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PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 139-551 BACKGROUND denotes Brazilian Spotted Fever (BSF), caused by the bacterium Rickettsia rickettsii, is the tick-borne disease that generates the largest number of human deaths in the world. In Brazil, the current increase of BSF human cases has been associated with the presence and expansion of capybaras Hydrochoerus hydrochaeris, which act as primary hosts for the tick Amblyomma sculptum, vector of the R. rickettsii in this area.
T2 561-959 METHODS denotes We proposed a semi-discrete-time stochastic model to evaluate the role of capybaras in the transmission dynamics of R. rickettsii. Through a sensitivity analysis, we identified the parameters with significant influence on the R. rickettsii establishment. Afterward, we implemented the Gillespie's algorithm to simulate the impact of potential public health interventions to prevent BSF human cases.
T3 969-1486 RESULTS denotes The introduction of a single infected capybara with at least one infected attached tick is enough to trigger the disease in a non-endemic area. We found that to avoid the formation of new BSF-endemic areas, it is crucial to impede the emigration of capybaras from endemic areas by reducing their birth rate by more than 58%. Model results were corroborated by ex-situ data generated from field studies, and this supports our proposal to prevent BSF human cases by implementing control strategies focused on capybaras.
T4 1499-1781 CONCLUSIONS denotes The proposed stochastic model illustrates how strategies for the control and prevention of vector-borne infectious diseases can be focused on amplifier hosts management practices. This work provides a basis for future prevention strategies for other neglected vector-borne diseases.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 164-167 CVCL_9T83|Spontaneously_immortalized_cell_line|Acanthopagrus schlegelii denotes BSF
T2 342-345 CVCL_9T83|Spontaneously_immortalized_cell_line|Acanthopagrus schlegelii denotes BSF
T3 358-361 CVCL_6758|Undefined_cell_line_type|Cricetulus griseus denotes has
T4 358-361 CVCL_E689|Transformed_cell_line|Homo sapiens denotes has
T5 561-563 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes We
T6 573-574 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T7 589-593 CVCL_0047|Telomerase_immortalized_cell_line|Homo sapiens denotes time
T8 700-701 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T9 724-726 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes we
T10 827-829 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes we
T11 943-946 CVCL_9T83|Spontaneously_immortalized_cell_line|Acanthopagrus schlegelii denotes BSF
T12 989-990 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T13 1030-1033 CVCL_Z424|Spontaneously_immortalized_cell_line|Ostrinia nubilalis denotes one
T14 1093-1094 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T15 1113-1115 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes We
T16 1157-1160 CVCL_9T83|Spontaneously_immortalized_cell_line|Acanthopagrus schlegelii denotes BSF
T17 1289-1291 CVCL_2564|Transformed_cell_line|Homo sapiens denotes 58
T18 1414-1417 CVCL_9T83|Spontaneously_immortalized_cell_line|Acanthopagrus schlegelii denotes BSF
T19 1465-1472 CVCL_7955|Cancer_cell_line|Homo sapiens denotes focused
T20 1630-1637 CVCL_7955|Cancer_cell_line|Homo sapiens denotes focused
T21 1698-1699 CVCL_6479|Finite_cell_line|Mus musculus denotes a

GoldHamster

Id Subject Object Predicate Lexical cue
T2 37-58 783 denotes Rickettsia rickettsii
T3 37-58 D012284 denotes Rickettsia rickettsii
T4 77-102 10149 denotes Hydrochoerus hydrochaeris
T7 107-125 1581419 denotes Amblyomma sculptum
T8 139-162 D012373 denotes Brazilian Spotted Fever
T9 139-162 D012373 denotes Brazilian Spotted Fever
T14 164-167 CVCL_9T83 denotes BSF
T15 184-193 115434 denotes bacterium
T16 184-193 2014293 denotes bacterium
T17 184-193 115436 denotes bacterium
T18 184-193 115437 denotes bacterium
T19 184-193 115435 denotes bacterium
T20 184-193 1869227 denotes bacterium
T21 184-193 115007 denotes bacterium
T23 194-215 783 denotes Rickettsia rickettsii
T24 194-215 D012284 denotes Rickettsia rickettsii
T25 224-228 D013987 denotes tick
T26 224-242 D017282 denotes tick-borne disease
T27 224-242 D017282 denotes tick-borne disease
T30 280-285 D006801 denotes human
T31 342-345 CVCL_9T83 denotes BSF
T32 346-351 D006801 denotes human
T33 413-422 D012377 denotes capybaras
T34 423-448 10149 denotes Hydrochoerus hydrochaeris
T36 485-489 D013987 denotes tick
T38 490-508 1581419 denotes Amblyomma sculptum
T39 510-516 SO:0000440 denotes vector
T40 635-644 D012377 denotes capybaras
T41 884-890 PR:Q54JW9 denotes impact
T42 884-890 PR:Q642J4 denotes impact
T43 943-946 CVCL_9T83 denotes BSF
T44 947-952 D006801 denotes human
T45 1007-1015 10149 denotes capybara
T46 1007-1015 D012377 denotes capybara
T47 1052-1056 D013987 denotes tick
T48 1082-1089 D004194 denotes disease
T49 1082-1089 D004194 denotes disease
T50 1140-1149 GO:0009058 denotes formation
T51 1157-1160 CVCL_9T83 denotes BSF
T52 1218-1227 D012377 denotes capybaras
T53 1265-1270 UBERON:0035946 denotes birth
T54 1414-1417 CVCL_9T83 denotes BSF
T55 1418-1423 D006801 denotes human
T56 1476-1485 D012377 denotes capybaras
T57 1590-1596 SO:0000440 denotes vector
T58 1603-1622 D003141 denotes infectious diseases
T59 1603-1622 D003141 denotes infectious diseases
T60 1759-1765 SO:0000440 denotes vector
T61 1759-1780 D000079426 denotes vector-borne diseases
T62 1759-1780 D000079426 denotes vector-borne diseases