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PubMed:29052990 JSONTXT

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mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 38-47 Disease denotes Influenza http://purl.obolibrary.org/obo/MONDO_0005812
T2 223-232 Disease denotes Influenza http://purl.obolibrary.org/obo/MONDO_0005812
T3 445-454 Disease denotes Influenza http://purl.obolibrary.org/obo/MONDO_0005812
T4 1592-1601 Disease denotes Influenza http://purl.obolibrary.org/obo/MONDO_0005812

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 74-80 Glycan denotes LacNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR
T2 958-964 Glycan denotes LacNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR
T3 1658-1664 Glycan denotes LacNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 38-55 OrganismTaxon denotes Influenza A Virus 11320
T2 223-240 OrganismTaxon denotes Influenza A virus 11320
T3 1592-1609 OrganismTaxon denotes Influenza A virus 11320

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-66 Sentence denotes Spatial Screening of Hemagglutinin on Influenza A Virus Particles:
T2 67-204 Sentence denotes Sialyl-LacNAc Displays on DNA and PEG Scaffolds Reveal the Requirements for Bivalency Enhanced Interactions with Weak Monovalent Binders.
T3 205-371 Sentence denotes Attachment of the Influenza A virus onto host cells involves multivalent interactions between virus surface hemagglutinin (HA) and sialoside-containing glyco ligands.
T4 372-627 Sentence denotes Despite the development of extremely powerful multivalent binders of the Influenza virus and other viruses, comparably little is known about the optimal spacing of HA ligands, which ought to bridge binding sites within or across the trimeric HA molecules.
T5 628-913 Sentence denotes To explore the criteria for ligand economical high affinity binding, we systematically probed distance-affinity relationships by means of two differently behaving scaffold types based on (i) flexible polyethylene glycol (PEG) conjugates and (ii) rigid self-assembled DNA·PNA complexes.
T6 914-994 Sentence denotes The bivalent scaffolds presented two sialyl-LacNAc ligands in 23-101 Å distance.
T7 995-1164 Sentence denotes A combined analysis of binding by means of microscale thermophoresis measurements and statistical mechanics models exposed the inherent limitations of PEG-based spacers.
T8 1165-1377 Sentence denotes Given the distance requirements of HA, the flexibility of PEG scaffolds is too high to raise the effective concentration of glyco ligands above a value that allows interactions with the low affinity binding site.
T9 1378-1672 Sentence denotes By contrast, spatial screening with less flexible, self-assembled peptide nucleic acid (PNA)·DNA complexes uncovered a well-defined and, surprisingly, bimodal distance-affinity relationship for interactions of the Influenza A virus HA with bivalent displays of the natural sialyl-LacNAc ligand.
T10 1673-1754 Sentence denotes Optimal constructs conferred 103-fold binding enhancements with only two ligands.
T11 1755-1934 Sentence denotes We discuss the existence of secondary binding sites and shine light on the preference for intramolecular rather than intermolecular recognition of HA trimers on the virus surface.

GlyCosmos15-Lectin-Jamboree

Id Subject Object Predicate Lexical cue glycosmos_id
T1 1466-1469 Lectin denotes PNA GL_003655

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 38-47 Disease denotes Influenza MONDO:0005812
T2 223-232 Disease denotes Influenza MONDO:0005812
T3 445-454 Disease denotes Influenza MONDO:0005812
T4 1592-1601 Disease denotes Influenza MONDO:0005812

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 38-55 OrganismTaxon denotes Influenza A Virus 11320
T2 223-240 OrganismTaxon denotes Influenza A virus 11320
T3 1592-1609 OrganismTaxon denotes Influenza A virus 11320

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 74-80 Glycan denotes LacNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR
T2 958-964 Glycan denotes LacNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR
T3 1658-1664 Glycan denotes LacNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR