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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 19-26 Glycan_Motif denotes mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ
T2 636-643 Glycan_Motif denotes mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ
T3 1003-1006 Glycan_Motif denotes GT2 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G36476BA|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G35228ZS

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 19-26 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T2 636-643 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T3 1003-1006 https://glytoucan.org/Structures/Glycans/G35228ZS denotes GT2
T4 1003-1006 https://glytoucan.org/Structures/Glycans/G36476BA denotes GT2

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-95 Sentence denotes Dolichol phosphate mannose synthase: a Glycosyltransferase with Unity in molecular diversities.
TextSentencer_T2 96-217 Sentence denotes N-glycans provide structural and functional stability to asparagine-linked (N-linked) glycoproteins, and add flexibility.
TextSentencer_T3 218-313 Sentence denotes Glycan biosynthesis is elaborative, multi-compartmental and involves many glycosyltransferases.
TextSentencer_T4 314-460 Sentence denotes Failure to assemble N-glycans leads to phenotypic changes developing infection, cancer, congenital disorders of glycosylation (CDGs) among others.
TextSentencer_T5 461-681 Sentence denotes Biosynthesis of N-glycans begins at the endoplasmic reticulum (ER) with the assembly of dolichol-linked tetra-decasaccharide (Glc3Man9GlcNAc2-PP-Dol) where dolichol phosphate mannose synthase (DPMS) plays a central role.
TextSentencer_T6 682-815 Sentence denotes DPMS is also essential for GPI anchor biosynthesis as well as for O- and C-mannosylation of proteins in yeast and in mammalian cells.
TextSentencer_T7 816-946 Sentence denotes DPMS has been purified from several sources and its gene has been cloned from 39 species (e.g., from protozoan parasite to human).
TextSentencer_T8 947-1066 Sentence denotes It is an inverting GT-A folded enzyme and classified as GT2 by CAZy (carbohydrate active enZyme; http://www.cazy.org ).
TextSentencer_T9 1067-1258 Sentence denotes The sequence alignment detects the presence of a metal binding DAD signature in DPMS from all 39 species but finds cAMP-dependent protein phosphorylation motif (PKA motif) in only 38 species.
TextSentencer_T10 1259-1295 Sentence denotes DPMS also has hydrophobic region(s).
TextSentencer_T11 1296-1452 Sentence denotes Hydropathy analysis of amino acid sequences from bovine, human, S. crevisiae and A. thaliana DPMS show PKA motif is present between the hydrophobic domains.
TextSentencer_T12 1453-1566 Sentence denotes The location of PKA motif as well as the hydrophobic domain(s) in the DPMS sequence vary from species to species.
TextSentencer_T13 1567-1656 Sentence denotes For example, the domain(s) could be located at the center or more towards the C-terminus.
TextSentencer_T14 1657-1878 Sentence denotes Irrespective of their catalytic similarity, the DNA sequence, the amino acid identity, and the lack of a stretch of hydrophobic amino acid residues at the C-terminus, DPMS is still classified as Type I and Type II enzyme.
TextSentencer_T15 1879-2001 Sentence denotes Because of an apparent bio-sensing ability, extracellular signaling and microenvironment regulate DPMS catalytic activity.
TextSentencer_T16 2002-2093 Sentence denotes In this review, we highlight some important features and the molecular diversities of DPMS.
T1 0-95 Sentence denotes Dolichol phosphate mannose synthase: a Glycosyltransferase with Unity in molecular diversities.
T2 96-217 Sentence denotes N-glycans provide structural and functional stability to asparagine-linked (N-linked) glycoproteins, and add flexibility.
T3 218-313 Sentence denotes Glycan biosynthesis is elaborative, multi-compartmental and involves many glycosyltransferases.
T4 314-460 Sentence denotes Failure to assemble N-glycans leads to phenotypic changes developing infection, cancer, congenital disorders of glycosylation (CDGs) among others.
T5 461-681 Sentence denotes Biosynthesis of N-glycans begins at the endoplasmic reticulum (ER) with the assembly of dolichol-linked tetra-decasaccharide (Glc3Man9GlcNAc2-PP-Dol) where dolichol phosphate mannose synthase (DPMS) plays a central role.
T6 682-815 Sentence denotes DPMS is also essential for GPI anchor biosynthesis as well as for O- and C-mannosylation of proteins in yeast and in mammalian cells.
T7 816-946 Sentence denotes DPMS has been purified from several sources and its gene has been cloned from 39 species (e.g., from protozoan parasite to human).
T8 947-1066 Sentence denotes It is an inverting GT-A folded enzyme and classified as GT2 by CAZy (carbohydrate active enZyme; http://www.cazy.org ).
T9 1067-1258 Sentence denotes The sequence alignment detects the presence of a metal binding DAD signature in DPMS from all 39 species but finds cAMP-dependent protein phosphorylation motif (PKA motif) in only 38 species.
T10 1259-1295 Sentence denotes DPMS also has hydrophobic region(s).
T11 1296-1452 Sentence denotes Hydropathy analysis of amino acid sequences from bovine, human, S. crevisiae and A. thaliana DPMS show PKA motif is present between the hydrophobic domains.
T12 1453-1566 Sentence denotes The location of PKA motif as well as the hydrophobic domain(s) in the DPMS sequence vary from species to species.
T13 1567-1656 Sentence denotes For example, the domain(s) could be located at the center or more towards the C-terminus.
T14 1657-1878 Sentence denotes Irrespective of their catalytic similarity, the DNA sequence, the amino acid identity, and the lack of a stretch of hydrophobic amino acid residues at the C-terminus, DPMS is still classified as Type I and Type II enzyme.
T15 1879-2001 Sentence denotes Because of an apparent bio-sensing ability, extracellular signaling and microenvironment regulate DPMS catalytic activity.
T16 2002-2093 Sentence denotes In this review, we highlight some important features and the molecular diversities of DPMS.

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 383-392 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T2 394-400 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T3 402-439 Disease denotes congenital disorders of glycosylation http://purl.obolibrary.org/obo/MONDO_0015286
T4 441-445 Disease denotes CDGs http://purl.obolibrary.org/obo/MONDO_0015286

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 1003-1006 Glycan denotes GT2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G36476BA

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 394-400 Phenotype denotes cancer HP:0002664

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 1003-1006 Glycan denotes GT2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G36476BA

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 1852-1858 Cell denotes Type I http://purl.obolibrary.org/obo/CL:0004120|http://purl.obolibrary.org/obo/CL:0004138

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 513-522 Body_part denotes reticulum http://purl.obolibrary.org/obo/UBERON_0007361
T2 1923-1936 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 383-392 Disease denotes infection MONDO:0005550
T2 394-400 Disease denotes cancer MONDO:0004992
T3 402-439 Disease denotes congenital disorders of glycosylation MONDO:0015286
T4 441-445 Disease denotes CDGs MONDO:0015286

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 799-808 Organism denotes mammalian 40674
T2 939-944 Organism denotes human 9606
T3 1345-1351 Organism denotes bovine 9913
T4 1353-1358 Organism denotes human 9606

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-95 Sentence denotes Dolichol phosphate mannose synthase: a Glycosyltransferase with Unity in molecular diversities.
T2 96-217 Sentence denotes N-glycans provide structural and functional stability to asparagine-linked (N-linked) glycoproteins, and add flexibility.
T3 218-313 Sentence denotes Glycan biosynthesis is elaborative, multi-compartmental and involves many glycosyltransferases.
T4 314-460 Sentence denotes Failure to assemble N-glycans leads to phenotypic changes developing infection, cancer, congenital disorders of glycosylation (CDGs) among others.
T5 461-681 Sentence denotes Biosynthesis of N-glycans begins at the endoplasmic reticulum (ER) with the assembly of dolichol-linked tetra-decasaccharide (Glc3Man9GlcNAc2-PP-Dol) where dolichol phosphate mannose synthase (DPMS) plays a central role.
T6 682-815 Sentence denotes DPMS is also essential for GPI anchor biosynthesis as well as for O- and C-mannosylation of proteins in yeast and in mammalian cells.
T7 816-946 Sentence denotes DPMS has been purified from several sources and its gene has been cloned from 39 species (e.g., from protozoan parasite to human).
T8 947-1066 Sentence denotes It is an inverting GT-A folded enzyme and classified as GT2 by CAZy (carbohydrate active enZyme; http://www.cazy.org ).
T9 1067-1258 Sentence denotes The sequence alignment detects the presence of a metal binding DAD signature in DPMS from all 39 species but finds cAMP-dependent protein phosphorylation motif (PKA motif) in only 38 species.
T10 1259-1295 Sentence denotes DPMS also has hydrophobic region(s).
T11 1296-1452 Sentence denotes Hydropathy analysis of amino acid sequences from bovine, human, S. crevisiae and A. thaliana DPMS show PKA motif is present between the hydrophobic domains.
T12 1453-1566 Sentence denotes The location of PKA motif as well as the hydrophobic domain(s) in the DPMS sequence vary from species to species.
T13 1567-1656 Sentence denotes For example, the domain(s) could be located at the center or more towards the C-terminus.
T14 1657-1878 Sentence denotes Irrespective of their catalytic similarity, the DNA sequence, the amino acid identity, and the lack of a stretch of hydrophobic amino acid residues at the C-terminus, DPMS is still classified as Type I and Type II enzyme.
T15 1879-2001 Sentence denotes Because of an apparent bio-sensing ability, extracellular signaling and microenvironment regulate DPMS catalytic activity.
T16 2002-2093 Sentence denotes In this review, we highlight some important features and the molecular diversities of DPMS.

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 501-522 Body_part denotes endoplasmic reticulum FMA:63842
T2 524-526 Body_part denotes ER FMA:63842

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 939-944 OrganismTaxon denotes human 9606
T2 1345-1351 OrganismTaxon denotes bovine 9913
T3 1353-1358 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 513-522 Body_part denotes reticulum http://purl.obolibrary.org/obo/UBERON_0007361
T2 1923-1936 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 394-400 Phenotype denotes cancer HP:0002664

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 1852-1858 Cell denotes Type I http://purl.obolibrary.org/obo/CL:0004120|http://purl.obolibrary.org/obo/CL:0004138