl.obolibrary.org/obo/MONDO_0010518
T2 195-216 Disease denotes inflammatory diseases http://purl.obolibrary.org/obo/MONDO_0021166
T3 358-382 Disease denotes Wiskott-Aldrich syndrome http://purl.obolibrary.org/obo/MONDO_0010518
T4 501-508 Disease denotes sterile http://purl.obolibrary.org/obo/MONDO_0005047
T5 509-521 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T6 773-782 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-102 Sentence denotes Wiskott-Aldrich syndrome protein regulates autophagy and inflammasome activity in innate immune cells.
T2 103-217 Sentence denotes Dysregulation of autophagy and inflammasome activity contributes to the development of auto-inflammatory diseases.
T3 218-325 Sentence denotes Emerging evidence highlights the importance of the actin cytoskeleton in modulating inflammatory responses.
T4 326-486 Sentence denotes Here we show that deficiency of Wiskott-Aldrich syndrome protein (WASp), which signals to the actin cytoskeleton, modulates autophagy and inflammasome function.
T5 487-695 Sentence denotes In a model of sterile inflammation utilizing TLR4 ligation followed by ATP or nigericin treatment, inflammasome activation is enhanced in monocytes from WAS patients and in WAS-knockout mouse dendritic cells.
T6 696-1050 Sentence denotes In ex vivo models of enteropathogenic Escherichia coli and Shigella flexneri infection, WASp deficiency causes defective bacterial clearance, excessive inflammasome activation and host cell death that are associated with dysregulated septin cage-like formation, impaired autophagic p62/LC3 recruitment and defective formation of canonical autophagosomes.
T7 1051-1263 Sentence denotes Taken together, we propose that dysregulation of autophagy and inflammasome activities contribute to the autoinflammatory manifestations of WAS, thereby identifying potential targets for therapeutic intervention.

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 0-24 Disease denotes Wiskott-Aldrich syndrome MONDO:0010518
T2 195-216 Disease denotes inflammatory diseases MONDO:0021166
T3 358-382 Disease denotes Wiskott-Aldrich syndrome MONDO:0010518
T4 501-508 Disease denotes sterile MONDO:0005047
T5 773-782 Disease denotes infection MONDO:0005550

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 644-652 Organism denotes patients 9606
T2 673-678 Organism denotes mouse 10088|10090
T4 734-750 Organism denotes Escherichia coli 562
T5 755-772 Organism denotes Shigella flexneri 623

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 89-101 Body_part denotes immune cells http://purl.obolibrary.org/obo/CL_0000738
T2 269-287 Body_part denotes actin cytoskeleton http://purl.obolibrary.org/obo/GO_0015629
T3 420-438 Body_part denotes actin cytoskeleton http://purl.obolibrary.org/obo/GO_0015629
T4 625-634 Body_part denotes monocytes http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T6 679-694 Body_part denotes dendritic cells http://purl.obolibrary.org/obo/CL_0000451

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 269-287 Body_part denotes actin cytoskeleton FMA:84684
T2 420-438 Body_part denotes actin cytoskeleton FMA:84684
T3 625-634 Body_part denotes monocytes FMA:62864
T4 679-694 Body_part denotes dendritic cells FMA:273565
T5 1035-1049 Body_part denotes autophagosomes FMA:0326100

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 673-678 OrganismTaxon denotes mouse 10088|10090
T3 734-750 OrganismTaxon denotes Escherichia coli 562
T4 755-772 OrganismTaxon denotes Shigella flexneri 623

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 89-101 Body_part denotes immune cells http://purl.obolibrary.org/obo/CL_0000738
T2 269-287 Body_part denotes actin cytoskeleton http://purl.obolibrary.org/obo/GO_0015629
T3 420-438 Body_part denotes actin cytoskeleton http://purl.obolibrary.org/obo/GO_0015629
T4 625-634 Body_part denotes monocytes http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T6 679-694 Body_part denotes dendritic cells http://purl.obolibrary.org/obo/CL_0000451

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 89-101 Cell denotes immune cells http://purl.obolibrary.org/obo/CL:0000738
T2 625-634 Cell denotes monocytes http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T4 679-694 Cell denotes dendritic cells http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056