PubMed:28871180 JSONTXT

{"project":"CL-cell","denotations":[{"id":"T1","span":{"begin":249,"end":257},"obj":"Cell"},{"id":"T3","span":{"begin":258,"end":268},"obj":"Cell"},{"id":"T5","span":{"begin":478,"end":497},"obj":"Cell"},{"id":"T6","span":{"begin":487,"end":497},"obj":"Cell"},{"id":"T8","span":{"begin":770,"end":778},"obj":"Cell"},{"id":"T10","span":{"begin":779,"end":789},"obj":"Cell"}],"attributes":[{"id":"A1","pred":"cl_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL:0000576"},{"id":"A2","pred":"cl_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL:0001054"},{"id":"A3","pred":"cl_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL:0000235"},{"id":"A4","pred":"cl_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL:0000394"},{"id":"A5","pred":"cl_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL:0000583"},{"id":"A6","pred":"cl_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CL:0000235"},{"id":"A7","pred":"cl_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CL:0000394"},{"id":"A8","pred":"cl_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CL:0000576"},{"id":"A9","pred":"cl_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CL:0001054"},{"id":"A10","pred":"cl_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CL:0000235"},{"id":"A11","pred":"cl_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CL:0000394"}],"text":"Phenotyping and susceptibility of established porcine cells lines to African Swine Fever Virus infection and viral production.\nAfrican swine fever virus (ASFV) is a highly pathogenic, double-stranded DNA virus with a marked tropism for cells of the monocyte-macrophage lineage, affecting swine species and provoking severe economic losses and health threats. In the present study, four established porcine cell lines, IPAM-WT, IPAM-CD163, C∆2+ and WSL, were compared to porcine alveolar macrophage (PAM) in terms of surface marker phenotype, susceptibility to ASFV infection and virus production. The virulent ASFV Armenia/07, E70 or the naturally attenuated NHV/P68 strains were used as viral models. Cells expressed only low levels of specific receptors linked to the monocyte/macrophage lineage, with low levels of infection overall, with the exception of WSL, which showed more efficient production of strain NHV/P68 but not of strains E70 and Armenia/07."}

{"project":"Goldhamster2_CellLineAnn","denotations":[{"id":"T1","span":{"begin":419,"end":426},"obj":"CellLine"},{"id":"T2","span":{"begin":428,"end":438},"obj":"CellLine"},{"id":"T3","span":{"begin":440,"end":444},"obj":"CellLine"},{"id":"T4","span":{"begin":449,"end":452},"obj":"CellLine"},{"id":"T5","span":{"begin":860,"end":863},"obj":"CellLine"}],"text":"Phenotyping and susceptibility of established porcine cells lines to African Swine Fever Virus infection and viral production.\nAfrican swine fever virus (ASFV) is a highly pathogenic, double-stranded DNA virus with a marked tropism for cells of the monocyte-macrophage lineage, affecting swine species and provoking severe economic losses and health threats. In the present study, four established porcine cell lines, IPAM-WT, IPAM-CD163, C∆2+ and WSL, were compared to porcine alveolar macrophage (PAM) in terms of surface marker phenotype, susceptibility to ASFV infection and virus production. The virulent ASFV Armenia/07, E70 or the naturally attenuated NHV/P68 strains were used as viral models. Cells expressed only low levels of specific receptors linked to the monocyte/macrophage lineage, with low levels of infection overall, with the exception of WSL, which showed more efficient production of strain NHV/P68 but not of strains E70 and Armenia/07."}

{"project":"PubMed_ArguminSci","denotations":[{"id":"T1","span":{"begin":127,"end":358},"obj":"DRI_Challenge"},{"id":"T2","span":{"begin":359,"end":596},"obj":"DRI_Background"},{"id":"T3","span":{"begin":597,"end":609},"obj":"DRI_Outcome"},{"id":"T4","span":{"begin":625,"end":701},"obj":"DRI_Outcome"},{"id":"T5","span":{"begin":702,"end":959},"obj":"DRI_Approach"}],"text":"Phenotyping and susceptibility of established porcine cells lines to African Swine Fever Virus infection and viral production.\nAfrican swine fever virus (ASFV) is a highly pathogenic, double-stranded DNA virus with a marked tropism for cells of the monocyte-macrophage lineage, affecting swine species and provoking severe economic losses and health threats. In the present study, four established porcine cell lines, IPAM-WT, IPAM-CD163, C∆2+ and WSL, were compared to porcine alveolar macrophage (PAM) in terms of surface marker phenotype, susceptibility to ASFV infection and virus production. The virulent ASFV Armenia/07, E70 or the naturally attenuated NHV/P68 strains were used as viral models. Cells expressed only low levels of specific receptors linked to the monocyte/macrophage lineage, with low levels of infection overall, with the exception of WSL, which showed more efficient production of strain NHV/P68 but not of strains E70 and Armenia/07."}

{"project":"mondo_disease","denotations":[{"id":"T1","span":{"begin":69,"end":88},"obj":"Disease"},{"id":"T2","span":{"begin":89,"end":104},"obj":"Disease"},{"id":"T3","span":{"begin":127,"end":146},"obj":"Disease"},{"id":"T4","span":{"begin":499,"end":502},"obj":"Disease"},{"id":"T5","span":{"begin":565,"end":574},"obj":"Disease"},{"id":"T6","span":{"begin":818,"end":827},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0025377"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0025377"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0018959"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"Phenotyping and susceptibility of established porcine cells lines to African Swine Fever Virus infection and viral production.\nAfrican swine fever virus (ASFV) is a highly pathogenic, double-stranded DNA virus with a marked tropism for cells of the monocyte-macrophage lineage, affecting swine species and provoking severe economic losses and health threats. In the present study, four established porcine cell lines, IPAM-WT, IPAM-CD163, C∆2+ and WSL, were compared to porcine alveolar macrophage (PAM) in terms of surface marker phenotype, susceptibility to ASFV infection and virus production. The virulent ASFV Armenia/07, E70 or the naturally attenuated NHV/P68 strains were used as viral models. Cells expressed only low levels of specific receptors linked to the monocyte/macrophage lineage, with low levels of infection overall, with the exception of WSL, which showed more efficient production of strain NHV/P68 but not of strains E70 and Armenia/07."}

{"project":"HP-phenotype","denotations":[{"id":"T1","span":{"begin":83,"end":88},"obj":"Phenotype"},{"id":"T2","span":{"begin":141,"end":146},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"HP:0001945"},{"id":"A2","pred":"hp_id","subj":"T2","obj":"HP:0001945"}],"namespaces":[{"prefix":"HP","uri":"http://purl.obolibrary.org/obo/HP_"}],"text":"Phenotyping and susceptibility of established porcine cells lines to African Swine Fever Virus infection and viral production.\nAfrican swine fever virus (ASFV) is a highly pathogenic, double-stranded DNA virus with a marked tropism for cells of the monocyte-macrophage lineage, affecting swine species and provoking severe economic losses and health threats. In the present study, four established porcine cell lines, IPAM-WT, IPAM-CD163, C∆2+ and WSL, were compared to porcine alveolar macrophage (PAM) in terms of surface marker phenotype, susceptibility to ASFV infection and virus production. The virulent ASFV Armenia/07, E70 or the naturally attenuated NHV/P68 strains were used as viral models. Cells expressed only low levels of specific receptors linked to the monocyte/macrophage lineage, with low levels of infection overall, with the exception of WSL, which showed more efficient production of strain NHV/P68 but not of strains E70 and Armenia/07."}

{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":69,"end":94},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":127,"end":152},"obj":"OrganismTaxon"},{"id":"T3","span":{"begin":288,"end":293},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"10497"},{"id":"A2","pred":"db_id","subj":"T2","obj":"10497"},{"id":"A3","pred":"db_id","subj":"T3","obj":"9823"}],"text":"Phenotyping and susceptibility of established porcine cells lines to African Swine Fever Virus infection and viral production.\nAfrican swine fever virus (ASFV) is a highly pathogenic, double-stranded DNA virus with a marked tropism for cells of the monocyte-macrophage lineage, affecting swine species and provoking severe economic losses and health threats. In the present study, four established porcine cell lines, IPAM-WT, IPAM-CD163, C∆2+ and WSL, were compared to porcine alveolar macrophage (PAM) in terms of surface marker phenotype, susceptibility to ASFV infection and virus production. The virulent ASFV Armenia/07, E70 or the naturally attenuated NHV/P68 strains were used as viral models. Cells expressed only low levels of specific receptors linked to the monocyte/macrophage lineage, with low levels of infection overall, with the exception of WSL, which showed more efficient production of strain NHV/P68 but not of strains E70 and Armenia/07."}

{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":249,"end":257},"obj":"Body_part"},{"id":"T3","span":{"begin":258,"end":268},"obj":"Body_part"},{"id":"T4","span":{"begin":487,"end":497},"obj":"Body_part"},{"id":"T5","span":{"begin":770,"end":778},"obj":"Body_part"},{"id":"T7","span":{"begin":779,"end":789},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"A2","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL_0001054"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL_0000235"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CL_0000235"},{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"A6","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL_0001054"},{"id":"A7","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CL_0000235"}],"text":"Phenotyping and susceptibility of established porcine cells lines to African Swine Fever Virus infection and viral production.\nAfrican swine fever virus (ASFV) is a highly pathogenic, double-stranded DNA virus with a marked tropism for cells of the monocyte-macrophage lineage, affecting swine species and provoking severe economic losses and health threats. In the present study, four established porcine cell lines, IPAM-WT, IPAM-CD163, C∆2+ and WSL, were compared to porcine alveolar macrophage (PAM) in terms of surface marker phenotype, susceptibility to ASFV infection and virus production. The virulent ASFV Armenia/07, E70 or the naturally attenuated NHV/P68 strains were used as viral models. Cells expressed only low levels of specific receptors linked to the monocyte/macrophage lineage, with low levels of infection overall, with the exception of WSL, which showed more efficient production of strain NHV/P68 but not of strains E70 and Armenia/07."}