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PubMed:28826027 JSONTXT

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PubTator4TogoVar

Id Subject Object Predicate Lexical cue proteinmutation
28826027_0 55-61 ProteinMutation denotes G2019S rs34637584
28826027_1 166-174 ProteinMutation denotes p.G2019S rs34637584
28826027_2 404-410 ProteinMutation denotes G2019S rs34637584
28826027_3 655-661 ProteinMutation denotes G2019S rs34637584
28826027_4 893-899 ProteinMutation denotes G2019S rs34637584
28826027_5 962-968 ProteinMutation denotes G2019S rs34637584
28826027_6 1306-1312 ProteinMutation denotes G2019S rs34637584
28826027_7 1454-1460 ProteinMutation denotes G2019S rs34637584

c_corpus

Id Subject Object Predicate Lexical cue
T1 0-6 SO:0001459 denotes CRISPR
T14 7-10 UBERON:0002920 denotes Cas
T4 7-10 GO:0005650 denotes Cas
T18 7-10 D001072 denotes Cas
T20 7-11 Q03LF7 denotes Cas9
T21 7-11 Q03JI6 denotes Cas9
T22 7-11 CVCL_8537 denotes Cas9
T23 49-54 PR:Q5S006 denotes LRRK2
T24 49-54 PR:000003033 denotes LRRK2
T25 49-54 PR:Q5S007 denotes LRRK2
T26 116-125 D051843 denotes Synuclein
T27 116-125 P37379 denotes Synuclein
T28 175-183 SO:0000109 denotes mutation
T30 191-198 6308 denotes leucine
T31 191-198 SO:0001437 denotes leucine
T29 191-198 CHEBI:15603 denotes leucine
T32 191-198 D007930 denotes leucine
T33 191-198 CHEBI:25017 denotes leucine
T34 191-198 D007930 denotes leucine
T35 204-210 SO:0001068 denotes repeat
T36 221-226 PR:Q5S006 denotes LRRK2
T37 221-226 PR:000003033 denotes LRRK2
T38 221-226 PR:Q5S007 denotes LRRK2
T43 309-328 D010300 denotes Parkinson's disease
T44 309-328 D010300 denotes Parkinson's disease
T47 339-342 SO:0001843 denotes Cre
T48 398-403 PR:Q5S006 denotes LRRK2
T49 398-403 PR:000003033 denotes LRRK2
T50 398-403 PR:Q5S007 denotes LRRK2
T51 411-419 SO:0000109 denotes mutation
T52 439-444 D006801 denotes human
T53 548-557 SO:0000346 denotes LoxP site
T54 572-576 SO:0000704 denotes gene
T55 572-587 GO:0010467 denotes gene expression
T56 649-654 PR:Q5S006 denotes LRRK2
T57 649-654 PR:000003033 denotes LRRK2
T58 649-654 PR:Q5S007 denotes LRRK2
T59 686-692 SO:0000116 denotes edited
T60 702-708 SO:0001459 denotes CRISPR
T73 709-712 UBERON:0002920 denotes Cas
T63 709-712 GO:0005650 denotes Cas
T77 709-712 D001072 denotes Cas
T79 709-713 Q03LF7 denotes Cas9
T80 709-713 Q03JI6 denotes Cas9
T81 709-713 CVCL_8537 denotes Cas9
T83 776-784 10962 denotes Tyrosine
T87 776-784 SO:0001446 denotes Tyrosine
T90 776-796 A0A060X6Z0 denotes Tyrosine Hydroxylase
T89 776-796 D014446 denotes Tyrosine Hydroxylase
T91 832-839 GO:0043005 denotes neurite
T96 887-892 PR:Q5S006 denotes LRRK2
T97 887-892 PR:000003033 denotes LRRK2
T98 887-892 PR:Q5S007 denotes LRRK2
T99 956-961 PR:Q5S006 denotes LRRK2
T100 956-961 PR:000003033 denotes LRRK2
T101 956-961 PR:Q5S007 denotes LRRK2
T102 1074-1081 GO:0043005 denotes neurite
T109 1118-1124 9671 denotes Serine
T111 1118-1124 SO:0001444 denotes Serine
T107 1118-1124 D012694 denotes Serine
T108 1118-1124 CHEBI:17822 denotes Serine
T110 1118-1124 D012694 denotes Serine
T112 1118-1124 CHEBI:17115 denotes Serine
T114 1152-1167 P37840 denotes alpha-Synuclein
T115 1152-1167 Q91448 denotes alpha-Synuclein
T117 1152-1167 P61140 denotes alpha-Synuclein
T118 1152-1167 Q3T0G8 denotes alpha-Synuclein
T119 1152-1167 P61139 denotes alpha-Synuclein
T120 1152-1167 P61146 denotes alpha-Synuclein
T121 1152-1167 P61141 denotes alpha-Synuclein
T122 1152-1167 P61144 denotes alpha-Synuclein
T123 1152-1167 PR:000015322 denotes alpha-Synuclein
T124 1152-1167 P61147 denotes alpha-Synuclein
T125 1152-1167 O55042 denotes alpha-Synuclein
T126 1152-1167 Q3I5G7 denotes alpha-Synuclein
T127 1152-1167 P61142 denotes alpha-Synuclein
T128 1152-1167 P37377 denotes alpha-Synuclein
T129 1152-1167 P61138 denotes alpha-Synuclein
T130 1152-1167 P61143 denotes alpha-Synuclein
T131 1152-1167 P61145 denotes alpha-Synuclein
T116 1152-1167 D051844 denotes alpha-Synuclein
T134 1241-1250 GO:0009058 denotes formation
T135 1300-1305 PR:Q5S006 denotes LRRK2
T136 1300-1305 PR:000003033 denotes LRRK2
T137 1300-1305 PR:Q5S007 denotes LRRK2
T138 1448-1453 PR:Q5S006 denotes LRRK2
T139 1448-1453 PR:000003033 denotes LRRK2
T140 1448-1453 PR:Q5S007 denotes LRRK2
T141 1481-1493 GO:0009405 denotes pathogenesis

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 162-334 DRI_Background denotes The p.G2019S mutation of the leucine-rich repeat kinase 2 (LRRK2) has been identified as the most prevalent genetic cause of familial and sporadic Parkinson's disease (PD).
T2 335-524 DRI_Background denotes The Cre-LoxP recombination system has been used to correct the LRRK2-G2019S mutation in patient derived human induced pluripotent stem cells (hiPSCs) in order to generate isogenic controls.
T3 525-588 DRI_Background denotes However, the remaining LoxP site can influence gene expression.
T4 589-633 DRI_Approach denotes In this study, we report the generation of a
T5 671-740 DRI_Approach denotes hiPS cell line edited with the CRISPR/Cas9 and piggyBac technologies.
T6 741-926 DRI_Outcome denotes We observed that the percentage of Tyrosine Hydroxylase (TH) positive neurons with a total neurite length of >2000μm was significantly reduced in LRRK2-G2019S dopaminergic (DA) neurons.
T7 927-999 DRI_Outcome denotes The average branch number in LRRK2-G2019S DA neurons was also decreased.
T8 1000-1268 DRI_Outcome denotes In addition, we have shown that in vitro TH positive neurons with a total neurite length of >2000μm were positive for Serine 129 phosphorylated (S129P) alpha-Synuclein (αS) and we hypothesize that S129P-αS plays a role in the maintenance or formation of long neurites.
T9 1269-1284 DRI_Approach denotes In summary, our
T10 1322-1500 DRI_Approach denotes cell lines allow standardized, genetic background independent, in vitro PD modeling and provide new insights into the role of LRRK2-G2019S and S129P-αS in the pathogenesis of PD.