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PubMed:28763035 JSONTXT

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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 197-297 DRI_Background denotes Rabbit haemorrhagic disease virus (RHDV) is a calicivirus that infects and frequently kills rabbits.
T2 298-509 DRI_Outcome denotes Previously, we showed that the RHDV RNA-dependent RNA polymerase (RdRp) is associated with distinct, but yet uncharacterised subcellular structures and is capable of inducing a redistribution of Golgi membranes.
T3 510-635 DRI_Approach denotes In this study, we identified a partially hidden hydrophobic motif that determines the subcellular localisation of recombinant
T4 646-667 DRI_Approach denotes in transfected cells.
T5 668-813 DRI_Approach denotes This novel motif, 189LLWGCDVGVAVCAAAVFHNICY210, is located within the F homomorph, between the conserved F3 and A motifs of the core RdRp domain.
T6 814-1015 DRI_Background denotes Amino acid substitutions that decrease the hydrophobicity of this motif reduced the ability of the protein to accumulate in multiple subcellular foci and to induce a rearrangement of the Golgi network.
T7 1016-1088 DRI_Challenge denotes Furthermore, preliminary molecular dynamics simulations suggest that the
T8 1099-1234 DRI_Challenge denotes could align with the negatively charged surfaces of biological membranes and undergo a conformational change involving the F homomorph.
T9 1235-1378 DRI_Background denotes These changes would expose the newly identified hydrophobic motif so it could immerse itself into the outer leaflet of intracellular membranes.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 0-1 CVCL_6479|Finite_cell_line|Mus musculus denotes A
T2 241-242 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T3 310-312 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes we
T4 473-474 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T5 525-527 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes we
T6 539-540 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T7 773-775 CVCL_1P60|Finite_cell_line|Homo sapiens denotes F3
T8 773-775 CVCL_CW34|Hybridoma|Mus musculus denotes F3
T9 773-775 CVCL_LJ44|Somatic_stem_cell|Homo sapiens denotes F3
T10 780-781 CVCL_6479|Finite_cell_line|Mus musculus denotes A
T11 978-979 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T12 1184-1185 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T13 1201-1207 CVCL_0238|Cancer_cell_line|Homo sapiens denotes change
T14 1241-1248 CVCL_0238|Cancer_cell_line|Homo sapiens denotes changes

GoldHamster

Id Subject Object Predicate Lexical cue
T1 2-7 SO:0100017 denotes Motif
T2 2-7 SO:0001067 denotes Motif
T4 30-36 813859 denotes Rabbit
T6 30-63 11976 denotes Rabbit Haemorrhagic Disease Virus
T7 30-63 D017929 denotes Rabbit Haemorrhagic Disease Virus
T10 50-63 D014777 denotes Disease Virus
T11 50-63 D014777 denotes Disease Virus
T13 108-120 GO:0051179 denotes Localisation
T14 128-135 CHEBI:16541 denotes Protein
T15 180-185 GO:0005794 denotes Golgi
T18 217-230 D014777 denotes disease virus
T19 217-230 D014777 denotes disease virus
T20 232-236 11976 denotes RHDV
T21 289-296 D011817 denotes rabbits
T22 289-296 9986 denotes rabbits
T23 329-333 11976 denotes RHDV
T27 334-337 SO:0000356 denotes RNA
T26 334-337 GO:0005562 denotes RNA
T28 334-362 D012324 denotes RNA-dependent RNA polymerase
T29 334-362 B3VML1 denotes RNA-dependent RNA polymerase
T30 334-362 Q85431 denotes RNA-dependent RNA polymerase
T34 348-351 SO:0000356 denotes RNA
T33 348-351 GO:0005562 denotes RNA
T36 364-368 Q9Q6Q5 denotes RdRp
T37 364-368 Q9IMM4 denotes RdRp
T38 364-368 Q9DIC5 denotes RdRp
T39 364-368 Q96631 denotes RdRp
T40 364-368 P12918 denotes RdRp
T41 364-368 Q8AZL8 denotes RdRp
T42 364-368 Q91CD5 denotes RdRp
T43 364-368 P31817 denotes RdRp
T44 364-368 P22173 denotes RdRp
T45 364-368 A7L9Z4 denotes RdRp
T46 364-368 Q993M1 denotes RdRp
T47 364-368 Q3KSM3 denotes RdRp
T49 364-368 Q9QAZ8 denotes RdRp
T50 364-368 Q67683 denotes RdRp
T51 364-368 Q992J0 denotes RdRp
T52 364-368 Q9J7Z2 denotes RdRp
T53 364-368 P22174 denotes RdRp
T54 364-368 Q66929 denotes RdRp
T55 364-368 PR:000036450 denotes RdRp
T56 364-368 Q82630 denotes RdRp
T57 364-368 Q6XNL5 denotes RdRp
T48 364-368 GO:0003968 denotes RdRp
T58 493-498 GO:0005794 denotes Golgi
T59 570-575 SO:0100017 denotes motif
T60 570-575 SO:0001067 denotes motif
T61 608-620 GO:0051179 denotes localisation
T62 636-640 11976 denotes RHDV
T63 641-645 Q9Q6Q5 denotes RdRp
T64 641-645 Q9IMM4 denotes RdRp
T65 641-645 Q9DIC5 denotes RdRp
T66 641-645 Q96631 denotes RdRp
T67 641-645 P12918 denotes RdRp
T68 641-645 Q8AZL8 denotes RdRp
T69 641-645 Q91CD5 denotes RdRp
T70 641-645 P31817 denotes RdRp
T71 641-645 P22173 denotes RdRp
T72 641-645 A7L9Z4 denotes RdRp
T73 641-645 Q993M1 denotes RdRp
T74 641-645 Q3KSM3 denotes RdRp
T76 641-645 Q9QAZ8 denotes RdRp
T77 641-645 Q67683 denotes RdRp
T78 641-645 Q992J0 denotes RdRp
T79 641-645 Q9J7Z2 denotes RdRp
T80 641-645 P22174 denotes RdRp
T81 641-645 Q66929 denotes RdRp
T82 641-645 PR:000036450 denotes RdRp
T83 641-645 Q82630 denotes RdRp
T84 641-645 Q6XNL5 denotes RdRp
T75 641-645 GO:0003968 denotes RdRp
T85 679-684 SO:0100017 denotes motif
T86 679-684 SO:0001067 denotes motif
T87 763-772 SO:0000856 denotes conserved
T88 796-800 GO:0019013 denotes core
T89 801-805 Q9Q6Q5 denotes RdRp
T90 801-805 Q9IMM4 denotes RdRp
T91 801-805 Q9DIC5 denotes RdRp
T92 801-805 Q96631 denotes RdRp
T93 801-805 P12918 denotes RdRp
T94 801-805 Q8AZL8 denotes RdRp
T95 801-805 Q91CD5 denotes RdRp
T96 801-805 P31817 denotes RdRp
T97 801-805 P22173 denotes RdRp
T98 801-805 A7L9Z4 denotes RdRp
T99 801-805 Q993M1 denotes RdRp
T100 801-805 Q3KSM3 denotes RdRp
T102 801-805 Q9QAZ8 denotes RdRp
T103 801-805 Q67683 denotes RdRp
T104 801-805 Q992J0 denotes RdRp
T105 801-805 Q9J7Z2 denotes RdRp
T106 801-805 P22174 denotes RdRp
T107 801-805 Q66929 denotes RdRp
T108 801-805 PR:000036450 denotes RdRp
T109 801-805 Q82630 denotes RdRp
T110 801-805 Q6XNL5 denotes RdRp
T101 801-805 GO:0003968 denotes RdRp
T111 806-812 SO:0000417 denotes domain
T114 814-824 SO:0001237 denotes Amino acid
T113 814-824 CHEBI:33704 denotes Amino acid
T115 814-824 CHEBI:33709 denotes Amino acid
T117 857-871 SO:0100013 denotes hydrophobicity
T118 880-885 SO:0100017 denotes motif
T119 880-885 SO:0001067 denotes motif
T120 913-920 GO:0003675 denotes protein
T124 913-920 SO:0000104 denotes protein
T123 913-920 PR:000000001 denotes protein
T121 913-920 CHEBI:36080 denotes protein
T122 913-920 CHEBI:11122 denotes protein
T125 1001-1006 GO:0005794 denotes Golgi
T126 1089-1093 11976 denotes RHDV
T127 1094-1098 Q9Q6Q5 denotes RdRp
T128 1094-1098 Q9IMM4 denotes RdRp
T129 1094-1098 Q9DIC5 denotes RdRp
T130 1094-1098 Q96631 denotes RdRp
T131 1094-1098 P12918 denotes RdRp
T132 1094-1098 Q8AZL8 denotes RdRp
T133 1094-1098 Q91CD5 denotes RdRp
T134 1094-1098 P31817 denotes RdRp
T135 1094-1098 P22173 denotes RdRp
T136 1094-1098 A7L9Z4 denotes RdRp
T137 1094-1098 Q993M1 denotes RdRp
T138 1094-1098 Q3KSM3 denotes RdRp
T140 1094-1098 Q9QAZ8 denotes RdRp
T141 1094-1098 Q67683 denotes RdRp
T142 1094-1098 Q992J0 denotes RdRp
T143 1094-1098 Q9J7Z2 denotes RdRp
T144 1094-1098 P22174 denotes RdRp
T145 1094-1098 Q66929 denotes RdRp
T146 1094-1098 PR:000036450 denotes RdRp
T147 1094-1098 Q82630 denotes RdRp
T148 1094-1098 Q6XNL5 denotes RdRp
T139 1094-1098 GO:0003968 denotes RdRp
T149 1105-1110 827148 denotes align
T150 1295-1300 SO:0100017 denotes motif
T151 1295-1300 SO:0001067 denotes motif
T152 1354-1367 GO:0005622 denotes intracellular