PubMed:28642124 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/28642124","sourcedb":"PubMed","sourceid":"28642124","text":"Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study.\nBACKGROUND: Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate a novel measure of disease progression and to identify genetic markers associated with this progression measure.\nMETHODS: We generated a progression score on the basis of principal component analysis of prospectively acquired longitudinal changes in motor, cognitive, and imaging measures in the 218 indivduals in the TRACK-HD cohort of Huntington's disease gene mutation carriers (data collected 2008-11). We generated a parallel progression score using data from 1773 previously genotyped participants from the European Huntington's Disease Network REGISTRY study of Huntington's disease mutation carriers (data collected 2003-13). We did a genome-wide association analyses in terms of progression for 216 TRACK-HD participants and 1773 REGISTRY participants, then a meta-analysis of these results was undertaken.\nFINDINGS: Longitudinal motor, cognitive, and imaging scores were correlated with each other in TRACK-HD participants, justifying use of a single, cross-domain measure of disease progression in both studies. The TRACK-HD and REGISTRY progression measures were correlated with each other (r=0·674), and with age at onset (TRACK-HD, r=0·315; REGISTRY, r=0·234). The meta-analysis of progression in TRACK-HD and REGISTRY gave a genome-wide significant signal (p=1·12 × 10(-10)) on chromosome 5 spanning three genes: MSH3, DHFR, and MTRNR2L2. The genes in this locus were associated with progression in TRACK-HD (MSH3 p=2·94 × 10(-8)DHFR p=8·37 × 10(-7) MTRNR2L2 p=2·15 × 10(-9)) and to a lesser extent in REGISTRY (MSH3 p=9·36 × 10(-4)DHFR p=8·45 × 10(-4)MTRNR2L2 p=1·20 × 10(-3)). The lead single nucleotide polymorphism (SNP) in TRACK-HD (rs557874766) was genome-wide significant in the meta-analysis (p=1·58 × 10(-8)), and encodes an aminoacid change (Pro67Ala) in MSH3. In TRACK-HD, each copy of the minor allele at this SNP was associated with a 0·4 units per year (95% CI 0·16-0·66) reduction in the rate of change of the Unified Huntington's Disease Rating Scale (UHDRS) Total Motor Score, and a reduction of 0·12 units per year (95% CI 0·06-0·18) in the rate of change of UHDRS Total Functional Capacity score. These associations remained significant after adjusting for age of onset.\nINTERPRETATION: The multidomain progression measure in TRACK-HD was associated with a functional variant that was genome-wide significant in our meta-analysis. The association in only 216 participants implies that the progression measure is a sensitive reflection of disease burden, that the effect size at this locus is large, or both. Knockout of Msh3 reduces somatic expansion in Huntington's disease mouse models, suggesting this mechanism as an area for future therapeutic investigation.\nFUNDING: The European Commission FP7 NeurOmics project; CHDI Foundation; the Medical Research Council UK; the Brain Research Trust; and the Guarantors of Brain.","tracks":[{"project":"PubTator4TogoVar","denotations":[{"id":"28642124_0","span":{"begin":2182,"end":2190},"obj":"ProteinMutation"}],"attributes":[{"id":"28642124_0_ProteinMutation","pred":"proteinmutation","subj":"28642124_0","obj":"rs557874766"},{"subj":"28642124_0","pred":"source","obj":"PubTator4TogoVar"}]},{"project":"c_corpus","denotations":[{"id":"T5","span":{"begin":51,"end":71},"obj":"D006816"},{"id":"T6","span":{"begin":51,"end":71},"obj":"D006816"},{"id":"T9","span":{"begin":64,"end":83},"obj":"D018450"},{"id":"T10","span":{"begin":64,"end":83},"obj":"D018450"},{"id":"T11","span":{"begin":87,"end":93},"obj":"SO:0001026"},{"id":"T16","span":{"begin":130,"end":150},"obj":"D006816"},{"id":"T17","span":{"begin":130,"end":150},"obj":"D006816"},{"id":"T20","span":{"begin":166,"end":169},"obj":"CVCL_D569"},{"id":"T21","span":{"begin":170,"end":176},"obj":"SO:0001068"},{"id":"T22","span":{"begin":194,"end":204},"obj":"P42858"},{"id":"T23","span":{"begin":194,"end":204},"obj":"P42859"},{"id":"T24","span":{"begin":194,"end":204},"obj":"P51111"},{"id":"T25","span":{"begin":194,"end":204},"obj":"PR:000008840"},{"id":"T26","span":{"begin":194,"end":204},"obj":"P51112"},{"id":"T27","span":{"begin":205,"end":209},"obj":"SO:0000704"},{"id":"T28","span":{"begin":211,"end":214},"obj":"PR:P51111"},{"id":"T29","span":{"begin":211,"end":214},"obj":"PR:000015189"},{"id":"T30","span":{"begin":211,"end":214},"obj":"PR:Q76P24"},{"id":"T31","span":{"begin":211,"end":214},"obj":"PR:P31645"},{"id":"T32","span":{"begin":211,"end":214},"obj":"PR:P42859"},{"id":"T33","span":{"begin":211,"end":214},"obj":"PR:Q60857"},{"id":"T34","span":{"begin":211,"end":214},"obj":"PR:P42858"},{"id":"T35","span":{"begin":211,"end":214},"obj":"PR:000008840"},{"id":"T40","span":{"begin":303,"end":323},"obj":"D006816"},{"id":"T41","span":{"begin":303,"end":323},"obj":"D006816"},{"id":"T46","span":{"begin":434,"end":453},"obj":"D018450"},{"id":"T47","span":{"begin":434,"end":453},"obj":"D018450"},{"id":"T48","span":{"begin":470,"end":485},"obj":"D005819"},{"id":"T49","span":{"begin":470,"end":485},"obj":"D005819"},{"id":"T50","span":{"begin":564,"end":569},"obj":"SO:0001685"},{"id":"T51","span":{"begin":742,"end":748},"obj":"CHEBI:34935"},{"id":"T56","span":{"begin":752,"end":772},"obj":"D006816"},{"id":"T57","span":{"begin":752,"end":772},"obj":"D006816"},{"id":"T60","span":{"begin":773,"end":777},"obj":"SO:0000704"},{"id":"T61","span":{"begin":778,"end":786},"obj":"SO:0000109"},{"id":"T62","span":{"begin":787,"end":795},"obj":"CHEBI:78059"},{"id":"T63","span":{"begin":858,"end":863},"obj":"SO:0001685"},{"id":"T68","span":{"begin":937,"end":957},"obj":"D006816"},{"id":"T69","span":{"begin":937,"end":957},"obj":"D006816"},{"id":"T76","span":{"begin":984,"end":1004},"obj":"D006816"},{"id":"T77","span":{"begin":984,"end":1004},"obj":"D006816"},{"id":"T80","span":{"begin":1005,"end":1013},"obj":"SO:0000109"},{"id":"T81","span":{"begin":1014,"end":1022},"obj":"CHEBI:78059"},{"id":"T82","span":{"begin":1058,"end":1064},"obj":"SO:0001026"},{"id":"T83","span":{"begin":1184,"end":1188},"obj":"PR:000023208"},{"id":"T84","span":{"begin":1184,"end":1188},"obj":"PR:P07623"},{"id":"T85","span":{"begin":1383,"end":1389},"obj":"SO:0000417"},{"id":"T88","span":{"begin":1401,"end":1420},"obj":"D018450"},{"id":"T89","span":{"begin":1401,"end":1420},"obj":"D018450"},{"id":"T90","span":{"begin":1594,"end":1598},"obj":"PR:000023208"},{"id":"T91","span":{"begin":1594,"end":1598},"obj":"PR:P07623"},{"id":"T92","span":{"begin":1655,"end":1661},"obj":"SO:0001026"},{"id":"T93","span":{"begin":1679,"end":1685},"obj":"SO:0000725"},{"id":"T94","span":{"begin":1679,"end":1685},"obj":"SO:0000418"},{"id":"T95","span":{"begin":1708,"end":1718},"obj":"GO:0005694"},{"id":"T96","span":{"begin":1708,"end":1718},"obj":"SO:0000340"},{"id":"T98","span":{"begin":1743,"end":1746},"obj":"CHEBI:16768"},{"id":"T102","span":{"begin":1743,"end":1746},"obj":"D009074"},{"id":"T103","span":{"begin":1743,"end":1746},"obj":"D009074"},{"id":"T104","span":{"begin":1743,"end":1747},"obj":"PR:O65607"},{"id":"T105","span":{"begin":1743,"end":1747},"obj":"PR:000010667"},{"id":"T106","span":{"begin":1743,"end":1747},"obj":"PR:Q59Y41"},{"id":"T107","span":{"begin":1743,"end":1747},"obj":"PR:P25336"},{"id":"T108","span":{"begin":1743,"end":1747},"obj":"PR:P20585"},{"id":"T109","span":{"begin":1743,"end":1747},"obj":"PR:P26359"},{"id":"T110","span":{"begin":1743,"end":1747},"obj":"PR:P13705"},{"id":"T111","span":{"begin":1743,"end":1747},"obj":"PR:Q1ZXH0"},{"id":"T112","span":{"begin":1749,"end":1753},"obj":"PR:P00374"},{"id":"T113","span":{"begin":1749,"end":1753},"obj":"PR:Q920D2"},{"id":"T114","span":{"begin":1749,"end":1753},"obj":"A8A0E8"},{"id":"T115","span":{"begin":1749,"end":1753},"obj":"Q6GGY1"},{"id":"T116","span":{"begin":1749,"end":1753},"obj":"Q320W2"},{"id":"T117","span":{"begin":1749,"end":1753},"obj":"Q83RC9"},{"id":"T118","span":{"begin":1749,"end":1753},"obj":"B1IQY4"},{"id":"T119","span":{"begin":1749,"end":1753},"obj":"PR:000006844"},{"id":"T121","span":{"begin":1749,"end":1753},"obj":"P0C0P0"},{"id":"T122","span":{"begin":1749,"end":1753},"obj":"A4W9Z4"},{"id":"T123","span":{"begin":1749,"end":1753},"obj":"P0AFS4"},{"id":"T124","span":{"begin":1749,"end":1753},"obj":"P0AFS3"},{"id":"T125","span":{"begin":1749,"end":1753},"obj":"A6T8N3"},{"id":"T126","span":{"begin":1749,"end":1753},"obj":"PR:P17719"},{"id":"T127","span":{"begin":1749,"end":1753},"obj":"Q8FHB1"},{"id":"T128","span":{"begin":1749,"end":1753},"obj":"PR:P00376"},{"id":"T129","span":{"begin":1749,"end":1753},"obj":"Q0T4H1"},{"id":"T130","span":{"begin":1749,"end":1753},"obj":"Q5HPB1"},{"id":"T131","span":{"begin":1749,"end":1753},"obj":"PR:P00378"},{"id":"T132","span":{"begin":1749,"end":1753},"obj":"B1LET0"},{"id":"T133","span":{"begin":1749,"end":1753},"obj":"Q6G9D5"},{"id":"T134","span":{"begin":1749,"end":1753},"obj":"Q8NWQ9"},{"id":"T135","span":{"begin":1749,"end":1753},"obj":"Q5HFZ7"},{"id":"T136","span":{"begin":1749,"end":1753},"obj":"Q32G72"},{"id":"T137","span":{"begin":1749,"end":1753},"obj":"P0A017"},{"id":"T138","span":{"begin":1749,"end":1753},"obj":"A8AGY5"},{"id":"T139","span":{"begin":1749,"end":1753},"obj":"A7ZM66"},{"id":"T140","span":{"begin":1749,"end":1753},"obj":"Q60034"},{"id":"T141","span":{"begin":1749,"end":1753},"obj":"A1ABF1"},{"id":"T142","span":{"begin":1749,"end":1753},"obj":"Q0THM2"},{"id":"T143","span":{"begin":1749,"end":1753},"obj":"PR:P00375"},{"id":"T144","span":{"begin":1749,"end":1753},"obj":"Q3Z1V9"},{"id":"T145","span":{"begin":1749,"end":1753},"obj":"Q1RBJ2"},{"id":"T146","span":{"begin":1749,"end":1753},"obj":"P0C0P1"},{"id":"T147","span":{"begin":1749,"end":1753},"obj":"P99079"},{"id":"T148","span":{"begin":1749,"end":1753},"obj":"PR:000022681"},{"id":"T149","span":{"begin":1749,"end":1753},"obj":"P0A016"},{"id":"T120","span":{"begin":1749,"end":1753},"obj":"GO:0004146"},{"id":"T150","span":{"begin":1759,"end":1767},"obj":"PR:P0CJ69"},{"id":"T151","span":{"begin":1759,"end":1767},"obj":"PR:000031623"},{"id":"T153","span":{"begin":1839,"end":1842},"obj":"CHEBI:16768"},{"id":"T157","span":{"begin":1839,"end":1842},"obj":"D009074"},{"id":"T158","span":{"begin":1839,"end":1842},"obj":"D009074"},{"id":"T159","span":{"begin":1839,"end":1843},"obj":"PR:O65607"},{"id":"T160","span":{"begin":1839,"end":1843},"obj":"PR:000010667"},{"id":"T161","span":{"begin":1839,"end":1843},"obj":"PR:Q59Y41"},{"id":"T162","span":{"begin":1839,"end":1843},"obj":"PR:P25336"},{"id":"T163","span":{"begin":1839,"end":1843},"obj":"PR:P20585"},{"id":"T164","span":{"begin":1839,"end":1843},"obj":"PR:P26359"},{"id":"T165","span":{"begin":1839,"end":1843},"obj":"PR:P13705"},{"id":"T166","span":{"begin":1839,"end":1843},"obj":"PR:Q1ZXH0"},{"id":"T167","span":{"begin":1859,"end":1863},"obj":"PR:P00374"},{"id":"T168","span":{"begin":1859,"end":1863},"obj":"PR:Q920D2"},{"id":"T169","span":{"begin":1859,"end":1863},"obj":"A8A0E8"},{"id":"T170","span":{"begin":1859,"end":1863},"obj":"Q6GGY1"},{"id":"T171","span":{"begin":1859,"end":1863},"obj":"Q320W2"},{"id":"T172","span":{"begin":1859,"end":1863},"obj":"Q83RC9"},{"id":"T173","span":{"begin":1859,"end":1863},"obj":"B1IQY4"},{"id":"T174","span":{"begin":1859,"end":1863},"obj":"PR:000006844"},{"id":"T176","span":{"begin":1859,"end":1863},"obj":"P0C0P0"},{"id":"T177","span":{"begin":1859,"end":1863},"obj":"A4W9Z4"},{"id":"T178","span":{"begin":1859,"end":1863},"obj":"P0AFS4"},{"id":"T179","span":{"begin":1859,"end":1863},"obj":"P0AFS3"},{"id":"T180","span":{"begin":1859,"end":1863},"obj":"A6T8N3"},{"id":"T181","span":{"begin":1859,"end":1863},"obj":"PR:P17719"},{"id":"T182","span":{"begin":1859,"end":1863},"obj":"Q8FHB1"},{"id":"T183","span":{"begin":1859,"end":1863},"obj":"PR:P00376"},{"id":"T184","span":{"begin":1859,"end":1863},"obj":"Q0T4H1"},{"id":"T185","span":{"begin":1859,"end":1863},"obj":"Q5HPB1"},{"id":"T186","span":{"begin":1859,"end":1863},"obj":"PR:P00378"},{"id":"T187","span":{"begin":1859,"end":1863},"obj":"B1LET0"},{"id":"T188","span":{"begin":1859,"end":1863},"obj":"Q6G9D5"},{"id":"T189","span":{"begin":1859,"end":1863},"obj":"Q8NWQ9"},{"id":"T190","span":{"begin":1859,"end":1863},"obj":"Q5HFZ7"},{"id":"T191","span":{"begin":1859,"end":1863},"obj":"Q32G72"},{"id":"T192","span":{"begin":1859,"end":1863},"obj":"P0A017"},{"id":"T193","span":{"begin":1859,"end":1863},"obj":"A8AGY5"},{"id":"T194","span":{"begin":1859,"end":1863},"obj":"A7ZM66"},{"id":"T195","span":{"begin":1859,"end":1863},"obj":"Q60034"},{"id":"T196","span":{"begin":1859,"end":1863},"obj":"A1ABF1"},{"id":"T197","span":{"begin":1859,"end":1863},"obj":"Q0THM2"},{"id":"T198","span":{"begin":1859,"end":1863},"obj":"PR:P00375"},{"id":"T199","span":{"begin":1859,"end":1863},"obj":"Q3Z1V9"},{"id":"T200","span":{"begin":1859,"end":1863},"obj":"Q1RBJ2"},{"id":"T201","span":{"begin":1859,"end":1863},"obj":"P0C0P1"},{"id":"T202","span":{"begin":1859,"end":1863},"obj":"P99079"},{"id":"T203","span":{"begin":1859,"end":1863},"obj":"PR:000022681"},{"id":"T204","span":{"begin":1859,"end":1863},"obj":"P0A016"},{"id":"T175","span":{"begin":1859,"end":1863},"obj":"GO:0004146"},{"id":"T205","span":{"begin":1880,"end":1888},"obj":"PR:P0CJ69"},{"id":"T206","span":{"begin":1880,"end":1888},"obj":"PR:000031623"},{"id":"T209","span":{"begin":1942,"end":1945},"obj":"CHEBI:16768"},{"id":"T213","span":{"begin":1942,"end":1945},"obj":"D009074"},{"id":"T214","span":{"begin":1942,"end":1945},"obj":"D009074"},{"id":"T215","span":{"begin":1942,"end":1946},"obj":"PR:O65607"},{"id":"T216","span":{"begin":1942,"end":1946},"obj":"PR:000010667"},{"id":"T217","span":{"begin":1942,"end":1946},"obj":"PR:Q59Y41"},{"id":"T218","span":{"begin":1942,"end":1946},"obj":"PR:P25336"},{"id":"T219","span":{"begin":1942,"end":1946},"obj":"PR:P20585"},{"id":"T220","span":{"begin":1942,"end":1946},"obj":"PR:P26359"},{"id":"T221","span":{"begin":1942,"end":1946},"obj":"PR:P13705"},{"id":"T222","span":{"begin":1942,"end":1946},"obj":"PR:Q1ZXH0"},{"id":"T223","span":{"begin":1962,"end":1966},"obj":"PR:P00374"},{"id":"T224","span":{"begin":1962,"end":1966},"obj":"PR:Q920D2"},{"id":"T225","span":{"begin":1962,"end":1966},"obj":"A8A0E8"},{"id":"T226","span":{"begin":1962,"end":1966},"obj":"Q6GGY1"},{"id":"T227","span":{"begin":1962,"end":1966},"obj":"Q320W2"},{"id":"T228","span":{"begin":1962,"end":1966},"obj":"Q83RC9"},{"id":"T229","span":{"begin":1962,"end":1966},"obj":"B1IQY4"},{"id":"T230","span":{"begin":1962,"end":1966},"obj":"PR:000006844"},{"id":"T232","span":{"begin":1962,"end":1966},"obj":"P0C0P0"},{"id":"T233","span":{"begin":1962,"end":1966},"obj":"A4W9Z4"},{"id":"T234","span":{"begin":1962,"end":1966},"obj":"P0AFS4"},{"id":"T235","span":{"begin":1962,"end":1966},"obj":"P0AFS3"},{"id":"T236","span":{"begin":1962,"end":1966},"obj":"A6T8N3"},{"id":"T237","span":{"begin":1962,"end":1966},"obj":"PR:P17719"},{"id":"T238","span":{"begin":1962,"end":1966},"obj":"Q8FHB1"},{"id":"T239","span":{"begin":1962,"end":1966},"obj":"PR:P00376"},{"id":"T240","span":{"begin":1962,"end":1966},"obj":"Q0T4H1"},{"id":"T241","span":{"begin":1962,"end":1966},"obj":"Q5HPB1"},{"id":"T242","span":{"begin":1962,"end":1966},"obj":"PR:P00378"},{"id":"T243","span":{"begin":1962,"end":1966},"obj":"B1LET0"},{"id":"T244","span":{"begin":1962,"end":1966},"obj":"Q6G9D5"},{"id":"T245","span":{"begin":1962,"end":1966},"obj":"Q8NWQ9"},{"id":"T246","span":{"begin":1962,"end":1966},"obj":"Q5HFZ7"},{"id":"T247","span":{"begin":1962,"end":1966},"obj":"Q32G72"},{"id":"T248","span":{"begin":1962,"end":1966},"obj":"P0A017"},{"id":"T249","span":{"begin":1962,"end":1966},"obj":"A8AGY5"},{"id":"T250","span":{"begin":1962,"end":1966},"obj":"A7ZM66"},{"id":"T251","span":{"begin":1962,"end":1966},"obj":"Q60034"},{"id":"T252","span":{"begin":1962,"end":1966},"obj":"A1ABF1"},{"id":"T253","span":{"begin":1962,"end":1966},"obj":"Q0THM2"},{"id":"T254","span":{"begin":1962,"end":1966},"obj":"PR:P00375"},{"id":"T255","span":{"begin":1962,"end":1966},"obj":"Q3Z1V9"},{"id":"T256","span":{"begin":1962,"end":1966},"obj":"Q1RBJ2"},{"id":"T257","span":{"begin":1962,"end":1966},"obj":"P0C0P1"},{"id":"T258","span":{"begin":1962,"end":1966},"obj":"P99079"},{"id":"T259","span":{"begin":1962,"end":1966},"obj":"PR:000022681"},{"id":"T260","span":{"begin":1962,"end":1966},"obj":"P0A016"},{"id":"T231","span":{"begin":1962,"end":1966},"obj":"GO:0004146"},{"id":"T261","span":{"begin":1982,"end":1990},"obj":"PR:P0CJ69"},{"id":"T262","span":{"begin":1982,"end":1990},"obj":"PR:000031623"},{"id":"T263","span":{"begin":2018,"end":2048},"obj":"SO:0000694"},{"id":"T264","span":{"begin":2025,"end":2035},"obj":"CHEBI:36976"},{"id":"T266","span":{"begin":2050,"end":2053},"obj":"P86981"},{"id":"T267","span":{"begin":2050,"end":2053},"obj":"SO:0000694"},{"id":"T265","span":{"begin":2050,"end":2053},"obj":"CVCL_IP76"},{"id":"T268","span":{"begin":2085,"end":2091},"obj":"SO:0001026"},{"id":"T269","span":{"begin":2116,"end":2120},"obj":"PR:000023208"},{"id":"T270","span":{"begin":2116,"end":2120},"obj":"PR:P07623"},{"id":"T272","span":{"begin":2182,"end":2185},"obj":"CHEBI:32871"},{"id":"T273","span":{"begin":2182,"end":2185},"obj":"CHEBI:32865"},{"id":"T274","span":{"begin":2182,"end":2185},"obj":"CHEBI:50342"},{"id":"T276","span":{"begin":2182,"end":2185},"obj":"CHEBI:32866"},{"id":"T275","span":{"begin":2182,"end":2185},"obj":"SO:0001439"},{"id":"T271","span":{"begin":2182,"end":2185},"obj":"CVCL_N817"},{"id":"T277","span":{"begin":2187,"end":2190},"obj":"CHEBI:32433"},{"id":"T279","span":{"begin":2187,"end":2190},"obj":"CHEBI:32434"},{"id":"T280","span":{"begin":2187,"end":2190},"obj":"CHEBI:16977"},{"id":"T281","span":{"begin":2187,"end":2190},"obj":"CHEBI:46217"},{"id":"T283","span":{"begin":2187,"end":2190},"obj":"CHEBI:27432"},{"id":"T284","span":{"begin":2187,"end":2190},"obj":"CHEBI:16449"},{"id":"T285","span":{"begin":2187,"end":2190},"obj":"UBERON:3010458"},{"id":"T282","span":{"begin":2187,"end":2190},"obj":"SO:0001435"},{"id":"T278","span":{"begin":2187,"end":2190},"obj":"CVCL_J358"},{"id":"T287","span":{"begin":2195,"end":2198},"obj":"CHEBI:16768"},{"id":"T291","span":{"begin":2195,"end":2198},"obj":"D009074"},{"id":"T292","span":{"begin":2195,"end":2198},"obj":"D009074"},{"id":"T293","span":{"begin":2195,"end":2199},"obj":"PR:O65607"},{"id":"T294","span":{"begin":2195,"end":2199},"obj":"PR:000010667"},{"id":"T295","span":{"begin":2195,"end":2199},"obj":"PR:Q59Y41"},{"id":"T296","span":{"begin":2195,"end":2199},"obj":"PR:P25336"},{"id":"T297","span":{"begin":2195,"end":2199},"obj":"PR:P20585"},{"id":"T298","span":{"begin":2195,"end":2199},"obj":"PR:P26359"},{"id":"T299","span":{"begin":2195,"end":2199},"obj":"PR:P13705"},{"id":"T300","span":{"begin":2195,"end":2199},"obj":"PR:Q1ZXH0"},{"id":"T301","span":{"begin":2237,"end":2243},"obj":"SO:0001023"},{"id":"T303","span":{"begin":2252,"end":2255},"obj":"P86981"},{"id":"T302","span":{"begin":2252,"end":2255},"obj":"CVCL_IP76"},{"id":"T304","span":{"begin":2252,"end":2255},"obj":"SO:0000694"},{"id":"T305","span":{"begin":2316,"end":2325},"obj":"MOP:0000569"},{"id":"T310","span":{"begin":2363,"end":2383},"obj":"D006816"},{"id":"T311","span":{"begin":2363,"end":2383},"obj":"D006816"},{"id":"T314","span":{"begin":2430,"end":2439},"obj":"MOP:0000569"},{"id":"T315","span":{"begin":2539,"end":2544},"obj":"SO:0001685"},{"id":"T316","span":{"begin":2706,"end":2724},"obj":"SO:0001536"},{"id":"T318","span":{"begin":2734,"end":2740},"obj":"SO:0001026"},{"id":"T319","span":{"begin":2765,"end":2769},"obj":"PR:000023208"},{"id":"T320","span":{"begin":2765,"end":2769},"obj":"PR:P07623"},{"id":"T321","span":{"begin":2887,"end":2894},"obj":"D004194"},{"id":"T322","span":{"begin":2887,"end":2894},"obj":"D004194"},{"id":"T324","span":{"begin":2969,"end":2972},"obj":"CHEBI:16768"},{"id":"T328","span":{"begin":2969,"end":2972},"obj":"D009074"},{"id":"T329","span":{"begin":2969,"end":2972},"obj":"D009074"},{"id":"T330","span":{"begin":2969,"end":2973},"obj":"PR:O65607"},{"id":"T331","span":{"begin":2969,"end":2973},"obj":"PR:000010667"},{"id":"T332","span":{"begin":2969,"end":2973},"obj":"PR:Q59Y41"},{"id":"T333","span":{"begin":2969,"end":2973},"obj":"PR:P25336"},{"id":"T334","span":{"begin":2969,"end":2973},"obj":"PR:P20585"},{"id":"T335","span":{"begin":2969,"end":2973},"obj":"PR:P26359"},{"id":"T336","span":{"begin":2969,"end":2973},"obj":"PR:P13705"},{"id":"T337","span":{"begin":2969,"end":2973},"obj":"PR:Q1ZXH0"},{"id":"T342","span":{"begin":3003,"end":3023},"obj":"D006816"},{"id":"T343","span":{"begin":3003,"end":3023},"obj":"D006816"},{"id":"T346","span":{"begin":3024,"end":3029},"obj":"10090"},{"id":"T347","span":{"begin":3024,"end":3029},"obj":"D051379"},{"id":"T348","span":{"begin":3146,"end":3149},"obj":"PR:Q93VP2"},{"id":"T349","span":{"begin":3219,"end":3228},"obj":"UBERON:0000955"}],"attributes":[{"subj":"T5","pred":"source","obj":"c_corpus"},{"subj":"T6","pred":"source","obj":"c_corpus"},{"subj":"T9","pred":"source","obj":"c_corpus"},{"subj":"T10","pred":"source","obj":"c_corpus"},{"subj":"T11","pred":"source","obj":"c_corpus"},{"subj":"T16","pred":"source","obj":"c_corpus"},{"subj":"T17","pred":"source","obj":"c_corpus"},{"subj":"T20","pred":"source","obj":"c_corpus"},{"subj":"T21","pred":"source","obj":"c_corpus"},{"subj":"T22","pred":"source","obj":"c_corpus"},{"subj":"T23","pred":"source","obj":"c_corpus"},{"subj":"T24","pred":"source","obj":"c_corpus"},{"subj":"T25","pred":"source","obj":"c_corpus"},{"subj":"T26","pred":"source","obj":"c_corpus"},{"subj":"T27","pred":"source","obj":"c_corpus"},{"subj":"T28","pred":"source","obj":"c_corpus"},{"subj":"T29","pred":"source","obj":"c_corpus"},{"subj":"T30","pred":"source","obj":"c_corpus"},{"subj":"T31","pred":"source","obj":"c_corpus"},{"subj":"T32","pred":"source","obj":"c_corpus"},{"subj":"T33","pred":"source","obj":"c_corpus"},{"subj":"T34","pred":"source","obj":"c_corpus"},{"subj":"T35","pred":"source","obj":"c_corpus"},{"subj":"T40","pred":"source","obj":"c_corpus"},{"subj":"T41","pred":"source","obj":"c_corpus"},{"subj":"T46","pred":"source","obj":"c_corpus"},{"subj":"T47","pred":"source","obj":"c_corpus"},{"subj":"T48","pred":"source","obj":"c_corpus"},{"subj":"T49","pred":"source","obj":"c_corpus"},{"subj":"T50","pred":"source","obj":"c_corpus"},{"subj":"T51","pred":"source","obj":"c_corpus"},{"subj":"T56","pred":"source","obj":"c_corpus"},{"subj":"T57","pred":"source","obj":"c_corpus"},{"subj":"T60","pred":"source","obj":"c_corpus"},{"subj":"T61","pred":"source","obj":"c_corpus"},{"subj":"T62","pred":"source","obj":"c_corpus"},{"subj":"T63","pred":"source","obj":"c_corpus"},{"subj":"T68","pred":"source","obj":"c_corpus"},{"subj":"T69","pred":"source","obj":"c_corpus"},{"subj":"T76","pred":"source","obj":"c_corpus"},{"subj":"T77","pred":"source","obj":"c_corpus"},{"subj":"T80","pred":"source","obj":"c_corpus"},{"subj":"T81","pred":"source","obj":"c_corpus"},{"subj":"T82","pred":"source","obj":"c_corpus"},{"subj":"T83","pred":"source","obj":"c_corpus"},{"subj":"T84","pred":"source","obj":"c_corpus"},{"subj":"T85","pred":"source","obj":"c_corpus"},{"subj":"T88","pred":"source","obj":"c_corpus"},{"subj":"T89","pred":"source","obj":"c_corpus"},{"subj":"T90","pred":"source","obj":"c_corpus"},{"subj":"T91","pred":"source","obj":"c_corpus"},{"subj":"T92","pred":"source","obj":"c_corpus"},{"subj":"T93","pred":"source","obj":"c_corpus"},{"subj":"T94","pred":"source","obj":"c_corpus"},{"subj":"T95","pred":"source","obj":"c_corpus"},{"subj":"T96","pred":"source","obj":"c_corpus"},{"subj":"T98","pred":"source","obj":"c_corpus"},{"subj":"T102","pred":"source","obj":"c_corpus"},{"subj":"T103","pred":"source","obj":"c_corpus"},{"subj":"T104","pred":"source","obj":"c_corpus"},{"subj":"T105","pred":"source","obj":"c_corpus"},{"subj":"T106","pred":"source","obj":"c_corpus"},{"subj":"T107","pred":"source","obj":"c_corpus"},{"subj":"T108","pred":"source","obj":"c_corpus"},{"subj":"T109","pred":"source","obj":"c_corpus"},{"subj":"T110","pred":"source","obj":"c_corpus"},{"subj":"T111","pred":"source","obj":"c_corpus"},{"subj":"T112","pred":"source","obj":"c_corpus"},{"subj":"T113","pred":"source","obj":"c_corpus"},{"subj":"T114","pred":"source","obj":"c_corpus"},{"subj":"T115","pred":"source","obj":"c_corpus"},{"subj":"T116","pred":"source","obj":"c_corpus"},{"subj":"T117","pred":"source","obj":"c_corpus"},{"subj":"T118","pred":"source","obj":"c_corpus"},{"subj":"T119","pred":"source","obj":"c_corpus"},{"subj":"T121","pred":"source","obj":"c_corpus"},{"subj":"T122","pred":"source","obj":"c_corpus"},{"subj":"T123","pred":"source","obj":"c_corpus"},{"subj":"T124","pred":"source","obj":"c_corpus"},{"subj":"T125","pred":"source","obj":"c_corpus"},{"subj":"T126","pred":"source","obj":"c_corpus"},{"subj":"T127","pred":"source","obj":"c_corpus"},{"subj":"T128","pred":"source","obj":"c_corpus"},{"subj":"T129","pred":"source","obj":"c_corpus"},{"subj":"T130","pred":"source","obj":"c_corpus"},{"subj":"T131","pred":"source","obj":"c_corpus"},{"subj":"T132","pred":"source","obj":"c_corpus"},{"subj":"T133","pred":"source","obj":"c_corpus"},{"subj":"T134","pred":"source","obj":"c_corpus"},{"subj":"T135","pred":"source","obj":"c_corpus"},{"subj":"T136","pred":"source","obj":"c_corpus"},{"subj":"T137","pred":"source","obj":"c_corpus"},{"subj":"T138","pred":"source","obj":"c_corpus"},{"subj":"T139","pred":"source","obj":"c_corpus"},{"subj":"T140","pred":"source","obj":"c_corpus"},{"subj":"T141","pred":"source","obj":"c_corpus"},{"subj":"T142","pred":"source","obj":"c_corpus"},{"subj":"T143","pred":"source","obj":"c_corpus"},{"subj":"T144","pred":"source","obj":"c_corpus"},{"subj":"T145","pred":"source","obj":"c_corpus"},{"subj":"T146","pred":"source","obj":"c_corpus"},{"subj":"T147","pred":"source","obj":"c_corpus"},{"subj":"T148","pred":"source","obj":"c_corpus"},{"subj":"T149","pred":"source","obj":"c_corpus"},{"subj":"T120","pred":"source","obj":"c_corpus"},{"subj":"T150","pred":"source","obj":"c_corpus"},{"subj":"T151","pred":"source","obj":"c_corpus"},{"subj":"T153","pred":"source","obj":"c_corpus"},{"subj":"T157","pred":"source","obj":"c_corpus"},{"subj":"T158","pred":"source","obj":"c_corpus"},{"subj":"T159","pred":"source","obj":"c_corpus"},{"subj":"T160","pred":"source","obj":"c_corpus"},{"subj":"T161","pred":"source","obj":"c_corpus"},{"subj":"T162","pred":"source","obj":"c_corpus"},{"subj":"T163","pred":"source","obj":"c_corpus"},{"subj":"T164","pred":"source","obj":"c_corpus"},{"subj":"T165","pred":"source","obj":"c_corpus"},{"subj":"T166","pred":"source","obj":"c_corpus"},{"subj":"T167","pred":"source","obj":"c_corpus"},{"subj":"T168","pred":"source","obj":"c_corpus"},{"subj":"T169","pred":"source","obj":"c_corpus"},{"subj":"T170","pred":"source","obj":"c_corpus"},{"subj":"T171","pred":"source","obj":"c_corpus"},{"subj":"T172","pred":"source","obj":"c_corpus"},{"subj":"T173","pred":"source","obj":"c_corpus"},{"subj":"T174","pred":"source","obj":"c_corpus"},{"subj":"T176","pred":"source","obj":"c_corpus"},{"subj":"T177","pred":"source","obj":"c_corpus"},{"subj":"T178","pred":"source","obj":"c_corpus"},{"subj":"T179","pred":"source","obj":"c_corpus"},{"subj":"T180","pred":"source","obj":"c_corpus"},{"subj":"T181","pred":"source","obj":"c_corpus"},{"subj":"T182","pred":"source","obj":"c_corpus"},{"subj":"T183","pred":"source","obj":"c_corpus"},{"subj":"T184","pred":"source","obj":"c_corpus"},{"subj":"T185","pred":"source","obj":"c_corpus"},{"subj":"T186","pred":"source","obj":"c_corpus"},{"subj":"T187","pred":"source","obj":"c_corpus"},{"subj":"T188","pred":"source","obj":"c_corpus"},{"subj":"T189","pred":"source","obj":"c_corpus"},{"subj":"T190","pred":"source","obj":"c_corpus"},{"subj":"T191","pred":"source","obj":"c_corpus"},{"subj":"T192","pred":"source","obj":"c_corpus"},{"subj":"T193","pred":"source","obj":"c_corpus"},{"subj":"T194","pred":"source","obj":"c_corpus"},{"subj":"T195","pred":"source","obj":"c_corpus"},{"subj":"T196","pred":"source","obj":"c_corpus"},{"subj":"T197","pred":"source","obj":"c_corpus"},{"subj":"T198","pred":"source","obj":"c_corpus"},{"subj":"T199","pred":"source","obj":"c_corpus"},{"subj":"T200","pred":"source","obj":"c_corpus"},{"subj":"T201","pred":"source","obj":"c_corpus"},{"subj":"T202","pred":"source","obj":"c_corpus"},{"subj":"T203","pred":"source","obj":"c_corpus"},{"subj":"T204","pred":"source","obj":"c_corpus"},{"subj":"T175","pred":"source","obj":"c_corpus"},{"subj":"T205","pred":"source","obj":"c_corpus"},{"subj":"T206","pred":"source","obj":"c_corpus"},{"subj":"T209","pred":"source","obj":"c_corpus"},{"subj":"T213","pred":"source","obj":"c_corpus"},{"subj":"T214","pred":"source","obj":"c_corpus"},{"subj":"T215","pred":"source","obj":"c_corpus"},{"subj":"T216","pred":"source","obj":"c_corpus"},{"subj":"T217","pred":"source","obj":"c_corpus"},{"subj":"T218","pred":"source","obj":"c_corpus"},{"subj":"T219","pred":"source","obj":"c_corpus"},{"subj":"T220","pred":"source","obj":"c_corpus"},{"subj":"T221","pred":"source","obj":"c_corpus"},{"subj":"T222","pred":"source","obj":"c_corpus"},{"subj":"T223","pred":"source","obj":"c_corpus"},{"subj":"T224","pred":"source","obj":"c_corpus"},{"subj":"T225","pred":"source","obj":"c_corpus"},{"subj":"T226","pred":"source","obj":"c_corpus"},{"subj":"T227","pred":"source","obj":"c_corpus"},{"subj":"T228","pred":"source","obj":"c_corpus"},{"subj":"T229","pred":"source","obj":"c_corpus"},{"subj":"T230","pred":"source","obj":"c_corpus"},{"subj":"T232","pred":"source","obj":"c_corpus"},{"subj":"T233","pred":"source","obj":"c_corpus"},{"subj":"T234","pred":"source","obj":"c_corpus"},{"subj":"T235","pred":"source","obj":"c_corpus"},{"subj":"T236","pred":"source","obj":"c_corpus"},{"subj":"T237","pred":"source","obj":"c_corpus"},{"subj":"T238","pred":"source","obj":"c_corpus"},{"subj":"T239","pred":"source","obj":"c_corpus"},{"subj":"T240","pred":"source","obj":"c_corpus"},{"subj":"T241","pred":"source","obj":"c_corpus"},{"subj":"T242","pred":"source","obj":"c_corpus"},{"subj":"T243","pred":"source","obj":"c_corpus"},{"subj":"T244","pred":"source","obj":"c_corpus"},{"subj":"T245","pred":"source","obj":"c_corpus"},{"subj":"T246","pred":"source","obj":"c_corpus"},{"subj":"T247","pred":"source","obj":"c_corpus"},{"subj":"T248","pred":"source","obj":"c_corpus"},{"subj":"T249","pred":"source","obj":"c_corpus"},{"subj":"T250","pred":"source","obj":"c_corpus"},{"subj":"T251","pred":"source","obj":"c_corpus"},{"subj":"T252","pred":"source","obj":"c_corpus"},{"subj":"T253","pred":"source","obj":"c_corpus"},{"subj":"T254","pred":"source","obj":"c_corpus"},{"subj":"T255","pred":"source","obj":"c_corpus"},{"subj":"T256","pred":"source","obj":"c_corpus"},{"subj":"T257","pred":"source","obj":"c_corpus"},{"subj":"T258","pred":"source","obj":"c_corpus"},{"subj":"T259","pred":"source","obj":"c_corpus"},{"subj":"T260","pred":"source","obj":"c_corpus"},{"subj":"T231","pred":"source","obj":"c_corpus"},{"subj":"T261","pred":"source","obj":"c_corpus"},{"subj":"T262","pred":"source","obj":"c_corpus"},{"subj":"T263","pred":"source","obj":"c_corpus"},{"subj":"T264","pred":"source","obj":"c_corpus"},{"subj":"T266","pred":"source","obj":"c_corpus"},{"subj":"T267","pred":"source","obj":"c_corpus"},{"subj":"T265","pred":"source","obj":"c_corpus"},{"subj":"T268","pred":"source","obj":"c_corpus"},{"subj":"T269","pred":"source","obj":"c_corpus"},{"subj":"T270","pred":"source","obj":"c_corpus"},{"subj":"T272","pred":"source","obj":"c_corpus"},{"subj":"T273","pred":"source","obj":"c_corpus"},{"subj":"T274","pred":"source","obj":"c_corpus"},{"subj":"T276","pred":"source","obj":"c_corpus"},{"subj":"T275","pred":"source","obj":"c_corpus"},{"subj":"T271","pred":"source","obj":"c_corpus"},{"subj":"T277","pred":"source","obj":"c_corpus"},{"subj":"T279","pred":"source","obj":"c_corpus"},{"subj":"T280","pred":"source","obj":"c_corpus"},{"subj":"T281","pred":"source","obj":"c_corpus"},{"subj":"T283","pred":"source","obj":"c_corpus"},{"subj":"T284","pred":"source","obj":"c_corpus"},{"subj":"T285","pred":"source","obj":"c_corpus"},{"subj":"T282","pred":"source","obj":"c_corpus"},{"subj":"T278","pred":"source","obj":"c_corpus"},{"subj":"T287","pred":"source","obj":"c_corpus"},{"subj":"T291","pred":"source","obj":"c_corpus"},{"subj":"T292","pred":"source","obj":"c_corpus"},{"subj":"T293","pred":"source","obj":"c_corpus"},{"subj":"T294","pred":"source","obj":"c_corpus"},{"subj":"T295","pred":"source","obj":"c_corpus"},{"subj":"T296","pred":"source","obj":"c_corpus"},{"subj":"T297","pred":"source","obj":"c_corpus"},{"subj":"T298","pred":"source","obj":"c_corpus"},{"subj":"T299","pred":"source","obj":"c_corpus"},{"subj":"T300","pred":"source","obj":"c_corpus"},{"subj":"T301","pred":"source","obj":"c_corpus"},{"subj":"T303","pred":"source","obj":"c_corpus"},{"subj":"T302","pred":"source","obj":"c_corpus"},{"subj":"T304","pred":"source","obj":"c_corpus"},{"subj":"T305","pred":"source","obj":"c_corpus"},{"subj":"T310","pred":"source","obj":"c_corpus"},{"subj":"T311","pred":"source","obj":"c_corpus"},{"subj":"T314","pred":"source","obj":"c_corpus"},{"subj":"T315","pred":"source","obj":"c_corpus"},{"subj":"T316","pred":"source","obj":"c_corpus"},{"subj":"T318","pred":"source","obj":"c_corpus"},{"subj":"T319","pred":"source","obj":"c_corpus"},{"subj":"T320","pred":"source","obj":"c_corpus"},{"subj":"T321","pred":"source","obj":"c_corpus"},{"subj":"T322","pred":"source","obj":"c_corpus"},{"subj":"T324","pred":"source","obj":"c_corpus"},{"subj":"T328","pred":"source","obj":"c_corpus"},{"subj":"T329","pred":"source","obj":"c_corpus"},{"subj":"T330","pred":"source","obj":"c_corpus"},{"subj":"T331","pred":"source","obj":"c_corpus"},{"subj":"T332","pred":"source","obj":"c_corpus"},{"subj":"T333","pred":"source","obj":"c_corpus"},{"subj":"T334","pred":"source","obj":"c_corpus"},{"subj":"T335","pred":"source","obj":"c_corpus"},{"subj":"T336","pred":"source","obj":"c_corpus"},{"subj":"T337","pred":"source","obj":"c_corpus"},{"subj":"T342","pred":"source","obj":"c_corpus"},{"subj":"T343","pred":"source","obj":"c_corpus"},{"subj":"T346","pred":"source","obj":"c_corpus"},{"subj":"T347","pred":"source","obj":"c_corpus"},{"subj":"T348","pred":"source","obj":"c_corpus"},{"subj":"T349","pred":"source","obj":"c_corpus"}]},{"project":"UseCases_ArguminSci_Discourse","denotations":[{"id":"T1","span":{"begin":0,"end":117},"obj":"DRI_Background"},{"id":"T2","span":{"begin":130,"end":215},"obj":"DRI_Approach"},{"id":"T3","span":{"begin":216,"end":382},"obj":"DRI_Background"},{"id":"T4","span":{"begin":383,"end":527},"obj":"DRI_Approach"},{"id":"T5","span":{"begin":537,"end":821},"obj":"DRI_Approach"},{"id":"T6","span":{"begin":822,"end":1048},"obj":"DRI_Approach"},{"id":"T7","span":{"begin":1049,"end":1230},"obj":"DRI_Outcome"},{"id":"T8","span":{"begin":1241,"end":1437},"obj":"DRI_Background"},{"id":"T9","span":{"begin":1438,"end":1589},"obj":"DRI_Approach"},{"id":"T10","span":{"begin":1590,"end":1687},"obj":"DRI_Outcome"},{"id":"T11","span":{"begin":1687,"end":1695},"obj":"Token_Label.OUTSIDE"},{"id":"T12","span":{"begin":1696,"end":1768},"obj":"DRI_Outcome"},{"id":"T13","span":{"begin":1769,"end":1839},"obj":"DRI_Approach"},{"id":"T14","span":{"begin":1839,"end":1872},"obj":"Token_Label.OUTSIDE"},{"id":"T15","span":{"begin":1873,"end":1878},"obj":"DRI_Approach"},{"id":"T16","span":{"begin":1880,"end":1897},"obj":"Token_Label.OUTSIDE"},{"id":"T17","span":{"begin":1898,"end":1942},"obj":"DRI_Approach"},{"id":"T18","span":{"begin":1942,"end":1999},"obj":"Token_Label.OUTSIDE"},{"id":"T19","span":{"begin":2000,"end":2008},"obj":"DRI_Approach"},{"id":"T20","span":{"begin":2009,"end":2131},"obj":"DRI_Approach"},{"id":"T21","span":{"begin":2131,"end":2139},"obj":"Token_Label.OUTSIDE"},{"id":"T22","span":{"begin":2140,"end":2200},"obj":"DRI_Approach"},{"id":"T23","span":{"begin":2201,"end":2545},"obj":"DRI_Approach"},{"id":"T24","span":{"begin":2546,"end":2619},"obj":"DRI_Background"},{"id":"T25","span":{"begin":2636,"end":2779},"obj":"DRI_Outcome"},{"id":"T26","span":{"begin":2780,"end":2956},"obj":"DRI_Outcome"},{"id":"T27","span":{"begin":2957,"end":3112},"obj":"DRI_Outcome"},{"id":"T28","span":{"begin":3122,"end":3273},"obj":"DRI_Unspecified"}],"attributes":[{"subj":"T1","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T2","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T3","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T4","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T5","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T6","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T7","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T8","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T9","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T10","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T11","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T12","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T13","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T14","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T15","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T16","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T17","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T18","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T19","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T20","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T21","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T22","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T23","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T24","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T25","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T26","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T27","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T28","pred":"source","obj":"UseCases_ArguminSci_Discourse"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PubTator4TogoVar","color":"#c493ec","default":true},{"id":"c_corpus","color":"#93ecaa"},{"id":"UseCases_ArguminSci_Discourse","color":"#ec9395"}]}]}}