> top > docs > PubMed:28883039 > annotations

PubMed:28883039 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 32-37 OrganismTaxon denotes human NCBItxid:9606
T2 557-567 OrganismTaxon denotes artificial NCBItxid:32630
T3 900-903 OrganismTaxon denotes rat NCBItxid:10116|NCBItxid:10114

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-86 Sentence denotes Disease-associated mutations in human BICD2 hyperactivate motility of dynein-dynactin.
T2 87-201 Sentence denotes Bicaudal D2 (BICD2) joins dynein with dynactin into a ternary complex (termed DDB) capable of processive movement.
T3 202-367 Sentence denotes Point mutations in the BICD2 gene have been identified in patients with a dominant form of spinal muscular atrophy, but how these mutations cause disease is unknown.
T4 368-514 Sentence denotes To investigate this question, we have developed in vitro motility assays with purified DDB and BICD2's membrane vesicle partner, the GTPase Rab6a.
T5 515-668 Sentence denotes Rab6a-GTP, either in solution or bound to artificial liposomes, released BICD2 from an autoinhibited state and promoted robust dynein-dynactin transport.
T6 669-756 Sentence denotes In these assays, BICD2 mutants showed an enhanced ability to form motile DDB complexes.
T7 757-877 Sentence denotes Increased retrograde transport by BICD2 mutants also was observed in cells using an inducible organelle transport assay.
T8 878-980 Sentence denotes When overexpressed in rat hippocampal neurons, the hyperactive BICD2 mutants decreased neurite growth.
T9 981-1193 Sentence denotes Our results reveal that dominant mutations in BICD2 hyperactivate DDB motility and suggest that an imbalance of minus versus plus end-directed microtubule motility in neurons may underlie spinal muscular atrophy.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
13439 32-37 OrganismTaxon denotes human NCBITaxon:9606
13440 38-43 GeneOrGeneProduct denotes BICD2 NCBIGene:23299
13441 70-76 GeneOrGeneProduct denotes dynein NCBIGene:1778
13442 77-85 GeneOrGeneProduct denotes dynactin NCBIGene:1639
13443 87-98 GeneOrGeneProduct denotes Bicaudal D2 NCBIGene:23299
13444 100-105 GeneOrGeneProduct denotes BICD2 NCBIGene:23299
13445 113-119 GeneOrGeneProduct denotes dynein NCBIGene:1778
13446 125-133 GeneOrGeneProduct denotes dynactin NCBIGene:1639
13447 165-168 GeneOrGeneProduct denotes DDB NCBIGene:1639|NCBIGene:1778|NCBIGene:23299
13448 225-230 GeneOrGeneProduct denotes BICD2 NCBIGene:23299
13449 260-268 OrganismTaxon denotes patients NCBITaxon:9606
13450 293-316 DiseaseOrPhenotypicFeature denotes spinal muscular atrophy MESH:D009134
13451 455-458 GeneOrGeneProduct denotes DDB NCBIGene:1639|NCBIGene:1778|NCBIGene:76895
13452 463-468 GeneOrGeneProduct denotes BICD2 NCBIGene:76895
13453 501-513 GeneOrGeneProduct denotes GTPase Rab6a NCBIGene:5870
13454 515-524 GeneOrGeneProduct denotes Rab6a-GTP NCBIGene:5870
13455 588-593 GeneOrGeneProduct denotes BICD2 NCBIGene:76895
13456 642-648 GeneOrGeneProduct denotes dynein NCBIGene:1778
13457 649-657 GeneOrGeneProduct denotes dynactin NCBIGene:1639
13458 686-691 GeneOrGeneProduct denotes BICD2 NCBIGene:76895
13459 742-745 GeneOrGeneProduct denotes DDB NCBIGene:1639|NCBIGene:1778|NCBIGene:23299
13460 791-796 GeneOrGeneProduct denotes BICD2 NCBIGene:76895
13461 900-903 OrganismTaxon denotes rat NCBITaxon:10116
13462 941-946 GeneOrGeneProduct denotes BICD2 NCBIGene:76895
13463 1027-1032 GeneOrGeneProduct denotes BICD2 NCBIGene:76895
13464 1047-1050 GeneOrGeneProduct denotes DDB NCBIGene:1639|NCBIGene:1778|NCBIGene:23299
13465 1169-1192 DiseaseOrPhenotypicFeature denotes spinal muscular atrophy MESH:D009134

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 293-316 DiseaseOrPhenotypicFeature denotes spinal muscular atrophy 0001516
T2 300-316 DiseaseOrPhenotypicFeature denotes muscular atrophy 0004323
T3 916-923 DiseaseOrPhenotypicFeature denotes neurons 0004466
T4 1148-1155 DiseaseOrPhenotypicFeature denotes neurons 0004466
T5 1169-1192 DiseaseOrPhenotypicFeature denotes spinal muscular atrophy 0001516
T6 1176-1192 DiseaseOrPhenotypicFeature denotes muscular atrophy 0004323

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 19-28 GeneOrGeneProduct denotes mutations
T2 38-43 GeneOrGeneProduct denotes BICD2
T3 70-76 GeneOrGeneProduct denotes dynein
T4 77-85 GeneOrGeneProduct denotes dynactin
T5 87-95 GeneOrGeneProduct denotes Bicaudal
T6 96-98 GeneOrGeneProduct denotes D2
T7 100-105 GeneOrGeneProduct denotes BICD2
T8 107-112 GeneOrGeneProduct denotes joins
T9 113-119 GeneOrGeneProduct denotes dynein
T10 125-133 GeneOrGeneProduct denotes dynactin
T11 158-164 GeneOrGeneProduct denotes termed
T12 170-177 GeneOrGeneProduct denotes capable
T13 181-191 GeneOrGeneProduct denotes processive
T14 202-207 GeneOrGeneProduct denotes Point
T15 208-217 GeneOrGeneProduct denotes mutations
T16 225-230 GeneOrGeneProduct denotes BICD2
T17 332-341 GeneOrGeneProduct denotes mutations
T18 359-366 GeneOrGeneProduct denotes unknown
T19 463-468 GeneOrGeneProduct denotes BICD2
T20 501-507 GeneOrGeneProduct denotes GTPase
T21 508-513 GeneOrGeneProduct denotes Rab6a
T22 515-520 GeneOrGeneProduct denotes Rab6a
T23 588-593 GeneOrGeneProduct denotes BICD2
T24 642-648 GeneOrGeneProduct denotes dynein
T25 649-657 GeneOrGeneProduct denotes dynactin
T26 658-667 GeneOrGeneProduct denotes transport
T27 686-691 GeneOrGeneProduct denotes BICD2
T28 692-699 GeneOrGeneProduct denotes mutants
T29 767-787 GeneOrGeneProduct denotes retrograde transport
T30 791-796 GeneOrGeneProduct denotes BICD2
T31 797-804 GeneOrGeneProduct denotes mutants
T32 826-831 GeneOrGeneProduct denotes cells
T33 841-850 GeneOrGeneProduct denotes inducible
T34 861-870 GeneOrGeneProduct denotes transport
T35 941-946 GeneOrGeneProduct denotes BICD2
T36 947-954 GeneOrGeneProduct denotes mutants
T37 973-979 GeneOrGeneProduct denotes growth
T38 1014-1023 GeneOrGeneProduct denotes mutations
T39 1027-1032 GeneOrGeneProduct denotes BICD2
T40 1093-1098 GeneOrGeneProduct denotes minus
T41 1111-1114 GeneOrGeneProduct denotes end

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 38-43 GeneOrGeneProduct denotes BICD2
T2 70-76 GeneOrGeneProduct denotes dynein
T3 77-85 GeneOrGeneProduct denotes dynactin
T4 87-95 GeneOrGeneProduct denotes Bicaudal
T5 100-105 GeneOrGeneProduct denotes BICD2
T6 113-119 GeneOrGeneProduct denotes dynein
T7 125-133 GeneOrGeneProduct denotes dynactin
T8 225-230 GeneOrGeneProduct denotes BICD2
T9 359-366 GeneOrGeneProduct denotes unknown
T10 463-468 GeneOrGeneProduct denotes BICD2
T11 501-507 GeneOrGeneProduct denotes GTPase
T12 508-513 GeneOrGeneProduct denotes Rab6a
T13 515-520 GeneOrGeneProduct denotes Rab6a
T14 588-593 GeneOrGeneProduct denotes BICD2
T15 642-648 GeneOrGeneProduct denotes dynein
T16 649-657 GeneOrGeneProduct denotes dynactin
T17 686-691 GeneOrGeneProduct denotes BICD2
T18 767-787 GeneOrGeneProduct denotes retrograde transport
T19 791-796 GeneOrGeneProduct denotes BICD2
T20 841-850 GeneOrGeneProduct denotes inducible
T21 941-946 GeneOrGeneProduct denotes BICD2
T22 973-979 GeneOrGeneProduct denotes growth
T23 1027-1032 GeneOrGeneProduct denotes BICD2
T24 1093-1098 GeneOrGeneProduct denotes minus

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 0-7 DiseaseOrPhenotypicFeature denotes Disease D004194
T2 293-316 DiseaseOrPhenotypicFeature denotes spinal muscular atrophy D009134
T3 348-355 DiseaseOrPhenotypicFeature denotes disease D004194
T4 929-940 DiseaseOrPhenotypicFeature denotes hyperactive DISEASE
T5 1169-1192 DiseaseOrPhenotypicFeature denotes spinal muscular atrophy D009134

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 38-43 GeneOrGeneProduct denotes BICD2
T2 70-76 GeneOrGeneProduct denotes dynein
T3 77-85 GeneOrGeneProduct denotes dynactin
T4 87-95 GeneOrGeneProduct denotes Bicaudal
T5 100-105 GeneOrGeneProduct denotes BICD2
T6 113-119 GeneOrGeneProduct denotes dynein
T7 125-133 GeneOrGeneProduct denotes dynactin
T8 225-230 GeneOrGeneProduct denotes BICD2
T9 463-468 GeneOrGeneProduct denotes BICD2
T10 508-513 GeneOrGeneProduct denotes Rab6a
T11 515-520 GeneOrGeneProduct denotes Rab6a
T12 588-593 GeneOrGeneProduct denotes BICD2
T13 642-648 GeneOrGeneProduct denotes dynein
T14 649-657 GeneOrGeneProduct denotes dynactin
T15 686-691 GeneOrGeneProduct denotes BICD2
T16 767-787 GeneOrGeneProduct denotes retrograde transport
T17 791-796 GeneOrGeneProduct denotes BICD2
T18 941-946 GeneOrGeneProduct denotes BICD2
T19 1027-1032 GeneOrGeneProduct denotes BICD2
T20 1093-1098 GeneOrGeneProduct denotes minus

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 293-316 DiseaseOrPhenotypicFeature denotes spinal muscular atrophy 0001516
T2 1169-1192 DiseaseOrPhenotypicFeature denotes spinal muscular atrophy 0001516

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 0-7 DiseaseOrPhenotypicFeature denotes Disease D004194
T2 293-316 DiseaseOrPhenotypicFeature denotes spinal muscular atrophy D009134
T3 348-355 DiseaseOrPhenotypicFeature denotes disease D004194
T4 1169-1192 DiseaseOrPhenotypicFeature denotes spinal muscular atrophy D009134

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 293-316 DiseaseOrPhenotypicFeature denotes spinal muscular atrophy D009134
T2 1169-1192 DiseaseOrPhenotypicFeature denotes spinal muscular atrophy D009134

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 32-37 OrganismTaxon denotes human
T2 260-268 OrganismTaxon denotes patients
T3 557-567 OrganismTaxon denotes artificial
T4 900-903 OrganismTaxon denotes rat

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 165-168 ChemicalEntity denotes DDB C010098
T2 455-458 ChemicalEntity denotes DDB C010098
T3 501-507 ChemicalEntity denotes GTPase D020558
T4 521-524 ChemicalEntity denotes GTP http://purl.obolibrary.org/obo/CHEBI_37565|http://purl.obolibrary.org/obo/CHEBI_15996
T6 536-544 ChemicalEntity denotes solution D012996|http://purl.obolibrary.org/obo/CHEBI_75958
T8 568-577 ChemicalEntity denotes liposomes D008081
T9 742-745 ChemicalEntity denotes DDB C010098
T10 1047-1050 ChemicalEntity denotes DDB C010098

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T10 1047-1050 ChemicalEntity denotes DDB C010098
T9 742-745 ChemicalEntity denotes DDB C010098
T8 568-577 ChemicalEntity denotes liposomes D008081
T6 536-544 ChemicalEntity denotes solution http://purl.obolibrary.org/obo/CHEBI_75958|D012996
T4 521-524 ChemicalEntity denotes GTP http://purl.obolibrary.org/obo/CHEBI_15996|http://purl.obolibrary.org/obo/CHEBI_37565
T3 501-507 ChemicalEntity denotes GTPase D020558
T2 455-458 ChemicalEntity denotes DDB C010098
T1 165-168 ChemicalEntity denotes DDB C010098
T20 1093-1098 GeneOrGeneProduct denotes minus
T19 1027-1032 GeneOrGeneProduct denotes BICD2
T18 941-946 GeneOrGeneProduct denotes BICD2
T17 791-796 GeneOrGeneProduct denotes BICD2
T16 767-787 GeneOrGeneProduct denotes retrograde transport
T15 686-691 GeneOrGeneProduct denotes BICD2
T14 649-657 GeneOrGeneProduct denotes dynactin
T13 642-648 GeneOrGeneProduct denotes dynein
T12 588-593 GeneOrGeneProduct denotes BICD2
T11 515-520 GeneOrGeneProduct denotes Rab6a
T33947 508-513 GeneOrGeneProduct denotes Rab6a
T58250 463-468 GeneOrGeneProduct denotes BICD2
T79488 225-230 GeneOrGeneProduct denotes BICD2
T7 125-133 GeneOrGeneProduct denotes dynactin
T62692 113-119 GeneOrGeneProduct denotes dynein
T5 100-105 GeneOrGeneProduct denotes BICD2
T48362 87-95 GeneOrGeneProduct denotes Bicaudal
T68032 77-85 GeneOrGeneProduct denotes dynactin
T77519 70-76 GeneOrGeneProduct denotes dynein
T97688 38-43 GeneOrGeneProduct denotes BICD2
T61109 1169-1192 DiseaseOrPhenotypicFeature denotes spinal muscular atrophy D009134
T48055 293-316 DiseaseOrPhenotypicFeature denotes spinal muscular atrophy D009134
T75641 900-903 OrganismTaxon denotes rat
T58480 557-567 OrganismTaxon denotes artificial
T42321 260-268 OrganismTaxon denotes patients
T1192 32-37 OrganismTaxon denotes human