
PubMed:28608583
Annnotations
PubMed_ArguminSci
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 127-240 | DRI_Background | denotes | The carbon dioxide released and dissolved in rumen fluid may easily permeate across the epithelial cell membrane. |
T2 | 241-353 | DRI_Approach | denotes | Thus, we hypothesized that CO2 may act as proton carrier and induce epithelial damage under acidotic conditions. |
T3 | 354-441 | DRI_Background | denotes | Ovine ruminal epithelia were mounted in Ussing chambers under short-circuit conditions. |
T4 | 442-569 | DRI_Approach | denotes | The serosal buffer solution had a constant pH of 7.4 and was gassed either with 100% oxygen or with carbogen (95% O2 /5% CO2 ). |
T5 | 570-649 | DRI_Outcome | denotes | The mucosal solution was gassed with either 100% oxygen or 100% carbon dioxide. |
T6 | 650-763 | DRI_Background | denotes | The mucosal pH was lowered stepwise from 6.6 to 5.0 in the presence or absence of short-chain fatty acids (SCFA). |
T7 | 764-959 | DRI_Outcome | denotes | The transepithelial conductance (Gt ) as an indicator of epithelial integrity and the short-circuit current (Isc ) as an indicator of active electrogenic ion transfer were continuously monitored. |
T8 | 960-1064 | DRI_Approach | denotes | At an initial mucosal pH of 6.6, there was no significant difference in Gt between the treatment groups. |
T9 | 1065-1174 | DRI_Outcome | denotes | In the absence of both SCFA and CO2 , Gt remained constant when the mucosal solution was acidified to pH 5.0. |
T10 | 1175-1298 | DRI_Outcome | denotes | In the presence of SCFA, mucosal acidification induced a significant rise in Gt when the solutions were gassed with oxygen. |
T11 | 1299-1367 | DRI_Outcome | denotes | A small increase in Gt was observed in the mucosal presence of CO2 . |
T12 | 1368-1532 | DRI_Outcome | denotes | However, no difference in final Gt was observed between SCFA-containing and SCFA-free conditions under carbon dioxide gassing during stepwise mucosal acidification. |
T13 | 1533-1629 | DRI_Outcome | denotes | The SCFA+proton-induced increase in Gt could also be minimized by serosal gassing with carbogen. |
T14 | 1630-1782 | DRI_Background | denotes | Because of the SCFA+proton-induced changes in Gt and their attenuation by CO2 , a protective role for mucosally available carbon dioxide may be assumed. |
T15 | 1783-1889 | DRI_Approach | denotes | We suggest that this effect may be due to the intraepithelial conversion of carbon dioxide to bicarbonate. |
T16 | 1890-2064 | DRI_Challenge | denotes | However, the serosal presence of CO2 at a physiological concentration may be sufficient to protect the epithelia from SCFA+proton-induced damage for a certain period of time. |
Goldhamster2_Cellosaurus
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 78-80 | CVCL_8754|Cancer_cell_line|Homo sapiens | denotes | An |
T2 | 78-80 | CVCL_H241|Cancer_cell_line|Homo sapiens | denotes | An |
T3 | 184-187 | CVCL_E773|Transformed_cell_line|Homo sapiens | denotes | may |
T4 | 247-249 | CVCL_5M23|Cancer_cell_line|Mesocricetus auratus | denotes | we |
T5 | 272-275 | CVCL_E773|Transformed_cell_line|Homo sapiens | denotes | may |
T6 | 474-475 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
T7 | 491-494 | CVCL_XY42|Hybridoma|Mus musculus | denotes | 7.4 |
T8 | 805-807 | CVCL_8754|Cancer_cell_line|Homo sapiens | denotes | an |
T9 | 805-807 | CVCL_H241|Cancer_cell_line|Homo sapiens | denotes | an |
T10 | 882-884 | CVCL_8754|Cancer_cell_line|Homo sapiens | denotes | an |
T11 | 882-884 | CVCL_H241|Cancer_cell_line|Homo sapiens | denotes | an |
T12 | 898-904 | CVCL_C410|Hybridoma|Mus musculus | denotes | active |
T13 | 963-965 | CVCL_8754|Cancer_cell_line|Homo sapiens | denotes | an |
T14 | 963-965 | CVCL_H241|Cancer_cell_line|Homo sapiens | denotes | an |
T15 | 1230-1231 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
T16 | 1299-1300 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | A |
T17 | 1665-1672 | CVCL_0238|Cancer_cell_line|Homo sapiens | denotes | changes |
T18 | 1710-1711 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
T19 | 1767-1770 | CVCL_E773|Transformed_cell_line|Homo sapiens | denotes | may |
T20 | 1783-1785 | CVCL_5M23|Cancer_cell_line|Mesocricetus auratus | denotes | We |
T21 | 1811-1814 | CVCL_E773|Transformed_cell_line|Homo sapiens | denotes | may |
T22 | 1930-1931 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
T23 | 1960-1963 | CVCL_E773|Transformed_cell_line|Homo sapiens | denotes | may |
T24 | 2039-2040 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
T25 | 2059-2063 | CVCL_0047|Telomerase_immortalized_cell_line|Homo sapiens | denotes | time |
GoldHamster
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T4 | 21-35 | 2034 | denotes | carbon dioxide |
T3 | 21-35 | D002245 | denotes | carbon dioxide |
T5 | 21-35 | CHEBI:16526 | denotes | carbon dioxide |
T6 | 21-35 | D002245 | denotes | carbon dioxide |
T8 | 60-76 | UBERON:0008285 | denotes | rumen epithelium |
T10 | 117-125 | D000138 | denotes | acidosis |
T11 | 117-125 | D000138 | denotes | acidosis |
T15 | 131-145 | 2034 | denotes | carbon dioxide |
T14 | 131-145 | D002245 | denotes | carbon dioxide |
T16 | 131-145 | CHEBI:16526 | denotes | carbon dioxide |
T17 | 131-145 | D002245 | denotes | carbon dioxide |
T18 | 172-177 | UBERON:0007365 | denotes | rumen |
T19 | 178-183 | UBERON:0006314 | denotes | fluid |
T20 | 215-230 | CL:0000066 | denotes | epithelial cell |
T21 | 226-239 | GO:0005886 | denotes | cell membrane |
T22 | 231-239 | UBERON:0000094 | denotes | membrane |
T24 | 231-239 | UBERON:0000158 | denotes | membrane |
T25 | 268-271 | CHEBI:29325 | denotes | CO2 |
T26 | 268-271 | CHEBI:48828 | denotes | CO2 |
T27 | 268-271 | CHEBI:16526 | denotes | CO2 |
T28 | 268-271 | CHEBI:29334 | denotes | CO2 |
T29 | 283-289 | CHEBI:24636 | denotes | proton |
T30 | 283-289 | D011522 | denotes | proton |
T31 | 283-289 | D011522 | denotes | proton |
T33 | 290-297 | CHEBI:78059 | denotes | carrier |
T32 | 290-297 | GO:0005215 | denotes | carrier |
T34 | 354-359 | D012757 | denotes | Ovine |
T35 | 354-359 | D012757 | denotes | Ovine |
T36 | 454-460 | CHEBI:35225 | denotes | buffer |
T37 | 461-469 | CHEBI:75958 | denotes | solution |
T39 | 527-533 | 7806 | denotes | oxygen |
T38 | 527-533 | CHEBI:25805 | denotes | oxygen |
T40 | 542-550 | C011700 | denotes | carbogen |
T41 | 542-550 | C011700 | denotes | carbogen |
T42 | 563-566 | CHEBI:29325 | denotes | CO2 |
T43 | 563-566 | CHEBI:48828 | denotes | CO2 |
T44 | 563-566 | CHEBI:16526 | denotes | CO2 |
T45 | 563-566 | CHEBI:29334 | denotes | CO2 |
T46 | 582-590 | CHEBI:75958 | denotes | solution |
T48 | 619-625 | 7806 | denotes | oxygen |
T47 | 619-625 | CHEBI:25805 | denotes | oxygen |
T52 | 634-648 | 2034 | denotes | carbon dioxide |
T51 | 634-648 | D002245 | denotes | carbon dioxide |
T53 | 634-648 | CHEBI:16526 | denotes | carbon dioxide |
T54 | 634-648 | D002245 | denotes | carbon dioxide |
T55 | 732-755 | CHEBI:26666 | denotes | short-chain fatty acids |
T56 | 732-755 | D005232 | denotes | short-chain fatty acids |
T57 | 732-755 | D005232 | denotes | short-chain fatty acids |
T58 | 738-743 | SO:0000419 | denotes | chain |
T63 | 757-761 | CHEBI:26666 | denotes | SCFA |
T64 | 808-817 | CHEBI:47867 | denotes | indicator |
T65 | 885-894 | CHEBI:47867 | denotes | indicator |
T66 | 918-921 | CHEBI:24870 | denotes | ion |
T67 | 960-965 | PR:O23702 | denotes | At an |
T68 | 1088-1092 | CHEBI:26666 | denotes | SCFA |
T69 | 1097-1100 | CHEBI:29325 | denotes | CO2 |
T70 | 1097-1100 | CHEBI:48828 | denotes | CO2 |
T71 | 1097-1100 | CHEBI:16526 | denotes | CO2 |
T72 | 1097-1100 | CHEBI:29334 | denotes | CO2 |
T73 | 1141-1149 | CHEBI:75958 | denotes | solution |
T74 | 1167-1171 | CVCL_5862 | denotes | pH 5 |
T75 | 1167-1171 | CHEBI:30285 | denotes | pH 5 |
T76 | 1194-1198 | CHEBI:26666 | denotes | SCFA |
T77 | 1208-1221 | GO:0045851 | denotes | acidification |
T79 | 1291-1297 | 7806 | denotes | oxygen |
T78 | 1291-1297 | CHEBI:25805 | denotes | oxygen |
T80 | 1362-1365 | CHEBI:29325 | denotes | CO2 |
T81 | 1362-1365 | CHEBI:48828 | denotes | CO2 |
T82 | 1362-1365 | CHEBI:16526 | denotes | CO2 |
T83 | 1362-1365 | CHEBI:29334 | denotes | CO2 |
T84 | 1424-1428 | CHEBI:26666 | denotes | SCFA |
T85 | 1444-1448 | CHEBI:26666 | denotes | SCFA |
T89 | 1471-1485 | 2034 | denotes | carbon dioxide |
T88 | 1471-1485 | D002245 | denotes | carbon dioxide |
T90 | 1471-1485 | CHEBI:16526 | denotes | carbon dioxide |
T91 | 1471-1485 | D002245 | denotes | carbon dioxide |
T92 | 1518-1531 | GO:0045851 | denotes | acidification |
T93 | 1537-1541 | CHEBI:26666 | denotes | SCFA |
T94 | 1542-1548 | CHEBI:24636 | denotes | proton |
T95 | 1542-1548 | D011522 | denotes | proton |
T96 | 1542-1548 | D011522 | denotes | proton |
T97 | 1620-1628 | C011700 | denotes | carbogen |
T98 | 1620-1628 | C011700 | denotes | carbogen |
T99 | 1645-1649 | CHEBI:26666 | denotes | SCFA |
T100 | 1650-1656 | CHEBI:24636 | denotes | proton |
T101 | 1650-1656 | D011522 | denotes | proton |
T102 | 1650-1656 | D011522 | denotes | proton |
T103 | 1704-1707 | CHEBI:29325 | denotes | CO2 |
T104 | 1704-1707 | CHEBI:48828 | denotes | CO2 |
T105 | 1704-1707 | CHEBI:16526 | denotes | CO2 |
T106 | 1704-1707 | CHEBI:29334 | denotes | CO2 |
T110 | 1752-1766 | 2034 | denotes | carbon dioxide |
T109 | 1752-1766 | D002245 | denotes | carbon dioxide |
T111 | 1752-1766 | CHEBI:16526 | denotes | carbon dioxide |
T112 | 1752-1766 | D002245 | denotes | carbon dioxide |
T116 | 1859-1873 | 2034 | denotes | carbon dioxide |
T115 | 1859-1873 | D002245 | denotes | carbon dioxide |
T117 | 1859-1873 | CHEBI:16526 | denotes | carbon dioxide |
T118 | 1859-1873 | D002245 | denotes | carbon dioxide |
T119 | 1877-1888 | CHEBI:17544 | denotes | bicarbonate |
T120 | 1923-1926 | CHEBI:29325 | denotes | CO2 |
T121 | 1923-1926 | CHEBI:48828 | denotes | CO2 |
T122 | 1923-1926 | CHEBI:16526 | denotes | CO2 |
T123 | 1923-1926 | CHEBI:29334 | denotes | CO2 |
T124 | 2008-2012 | CHEBI:26666 | denotes | SCFA |
T125 | 2013-2019 | CHEBI:24636 | denotes | proton |
T126 | 2013-2019 | D011522 | denotes | proton |
T127 | 2013-2019 | D011522 | denotes | proton |