| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
117-212 |
DRI_Background |
denotes |
Alzheimer's disease (AD) is the most common form of irreversible dementia among elderly people. |
| T2 |
213-434 |
DRI_Background |
denotes |
In the postmortem brains of AD patients, the deposition of senile plaques composed of β-amyloid (Aβ) peptides and neurofibrillary tangles composed of highly phosphorylated tau proteins are two neuropathological hallmarks. |
| T3 |
435-686 |
DRI_Background |
denotes |
Therefore, the in vivo imaging of Aβ and tau aggregates with positron-emission tomography (PET) or single-photon emission computed tomography (SPECT) would promote drug development, early diagnosis, and monitoring of the disease status in AD patients. |
| T4 |
687-772 |
DRI_Approach |
denotes |
In this study, we designed and synthesized novel Aβ and tau imaging probes for SPECT. |
| T5 |
773-871 |
DRI_Background |
denotes |
[(125)I]PBOX-3, developed as an Aβ imaging probe, showed high affinity for Aβ aggregates in vitro. |
| T6 |
872-1024 |
DRI_Background |
denotes |
A SPECT/CT study with [(123)I]PBOX-3 revealed a higher level of radioactivity in a Tg2576 mouse, which is the AD model mouse, than in a wild-type mouse. |
| T7 |
1025-1180 |
DRI_Background |
denotes |
In addition, ex vivo autoradiograms of brain sections from a Tg2576 mouse after the injection of [(123)I]PBOX-3 showed the selective binding of Aβ plaques. |
| T8 |
1181-1300 |
DRI_Background |
denotes |
BIP-NMe2, developed as a tau imaging probe, showed high and selective affinity for tau aggregates in AD brain sections. |
| T9 |
1301-1520 |
DRI_Outcome |
denotes |
In addition, [(125)I]BIP-NMe2 displayed high initial uptake into, and fast washout from, the normal mouse brain, suggesting that [(125)I]BIP-NMe2 has favorable pharmacokinetics for the in vivo imaging of tau aggregates. |
| T10 |
1521-1626 |
DRI_Approach |
denotes |
Taken together, we successfully developed an Aβ imaging probe, PBOX-3, and a tau imaging probe, BIP-NMe2. |
| T11 |
1627-1739 |
DRI_Background |
denotes |
These probes may be used to develop novel methods for the diagnosis, treatment and monitoring of AD progression. |
