| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
127-209 |
DRI_Background |
denotes |
Arterial pressure is an important diagnostic parameter for cardiovascular disease. |
| T2 |
210-348 |
DRI_Background |
denotes |
However relative contributions of individual ventricular and arterial parameters in generating and augmenting pressure are not understood. |
| T3 |
349-498 |
DRI_Background |
denotes |
Using a novel experimental arterial model, our aim was to characterise individual parameter contributions to arterial pressure and its amplification. |
| T4 |
499-619 |
DRI_Background |
denotes |
A piston-driven ventricle provided programmable stroke profiles into various silicone arterial trees and a bovine aorta. |
| T5 |
620-810 |
DRI_Background |
denotes |
Inotropy was varied in the ventricle, and arterial parameters modulated included wall thickness, taper and diameter, the presence of bifurcation, and a native aorta (bovine) versus silicone. |
| T6 |
811-942 |
DRI_Background |
denotes |
Wave reflection at bifurcations were measured and compared to theory, varying parent/child tube diameter ratios, and branch angles. |
| T7 |
943-1030 |
DRI_Background |
denotes |
Intravascular pressure-tip wires and ultrasonic flow probes measured pressure and flow. |
| T8 |
1031-1261 |
DRI_Background |
denotes |
Increasing ventricular inotropy independently augmented pressure amplification from 17 to 61% between the lower and higher systolic gradient stroke profiles in the silicone arterial network, and from 10 to 32% in the bovine aorta. |
| T9 |
1262-1361 |
DRI_Background |
denotes |
Amplification increased with presence of a bifurcation, decreasing wall thickness and vessel taper. |
| T10 |
1362-1471 |
DRI_Background |
denotes |
Pulse pressure increased with increasing wall thickness (stiffness) and taper angle, and decreasing diameter. |
| T11 |
1472-1721 |
DRI_Background |
denotes |
Theoretical predictions of wave transmission through bifurcations was similar to measurements (correlation 0.91, R(2)=0.94); but underestimated wave reflection (correlation 0.75, R(2)=0.94) indicating energy losses during mechanical wave reflection. |
| T12 |
1722-1869 |
DRI_Background |
denotes |
This study offers the first comprehensive investigation of contributors to hypertensive pressure, and its propagation throughout the arterial tree. |
| T13 |
1870-2050 |
DRI_Challenge |
denotes |
Importantly, ventricular inotropy plays a crucial role in the amplification of peripheral pressure wave, which offers opportunity for non-invasive assessment of ventricular health. |
