PubMed:28824193 JSONTXT

{"project":"maxiaofeng52_800_3","denotations":[{"id":"T1","span":{"begin":351,"end":387},"obj":"CI"},{"id":"T2","span":{"begin":389,"end":395},"obj":"CI"},{"id":"T3","span":{"begin":491,"end":497},"obj":"CI"},{"id":"T4","span":{"begin":866,"end":872},"obj":"CI"},{"id":"T5","span":{"begin":402,"end":409},"obj":"CI"},{"id":"T6","span":{"begin":620,"end":627},"obj":"CI"},{"id":"T7","span":{"begin":878,"end":885},"obj":"CI"},{"id":"T8","span":{"begin":116,"end":123},"obj":"CI"},{"id":"T9","span":{"begin":90,"end":100},"obj":"CI"},{"id":"T10","span":{"begin":698,"end":708},"obj":"CI"},{"id":"T11","span":{"begin":747,"end":767},"obj":"CI"}],"text":"A Multicenter, Prospective, Randomized Controlled Trial Evaluating the Efficacy of Rectal Diclofenac and Sublingual Nitrate as a Combined Prophylactic Treatment for Post-ERCP Pancreatitis.\nAcute pancreatitis is the major complication of endoscopic retrograde cholangiopancreatography(ERCP). A preliminary research suggested that the administration of nonsteroidal anti-inflammatory drugs (NSAIDs) with nitrate might reduce the incidence of post-ERCP pancreatitis (PEP) more effectively than NSAIDs alone. We conduct a two-arm, multicenter, prospective, randomized, superiority trial to evaluate the additional effect of nitrate for prevention of PEP. A total of 900 patients randomly receive 50 mg diclofenac suppository either alone or with 5 mg isosorbide dinitrate sublingual tablet. The primary endpoint is the occurrence of PEP. This study will clarify whether NSAIDs plus nitrate can prevent PEP."}

{"project":"wangzhuo19_800_3","denotations":[{"id":"T1","span":{"begin":90,"end":100},"obj":"CI"},{"id":"T2","span":{"begin":116,"end":123},"obj":"CI"},{"id":"T3","span":{"begin":698,"end":708},"obj":"CI"},{"id":"T4","span":{"begin":747,"end":767},"obj":"CI"},{"id":"T5","span":{"begin":402,"end":409},"obj":"CI"},{"id":"T6","span":{"begin":620,"end":627},"obj":"CI"},{"id":"T7","span":{"begin":878,"end":885},"obj":"CI"},{"id":"T8","span":{"begin":351,"end":387},"obj":"CI"},{"id":"T9","span":{"begin":389,"end":395},"obj":"CI"},{"id":"T10","span":{"begin":491,"end":497},"obj":"CI"},{"id":"T11","span":{"begin":866,"end":872},"obj":"CI"}],"text":"A Multicenter, Prospective, Randomized Controlled Trial Evaluating the Efficacy of Rectal Diclofenac and Sublingual Nitrate as a Combined Prophylactic Treatment for Post-ERCP Pancreatitis.\nAcute pancreatitis is the major complication of endoscopic retrograde cholangiopancreatography(ERCP). A preliminary research suggested that the administration of nonsteroidal anti-inflammatory drugs (NSAIDs) with nitrate might reduce the incidence of post-ERCP pancreatitis (PEP) more effectively than NSAIDs alone. We conduct a two-arm, multicenter, prospective, randomized, superiority trial to evaluate the additional effect of nitrate for prevention of PEP. A total of 900 patients randomly receive 50 mg diclofenac suppository either alone or with 5 mg isosorbide dinitrate sublingual tablet. The primary endpoint is the occurrence of PEP. This study will clarify whether NSAIDs plus nitrate can prevent PEP."}