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PubMed:28566510 JSONTXT

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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 109-305 DRI_Challenge denotes Vein graft failure is a prevalent problem in vascular surgeries, including bypass grafting and arteriovenous fistula procedures in which veins are subjected to severe changes in pressure and flow.
T2 306-466 DRI_Background denotes Animal and clinical studies provide significant insight, but understanding the complex underlying coupled mechanisms can be advanced using computational models.
T3 467-585 DRI_Approach denotes Towards this end, we propose a new model of venous growth and remodelling (G&R) based on a constrained mixture theory.
T4 586-717 DRI_Approach denotes First, we identify constitutive relations and parameters that enable venous adaptations to moderate perturbations in haemodynamics.
T5 718-927 DRI_Approach denotes We then fix these relations and parameters, and subject the vein to a range of combined loads (pressure and flow), from moderate to severe, and identify plausible mechanisms of adaptation versus maladaptation.
T6 928-1010 DRI_Outcome denotes We also explore the beneficial effects of gradual increases in load on adaptation.
T7 1011-1232 DRI_Background denotes A gradual change in flow over 3 days plus an initial step change in pressure results in fewer maladaptations compared with step changes in both flow and pressure, or even a gradual change in pressure and flow over 3 days.
T8 1233-1369 DRI_Background denotes A gradual change in flow and pressure over 8 days also enabled a successful venous adaptation for loads as severe as the arterial loads.
T9 1370-1549 DRI_Approach denotes Optimization is used to accelerate parameter estimation and the proposed framework is general enough to provide a good starting point for parameter estimations in G&R simulations.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 131-132 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T2 276-283 CVCL_0238|Cancer_cell_line|Homo sapiens denotes changes
T3 485-487 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes we
T4 496-497 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T5 556-557 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T6 593-595 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes we
T7 718-720 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes We
T8 786-787 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T9 928-930 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes We
T10 1011-1012 CVCL_6479|Finite_cell_line|Mus musculus denotes A
T11 1021-1027 CVCL_0238|Cancer_cell_line|Homo sapiens denotes change
T12 1053-1055 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T13 1053-1055 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T14 1069-1075 CVCL_0238|Cancer_cell_line|Homo sapiens denotes change
T15 1139-1146 CVCL_0238|Cancer_cell_line|Homo sapiens denotes changes
T16 1182-1183 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T17 1192-1198 CVCL_0238|Cancer_cell_line|Homo sapiens denotes change
T18 1233-1234 CVCL_6479|Finite_cell_line|Mus musculus denotes A
T19 1243-1249 CVCL_0238|Cancer_cell_line|Homo sapiens denotes change
T20 1296-1297 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T21 1482-1483 CVCL_6479|Finite_cell_line|Mus musculus denotes a

GoldHamster

Id Subject Object Predicate Lexical cue
T1 74-78 UBERON:0001638 denotes vein
T2 204-225 D001164 denotes arteriovenous fistula
T3 204-225 D001164 denotes arteriovenous fistula
T6 306-312 D000818 denotes Animal
T7 570-577 CHEBI:60004 denotes mixture
T8 778-782 UBERON:0001638 denotes vein