PubMed:29099167
Annnotations
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 115-128 | Disease | denotes | Fabry Disease | http://purl.obolibrary.org/obo/MONDO_0010526 |
| T2 | 139-152 | Disease | denotes | Fabry disease | http://purl.obolibrary.org/obo/MONDO_0010526 |
| T3 | 168-194 | Disease | denotes | lysosomal storage disorder | http://purl.obolibrary.org/obo/MONDO_0002561 |
| T4 | 345-348 | Disease | denotes | Ga2 | http://purl.obolibrary.org/obo/MONDO_0009282 |
| T5 | 590-603 | Disease | denotes | Fabry disease | http://purl.obolibrary.org/obo/MONDO_0010526 |
| T6 | 649-652 | Disease | denotes | Ga2 | http://purl.obolibrary.org/obo/MONDO_0009282 |
| T7 | 928-931 | Disease | denotes | Ga2 | http://purl.obolibrary.org/obo/MONDO_0009282 |
| T8 | 1153-1156 | Disease | denotes | Ga2 | http://purl.obolibrary.org/obo/MONDO_0009282 |
| T9 | 1463-1466 | Disease | denotes | Ga2 | http://purl.obolibrary.org/obo/MONDO_0009282 |
| T10 | 1625-1628 | Disease | denotes | Ga2 | http://purl.obolibrary.org/obo/MONDO_0009282 |
| T11 | 1694-1697 | Disease | denotes | Ga2 | http://purl.obolibrary.org/obo/MONDO_0009282 |
| T12 | 1868-1881 | Disease | denotes | Fabry disease | http://purl.obolibrary.org/obo/MONDO_0010526 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 27-43 | Glycan | denotes | Lactosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T2 | 45-63 | Glycan | denotes | Galabiosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G67988RO |
| T3 | 325-343 | Glycan | denotes | galabiosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G67988RO |
| T4 | 374-377 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T5 | 415-418 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T6 | 711-727 | Glycan | denotes | lactosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T7 | 729-735 | Glycan | denotes | LacCer | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T8 | 962-978 | Glycan | denotes | lactosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T9 | 1082-1085 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T10 | 1472-1478 | Glycan | denotes | LacCer | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T11 | 1650-1653 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T12 | 1714-1717 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T13 | 1747-1753 | Glycan | denotes | LacCer | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T14 | 1833-1839 | Glycan | denotes | LacCer | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 27-43 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Lactosylceramide | http://www.glycoepitope.jp/epitopes/EP0078 |
| T2 | 45-63 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Galabiosylceramide | http://www.glycoepitope.jp/epitopes/EP0113 |
| T3 | 325-343 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | galabiosylceramide | http://www.glycoepitope.jp/epitopes/EP0113 |
| T4 | 374-377 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T5 | 415-418 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T6 | 711-727 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | lactosylceramide | http://www.glycoepitope.jp/epitopes/EP0078 |
| T7 | 729-735 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | LacCer | http://www.glycoepitope.jp/epitopes/EP0078 |
| T8 | 962-978 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | lactosylceramide | http://www.glycoepitope.jp/epitopes/EP0078 |
| T9 | 1082-1085 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T10 | 1472-1478 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | LacCer | http://www.glycoepitope.jp/epitopes/EP0078 |
| T11 | 1650-1653 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T12 | 1714-1717 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T13 | 1747-1753 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | LacCer | http://www.glycoepitope.jp/epitopes/EP0078 |
| T14 | 1833-1839 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | LacCer | http://www.glycoepitope.jp/epitopes/EP0078 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 115-128 | Disease | denotes | Fabry Disease | http://purl.obolibrary.org/obo/MONDO_0010526 |
| T2 | 139-152 | Disease | denotes | Fabry disease | http://purl.obolibrary.org/obo/MONDO_0010526 |
| T3 | 168-194 | Disease | denotes | lysosomal storage disorder | http://purl.obolibrary.org/obo/MONDO_0002561 |
| T4 | 345-348 | Disease | denotes | Ga2 | http://purl.obolibrary.org/obo/MONDO_0009282 |
| T5 | 590-603 | Disease | denotes | Fabry disease | http://purl.obolibrary.org/obo/MONDO_0010526 |
| T6 | 649-652 | Disease | denotes | Ga2 | http://purl.obolibrary.org/obo/MONDO_0009282 |
| T7 | 928-931 | Disease | denotes | Ga2 | http://purl.obolibrary.org/obo/MONDO_0009282 |
| T8 | 1153-1156 | Disease | denotes | Ga2 | http://purl.obolibrary.org/obo/MONDO_0009282 |
| T9 | 1463-1466 | Disease | denotes | Ga2 | http://purl.obolibrary.org/obo/MONDO_0009282 |
| T10 | 1625-1628 | Disease | denotes | Ga2 | http://purl.obolibrary.org/obo/MONDO_0009282 |
| T11 | 1694-1697 | Disease | denotes | Ga2 | http://purl.obolibrary.org/obo/MONDO_0009282 |
| T12 | 1868-1881 | Disease | denotes | Fabry disease | http://purl.obolibrary.org/obo/MONDO_0010526 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 106-111 | Body_part | denotes | Urine | http://purl.obolibrary.org/obo/UBERON_0001088 |
| T2 | 469-474 | Body_part | denotes | Urine | http://purl.obolibrary.org/obo/UBERON_0001088 |
| T3 | 479-485 | Body_part | denotes | plasma | http://purl.obolibrary.org/obo/UBERON_0001969 |
| T4 | 1024-1029 | Body_part | denotes | urine | http://purl.obolibrary.org/obo/UBERON_0001088 |
| T5 | 1219-1224 | Body_part | denotes | Urine | http://purl.obolibrary.org/obo/UBERON_0001088 |
| T6 | 1741-1746 | Body_part | denotes | urine | http://purl.obolibrary.org/obo/UBERON_0001088 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 106-111 | Body_part | denotes | Urine | http://purl.obolibrary.org/obo/MAT_0000058 |
| T2 | 469-474 | Body_part | denotes | Urine | http://purl.obolibrary.org/obo/MAT_0000058 |
| T3 | 1024-1029 | Body_part | denotes | urine | http://purl.obolibrary.org/obo/MAT_0000058 |
| T4 | 1219-1224 | Body_part | denotes | Urine | http://purl.obolibrary.org/obo/MAT_0000058 |
| T5 | 1277-1282 | Body_part | denotes | males | http://purl.obolibrary.org/obo/MAT_0000029 |
| T6 | 1392-1396 | Body_part | denotes | male | http://purl.obolibrary.org/obo/MAT_0000029 |
| T7 | 1741-1746 | Body_part | denotes | urine | http://purl.obolibrary.org/obo/MAT_0000058 |
| T8 | 1816-1821 | Body_part | denotes | males | http://purl.obolibrary.org/obo/MAT_0000029 |
| T9 | 1891-1896 | Body_part | denotes | males | http://purl.obolibrary.org/obo/MAT_0000029 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-138 | Sentence | denotes | Separation and Analysis of Lactosylceramide, Galabiosylceramide, and Globotriaosylceramide by LC-MS/MS in Urine of Fabry Disease Patients. |
| T2 | 139-244 | Sentence | denotes | Fabry disease is an X-linked lysosomal storage disorder caused by α-galactosidase A (α-GAL A) deficiency. |
| T3 | 245-468 | Sentence | denotes | This enzyme contributes to the cellular recycling of glycosphingolipids such as galabiosylceramide (Ga2), globotriaosylceramide (Gb3), and globotriaosylsphingosine (lyso-Gb3) by hydrolyzing the terminal α-galactosyl moiety. |
| T4 | 469-613 | Sentence | denotes | Urine and plasma α-GAL A substrates are currently analyzed as biomarkers for the detection, monitoring, and follow-up of Fabry disease patients. |
| T5 | 614-772 | Sentence | denotes | The sensitivity of the analysis of Ga2 is decreased by the co-analysis of its structural isomer, lactosylceramide (LacCer), which is not an α-GAL A substrate. |
| T6 | 773-1030 | Sentence | denotes | A normal-phase ultraperformance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS) methodology, allowing the baseline separation of 12 Ga2 isoforms/analogues from their lactosylceramide counterparts, was developed and validated in urine. |
| T7 | 1031-1218 | Sentence | denotes | The method was multiplexed with the analysis of 12 Gb3 isoforms/analogues having the same fatty acid moieties as those of Ga2 for comparison, and with creatinine for sample normalization. |
| T8 | 1219-1428 | Sentence | denotes | Urine samples were studied from 34 untreated and 33 Fabry males treated by enzyme replacement therapy (ERT) and 54 untreated and 19 ERT-treated Fabry females, along with 34 male and 25 female healthy controls. |
| T9 | 1429-1538 | Sentence | denotes | The chromatographic separation of Ga2 from LacCer increased the sensitivity of analysis, especially in women. |
| T10 | 1539-1718 | Sentence | denotes | One untreated Fabry female and two treated Fabry females presented abnormal levels of Ga2 but normal levels of Gb3, supporting the importance of analyzing Ga2, in addition to Gb3. |
| T11 | 1719-1822 | Sentence | denotes | Our results show that urine LacCer levels from females were significantly higher than those from males. |
| T12 | 1823-1909 | Sentence | denotes | Moreover, LacCer levels were not affected by Fabry disease for both males and females. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 27-43 | Glycan | denotes | Lactosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T2 | 45-63 | Glycan | denotes | Galabiosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G67988RO |
| T3 | 325-343 | Glycan | denotes | galabiosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G67988RO |
| T4 | 374-377 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T5 | 415-418 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T6 | 711-727 | Glycan | denotes | lactosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T7 | 729-735 | Glycan | denotes | LacCer | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T8 | 962-978 | Glycan | denotes | lactosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T9 | 1082-1085 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T10 | 1472-1478 | Glycan | denotes | LacCer | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T11 | 1650-1653 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T12 | 1714-1717 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T13 | 1747-1753 | Glycan | denotes | LacCer | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T14 | 1833-1839 | Glycan | denotes | LacCer | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 27-43 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Lactosylceramide | http://www.glycoepitope.jp/epitopes/EP0078 |
| T2 | 45-63 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Galabiosylceramide | http://www.glycoepitope.jp/epitopes/EP0113 |
| T3 | 325-343 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | galabiosylceramide | http://www.glycoepitope.jp/epitopes/EP0113 |
| T4 | 374-377 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T5 | 415-418 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T6 | 711-727 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | lactosylceramide | http://www.glycoepitope.jp/epitopes/EP0078 |
| T7 | 729-735 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | LacCer | http://www.glycoepitope.jp/epitopes/EP0078 |
| T8 | 962-978 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | lactosylceramide | http://www.glycoepitope.jp/epitopes/EP0078 |
| T9 | 1082-1085 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T10 | 1472-1478 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | LacCer | http://www.glycoepitope.jp/epitopes/EP0078 |
| T11 | 1650-1653 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T12 | 1714-1717 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T13 | 1747-1753 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | LacCer | http://www.glycoepitope.jp/epitopes/EP0078 |
| T14 | 1833-1839 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | LacCer | http://www.glycoepitope.jp/epitopes/EP0078 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 106-111 | Body_part | denotes | Urine | http://purl.obolibrary.org/obo/MAT_0000058 |
| T2 | 469-474 | Body_part | denotes | Urine | http://purl.obolibrary.org/obo/MAT_0000058 |
| T3 | 1024-1029 | Body_part | denotes | urine | http://purl.obolibrary.org/obo/MAT_0000058 |
| T4 | 1219-1224 | Body_part | denotes | Urine | http://purl.obolibrary.org/obo/MAT_0000058 |
| T5 | 1277-1282 | Body_part | denotes | males | http://purl.obolibrary.org/obo/MAT_0000029 |
| T6 | 1392-1396 | Body_part | denotes | male | http://purl.obolibrary.org/obo/MAT_0000029 |
| T7 | 1741-1746 | Body_part | denotes | urine | http://purl.obolibrary.org/obo/MAT_0000058 |
| T8 | 1816-1821 | Body_part | denotes | males | http://purl.obolibrary.org/obo/MAT_0000029 |
| T9 | 1891-1896 | Body_part | denotes | males | http://purl.obolibrary.org/obo/MAT_0000029 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 106-111 | Body_part | denotes | Urine | http://purl.obolibrary.org/obo/UBERON_0001088 |
| T2 | 469-474 | Body_part | denotes | Urine | http://purl.obolibrary.org/obo/UBERON_0001088 |
| T3 | 479-485 | Body_part | denotes | plasma | http://purl.obolibrary.org/obo/UBERON_0001969 |
| T4 | 1024-1029 | Body_part | denotes | urine | http://purl.obolibrary.org/obo/UBERON_0001088 |
| T5 | 1219-1224 | Body_part | denotes | Urine | http://purl.obolibrary.org/obo/UBERON_0001088 |
| T6 | 1741-1746 | Body_part | denotes | urine | http://purl.obolibrary.org/obo/UBERON_0001088 |