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PubMed:29093350 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-129 Sentence denotes In Vivo Microdialysis for Dynamic Monitoring of the Effectiveness of Nano-liposomes as Vehicles for Topical Psoralen Application.
T2 130-245 Sentence denotes In this study, the skin permeation of liposomes containing psoralen was investigated by in vivo skin microdialysis.
T3 246-454 Sentence denotes Psoralen-loaded nano-sized liposomes were prepared with a mean size of 117.5 nm and a polydispersity index of 0.21, indicating the uniform dispersion of phosphatidylcholine vesicles in the liposomal solution.
T4 455-672 Sentence denotes Based on in vivo microdialysis experiments, the drug concentration in local deep skin of rat increased rapidly and reached a peak concentration (Cmax) of 319.35±23.72 µg/mL at 180 min, and decreased slowly thereafter.
T5 673-790 Sentence denotes The local area under the concentration-time curve (AUC)0-t was 3.81-fold higher than the compared aqueous suspension.
T6 791-995 Sentence denotes The in vivo systemic pharmacokinetics were in agreement with the microdialysis results, in view of the Cmax and AUC0-t from liposomal group were both significantly higher (p<0.05) than the compared group.
T7 996-1119 Sentence denotes Liposome-associated transdermal psoralen delivery was significantly more effective than delivery via an aqueous suspension.
T8 1120-1326 Sentence denotes The enhanced skin permeability may be associated with improved skin hydration, lipid exchange and fusion with the stratum corneum (SC), and changes in SC structure, promoting drug permeation into deep skin.
T9 1327-1470 Sentence denotes After 10 h of treatment with the perfusate, the microstructure of the microdialysis probe exhibited no obvious differences with control probes.
T10 1471-1555 Sentence denotes The skin surface and the tissue around the probe showed no swelling or inflammation.
T11 1556-1834 Sentence denotes These findings indicated that liposomes effectively enhanced the skin deposition of psoralen and showed good biocompatibility with skin tissues; additionally, ethanol at a low concentration in ringer's solution is an alternative perfusate for in vivo skin microdialysis studies.
T1 0-129 Sentence denotes In Vivo Microdialysis for Dynamic Monitoring of the Effectiveness of Nano-liposomes as Vehicles for Topical Psoralen Application.
T2 130-245 Sentence denotes In this study, the skin permeation of liposomes containing psoralen was investigated by in vivo skin microdialysis.
T3 246-454 Sentence denotes Psoralen-loaded nano-sized liposomes were prepared with a mean size of 117.5 nm and a polydispersity index of 0.21, indicating the uniform dispersion of phosphatidylcholine vesicles in the liposomal solution.
T4 455-672 Sentence denotes Based on in vivo microdialysis experiments, the drug concentration in local deep skin of rat increased rapidly and reached a peak concentration (Cmax) of 319.35±23.72 µg/mL at 180 min, and decreased slowly thereafter.
T5 673-790 Sentence denotes The local area under the concentration-time curve (AUC)0-t was 3.81-fold higher than the compared aqueous suspension.
T6 791-995 Sentence denotes The in vivo systemic pharmacokinetics were in agreement with the microdialysis results, in view of the Cmax and AUC0-t from liposomal group were both significantly higher (p<0.05) than the compared group.
T7 996-1119 Sentence denotes Liposome-associated transdermal psoralen delivery was significantly more effective than delivery via an aqueous suspension.
T8 1120-1326 Sentence denotes The enhanced skin permeability may be associated with improved skin hydration, lipid exchange and fusion with the stratum corneum (SC), and changes in SC structure, promoting drug permeation into deep skin.
T9 1327-1470 Sentence denotes After 10 h of treatment with the perfusate, the microstructure of the microdialysis probe exhibited no obvious differences with control probes.
T10 1471-1555 Sentence denotes The skin surface and the tissue around the probe showed no swelling or inflammation.
T11 1556-1834 Sentence denotes These findings indicated that liposomes effectively enhanced the skin deposition of psoralen and showed good biocompatibility with skin tissues; additionally, ethanol at a low concentration in ringer's solution is an alternative perfusate for in vivo skin microdialysis studies.