PubMed:28650467
Annnotations
LitCoin-entities-OrganismTaxon-PD
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 1831-1838 | OrganismTaxon | denotes | time, a | NCBItxid:269051 |
LitCoin-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-167 | Sentence | denotes | Genome-wide loss-of-function genetic screening identifies opioid receptor μ1 as a key regulator of L-asparaginase resistance in pediatric acute lymphoblastic leukemia. |
| T2 | 168-259 | Sentence | denotes | L-asparaginase is a critical chemotherapeutic agent for acute lymphoblastic leukemia (ALL). |
| T3 | 260-415 | Sentence | denotes | It hydrolyzes plasma asparagine into aspartate and NH3, causing asparagine deficit and inhibition of protein synthesis and eventually, leukemic cell death. |
| T4 | 416-487 | Sentence | denotes | However, patient relapse often occurs due to development of resistance. |
| T5 | 488-579 | Sentence | denotes | The molecular mechanism by which ALL cells acquire resistance to L-asparaginase is unknown. |
| T6 | 580-692 | Sentence | denotes | Therefore, we sought to identify genes that are involved in L-asparaginase resistance in primary leukemic cells. |
| T7 | 693-942 | Sentence | denotes | By unbiased genome-wide RNAi screening, we found that among 10 resistant ALL clones, six hits were for opioid receptor mu 1 (oprm1), two hits were for carbonic anhydrase 1 (ca1) and another two hits were for ubiquitin-conjugating enzyme E2C (ube2c). |
| T8 | 943-1010 | Sentence | denotes | We also found that OPRM1 is expressed in all leukemic cells tested. |
| T9 | 1011-1141 | Sentence | denotes | Specific knockdown of OPRM1 confers L-asparaginase resistance, validating our genome-wide retroviral shRNA library screening data. |
| T10 | 1142-1502 | Sentence | denotes | Methadone, an agonist of OPRM1, enhances the sensitivity of parental leukemic cells, but not OPRM1-depleted cells, to L-asparaginase treatment, indicating that OPRM1 is required for the synergistic action of L-asparaginase and methadone, and that OPRM1 loss promotes leukemic cell survival likely through downregulation of the OPRM1-mediated apoptotic pathway. |
| T11 | 1503-1787 | Sentence | denotes | Consistent with this premise, patient leukemic cells with relatively high levels of OPRM1 are more sensitive to L-asparaginase treatment compared to OPRM1-depleted leukemic cells, further indicating that OPRM1 loss has a crucial role in L-asparaginase resistance in leukemic patients. |
| T12 | 1788-2044 | Sentence | denotes | Thus, our study demonstrates for the first time, a novel OPRM1-mediated mechanism for L-asparaginase resistance in ALL, and identifies OPRM1 as a functional biomarker for defining high-risk subpopulations and for the detection of evolving resistant clones. |
| T13 | 2045-2204 | Sentence | denotes | Oprm1 may also be utilized for effective treatment of L-asparaginase-resistant ALL.Oncogene advance online publication, 26 June 2017; doi:10.1038/onc.2017.211. |
LitCoin-entities
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| 13101 | 58-76 | GeneOrGeneProduct | denotes | opioid receptor μ1 | NCBIGene:4988 |
| 13102 | 99-113 | ChemicalEntity | denotes | L-asparaginase | MESH:D001215 |
| 13103 | 138-166 | DiseaseOrPhenotypicFeature | denotes | acute lymphoblastic leukemia | MESH:D054198 |
| 13104 | 168-182 | ChemicalEntity | denotes | L-asparaginase | MESH:D001215 |
| 13105 | 224-252 | DiseaseOrPhenotypicFeature | denotes | acute lymphoblastic leukemia | MESH:D054198 |
| 13106 | 254-257 | DiseaseOrPhenotypicFeature | denotes | ALL | MESH:D054198 |
| 13107 | 281-291 | ChemicalEntity | denotes | asparagine | MESH:D001216 |
| 13108 | 297-306 | ChemicalEntity | denotes | aspartate | MESH:D001224 |
| 13109 | 311-314 | ChemicalEntity | denotes | NH3 | MESH:D000641 |
| 13110 | 324-342 | DiseaseOrPhenotypicFeature | denotes | asparagine deficit | OMIM:615574 |
| 13111 | 395-403 | DiseaseOrPhenotypicFeature | denotes | leukemic | MESH:D007938 |
| 13112 | 425-432 | OrganismTaxon | denotes | patient | NCBITaxon:9606 |
| 13113 | 521-524 | DiseaseOrPhenotypicFeature | denotes | ALL | MESH:D054198 |
| 13114 | 553-567 | ChemicalEntity | denotes | L-asparaginase | MESH:D001215 |
| 13115 | 640-654 | ChemicalEntity | denotes | L-asparaginase | MESH:D001215 |
| 13116 | 677-685 | DiseaseOrPhenotypicFeature | denotes | leukemic | MESH:D007938 |
| 13117 | 766-769 | DiseaseOrPhenotypicFeature | denotes | ALL | MESH:D054198 |
| 13118 | 796-816 | GeneOrGeneProduct | denotes | opioid receptor mu 1 | NCBIGene:4988 |
| 13119 | 818-823 | GeneOrGeneProduct | denotes | oprm1 | NCBIGene:4988 |
| 13120 | 844-864 | GeneOrGeneProduct | denotes | carbonic anhydrase 1 | NCBIGene:759 |
| 13121 | 866-869 | GeneOrGeneProduct | denotes | ca1 | NCBIGene:759 |
| 13122 | 901-933 | GeneOrGeneProduct | denotes | ubiquitin-conjugating enzyme E2C | NCBIGene:11065 |
| 13123 | 935-940 | GeneOrGeneProduct | denotes | ube2c | NCBIGene:11065 |
| 13124 | 962-967 | GeneOrGeneProduct | denotes | OPRM1 | NCBIGene:4988 |
| 13125 | 988-996 | DiseaseOrPhenotypicFeature | denotes | leukemic | MESH:D007938 |
| 13126 | 1033-1038 | GeneOrGeneProduct | denotes | OPRM1 | NCBIGene:4988 |
| 13127 | 1047-1061 | ChemicalEntity | denotes | L-asparaginase | MESH:D001215 |
| 13128 | 1142-1151 | ChemicalEntity | denotes | Methadone | MESH:D008691 |
| 13129 | 1167-1172 | GeneOrGeneProduct | denotes | OPRM1 | NCBIGene:4988 |
| 13130 | 1211-1219 | DiseaseOrPhenotypicFeature | denotes | leukemic | MESH:D007938 |
| 13131 | 1235-1240 | GeneOrGeneProduct | denotes | OPRM1 | NCBIGene:4988 |
| 13132 | 1260-1274 | ChemicalEntity | denotes | L-asparaginase | MESH:D001215 |
| 13133 | 1302-1307 | GeneOrGeneProduct | denotes | OPRM1 | NCBIGene:4988 |
| 13134 | 1350-1364 | ChemicalEntity | denotes | L-asparaginase | MESH:D001215 |
| 13135 | 1369-1378 | ChemicalEntity | denotes | methadone | MESH:D008691 |
| 13136 | 1389-1394 | GeneOrGeneProduct | denotes | OPRM1 | NCBIGene:4988 |
| 13137 | 1409-1417 | DiseaseOrPhenotypicFeature | denotes | leukemic | MESH:D007938 |
| 13138 | 1469-1474 | GeneOrGeneProduct | denotes | OPRM1 | NCBIGene:4988 |
| 13139 | 1533-1540 | OrganismTaxon | denotes | patient | NCBITaxon:9606 |
| 13140 | 1541-1549 | DiseaseOrPhenotypicFeature | denotes | leukemic | MESH:D007938 |
| 13141 | 1587-1592 | GeneOrGeneProduct | denotes | OPRM1 | NCBIGene:4988 |
| 13142 | 1615-1629 | ChemicalEntity | denotes | L-asparaginase | MESH:D001215 |
| 13143 | 1652-1657 | GeneOrGeneProduct | denotes | OPRM1 | NCBIGene:4988 |
| 13144 | 1667-1675 | DiseaseOrPhenotypicFeature | denotes | leukemic | MESH:D007938 |
| 13145 | 1707-1712 | GeneOrGeneProduct | denotes | OPRM1 | NCBIGene:4988 |
| 13146 | 1740-1754 | ChemicalEntity | denotes | L-asparaginase | MESH:D001215 |
| 13147 | 1769-1777 | DiseaseOrPhenotypicFeature | denotes | leukemic | MESH:D007938 |
| 13148 | 1778-1786 | OrganismTaxon | denotes | patients | NCBITaxon:9606 |
| 13149 | 1845-1850 | GeneOrGeneProduct | denotes | OPRM1 | NCBIGene:4988 |
| 13150 | 1874-1888 | ChemicalEntity | denotes | L-asparaginase | MESH:D001215 |
| 13151 | 1903-1906 | DiseaseOrPhenotypicFeature | denotes | ALL | MESH:D054198 |
| 13152 | 1923-1928 | GeneOrGeneProduct | denotes | OPRM1 | NCBIGene:4988 |
| 13153 | 2045-2050 | GeneOrGeneProduct | denotes | Oprm1 | NCBIGene:4988 |
| 13154 | 2099-2113 | ChemicalEntity | denotes | L-asparaginase | MESH:D001215 |
| 13155 | 2124-2127 | DiseaseOrPhenotypicFeature | denotes | ALL | MESH:D054198 |
LitCoin_Mondo
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 138-166 | DiseaseOrPhenotypicFeature | denotes | acute lymphoblastic leukemia | 0004967 |
| T2 | 158-166 | DiseaseOrPhenotypicFeature | denotes | leukemia | 0005059 |
| T3 | 224-252 | DiseaseOrPhenotypicFeature | denotes | acute lymphoblastic leukemia | 0004967 |
| T4 | 244-252 | DiseaseOrPhenotypicFeature | denotes | leukemia | 0005059 |
| T5 | 531-538 | DiseaseOrPhenotypicFeature | denotes | acquire | 0021141 |
LitCoin-SeqVar
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 930-933 | SequenceVariant | denotes | E2C |
LitCoin-GeneOrGeneProduct-v0
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 65-73 | GeneOrGeneProduct | denotes | receptor |
| T2 | 86-95 | GeneOrGeneProduct | denotes | regulator |
| T3 | 99-113 | GeneOrGeneProduct | denotes | L-asparaginase |
| T4 | 168-182 | GeneOrGeneProduct | denotes | L-asparaginase |
| T5 | 254-257 | GeneOrGeneProduct | denotes | ALL |
| T6 | 297-306 | GeneOrGeneProduct | denotes | aspartate |
| T7 | 361-368 | GeneOrGeneProduct | denotes | protein |
| T8 | 404-408 | GeneOrGeneProduct | denotes | cell |
| T9 | 521-524 | GeneOrGeneProduct | denotes | ALL |
| T10 | 525-530 | GeneOrGeneProduct | denotes | cells |
| T11 | 553-567 | GeneOrGeneProduct | denotes | L-asparaginase |
| T12 | 571-578 | GeneOrGeneProduct | denotes | unknown |
| T13 | 640-654 | GeneOrGeneProduct | denotes | L-asparaginase |
| T14 | 686-691 | GeneOrGeneProduct | denotes | cells |
| T15 | 717-721 | GeneOrGeneProduct | denotes | RNAi |
| T16 | 766-769 | GeneOrGeneProduct | denotes | ALL |
| T17 | 770-776 | GeneOrGeneProduct | denotes | clones |
| T18 | 782-786 | GeneOrGeneProduct | denotes | hits |
| T19 | 796-816 | GeneOrGeneProduct | denotes | opioid receptor mu 1 |
| T20 | 818-823 | GeneOrGeneProduct | denotes | oprm1 |
| T21 | 830-834 | GeneOrGeneProduct | denotes | hits |
| T22 | 844-864 | GeneOrGeneProduct | denotes | carbonic anhydrase 1 |
| T23 | 866-869 | GeneOrGeneProduct | denotes | ca1 |
| T24 | 887-891 | GeneOrGeneProduct | denotes | hits |
| T25 | 901-933 | GeneOrGeneProduct | denotes | ubiquitin-conjugating enzyme E2C |
| T26 | 935-940 | GeneOrGeneProduct | denotes | ube2c |
| T27 | 962-967 | GeneOrGeneProduct | denotes | OPRM1 |
| T28 | 984-987 | GeneOrGeneProduct | denotes | all |
| T29 | 997-1002 | GeneOrGeneProduct | denotes | cells |
| T30 | 1003-1009 | GeneOrGeneProduct | denotes | tested |
| T31 | 1020-1029 | GeneOrGeneProduct | denotes | knockdown |
| T32 | 1033-1038 | GeneOrGeneProduct | denotes | OPRM1 |
| T33 | 1047-1061 | GeneOrGeneProduct | denotes | L-asparaginase |
| T34 | 1167-1172 | GeneOrGeneProduct | denotes | OPRM1 |
| T35 | 1220-1225 | GeneOrGeneProduct | denotes | cells |
| T36 | 1235-1240 | GeneOrGeneProduct | denotes | OPRM1 |
| T37 | 1241-1249 | GeneOrGeneProduct | denotes | depleted |
| T38 | 1250-1255 | GeneOrGeneProduct | denotes | cells |
| T39 | 1260-1274 | GeneOrGeneProduct | denotes | L-asparaginase |
| T40 | 1302-1307 | GeneOrGeneProduct | denotes | OPRM1 |
| T41 | 1350-1364 | GeneOrGeneProduct | denotes | L-asparaginase |
| T42 | 1389-1394 | GeneOrGeneProduct | denotes | OPRM1 |
| T43 | 1418-1422 | GeneOrGeneProduct | denotes | cell |
| T44 | 1432-1438 | GeneOrGeneProduct | denotes | likely |
| T45 | 1469-1474 | GeneOrGeneProduct | denotes | OPRM1 |
| T46 | 1475-1483 | GeneOrGeneProduct | denotes | mediated |
| T47 | 1550-1555 | GeneOrGeneProduct | denotes | cells |
| T48 | 1572-1576 | GeneOrGeneProduct | denotes | high |
| T49 | 1587-1592 | GeneOrGeneProduct | denotes | OPRM1 |
| T50 | 1615-1629 | GeneOrGeneProduct | denotes | L-asparaginase |
| T51 | 1652-1657 | GeneOrGeneProduct | denotes | OPRM1 |
| T52 | 1658-1666 | GeneOrGeneProduct | denotes | depleted |
| T53 | 1676-1681 | GeneOrGeneProduct | denotes | cells |
| T54 | 1707-1712 | GeneOrGeneProduct | denotes | OPRM1 |
| T55 | 1718-1723 | GeneOrGeneProduct | denotes | has a |
| T56 | 1740-1754 | GeneOrGeneProduct | denotes | L-asparaginase |
| T57 | 1831-1835 | GeneOrGeneProduct | denotes | time |
| T58 | 1839-1844 | GeneOrGeneProduct | denotes | novel |
| T59 | 1845-1850 | GeneOrGeneProduct | denotes | OPRM1 |
| T60 | 1851-1859 | GeneOrGeneProduct | denotes | mediated |
| T61 | 1874-1888 | GeneOrGeneProduct | denotes | L-asparaginase |
| T62 | 1903-1906 | GeneOrGeneProduct | denotes | ALL |
| T63 | 1923-1928 | GeneOrGeneProduct | denotes | OPRM1 |
| T64 | 1968-1972 | GeneOrGeneProduct | denotes | high |
| T65 | 2037-2043 | GeneOrGeneProduct | denotes | clones |
| T66 | 2045-2050 | GeneOrGeneProduct | denotes | Oprm1 |
| T67 | 2099-2113 | GeneOrGeneProduct | denotes | L-asparaginase |
| T68 | 2168-2172 | GeneOrGeneProduct | denotes | June |
LitCoin-GeneOrGeneProduct-v2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 65-73 | GeneOrGeneProduct | denotes | receptor |
| T2 | 86-95 | GeneOrGeneProduct | denotes | regulator |
| T3 | 99-113 | GeneOrGeneProduct | denotes | L-asparaginase |
| T4 | 168-182 | GeneOrGeneProduct | denotes | L-asparaginase |
| T5 | 297-306 | GeneOrGeneProduct | denotes | aspartate |
| T6 | 361-368 | GeneOrGeneProduct | denotes | protein |
| T7 | 404-408 | GeneOrGeneProduct | denotes | cell |
| T8 | 553-567 | GeneOrGeneProduct | denotes | L-asparaginase |
| T9 | 571-578 | GeneOrGeneProduct | denotes | unknown |
| T10 | 640-654 | GeneOrGeneProduct | denotes | L-asparaginase |
| T11 | 796-816 | GeneOrGeneProduct | denotes | opioid receptor mu 1 |
| T12 | 818-823 | GeneOrGeneProduct | denotes | oprm1 |
| T13 | 844-864 | GeneOrGeneProduct | denotes | carbonic anhydrase 1 |
| T14 | 866-869 | GeneOrGeneProduct | denotes | ca1 |
| T15 | 901-933 | GeneOrGeneProduct | denotes | ubiquitin-conjugating enzyme E2C |
| T16 | 935-940 | GeneOrGeneProduct | denotes | ube2c |
| T17 | 962-967 | GeneOrGeneProduct | denotes | OPRM1 |
| T18 | 1020-1029 | GeneOrGeneProduct | denotes | knockdown |
| T19 | 1033-1038 | GeneOrGeneProduct | denotes | OPRM1 |
| T20 | 1047-1061 | GeneOrGeneProduct | denotes | L-asparaginase |
| T21 | 1167-1172 | GeneOrGeneProduct | denotes | OPRM1 |
| T22 | 1235-1240 | GeneOrGeneProduct | denotes | OPRM1 |
| T23 | 1241-1249 | GeneOrGeneProduct | denotes | depleted |
| T24 | 1260-1274 | GeneOrGeneProduct | denotes | L-asparaginase |
| T25 | 1302-1307 | GeneOrGeneProduct | denotes | OPRM1 |
| T26 | 1350-1364 | GeneOrGeneProduct | denotes | L-asparaginase |
| T27 | 1389-1394 | GeneOrGeneProduct | denotes | OPRM1 |
| T28 | 1418-1422 | GeneOrGeneProduct | denotes | cell |
| T29 | 1469-1474 | GeneOrGeneProduct | denotes | OPRM1 |
| T30 | 1572-1576 | GeneOrGeneProduct | denotes | high |
| T31 | 1587-1592 | GeneOrGeneProduct | denotes | OPRM1 |
| T32 | 1615-1629 | GeneOrGeneProduct | denotes | L-asparaginase |
| T33 | 1652-1657 | GeneOrGeneProduct | denotes | OPRM1 |
| T34 | 1658-1666 | GeneOrGeneProduct | denotes | depleted |
| T35 | 1707-1712 | GeneOrGeneProduct | denotes | OPRM1 |
| T36 | 1740-1754 | GeneOrGeneProduct | denotes | L-asparaginase |
| T37 | 1839-1844 | GeneOrGeneProduct | denotes | novel |
| T38 | 1845-1850 | GeneOrGeneProduct | denotes | OPRM1 |
| T39 | 1874-1888 | GeneOrGeneProduct | denotes | L-asparaginase |
| T40 | 1923-1928 | GeneOrGeneProduct | denotes | OPRM1 |
| T41 | 1968-1972 | GeneOrGeneProduct | denotes | high |
| T42 | 2045-2050 | GeneOrGeneProduct | denotes | Oprm1 |
| T43 | 2099-2113 | GeneOrGeneProduct | denotes | L-asparaginase |
LitCoin-Disease-MeSH
| Id | Subject | Object | Predicate | Lexical cue | originalLabel |
|---|---|---|---|---|---|
| T1 | 138-166 | DiseaseOrPhenotypicFeature | denotes | acute lymphoblastic leukemia | D054198 |
| T2 | 224-252 | DiseaseOrPhenotypicFeature | denotes | acute lymphoblastic leukemia | D054198 |
| T3 | 254-257 | DiseaseOrPhenotypicFeature | denotes | ALL | D054198 |
| T4 | 409-414 | DiseaseOrPhenotypicFeature | denotes | death | D003643 |
| T5 | 433-440 | DiseaseOrPhenotypicFeature | denotes | relapse | D012008 |
| T6 | 521-524 | DiseaseOrPhenotypicFeature | denotes | ALL | D054198 |
| T7 | 766-769 | DiseaseOrPhenotypicFeature | denotes | ALL | D054198 |
| T8 | 1903-1906 | DiseaseOrPhenotypicFeature | denotes | ALL | D054198 |
LitCoin-GeneOrGeneProduct-v3
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 101-113 | GeneOrGeneProduct | denotes | asparaginase |
| T2 | 170-182 | GeneOrGeneProduct | denotes | asparaginase |
| T3 | 555-567 | GeneOrGeneProduct | denotes | asparaginase |
| T4 | 642-654 | GeneOrGeneProduct | denotes | asparaginase |
| T5 | 796-816 | GeneOrGeneProduct | denotes | opioid receptor mu 1 |
| T6 | 818-823 | GeneOrGeneProduct | denotes | oprm1 |
| T7 | 844-864 | GeneOrGeneProduct | denotes | carbonic anhydrase 1 |
| T8 | 866-869 | GeneOrGeneProduct | denotes | ca1 |
| T9 | 901-933 | GeneOrGeneProduct | denotes | ubiquitin-conjugating enzyme E2C |
| T10 | 935-940 | GeneOrGeneProduct | denotes | ube2c |
| T11 | 962-967 | GeneOrGeneProduct | denotes | OPRM1 |
| T12 | 1033-1038 | GeneOrGeneProduct | denotes | OPRM1 |
| T13 | 1049-1061 | GeneOrGeneProduct | denotes | asparaginase |
| T14 | 1167-1172 | GeneOrGeneProduct | denotes | OPRM1 |
| T15 | 1235-1240 | GeneOrGeneProduct | denotes | OPRM1 |
| T16 | 1262-1274 | GeneOrGeneProduct | denotes | asparaginase |
| T17 | 1302-1307 | GeneOrGeneProduct | denotes | OPRM1 |
| T18 | 1352-1364 | GeneOrGeneProduct | denotes | asparaginase |
| T19 | 1389-1394 | GeneOrGeneProduct | denotes | OPRM1 |
| T20 | 1469-1474 | GeneOrGeneProduct | denotes | OPRM1 |
| T21 | 1587-1592 | GeneOrGeneProduct | denotes | OPRM1 |
| T22 | 1617-1629 | GeneOrGeneProduct | denotes | asparaginase |
| T23 | 1652-1657 | GeneOrGeneProduct | denotes | OPRM1 |
| T24 | 1707-1712 | GeneOrGeneProduct | denotes | OPRM1 |
| T25 | 1742-1754 | GeneOrGeneProduct | denotes | asparaginase |
| T26 | 1845-1850 | GeneOrGeneProduct | denotes | OPRM1 |
| T27 | 1876-1888 | GeneOrGeneProduct | denotes | asparaginase |
| T28 | 1923-1928 | GeneOrGeneProduct | denotes | OPRM1 |
| T29 | 2045-2050 | GeneOrGeneProduct | denotes | Oprm1 |
| T30 | 2101-2113 | GeneOrGeneProduct | denotes | asparaginase |
LitCoin_Mondo_095
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 128-166 | DiseaseOrPhenotypicFeature | denotes | pediatric acute lymphoblastic leukemia | 0000870 |
| T2 | 224-258 | DiseaseOrPhenotypicFeature | denotes | acute lymphoblastic leukemia (ALL) | 0004967|0003541|0000870 |
| T5 | 521-524 | DiseaseOrPhenotypicFeature | denotes | ALL | 0013108|0004967 |
| T7 | 766-769 | DiseaseOrPhenotypicFeature | denotes | ALL | 0013108|0004967 |
| T9 | 1187-1198 | DiseaseOrPhenotypicFeature | denotes | sensitivity | 0000605 |
| T10 | 1602-1611 | DiseaseOrPhenotypicFeature | denotes | sensitive | 0000605 |
| T11 | 1903-1906 | DiseaseOrPhenotypicFeature | denotes | ALL | 0013108|0004967 |
LitCoin-NCBITaxon-2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 425-432 | OrganismTaxon | denotes | patient |
| T2 | 1533-1540 | OrganismTaxon | denotes | patient |
| T3 | 1778-1786 | OrganismTaxon | denotes | patients |
| T4 | 1831-1838 | OrganismTaxon | denotes | time, a |
LitCoin-MeSH-Disease-2
| Id | Subject | Object | Predicate | Lexical cue | ID: |
|---|---|---|---|---|---|
| T1 | 138-166 | DiseaseOrPhenotypicFeature | denotes | acute lymphoblastic leukemia | D054198 |
| T2 | 224-252 | DiseaseOrPhenotypicFeature | denotes | acute lymphoblastic leukemia | D054198 |
| T3 | 254-257 | DiseaseOrPhenotypicFeature | denotes | ALL | DISEASE|D054198 |
| T5 | 324-342 | DiseaseOrPhenotypicFeature | denotes | asparagine deficit | DISEASE |
| T6 | 395-403 | DiseaseOrPhenotypicFeature | denotes | leukemic | DISEASE |
| T7 | 409-414 | DiseaseOrPhenotypicFeature | denotes | death | D003643 |
| T8 | 433-440 | DiseaseOrPhenotypicFeature | denotes | relapse | D012008 |
| T9 | 521-524 | DiseaseOrPhenotypicFeature | denotes | ALL | DISEASE|D054198 |
| T11 | 677-685 | DiseaseOrPhenotypicFeature | denotes | leukemic | DISEASE |
| T12 | 766-769 | DiseaseOrPhenotypicFeature | denotes | ALL | DISEASE|D054198 |
| T14 | 988-996 | DiseaseOrPhenotypicFeature | denotes | leukemic | DISEASE |
| T15 | 1211-1219 | DiseaseOrPhenotypicFeature | denotes | leukemic | DISEASE |
| T16 | 1409-1417 | DiseaseOrPhenotypicFeature | denotes | leukemic | DISEASE |
| T17 | 1541-1549 | DiseaseOrPhenotypicFeature | denotes | leukemic | DISEASE |
| T18 | 1667-1675 | DiseaseOrPhenotypicFeature | denotes | leukemic | DISEASE |
| T19 | 1769-1777 | DiseaseOrPhenotypicFeature | denotes | leukemic | DISEASE |
| T20 | 1903-1906 | DiseaseOrPhenotypicFeature | denotes | ALL | DISEASE|D054198 |
LitCoin-MONDO_bioort2019
| Id | Subject | Object | Predicate | Lexical cue | #label |
|---|---|---|---|---|---|
| T1 | 138-166 | DiseaseOrPhenotypicFeature | denotes | acute lymphoblastic leukemia | D054198 |
| T2 | 224-252 | DiseaseOrPhenotypicFeature | denotes | acute lymphoblastic leukemia | D054198 |
| T3 | 254-257 | DiseaseOrPhenotypicFeature | denotes | ALL | DISEASE|D054198 |
| T5 | 324-342 | DiseaseOrPhenotypicFeature | denotes | asparagine deficit | DISEASE |
| T6 | 395-403 | DiseaseOrPhenotypicFeature | denotes | leukemic | DISEASE |
| T7 | 521-524 | DiseaseOrPhenotypicFeature | denotes | ALL | DISEASE|D054198 |
| T9 | 677-685 | DiseaseOrPhenotypicFeature | denotes | leukemic | DISEASE |
| T10 | 766-769 | DiseaseOrPhenotypicFeature | denotes | ALL | DISEASE|D054198 |
| T12 | 988-996 | DiseaseOrPhenotypicFeature | denotes | leukemic | DISEASE |
| T13 | 1211-1219 | DiseaseOrPhenotypicFeature | denotes | leukemic | DISEASE |
| T14 | 1409-1417 | DiseaseOrPhenotypicFeature | denotes | leukemic | DISEASE |
| T15 | 1541-1549 | DiseaseOrPhenotypicFeature | denotes | leukemic | DISEASE |
| T16 | 1667-1675 | DiseaseOrPhenotypicFeature | denotes | leukemic | DISEASE |
| T17 | 1769-1777 | DiseaseOrPhenotypicFeature | denotes | leukemic | DISEASE |
| T18 | 1903-1906 | DiseaseOrPhenotypicFeature | denotes | ALL | DISEASE|D054198 |
LitCoin-Chemical-MeSH-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | ID: |
|---|---|---|---|---|---|
| T1 | 58-64 | ChemicalEntity | denotes | opioid | ChemicalEntity |
| T2 | 99-113 | ChemicalEntity | denotes | L-asparaginase | ChemicalEntity |
| T3 | 168-182 | ChemicalEntity | denotes | L-asparaginase | ChemicalEntity |
| T4 | 281-291 | ChemicalEntity | denotes | asparagine | http://purl.obolibrary.org/obo/CHEBI_22653 |
| T5 | 297-306 | ChemicalEntity | denotes | aspartate | http://purl.obolibrary.org/obo/CHEBI_72314|http://purl.obolibrary.org/obo/CHEBI_29995|http://purl.obolibrary.org/obo/CHEBI_132943 |
| T8 | 311-314 | ChemicalEntity | denotes | NH3 | http://purl.obolibrary.org/obo/CHEBI_16134 |
| T9 | 324-334 | ChemicalEntity | denotes | asparagine | http://purl.obolibrary.org/obo/CHEBI_22653 |
| T10 | 553-567 | ChemicalEntity | denotes | L-asparaginase | ChemicalEntity |
| T11 | 640-654 | ChemicalEntity | denotes | L-asparaginase | ChemicalEntity |
| T12 | 796-802 | ChemicalEntity | denotes | opioid | ChemicalEntity |
| T13 | 844-862 | ChemicalEntity | denotes | carbonic anhydrase | D002256 |
| T14 | 901-929 | ChemicalEntity | denotes | ubiquitin-conjugating enzyme | D044763 |
| T15 | 1047-1061 | ChemicalEntity | denotes | L-asparaginase | ChemicalEntity |
| T16 | 1142-1151 | ChemicalEntity | denotes | Methadone | D008691|http://purl.obolibrary.org/obo/CHEBI_6807 |
| T18 | 1260-1274 | ChemicalEntity | denotes | L-asparaginase | ChemicalEntity |
| T19 | 1350-1364 | ChemicalEntity | denotes | L-asparaginase | ChemicalEntity |
| T20 | 1369-1378 | ChemicalEntity | denotes | methadone | D008691|http://purl.obolibrary.org/obo/CHEBI_6807 |
| T22 | 1615-1629 | ChemicalEntity | denotes | L-asparaginase | ChemicalEntity |
| T23 | 1740-1754 | ChemicalEntity | denotes | L-asparaginase | ChemicalEntity |
| T24 | 1874-1888 | ChemicalEntity | denotes | L-asparaginase | ChemicalEntity |
| T25 | 2099-2113 | ChemicalEntity | denotes | L-asparaginase | ChemicalEntity |
LitCoin-training-merged
| Id | Subject | Object | Predicate | Lexical cue | #label | ID: |
|---|---|---|---|---|---|---|
| T25 | 2099-2113 | ChemicalEntity | denotes | L-asparaginase | ChemicalEntity | |
| T24 | 1874-1888 | ChemicalEntity | denotes | L-asparaginase | ChemicalEntity | |
| T23 | 1740-1754 | ChemicalEntity | denotes | L-asparaginase | ChemicalEntity | |
| T22 | 1615-1629 | ChemicalEntity | denotes | L-asparaginase | ChemicalEntity | |
| T20 | 1369-1378 | ChemicalEntity | denotes | methadone | http://purl.obolibrary.org/obo/CHEBI_6807|D008691 | |
| T19 | 1350-1364 | ChemicalEntity | denotes | L-asparaginase | ChemicalEntity | |
| T18 | 1260-1274 | ChemicalEntity | denotes | L-asparaginase | ChemicalEntity | |
| T16 | 1142-1151 | ChemicalEntity | denotes | Methadone | http://purl.obolibrary.org/obo/CHEBI_6807|D008691 | |
| T15 | 1047-1061 | ChemicalEntity | denotes | L-asparaginase | ChemicalEntity | |
| T14 | 901-929 | ChemicalEntity | denotes | ubiquitin-conjugating enzyme | D044763 | |
| T13 | 844-862 | ChemicalEntity | denotes | carbonic anhydrase | D002256 | |
| T12 | 796-802 | ChemicalEntity | denotes | opioid | ChemicalEntity | |
| T11 | 640-654 | ChemicalEntity | denotes | L-asparaginase | ChemicalEntity | |
| T10 | 553-567 | ChemicalEntity | denotes | L-asparaginase | ChemicalEntity | |
| T9 | 324-334 | ChemicalEntity | denotes | asparagine | http://purl.obolibrary.org/obo/CHEBI_22653 | |
| T8 | 311-314 | ChemicalEntity | denotes | NH3 | http://purl.obolibrary.org/obo/CHEBI_16134 | |
| T5 | 297-306 | ChemicalEntity | denotes | aspartate | http://purl.obolibrary.org/obo/CHEBI_132943|http://purl.obolibrary.org/obo/CHEBI_29995|http://purl.obolibrary.org/obo/CHEBI_72314 | |
| T4 | 281-291 | ChemicalEntity | denotes | asparagine | http://purl.obolibrary.org/obo/CHEBI_22653 | |
| T3 | 168-182 | ChemicalEntity | denotes | L-asparaginase | ChemicalEntity | |
| T2 | 99-113 | ChemicalEntity | denotes | L-asparaginase | ChemicalEntity | |
| T1 | 58-64 | ChemicalEntity | denotes | opioid | ChemicalEntity | |
| T30 | 2101-2113 | GeneOrGeneProduct | denotes | asparaginase | ||
| T29 | 2045-2050 | GeneOrGeneProduct | denotes | Oprm1 | ||
| T28 | 1923-1928 | GeneOrGeneProduct | denotes | OPRM1 | ||
| T27 | 1876-1888 | GeneOrGeneProduct | denotes | asparaginase | ||
| T26 | 1845-1850 | GeneOrGeneProduct | denotes | OPRM1 | ||
| T28284 | 1742-1754 | GeneOrGeneProduct | denotes | asparaginase | ||
| T10840 | 1707-1712 | GeneOrGeneProduct | denotes | OPRM1 | ||
| T7265 | 1652-1657 | GeneOrGeneProduct | denotes | OPRM1 | ||
| T66887 | 1617-1629 | GeneOrGeneProduct | denotes | asparaginase | ||
| T21 | 1587-1592 | GeneOrGeneProduct | denotes | OPRM1 | ||
| T83543 | 1469-1474 | GeneOrGeneProduct | denotes | OPRM1 | ||
| T20800 | 1389-1394 | GeneOrGeneProduct | denotes | OPRM1 | ||
| T5329 | 1352-1364 | GeneOrGeneProduct | denotes | asparaginase | ||
| T17 | 1302-1307 | GeneOrGeneProduct | denotes | OPRM1 | ||
| T46155 | 1262-1274 | GeneOrGeneProduct | denotes | asparaginase | ||
| T10811 | 1235-1240 | GeneOrGeneProduct | denotes | OPRM1 | ||
| T68205 | 1167-1172 | GeneOrGeneProduct | denotes | OPRM1 | ||
| T77715 | 1049-1061 | GeneOrGeneProduct | denotes | asparaginase | ||
| T11832 | 1033-1038 | GeneOrGeneProduct | denotes | OPRM1 | ||
| T92706 | 962-967 | GeneOrGeneProduct | denotes | OPRM1 | ||
| T8522 | 935-940 | GeneOrGeneProduct | denotes | ube2c | ||
| T96940 | 901-933 | GeneOrGeneProduct | denotes | ubiquitin-conjugating enzyme E2C | ||
| T50729 | 866-869 | GeneOrGeneProduct | denotes | ca1 | ||
| T7 | 844-864 | GeneOrGeneProduct | denotes | carbonic anhydrase 1 | ||
| T6 | 818-823 | GeneOrGeneProduct | denotes | oprm1 | ||
| T99486 | 796-816 | GeneOrGeneProduct | denotes | opioid receptor mu 1 | ||
| T16536 | 642-654 | GeneOrGeneProduct | denotes | asparaginase | ||
| T58986 | 555-567 | GeneOrGeneProduct | denotes | asparaginase | ||
| T32874 | 170-182 | GeneOrGeneProduct | denotes | asparaginase | ||
| T31025 | 101-113 | GeneOrGeneProduct | denotes | asparaginase | ||
| T82791 | 1903-1906 | DiseaseOrPhenotypicFeature | denotes | ALL | D054198|DISEASE | |
| T52213 | 1769-1777 | DiseaseOrPhenotypicFeature | denotes | leukemic | DISEASE | |
| T32181 | 1667-1675 | DiseaseOrPhenotypicFeature | denotes | leukemic | DISEASE | |
| T45209 | 1541-1549 | DiseaseOrPhenotypicFeature | denotes | leukemic | DISEASE | |
| T87327 | 1409-1417 | DiseaseOrPhenotypicFeature | denotes | leukemic | DISEASE | |
| T43560 | 1211-1219 | DiseaseOrPhenotypicFeature | denotes | leukemic | DISEASE | |
| T21336 | 988-996 | DiseaseOrPhenotypicFeature | denotes | leukemic | DISEASE | |
| T77788 | 766-769 | DiseaseOrPhenotypicFeature | denotes | ALL | D054198|DISEASE | |
| T99648 | 677-685 | DiseaseOrPhenotypicFeature | denotes | leukemic | DISEASE | |
| T74164 | 521-524 | DiseaseOrPhenotypicFeature | denotes | ALL | D054198|DISEASE | |
| T53983 | 395-403 | DiseaseOrPhenotypicFeature | denotes | leukemic | DISEASE | |
| T73345 | 324-342 | DiseaseOrPhenotypicFeature | denotes | asparagine deficit | DISEASE | |
| T8200 | 254-257 | DiseaseOrPhenotypicFeature | denotes | ALL | D054198|DISEASE | |
| T38861 | 224-252 | DiseaseOrPhenotypicFeature | denotes | acute lymphoblastic leukemia | D054198 | |
| T29857 | 138-166 | DiseaseOrPhenotypicFeature | denotes | acute lymphoblastic leukemia | D054198 | |
| T38036 | 1831-1838 | OrganismTaxon | denotes | time, a | ||
| T39182 | 1778-1786 | OrganismTaxon | denotes | patients | ||
| T29333 | 1533-1540 | OrganismTaxon | denotes | patient | ||
| T55818 | 425-432 | OrganismTaxon | denotes | patient | ||
| T96405 | 930-933 | SequenceVariant | denotes | E2C |