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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 95-196 DRI_Background denotes Gut innate immune defenses control bacterial populations and protect the host interior from invasion.
T2 197-422 DRI_Background denotes Although excess intestinal immune activity frequently promotes inflammatory illnesses, we know little about the consequences of chronic innate immune activity exclusively in endodermal gut cells of an otherwise normal animal.
T3 423-554 DRI_Challenge denotes To address this question, we examined the consequences of persistent inflammatory signals in adult fly intestinal progenitor cells.
T4 555-720 DRI_Outcome denotes We found that constitutive immune activity disrupts expression of homeostatic regulators such as Notch pathway components and induces hyperplasia throughout the gut.
T5 721-910 DRI_Outcome denotes Consistent with these observations, we found that persistent immune signals interfere with progenitor cell differentiation and exacerbate the formation of Notch-dependent intestinal tumors.
T6 911-1021 DRI_Background denotes These findings uncover a link between constitutive immune activity and tumorigenesis in intestinal stem cells.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 20-28 CVCL_C410|Hybridoma|Mus musculus denotes Activity
T2 231-239 CVCL_C410|Hybridoma|Mus musculus denotes activity
T3 284-286 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes we
T4 347-355 CVCL_C410|Hybridoma|Mus musculus denotes activity
T5 395-397 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T6 395-397 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T7 449-451 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes we
T8 555-557 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes We
T9 589-597 CVCL_C410|Hybridoma|Mus musculus denotes activity
T10 757-759 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes we
T11 934-935 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T12 969-977 CVCL_C410|Hybridoma|Mus musculus denotes activity

GoldHamster

Id Subject Object Predicate Lexical cue
T1 38-51 D063646 denotes Tumorigenesis
T2 38-51 D063646 denotes Tumorigenesis
T3 55-65 2294143 denotes Drosophila
T4 55-65 504603 denotes Drosophila
T5 55-65 2294139 denotes Drosophila
T6 55-65 2294145 denotes Drosophila
T7 55-65 2294141 denotes Drosophila
T8 55-65 2294142 denotes Drosophila
T9 55-65 2294144 denotes Drosophila
T10 55-65 2294140 denotes Drosophila
T11 55-65 D004330 denotes Drosophila
T12 55-65 2080301 denotes Drosophila
T13 371-385 UBERON:0004185 denotes endodermal gut
T17 415-421 UBERON:3010325 denotes animal
T18 415-421 UBERON:0000468 denotes animal
T19 516-521 UBERON:0007023 denotes adult
T20 652-657 PR:P46530 denotes Notch
T21 658-665 CHEBI:34922 denotes pathway
T22 689-700 D006965 denotes hyperplasia
T23 689-700 D006965 denotes hyperplasia
T24 716-719 UBERON:0001555 denotes gut
T25 716-719 UBERON:0004907 denotes gut
T26 716-719 UBERON:0001007 denotes gut
T27 823-843 GO:0030154 denotes cell differentiation
T28 863-872 GO:0009058 denotes formation
T29 876-881 PR:P46530 denotes Notch
T30 903-909 D009369 denotes tumors
T31 903-909 D009369 denotes tumors
T32 982-995 D063646 denotes tumorigenesis
T33 982-995 D063646 denotes tumorigenesis

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-94 Sentence denotes Constitutive Immune Activity Promotes Tumorigenesis in Drosophila Intestinal Progenitor Cells.
T2 95-196 Sentence denotes Gut innate immune defenses control bacterial populations and protect the host interior from invasion.
T3 197-422 Sentence denotes Although excess intestinal immune activity frequently promotes inflammatory illnesses, we know little about the consequences of chronic innate immune activity exclusively in endodermal gut cells of an otherwise normal animal.
T4 423-554 Sentence denotes To address this question, we examined the consequences of persistent inflammatory signals in adult fly intestinal progenitor cells.
T5 555-720 Sentence denotes We found that constitutive immune activity disrupts expression of homeostatic regulators such as Notch pathway components and induces hyperplasia throughout the gut.
T6 721-910 Sentence denotes Consistent with these observations, we found that persistent immune signals interfere with progenitor cell differentiation and exacerbate the formation of Notch-dependent intestinal tumors.
T7 911-1021 Sentence denotes These findings uncover a link between constitutive immune activity and tumorigenesis in intestinal stem cells.
T1 0-94 Sentence denotes Constitutive Immune Activity Promotes Tumorigenesis in Drosophila Intestinal Progenitor Cells.
T2 95-196 Sentence denotes Gut innate immune defenses control bacterial populations and protect the host interior from invasion.
T3 197-422 Sentence denotes Although excess intestinal immune activity frequently promotes inflammatory illnesses, we know little about the consequences of chronic innate immune activity exclusively in endodermal gut cells of an otherwise normal animal.
T4 423-554 Sentence denotes To address this question, we examined the consequences of persistent inflammatory signals in adult fly intestinal progenitor cells.
T5 555-720 Sentence denotes We found that constitutive immune activity disrupts expression of homeostatic regulators such as Notch pathway components and induces hyperplasia throughout the gut.
T6 721-910 Sentence denotes Consistent with these observations, we found that persistent immune signals interfere with progenitor cell differentiation and exacerbate the formation of Notch-dependent intestinal tumors.
T7 911-1021 Sentence denotes These findings uncover a link between constitutive immune activity and tumorigenesis in intestinal stem cells.