PubMed:28571798 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/28571798","sourcedb":"PubMed","sourceid":"28571798","text":"Olfactory vector hypothesis for encephalitis lethargica.\nViruses have long been implicated in the pathogenesis of classical encephalitis lethargica, which was first described by Constantin von Economo in 1917. In this article, I propose the hypothesis that an airborne virus travels along the olfactory conduit to infect the olfactory bulb; this local infection or induced neuroinflammation, in turn, retrogradely targets certain neuronal populations with sleep-wake regulatory functions in the hypothalamus and midbrain, leading to the development of wakeful inactivity, a hallmark clinical feature of the disease. Furthermore, the olfactory vector hypothesis may also explain the pathomechanism of the debilitating complication of the disease, i.e., postencephalitic parkinsonism, in terms of a recently discovered nigro-olfactory projection.","tracks":[{"project":"RDoCTask1SampleData","denotations":[{"id":"T1","span":{"begin":0,"end":56},"obj":"Sleep-Wakefulness"}],"attributes":[{"subj":"T1","pred":"source","obj":"RDoCTask1SampleData"}]},{"project":"Inflammaging","denotations":[{"id":"T1","span":{"begin":0,"end":56},"obj":"Sentence"},{"id":"T2","span":{"begin":57,"end":209},"obj":"Sentence"},{"id":"T3","span":{"begin":210,"end":615},"obj":"Sentence"},{"id":"T4","span":{"begin":616,"end":844},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":56},"obj":"Sentence"},{"id":"T2","span":{"begin":57,"end":209},"obj":"Sentence"},{"id":"T3","span":{"begin":210,"end":615},"obj":"Sentence"},{"id":"T4","span":{"begin":616,"end":844},"obj":"Sentence"}],"attributes":[{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"RDoCTask1SampleData","color":"#ecc393","default":true},{"id":"Inflammaging","color":"#a993ec"}]}]}}