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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 72-206 DRI_Background denotes In utero hypoxia influences the structure and function of most fetal arteries, including those of the developing cerebral circulation.
T2 207-374 DRI_Outcome denotes Whereas the signals that initiate this hypoxic remodeling remain uncertain, these appear to be distinct from the mechanisms that maintain the remodeled vascular state.
T3 375-566 DRI_Challenge denotes The present study explores the hypothesis that chronic hypoxia elicits sustained changes in fetal cerebrovascular reactivity to endothelin-1 (ET-1), a potent vascular contractant and mitogen.
T4 567-816 DRI_Outcome denotes In fetal lambs, chronic hypoxia (3,820-m altitude for the last 110 days of gestation) had no significant effect on plasma ET-1 levels or ETA receptor density in cerebral arteries but enhanced contractile responses to ET-1 in an ETA-dependent manner.
T5 817-1140 DRI_Background denotes In organ culture (24 h), 10 nM ET-1 increased medial thicknesses less in hypoxic than in normoxic arteries, and these increases were ablated by inhibition of PKC (chelerythrine) in both normoxic and hypoxic arteries but were attenuated by inhibition of CaMKII (KN93) and p38 (SB203580) in normoxic but not hypoxic arteries.
T6 1141-1156 DRI_Background denotes As indicated by
T7 1177-1229 DRI_Background denotes , ET-1 increased medial thicknesses via hypertrophy.
T8 1230-1472 DRI_Background denotes Measurements of colocalization between MLCK and SMαA revealed that organ culture with ET-1 also promoted contractile dedifferentiation in normoxic, but not hypoxic, arteries through mechanisms attenuated by inhibitors of PKC, CaMKII, and p38.
T9 1473-1828 DRI_Challenge denotes These results support the hypothesis that chronic hypoxia elicits sustained changes in fetal cerebrovascular reactivity to ET-1 through pathways dependent upon PKC, CaMKII, and p38 that cause increased ET-1-mediated contractility, decreased ET-1-mediated smooth muscle hypertrophy, and a depressed ability of ET-1 to promote contractile dedifferentiation.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 456-463 CVCL_0238|Cancer_cell_line|Homo sapiens denotes changes
T2 524-525 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T3 787-791 CVCL_W473|Cancer_cell_line|Homo sapiens denotes 1 in
T4 792-794 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T5 792-794 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T6 835-839 CVCL_8262|Cancer_cell_line|Homo sapiens denotes 24 h
T7 1157-1159 CVCL_E725|Transformed_cell_line|Homo sapiens denotes Ki
T8 1278-1280 CVCL_7004|Cancer_cell_line|Homo sapiens denotes SM
T9 1281-1282 CVCL_6479|Finite_cell_line|Mus musculus denotes A
T10 1549-1556 CVCL_0238|Cancer_cell_line|Homo sapiens denotes changes
T11 1759-1760 CVCL_6479|Finite_cell_line|Mus musculus denotes a

GoldHamster

Id Subject Object Predicate Lexical cue
T1 8-15 D000860 denotes hypoxia
T2 8-15 D000860 denotes hypoxia
T5 58-70 Q5NRQ1 denotes endothelin-1
T6 58-70 P17322 denotes endothelin-1
T8 58-70 PR:000006897 denotes endothelin-1
T9 58-70 P05305 denotes endothelin-1
T10 58-70 P97740 denotes endothelin-1
T11 58-70 Q28469 denotes endothelin-1
T12 58-70 P29560 denotes endothelin-1
T13 58-70 P22388 denotes endothelin-1
T14 58-70 P09558 denotes endothelin-1
T16 58-70 P22387 denotes endothelin-1
T17 58-70 P13206 denotes endothelin-1
T18 58-70 Q9BG76 denotes endothelin-1
T19 58-70 Q5NRP9 denotes endothelin-1
T7 58-70 CHEBI:80240 denotes endothelin-1
T15 58-70 D019332 denotes endothelin-1
T20 58-70 D019332 denotes endothelin-1
T24 81-88 D000860 denotes hypoxia
T25 81-88 D000860 denotes hypoxia
T26 141-149 UBERON:0001637 denotes arteries
T27 430-437 D000860 denotes hypoxia
T28 430-437 D000860 denotes hypoxia
T31 503-515 Q5NRQ1 denotes endothelin-1
T32 503-515 P17322 denotes endothelin-1
T34 503-515 PR:000006897 denotes endothelin-1
T35 503-515 P05305 denotes endothelin-1
T36 503-515 P97740 denotes endothelin-1
T37 503-515 Q28469 denotes endothelin-1
T38 503-515 P29560 denotes endothelin-1
T39 503-515 P22388 denotes endothelin-1
T40 503-515 P09558 denotes endothelin-1
T42 503-515 P22387 denotes endothelin-1
T43 503-515 P13206 denotes endothelin-1
T44 503-515 Q9BG76 denotes endothelin-1
T45 503-515 Q5NRP9 denotes endothelin-1
T33 503-515 CHEBI:80240 denotes endothelin-1
T41 503-515 D019332 denotes endothelin-1
T46 503-515 D019332 denotes endothelin-1
T47 517-521 Q5NRQ1 denotes ET-1
T48 517-521 PR:F4JU69 denotes ET-1
T49 517-521 P17322 denotes ET-1
T50 517-521 PR:000006897 denotes ET-1
T51 517-521 P97740 denotes ET-1
T52 517-521 Q28469 denotes ET-1
T53 517-521 P29560 denotes ET-1
T54 517-521 P22388 denotes ET-1
T55 517-521 P09558 denotes ET-1
T56 517-521 P13206 denotes ET-1
T57 517-521 Q9BG76 denotes ET-1
T58 517-521 Q5NRP9 denotes ET-1
T59 517-521 P22387 denotes ET-1
T60 558-565 CHEBI:52290 denotes mitogen
T61 576-581 9940 denotes lambs
T62 591-598 D000860 denotes hypoxia
T63 591-598 D000860 denotes hypoxia
T64 642-651 GO:0007565 denotes gestation
T65 682-688 UBERON:0001969 denotes plasma
T66 689-693 Q5NRQ1 denotes ET-1
T67 689-693 PR:F4JU69 denotes ET-1
T68 689-693 P17322 denotes ET-1
T69 689-693 PR:000006897 denotes ET-1
T70 689-693 P97740 denotes ET-1
T71 689-693 Q28469 denotes ET-1
T72 689-693 P29560 denotes ET-1
T73 689-693 P22388 denotes ET-1
T74 689-693 P09558 denotes ET-1
T75 689-693 P13206 denotes ET-1
T76 689-693 Q9BG76 denotes ET-1
T77 689-693 Q5NRP9 denotes ET-1
T78 689-693 P22387 denotes ET-1
T79 704-707 PR:000029023 denotes ETA
T80 704-707 PR:000001221 denotes ETA
T84 704-707 PR:P09331 denotes ETA
T85 704-707 PR:P25101 denotes ETA
T86 704-707 P11439 denotes ETA
T81 704-707 CHEBI:53460 denotes ETA
T82 704-707 CHEBI:71488 denotes ETA
T83 704-707 CHEBI:16000 denotes ETA
T87 737-745 UBERON:0001637 denotes arteries
T88 784-788 Q5NRQ1 denotes ET-1
T89 784-788 PR:F4JU69 denotes ET-1
T90 784-788 P17322 denotes ET-1
T91 784-788 PR:000006897 denotes ET-1
T92 784-788 P97740 denotes ET-1
T93 784-788 Q28469 denotes ET-1
T94 784-788 P29560 denotes ET-1
T95 784-788 P22388 denotes ET-1
T96 784-788 P09558 denotes ET-1
T97 784-788 P13206 denotes ET-1
T98 784-788 Q9BG76 denotes ET-1
T99 784-788 Q5NRP9 denotes ET-1
T100 784-788 P22387 denotes ET-1
T101 795-798 PR:000029023 denotes ETA
T102 795-798 PR:000001221 denotes ETA
T106 795-798 PR:P09331 denotes ETA
T107 795-798 PR:P25101 denotes ETA
T108 795-798 P11439 denotes ETA
T103 795-798 CHEBI:53460 denotes ETA
T104 795-798 CHEBI:71488 denotes ETA
T105 795-798 CHEBI:16000 denotes ETA
T109 820-825 UBERON:0000062 denotes organ
T110 820-825 UBERON:0003103 denotes organ
T111 835-839 CVCL_8262 denotes 24 h
T113 838-844 Q8I912 denotes h), 10
T112 838-844 CVCL_W080 denotes h), 10
T114 848-852 Q5NRQ1 denotes ET-1
T115 848-852 PR:F4JU69 denotes ET-1
T116 848-852 P17322 denotes ET-1
T117 848-852 PR:000006897 denotes ET-1
T118 848-852 P97740 denotes ET-1
T119 848-852 Q28469 denotes ET-1
T120 848-852 P29560 denotes ET-1
T121 848-852 P22388 denotes ET-1
T122 848-852 P09558 denotes ET-1
T123 848-852 P13206 denotes ET-1
T124 848-852 Q9BG76 denotes ET-1
T125 848-852 Q5NRP9 denotes ET-1
T126 848-852 P22387 denotes ET-1
T127 915-923 UBERON:0001637 denotes arteries
T128 975-978 P34722 denotes PKC
T129 975-978 P13678 denotes PKC
T130 975-978 P05130 denotes PKC
T132 975-978 PR:000045382 denotes PKC
T131 975-978 GO:0004697 denotes PKC
T133 975-978 C537180 denotes PKC
T134 980-993 C016299 denotes chelerythrine
T135 980-993 CHEBI:78373 denotes chelerythrine
T136 980-993 C016299 denotes chelerythrine
T137 1024-1032 UBERON:0001637 denotes arteries
T138 1070-1076 GO:0005954 denotes CaMKII
T141 1070-1076 PR:Q00168 denotes CaMKII
T142 1070-1076 PR:000003197 denotes CaMKII
T139 1070-1076 D054732 denotes CaMKII
T140 1070-1076 GO:0004683 denotes CaMKII
T143 1078-1082 CHEBI:91460 denotes KN93
T144 1078-1082 C072105 denotes KN93
T145 1078-1082 C072105 denotes KN93
T146 1088-1091 PR:000005882 denotes p38
T147 1088-1091 O24473 denotes p38
T148 1088-1091 P46108 denotes p38
T149 1088-1091 Q64010 denotes p38
T150 1088-1091 A0A0H3M950 denotes p38
T151 1088-1091 P0C797 denotes p38
T152 1088-1091 P04383 denotes p38
T153 1088-1091 O95433 denotes p38
T154 1088-1091 Q63768 denotes p38
T155 1088-1091 PR:Q9LDA4 denotes p38
T156 1088-1091 P06663 denotes p38
T157 1088-1091 P0C796 denotes p38
T158 1088-1091 PR:000003860 denotes p38
T159 1088-1091 Q9NV58 denotes p38
T160 1088-1091 O75791 denotes p38
T161 1088-1091 PR:000008220 denotes p38
T162 1088-1091 A0A0H3MBK5 denotes p38
T163 1088-1091 P80350 denotes p38
T164 1088-1091 PR:000012967 denotes p38
T165 1088-1091 O97628 denotes p38
T166 1088-1091 A0A0H3MBL5 denotes p38
T167 1088-1091 Q9Y2S7 denotes p38
T168 1088-1091 PR:000014113 denotes p38
T169 1088-1091 P82869 denotes p38
T170 1088-1091 Q9Q6X7 denotes p38
T171 1088-1091 P9WGU1 denotes p38
T172 1088-1091 Q04929 denotes p38
T173 1093-1101 CHEBI:90705 denotes SB203580
T174 1093-1101 C093642 denotes SB203580
T175 1093-1101 C093642 denotes SB203580
T176 1131-1139 UBERON:0001637 denotes arteries
T177 1179-1183 Q5NRQ1 denotes ET-1
T178 1179-1183 PR:F4JU69 denotes ET-1
T179 1179-1183 P17322 denotes ET-1
T226 1451-1454 P05130 denotes PKC
T180 1179-1183 PR:000006897 denotes ET-1
T181 1179-1183 P97740 denotes ET-1
T182 1179-1183 Q28469 denotes ET-1
T183 1179-1183 P29560 denotes ET-1
T184 1179-1183 P22388 denotes ET-1
T185 1179-1183 P09558 denotes ET-1
T186 1179-1183 P13206 denotes ET-1
T187 1179-1183 Q9BG76 denotes ET-1
T188 1179-1183 Q5NRP9 denotes ET-1
T189 1179-1183 P22387 denotes ET-1
T190 1217-1228 D006984 denotes hypertrophy
T191 1217-1228 D006984 denotes hypertrophy
T192 1269-1273 PR:Q32MK0 denotes MLCK
T193 1269-1273 PR:A8C984 denotes MLCK
T194 1269-1273 PR:Q15746 denotes MLCK
T195 1269-1273 O02827 denotes MLCK
T196 1269-1273 PR:000010845 denotes MLCK
T197 1269-1273 P79280 denotes MLCK
T198 1269-1273 P11799 denotes MLCK
T199 1269-1273 Q28824 denotes MLCK
T200 1269-1273 Q15746 denotes MLCK
T201 1269-1273 PR:000029126 denotes MLCK
T203 1269-1273 Q6PDN3 denotes MLCK
T204 1269-1273 P29294 denotes MLCK
T205 1269-1273 PR:P06240 denotes MLCK
T202 1269-1273 GO:0004687 denotes MLCK
T206 1297-1302 UBERON:0000062 denotes organ
T207 1297-1302 UBERON:0003103 denotes organ
T208 1316-1320 Q5NRQ1 denotes ET-1
T209 1316-1320 PR:F4JU69 denotes ET-1
T210 1316-1320 P17322 denotes ET-1
T211 1316-1320 PR:000006897 denotes ET-1
T212 1316-1320 P97740 denotes ET-1
T213 1316-1320 Q28469 denotes ET-1
T214 1316-1320 P29560 denotes ET-1
T215 1316-1320 P22388 denotes ET-1
T216 1316-1320 P09558 denotes ET-1
T217 1316-1320 P13206 denotes ET-1
T218 1316-1320 Q9BG76 denotes ET-1
T219 1316-1320 Q5NRP9 denotes ET-1
T220 1316-1320 P22387 denotes ET-1
T221 1347-1364 GO:0043696 denotes dedifferentiation
T222 1395-1403 UBERON:0001637 denotes arteries
T223 1437-1447 CHEBI:35222 denotes inhibitors
T224 1451-1454 P34722 denotes PKC
T225 1451-1454 P13678 denotes PKC
T228 1451-1454 PR:000045382 denotes PKC
T227 1451-1454 GO:0004697 denotes PKC
T229 1451-1454 C537180 denotes PKC
T233 1456-1462 PR:Q00168 denotes CaMKII
T234 1456-1462 PR:000003197 denotes CaMKII
T230 1456-1462 GO:0005954 denotes CaMKII
T231 1456-1462 D054732 denotes CaMKII
T232 1456-1462 GO:0004683 denotes CaMKII
T235 1468-1471 PR:000005882 denotes p38
T236 1468-1471 O24473 denotes p38
T237 1468-1471 P46108 denotes p38
T238 1468-1471 Q64010 denotes p38
T239 1468-1471 A0A0H3M950 denotes p38
T240 1468-1471 P0C797 denotes p38
T241 1468-1471 P04383 denotes p38
T242 1468-1471 O95433 denotes p38
T243 1468-1471 Q63768 denotes p38
T244 1468-1471 PR:Q9LDA4 denotes p38
T245 1468-1471 P06663 denotes p38
T246 1468-1471 P0C796 denotes p38
T247 1468-1471 PR:000003860 denotes p38
T248 1468-1471 Q9NV58 denotes p38
T249 1468-1471 O75791 denotes p38
T250 1468-1471 PR:000008220 denotes p38
T251 1468-1471 A0A0H3MBK5 denotes p38
T252 1468-1471 P80350 denotes p38
T253 1468-1471 PR:000012967 denotes p38
T254 1468-1471 O97628 denotes p38
T255 1468-1471 A0A0H3MBL5 denotes p38
T256 1468-1471 Q9Y2S7 denotes p38
T257 1468-1471 PR:000014113 denotes p38
T258 1468-1471 P82869 denotes p38
T259 1468-1471 Q9Q6X7 denotes p38
T260 1468-1471 P9WGU1 denotes p38
T261 1468-1471 Q04929 denotes p38
T262 1523-1530 D000860 denotes hypoxia
T263 1523-1530 D000860 denotes hypoxia
T264 1596-1600 Q5NRQ1 denotes ET-1
T265 1596-1600 PR:F4JU69 denotes ET-1
T266 1596-1600 P17322 denotes ET-1
T267 1596-1600 PR:000006897 denotes ET-1
T268 1596-1600 P97740 denotes ET-1
T269 1596-1600 Q28469 denotes ET-1
T270 1596-1600 P29560 denotes ET-1
T271 1596-1600 P22388 denotes ET-1
T272 1596-1600 P09558 denotes ET-1
T273 1596-1600 P13206 denotes ET-1
T274 1596-1600 Q9BG76 denotes ET-1
T275 1596-1600 Q5NRP9 denotes ET-1
T276 1596-1600 P22387 denotes ET-1
T277 1633-1636 P34722 denotes PKC
T278 1633-1636 P13678 denotes PKC
T279 1633-1636 P05130 denotes PKC
T281 1633-1636 PR:000045382 denotes PKC
T280 1633-1636 GO:0004697 denotes PKC
T282 1633-1636 C537180 denotes PKC
T286 1638-1644 PR:Q00168 denotes CaMKII
T287 1638-1644 PR:000003197 denotes CaMKII
T283 1638-1644 GO:0005954 denotes CaMKII
T284 1638-1644 D054732 denotes CaMKII
T285 1638-1644 GO:0004683 denotes CaMKII
T288 1650-1653 PR:000005882 denotes p38
T289 1650-1653 O24473 denotes p38
T290 1650-1653 P46108 denotes p38
T291 1650-1653 Q64010 denotes p38
T292 1650-1653 A0A0H3M950 denotes p38
T293 1650-1653 P0C797 denotes p38
T294 1650-1653 P04383 denotes p38
T295 1650-1653 O95433 denotes p38
T296 1650-1653 Q63768 denotes p38
T297 1650-1653 PR:Q9LDA4 denotes p38
T298 1650-1653 P06663 denotes p38
T299 1650-1653 P0C796 denotes p38
T300 1650-1653 PR:000003860 denotes p38
T301 1650-1653 Q9NV58 denotes p38
T302 1650-1653 O75791 denotes p38
T303 1650-1653 PR:000008220 denotes p38
T304 1650-1653 A0A0H3MBK5 denotes p38
T305 1650-1653 P80350 denotes p38
T306 1650-1653 PR:000012967 denotes p38
T307 1650-1653 O97628 denotes p38
T308 1650-1653 A0A0H3MBL5 denotes p38
T309 1650-1653 Q9Y2S7 denotes p38
T310 1650-1653 PR:000014113 denotes p38
T311 1650-1653 P82869 denotes p38
T312 1650-1653 Q9Q6X7 denotes p38
T313 1650-1653 P9WGU1 denotes p38
T314 1650-1653 Q04929 denotes p38
T315 1675-1679 Q5NRQ1 denotes ET-1
T316 1675-1679 PR:F4JU69 denotes ET-1
T317 1675-1679 P17322 denotes ET-1
T318 1675-1679 PR:000006897 denotes ET-1
T319 1675-1679 P97740 denotes ET-1
T320 1675-1679 Q28469 denotes ET-1
T321 1675-1679 P29560 denotes ET-1
T322 1675-1679 P22388 denotes ET-1
T323 1675-1679 P09558 denotes ET-1
T324 1675-1679 P13206 denotes ET-1
T325 1675-1679 Q9BG76 denotes ET-1
T326 1675-1679 Q5NRP9 denotes ET-1
T327 1675-1679 P22387 denotes ET-1
T328 1714-1718 Q5NRQ1 denotes ET-1
T329 1714-1718 PR:F4JU69 denotes ET-1
T330 1714-1718 P17322 denotes ET-1
T331 1714-1718 PR:000006897 denotes ET-1
T332 1714-1718 P97740 denotes ET-1
T333 1714-1718 Q28469 denotes ET-1
T334 1714-1718 P29560 denotes ET-1
T335 1714-1718 P22388 denotes ET-1
T336 1714-1718 P09558 denotes ET-1
T337 1714-1718 P13206 denotes ET-1
T338 1714-1718 Q9BG76 denotes ET-1
T339 1714-1718 Q5NRP9 denotes ET-1
T340 1714-1718 P22387 denotes ET-1
T341 1728-1741 UBERON:0001135 denotes smooth muscle
T342 1728-1741 UBERON:0000953 denotes smooth muscle
T343 1728-1753 GO:0014895 denotes smooth muscle hypertrophy
T347 1735-1753 614160 denotes muscle hypertrophy
T350 1782-1786 Q5NRQ1 denotes ET-1
T351 1782-1786 PR:F4JU69 denotes ET-1
T352 1782-1786 P17322 denotes ET-1
T353 1782-1786 PR:000006897 denotes ET-1
T354 1782-1786 P97740 denotes ET-1
T355 1782-1786 Q28469 denotes ET-1
T356 1782-1786 P29560 denotes ET-1
T357 1782-1786 P22388 denotes ET-1
T358 1782-1786 P09558 denotes ET-1
T359 1782-1786 P13206 denotes ET-1
T360 1782-1786 Q9BG76 denotes ET-1
T361 1782-1786 Q5NRP9 denotes ET-1
T362 1782-1786 P22387 denotes ET-1
T363 1810-1827 GO:0043696 denotes dedifferentiation