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PubMed:28973141 JSONTXT

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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 378-388 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T3 619-640 Cell denotes embryonic fibroblasts http://purl.obolibrary.org/obo/CL:2000042

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 5-11 Glycan_Motif denotes fucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G82576YO
T2 233-239 Glycan_Motif denotes fucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G82576YO
T3 500-506 Glycan_Motif denotes fucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G82576YO

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 5-11 https://glytoucan.org/Structures/Glycans/G82576YO denotes fucose
T2 233-239 https://glytoucan.org/Structures/Glycans/G82576YO denotes fucose
T3 500-506 https://glytoucan.org/Structures/Glycans/G82576YO denotes fucose

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-74 Sentence denotes Core fucose is critical for CD14-dependent Toll-like receptor 4 signaling.
TextSentencer_T2 75-227 Sentence denotes Core fucosylation, a posttranslational modification of N-glycans, modifies several growth factor receptors and impacts on their ligand binding affinity.
TextSentencer_T3 228-458 Sentence denotes Core-fucose-deficient mice generated by ablating the α1,6 fucosyltransferase enzyme, Fut8, exhibit severe pulmonary emphysema, partly due to impaired macrophage function, similar to aged Toll-like receptor 4 (Tlr4)-deficient mice.
TextSentencer_T4 459-552 Sentence denotes We therefore suspect that a lack of core fucose affects the TLR4-dependent signaling pathway.
TextSentencer_T5 553-770 Sentence denotes Indeed, upon lipopolysaccharide stimulation, Fut8-deficient mouse embryonic fibroblasts (MEFs) produced similar levels of interleukin-6 but markedly reduced levels of interferon-β (IFN-β) compared with wild-type MEFs.
TextSentencer_T6 771-885 Sentence denotes Lectin blot analysis of the TLR4 signaling complex revealed that core fucosylation was specifically found on CD14.
TextSentencer_T7 886-1124 Sentence denotes Even though similar levels of TLR4/myeloid differentiation factor 2 (MD2) activation and dimerization were observed in Fut8-deficient cells after lipopolysaccharide stimulation, internalization of TLR4 and CD14 was significantly impaired.
TextSentencer_T8 1125-1283 Sentence denotes Given that internalized TLR4/MD2 induces IFN-β production, impaired IFN-β production in Fut8-deficient cells is ascribed to impaired TLR4/MD2 internalization.
TextSentencer_T9 1284-1374 Sentence denotes These data show for the first time that glycosylation critically regulates TLR4 signaling.
T1 0-74 Sentence denotes Core fucose is critical for CD14-dependent Toll-like receptor 4 signaling.
T2 75-227 Sentence denotes Core fucosylation, a posttranslational modification of N-glycans, modifies several growth factor receptors and impacts on their ligand binding affinity.
T3 228-458 Sentence denotes Core-fucose-deficient mice generated by ablating the α1,6 fucosyltransferase enzyme, Fut8, exhibit severe pulmonary emphysema, partly due to impaired macrophage function, similar to aged Toll-like receptor 4 (Tlr4)-deficient mice.
T4 459-552 Sentence denotes We therefore suspect that a lack of core fucose affects the TLR4-dependent signaling pathway.
T5 553-770 Sentence denotes Indeed, upon lipopolysaccharide stimulation, Fut8-deficient mouse embryonic fibroblasts (MEFs) produced similar levels of interleukin-6 but markedly reduced levels of interferon-β (IFN-β) compared with wild-type MEFs.
T6 771-885 Sentence denotes Lectin blot analysis of the TLR4 signaling complex revealed that core fucosylation was specifically found on CD14.
T7 886-1124 Sentence denotes Even though similar levels of TLR4/myeloid differentiation factor 2 (MD2) activation and dimerization were observed in Fut8-deficient cells after lipopolysaccharide stimulation, internalization of TLR4 and CD14 was significantly impaired.
T8 1125-1283 Sentence denotes Given that internalized TLR4/MD2 induces IFN-β production, impaired IFN-β production in Fut8-deficient cells is ascribed to impaired TLR4/MD2 internalization.
T9 1284-1374 Sentence denotes These data show for the first time that glycosylation critically regulates TLR4 signaling.

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 334-353 Disease denotes pulmonary emphysema http://purl.obolibrary.org/obo/MONDO_0004849

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 334-353 Phenotype denotes pulmonary emphysema HP:0002097

Lectin-Jamboree-Sentence

Id Subject Object Predicate Lexical cue
T1 0-74 Sentence denotes Core fucose is critical for CD14-dependent Toll-like receptor 4 signaling.
T2 75-227 Sentence denotes Core fucosylation, a posttranslational modification of N-glycans, modifies several growth factor receptors and impacts on their ligand binding affinity.
T3 228-458 Sentence denotes Core-fucose-deficient mice generated by ablating the α1,6 fucosyltransferase enzyme, Fut8, exhibit severe pulmonary emphysema, partly due to impaired macrophage function, similar to aged Toll-like receptor 4 (Tlr4)-deficient mice.
T4 459-552 Sentence denotes We therefore suspect that a lack of core fucose affects the TLR4-dependent signaling pathway.
T5 553-770 Sentence denotes Indeed, upon lipopolysaccharide stimulation, Fut8-deficient mouse embryonic fibroblasts (MEFs) produced similar levels of interleukin-6 but markedly reduced levels of interferon-β (IFN-β) compared with wild-type MEFs.
T6 771-885 Sentence denotes Lectin blot analysis of the TLR4 signaling complex revealed that core fucosylation was specifically found on CD14.
T7 886-1124 Sentence denotes Even though similar levels of TLR4/myeloid differentiation factor 2 (MD2) activation and dimerization were observed in Fut8-deficient cells after lipopolysaccharide stimulation, internalization of TLR4 and CD14 was significantly impaired.
T8 1125-1283 Sentence denotes Given that internalized TLR4/MD2 induces IFN-β production, impaired IFN-β production in Fut8-deficient cells is ascribed to impaired TLR4/MD2 internalization.
T9 1284-1374 Sentence denotes These data show for the first time that glycosylation critically regulates TLR4 signaling.

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 250-254 OrganismTaxon denotes mice 10088
T2 453-457 OrganismTaxon denotes mice 10088
T3 613-618 OrganismTaxon denotes mouse 10088|10090

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 378-388 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235
T2 619-640 Body_part denotes embryonic fibroblasts http://purl.obolibrary.org/obo/CL_2000042