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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-102 Sentence denotes SOX9 predicts progression toward cirrhosis in patients while its loss protects against liver fibrosis.
T2 103-183 Sentence denotes Fibrosis and organ failure is a common endpoint for many chronic liver diseases.
T3 184-307 Sentence denotes Much is known about the upstream inflammatory mechanisms provoking fibrosis and downstream potential for tissue remodeling.
T4 308-437 Sentence denotes However, less is known about the transcriptional regulation in vivo governing fibrotic matrix deposition by liver myofibroblasts.
T5 438-601 Sentence denotes This gap in understanding has hampered molecular predictions of disease severity and clinical progression and restricted targets for antifibrotic drug development.
T6 602-797 Sentence denotes In this study, we show the prevalence of SOX9 in biopsies from patients with chronic liver disease correlated with fibrosis severity and accurately predicted disease progression toward cirrhosis.
T7 798-949 Sentence denotes Inactivation of Sox9 in mice protected against both parenchymal and biliary fibrosis, and improved liver function and ameliorated chronic inflammation.
T8 950-1003 Sentence denotes SOX9 was downstream of mechanosignaling factor, YAP1.
T9 1004-1221 Sentence denotes These data demonstrate a role for SOX9 in liver fibrosis and open the way for the transcription factor and its dependent pathways as new diagnostic, prognostic, and therapeutic targets in patients with liver fibrosis.
T1 0-102 Sentence denotes SOX9 predicts progression toward cirrhosis in patients while its loss protects against liver fibrosis.
T2 103-183 Sentence denotes Fibrosis and organ failure is a common endpoint for many chronic liver diseases.
T3 184-307 Sentence denotes Much is known about the upstream inflammatory mechanisms provoking fibrosis and downstream potential for tissue remodeling.
T4 308-437 Sentence denotes However, less is known about the transcriptional regulation in vivo governing fibrotic matrix deposition by liver myofibroblasts.
T5 438-601 Sentence denotes This gap in understanding has hampered molecular predictions of disease severity and clinical progression and restricted targets for antifibrotic drug development.
T6 602-797 Sentence denotes In this study, we show the prevalence of SOX9 in biopsies from patients with chronic liver disease correlated with fibrosis severity and accurately predicted disease progression toward cirrhosis.
T7 798-949 Sentence denotes Inactivation of Sox9 in mice protected against both parenchymal and biliary fibrosis, and improved liver function and ameliorated chronic inflammation.
T8 950-1003 Sentence denotes SOX9 was downstream of mechanosignaling factor, YAP1.
T9 1004-1221 Sentence denotes These data demonstrate a role for SOX9 in liver fibrosis and open the way for the transcription factor and its dependent pathways as new diagnostic, prognostic, and therapeutic targets in patients with liver fibrosis.