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PubMed:29045486 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-124 Sentence denotes Thiamine deficiency activates hypoxia inducible factor-1α to facilitate pro-apoptotic responses in mouse primary astrocytes.
T2 125-270 Sentence denotes Thiamine is an essential enzyme cofactor required for proper metabolic function and maintenance of metabolism and energy production in the brain.
T3 271-477 Sentence denotes In developed countries, thiamine deficiency (TD) is most often manifested following chronic alcohol consumption leading to impaired mitochondrial function, oxidative stress, inflammation and excitotoxicity.
T4 478-566 Sentence denotes These biochemical lesions result in apoptotic cell death in both neurons and astrocytes.
T5 567-773 Sentence denotes Comparable histological injuries in patients with hypoxia/ischemia and TD have been described in the thalamus and mammillary bodies, suggesting a congruency between the cellular responses to these stresses.
T6 774-907 Sentence denotes Consistent with hypoxia/ischemia, TD stabilizes and activates Hypoxia Inducible Factor-1α (HIF-1α) under physiological oxygen levels.
T7 908-991 Sentence denotes However, the role of TD-induced HIF-1α in neurological injury is currently unknown.
T8 992-1128 Sentence denotes Using Western blot analysis and RT-PCR, we have demonstrated that TD induces HIF-1α expression and activity in primary mouse astrocytes.
T9 1129-1296 Sentence denotes We observed a time-dependent increase in mRNA and protein expression of the pro-apoptotic and pro-inflammatory HIF-1α target genes MCP1, BNIP3, Nix and Noxa during TD.
T10 1297-1417 Sentence denotes We also observed apoptotic cell death in TD as demonstrated by PI/Annexin V staining, TUNEL assay, and Cell Death ELISA.
T11 1418-1589 Sentence denotes Pharmacological inhibition of HIF-1α activity using YC1 and thiamine repletion both reduced expression of pro-apoptotic HIF-1α target genes and apoptotic cell death in TD.
T12 1590-1783 Sentence denotes These results demonstrate that induction of HIF-1α mediated transcriptional up-regulation of pro-apoptotic/inflammatory signaling contributes to astrocyte cell death during thiamine deficiency.
T1 0-124 Sentence denotes Thiamine deficiency activates hypoxia inducible factor-1α to facilitate pro-apoptotic responses in mouse primary astrocytes.
T2 125-270 Sentence denotes Thiamine is an essential enzyme cofactor required for proper metabolic function and maintenance of metabolism and energy production in the brain.
T3 271-477 Sentence denotes In developed countries, thiamine deficiency (TD) is most often manifested following chronic alcohol consumption leading to impaired mitochondrial function, oxidative stress, inflammation and excitotoxicity.
T4 478-566 Sentence denotes These biochemical lesions result in apoptotic cell death in both neurons and astrocytes.
T5 567-773 Sentence denotes Comparable histological injuries in patients with hypoxia/ischemia and TD have been described in the thalamus and mammillary bodies, suggesting a congruency between the cellular responses to these stresses.
T6 774-907 Sentence denotes Consistent with hypoxia/ischemia, TD stabilizes and activates Hypoxia Inducible Factor-1α (HIF-1α) under physiological oxygen levels.
T7 908-991 Sentence denotes However, the role of TD-induced HIF-1α in neurological injury is currently unknown.
T8 992-1128 Sentence denotes Using Western blot analysis and RT-PCR, we have demonstrated that TD induces HIF-1α expression and activity in primary mouse astrocytes.
T9 1129-1296 Sentence denotes We observed a time-dependent increase in mRNA and protein expression of the pro-apoptotic and pro-inflammatory HIF-1α target genes MCP1, BNIP3, Nix and Noxa during TD.
T10 1297-1417 Sentence denotes We also observed apoptotic cell death in TD as demonstrated by PI/Annexin V staining, TUNEL assay, and Cell Death ELISA.
T11 1418-1589 Sentence denotes Pharmacological inhibition of HIF-1α activity using YC1 and thiamine repletion both reduced expression of pro-apoptotic HIF-1α target genes and apoptotic cell death in TD.
T12 1590-1783 Sentence denotes These results demonstrate that induction of HIF-1α mediated transcriptional up-regulation of pro-apoptotic/inflammatory signaling contributes to astrocyte cell death during thiamine deficiency.

TEST-DiseaseOrPhenotypicFeature

Id Subject Object Predicate Lexical cue #label
T1 0-19 DiseaseOrPhenotypicFeature denotes Thiamine deficiency D013832
T2 30-37 DiseaseOrPhenotypicFeature denotes hypoxia D000860
T3 295-314 DiseaseOrPhenotypicFeature denotes thiamine deficiency D013832
T4 316-318 DiseaseOrPhenotypicFeature denotes TD D013832
T5 445-457 DiseaseOrPhenotypicFeature denotes inflammation D007249
T6 591-599 DiseaseOrPhenotypicFeature denotes injuries D014947
T7 617-624 DiseaseOrPhenotypicFeature denotes hypoxia D000860
T8 625-633 DiseaseOrPhenotypicFeature denotes ischemia D007511
T9 638-640 DiseaseOrPhenotypicFeature denotes TD D013832
T10 790-797 DiseaseOrPhenotypicFeature denotes hypoxia D000860
T11 798-806 DiseaseOrPhenotypicFeature denotes ischemia D007511
T12 808-810 DiseaseOrPhenotypicFeature denotes TD D013832
T13 836-843 DiseaseOrPhenotypicFeature denotes Hypoxia D000860
T14 929-931 DiseaseOrPhenotypicFeature denotes TD D013832
T15 1058-1060 DiseaseOrPhenotypicFeature denotes TD D013832
T16 1223-1239 DiseaseOrPhenotypicFeature denotes pro-inflammatory DISEASE
T17 1293-1295 DiseaseOrPhenotypicFeature denotes TD D013832
T18 1338-1340 DiseaseOrPhenotypicFeature denotes TD D013832
T19 1586-1588 DiseaseOrPhenotypicFeature denotes TD D013832
T20 1763-1782 DiseaseOrPhenotypicFeature denotes thiamine deficiency D013832

TEST-ChemicalEntity

Id Subject Object Predicate Lexical cue ID:
T1 0-8 ChemicalEntity denotes Thiamine http://purl.obolibrary.org/obo/CHEBI_18385
T2 125-133 ChemicalEntity denotes Thiamine http://purl.obolibrary.org/obo/CHEBI_18385
T3 150-165 ChemicalEntity denotes enzyme cofactor D003067
T4 295-303 ChemicalEntity denotes thiamine D013831|http://purl.obolibrary.org/obo/CHEBI_33283|http://purl.obolibrary.org/obo/CHEBI_26948|http://purl.obolibrary.org/obo/CHEBI_18385
T8 363-370 ChemicalEntity denotes alcohol http://purl.obolibrary.org/obo/CHEBI_30879|http://purl.obolibrary.org/obo/CHEBI_16236|ChemicalEntity
T11 893-899 ChemicalEntity denotes oxygen D010100|http://purl.obolibrary.org/obo/CHEBI_25805
T13 1478-1486 ChemicalEntity denotes thiamine D013831|http://purl.obolibrary.org/obo/CHEBI_33283|http://purl.obolibrary.org/obo/CHEBI_26948|http://purl.obolibrary.org/obo/CHEBI_18385
T17 1763-1771 ChemicalEntity denotes thiamine D013831|http://purl.obolibrary.org/obo/CHEBI_33283|http://purl.obolibrary.org/obo/CHEBI_26948|http://purl.obolibrary.org/obo/CHEBI_18385

TEST-OrganismTaxon

Id Subject Object Predicate Lexical cue
T1 99-104 OrganismTaxon denotes mouse
T2 603-611 OrganismTaxon denotes patients
T3 1111-1116 OrganismTaxon denotes mouse

Test-GeneOrGeneProduct

Id Subject Object Predicate Lexical cue
T1 30-54 GeneOrGeneProduct denotes hypoxia inducible factor
T2 836-860 GeneOrGeneProduct denotes Hypoxia Inducible Factor
T3 865-871 GeneOrGeneProduct denotes HIF-1α
T4 940-946 GeneOrGeneProduct denotes HIF-1α
T5 1069-1075 GeneOrGeneProduct denotes HIF-1α
T6 1179-1197 GeneOrGeneProduct denotes protein expression
T7 1240-1246 GeneOrGeneProduct denotes HIF-1α
T8 1260-1264 GeneOrGeneProduct denotes MCP1
T9 1266-1271 GeneOrGeneProduct denotes BNIP3
T10 1281-1285 GeneOrGeneProduct denotes Noxa
T11 1363-1372 GeneOrGeneProduct denotes Annexin V
T12 1448-1454 GeneOrGeneProduct denotes HIF-1α
T13 1538-1544 GeneOrGeneProduct denotes HIF-1α
T14 1634-1640 GeneOrGeneProduct denotes HIF-1α

Test-merged-2

Id Subject Object Predicate Lexical cue #label ID:
T69710 0-8 ChemicalEntity denotes Thiamine http://purl.obolibrary.org/obo/CHEBI_18385
T12919 125-133 ChemicalEntity denotes Thiamine http://purl.obolibrary.org/obo/CHEBI_18385
T93697 150-165 ChemicalEntity denotes enzyme cofactor D003067
T78094 295-303 ChemicalEntity denotes thiamine D013831|http://purl.obolibrary.org/obo/CHEBI_33283|http://purl.obolibrary.org/obo/CHEBI_26948|http://purl.obolibrary.org/obo/CHEBI_18385
T38510 363-370 ChemicalEntity denotes alcohol http://purl.obolibrary.org/obo/CHEBI_30879|http://purl.obolibrary.org/obo/CHEBI_16236|ChemicalEntity
T73918 893-899 ChemicalEntity denotes oxygen D010100|http://purl.obolibrary.org/obo/CHEBI_25805
T43353 1478-1486 ChemicalEntity denotes thiamine D013831|http://purl.obolibrary.org/obo/CHEBI_33283|http://purl.obolibrary.org/obo/CHEBI_26948|http://purl.obolibrary.org/obo/CHEBI_18385
T70548 1763-1771 ChemicalEntity denotes thiamine D013831|http://purl.obolibrary.org/obo/CHEBI_33283|http://purl.obolibrary.org/obo/CHEBI_26948|http://purl.obolibrary.org/obo/CHEBI_18385
T57056 30-54 GeneOrGeneProduct denotes hypoxia inducible factor
T59116 836-860 GeneOrGeneProduct denotes Hypoxia Inducible Factor
T82673 865-871 GeneOrGeneProduct denotes HIF-1α
T97172 940-946 GeneOrGeneProduct denotes HIF-1α
T46766 1069-1075 GeneOrGeneProduct denotes HIF-1α
T2643 1179-1197 GeneOrGeneProduct denotes protein expression
T50236 1240-1246 GeneOrGeneProduct denotes HIF-1α
T73119 1260-1264 GeneOrGeneProduct denotes MCP1
T43848 1266-1271 GeneOrGeneProduct denotes BNIP3
T71558 1281-1285 GeneOrGeneProduct denotes Noxa
T28237 1363-1372 GeneOrGeneProduct denotes Annexin V
T90401 1448-1454 GeneOrGeneProduct denotes HIF-1α
T42948 1538-1544 GeneOrGeneProduct denotes HIF-1α
T95548 1634-1640 GeneOrGeneProduct denotes HIF-1α
T82670 99-104 OrganismTaxon denotes mouse
T53964 603-611 OrganismTaxon denotes patients
T38186 1111-1116 OrganismTaxon denotes mouse
T1 0-19 DiseaseOrPhenotypicFeature denotes Thiamine deficiency D013832
T2 30-37 DiseaseOrPhenotypicFeature denotes hypoxia D000860
T3 295-314 DiseaseOrPhenotypicFeature denotes thiamine deficiency D013832
T4 316-318 DiseaseOrPhenotypicFeature denotes TD D013832
T5 445-457 DiseaseOrPhenotypicFeature denotes inflammation D007249
T6 591-599 DiseaseOrPhenotypicFeature denotes injuries D014947
T7 617-624 DiseaseOrPhenotypicFeature denotes hypoxia D000860
T8 625-633 DiseaseOrPhenotypicFeature denotes ischemia D007511
T9 638-640 DiseaseOrPhenotypicFeature denotes TD D013832
T10 790-797 DiseaseOrPhenotypicFeature denotes hypoxia D000860
T11 798-806 DiseaseOrPhenotypicFeature denotes ischemia D007511
T12 808-810 DiseaseOrPhenotypicFeature denotes TD D013832
T13 836-843 DiseaseOrPhenotypicFeature denotes Hypoxia D000860
T14 929-931 DiseaseOrPhenotypicFeature denotes TD D013832
T15 1058-1060 DiseaseOrPhenotypicFeature denotes TD D013832
T16 1223-1239 DiseaseOrPhenotypicFeature denotes pro-inflammatory DISEASE
T17 1293-1295 DiseaseOrPhenotypicFeature denotes TD D013832
T18 1338-1340 DiseaseOrPhenotypicFeature denotes TD D013832
T19 1586-1588 DiseaseOrPhenotypicFeature denotes TD D013832
T20 1763-1782 DiseaseOrPhenotypicFeature denotes thiamine deficiency D013832