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PubMed:28606148 JSONTXT

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PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 175-1409 BACKGROUND denotes The objective of the current study was to develop a stochastic agent-based model using empirical data from Ontario (Canada) swine sites in order to evaluate different surveillance strategies for detection of emerging porcine reproductive and respiratory syndrome virus (PRRSV) strains at the regional level. Four strategies were evaluated, including (i) random sampling of fixed numbers of swine sites monthly; (ii) risk-based sampling of fixed numbers, specifically of breeding sites (high-consequence sites); (iii) risk-based sampling of fixed numbers of low biosecurity sites (high-risk); and (iv) risk-based sampling of breeding sites that are characterized as low biosecurity sites (high-risk/high-consequence). The model simulated transmission of a hypothetical emerging PRRSV strain between swine sites through three important industry networks (production system, truck and feed networks) while considering sites' underlying immunity due to past or recent exposure to heterologous PRRSV strains, as well as demographic, geographic and biosecurity-related PRRS risk factors. Outcomes of interest included surveillance system sensitivity and time to detection of the three first cases over a period of approximately three years.
T2 1419-1544 RESULTS denotes Surveillance system sensitivities were low and time to detection of three first cases was long across all examined scenarios.
T3 1557-2128 CONCLUSIONS denotes Traditional modes of implementing high-risk and high-consequence risk-based surveillance based on site's static characteristics do not appear to substantially improve surveillance system sensitivity. Novel strategies need to be developed and considered for rapid detection of this and other emerging swine infectious diseases. None of the four strategies compared herein appeared optimal for early detection of an emerging PPRSV strain at the regional level considering model assumptions, the underlying population of interest, and absence of other forms of surveillance.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 15-16 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T2 225-226 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T3 928-929 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T4 1124-1128 CVCL_JY46|Spontaneously_immortalized_cell_line|Rattus norvegicus denotes past
T5 1323-1327 CVCL_0047|Telomerase_immortalized_cell_line|Homo sapiens denotes time
T6 1371-1372 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T7 1466-1470 CVCL_0047|Telomerase_immortalized_cell_line|Homo sapiens denotes time
T8 1968-1970 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T9 1968-1970 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an

GoldHamster

Id Subject Object Predicate Lexical cue
T1 108-153 D019318 denotes porcine reproductive and respiratory syndrome
T2 108-153 D019318 denotes porcine reproductive and respiratory syndrome
T3 154-161 D013180 denotes strains
T4 154-161 D013180 denotes strains
T5 299-304 D013552 denotes swine
T6 299-304 9823 denotes swine
T7 392-437 D019318 denotes porcine reproductive and respiratory syndrome
T8 392-437 D019318 denotes porcine reproductive and respiratory syndrome
T11 392-450 28344 denotes porcine reproductive and respiratory syndrome virus (PRRSV
T14 452-459 D013180 denotes strains
T15 452-459 D013180 denotes strains
T16 565-570 D013552 denotes swine
T17 565-570 9823 denotes swine
T18 952-957 28344 denotes PRRSV
T19 952-957 D019316 denotes PRRSV
T20 973-978 D013552 denotes swine
T21 973-978 9823 denotes swine
T22 1164-1169 28344 denotes PRRSV
T23 1164-1169 D019316 denotes PRRSV
T24 1170-1177 D013180 denotes strains
T25 1170-1177 D013180 denotes strains
T26 1238-1242 D019318 denotes PRRS
T27 1238-1242 D019318 denotes PRRS
T28 1857-1862 D013552 denotes swine
T29 1857-1862 9823 denotes swine
T30 1863-1882 D003141 denotes infectious diseases
T31 1863-1882 D003141 denotes infectious diseases