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c_corpus

Id Subject Object Predicate Lexical cue
T1 8-34 Q9RQJ2 denotes peptidylarginine deiminase
T2 8-34 D000076342 denotes peptidylarginine deiminase
T3 38-41 UBERON:2001977 denotes PAD
T22 38-42 PR:O24616 denotes PAD2
T23 38-42 PR:Q08642 denotes PAD2
T24 38-42 PR:000012220 denotes PAD2
T25 38-42 PR:P20717 denotes PAD2
T26 38-42 PR:P46309 denotes PAD2
T27 38-42 PR:Q8WR51 denotes PAD2
T28 38-42 PR:Q9Y2J8 denotes PAD2
T29 55-64 D002277 denotes carcinoma
T30 55-64 D002277 denotes carcinoma
T31 65-79 GO:0016477 denotes cell migration
T32 112-125 UBERON:0001911 denotes mammary gland
T33 112-125 UBERON:0005200 denotes mammary gland
T35 126-143 GO:0005604 denotes basement membrane
T36 126-143 UBERON:0005769 denotes basement membrane
T40 187-192 D009369 denotes tumor
T41 187-192 D009369 denotes tumor
T42 209-216 MGI:87853 denotes a mouse
T43 211-216 10090 denotes mouse
T44 211-216 D051379 denotes mouse
T47 226-250 D002285 denotes ductal carcinoma in situ
T48 226-250 D002285 denotes ductal carcinoma in situ
T53 291-317 Q9RQJ2 denotes peptidylarginine deiminase
T54 291-317 D000076342 denotes peptidylarginine deiminase
T55 321-324 UBERON:2001977 denotes PAD
T74 321-325 PR:O24616 denotes PAD2
T75 321-325 PR:Q08642 denotes PAD2
T76 321-325 PR:000012220 denotes PAD2
T77 321-325 PR:P20717 denotes PAD2
T78 321-325 PR:P46309 denotes PAD2
T79 321-325 PR:Q8WR51 denotes PAD2
T80 321-325 PR:Q9Y2J8 denotes PAD2
T81 327-330 PR:M9NDE3 denotes aka
T82 327-330 172644 denotes aka
T83 331-336 PR:P20717 denotes PADI2
T84 331-336 PR:Q9Y2J8 denotes PADI2
T85 331-336 PR:Q08642 denotes PADI2
T86 331-336 PR:000012220 denotes PADI2
T87 367-384 GO:0005604 denotes basement membrane
T88 367-384 UBERON:0005769 denotes basement membrane
T92 408-414 D009369 denotes tumors
T93 408-414 D009369 denotes tumors
T94 454-458 SO:0001742 denotes gain
T95 496-499 UBERON:2001977 denotes PAD
T114 496-500 PR:O24616 denotes PAD2
T115 496-500 PR:Q08642 denotes PAD2
T116 496-500 PR:000012220 denotes PAD2
T117 496-500 PR:P20717 denotes PAD2
T118 496-500 PR:P46309 denotes PAD2
T119 496-500 PR:Q8WR51 denotes PAD2
T120 496-500 PR:Q9Y2J8 denotes PAD2
T121 561-564 UBERON:2001977 denotes PAD
T140 561-565 PR:O24616 denotes PAD2
T141 561-565 PR:Q08642 denotes PAD2
T142 561-565 PR:000012220 denotes PAD2
T143 561-565 PR:P20717 denotes PAD2
T144 561-565 PR:P46309 denotes PAD2
T145 561-565 PR:Q8WR51 denotes PAD2
T146 561-565 PR:Q9Y2J8 denotes PAD2
T147 578-602 D018270 denotes mammary ductal carcinoma
T148 578-602 D018270 denotes mammary ductal carcinoma
T154 623-628 SO:0002031 denotes shRNA
T153 623-628 D034741 denotes shRNA
T155 669-672 UBERON:2001977 denotes PAD
T174 669-673 PR:O24616 denotes PAD2
T175 669-673 PR:Q08642 denotes PAD2
T176 669-673 PR:000012220 denotes PAD2
T177 669-673 PR:P20717 denotes PAD2
T178 669-673 PR:P46309 denotes PAD2
T179 669-673 PR:Q8WR51 denotes PAD2
T180 669-673 PR:Q9Y2J8 denotes PAD2
T182 693-696 O07006 denotes PAD
T183 693-696 P33751 denotes PAD
T184 693-696 PR:000022589 denotes PAD
T185 693-696 C0H3U9 denotes PAD
T186 693-696 O06837 denotes PAD
T187 693-696 Q8X7Z8 denotes PAD
T188 693-696 Q9X697 denotes PAD
T189 693-696 Q9X698 denotes PAD
T190 693-696 Q7DBA7 denotes PAD
T191 693-696 P94404 denotes PAD
T192 693-696 Q4R101 denotes PAD
T193 693-696 Q9KPX2 denotes PAD
T194 693-696 Q9S4M7 denotes PAD
T195 693-696 P69772 denotes PAD
T196 693-696 Q4R102 denotes PAD
T197 693-696 Q9X696 denotes PAD
T198 693-696 P94405 denotes PAD
T199 693-696 P80668 denotes PAD
T181 693-696 UBERON:2001977 denotes PAD
T200 767-781 GO:0016477 denotes cell migration
T201 822-825 UBERON:2001977 denotes PAD
T220 822-826 PR:O24616 denotes PAD2
T221 822-826 PR:Q08642 denotes PAD2
T222 822-826 PR:000012220 denotes PAD2
T223 822-826 PR:P20717 denotes PAD2
T224 822-826 PR:P46309 denotes PAD2
T225 822-826 PR:Q8WR51 denotes PAD2
T226 822-826 PR:Q9Y2J8 denotes PAD2
T227 859-862 UBERON:2001977 denotes PAD
T246 859-863 PR:O24616 denotes PAD2
T247 859-863 PR:Q08642 denotes PAD2
T248 859-863 PR:000012220 denotes PAD2
T249 859-863 PR:P20717 denotes PAD2
T250 859-863 PR:P46309 denotes PAD2
T251 859-863 PR:Q8WR51 denotes PAD2
T252 859-863 PR:Q9Y2J8 denotes PAD2
T253 884-887 Q95ND4 denotes EGF
T255 884-887 PR:P01133 denotes EGF
T256 884-887 P01133 denotes EGF
T257 884-887 PR:P07522 denotes EGF
T258 884-887 PR:P01132 denotes EGF
T259 884-887 Q9BEA0 denotes EGF
T260 884-887 P01132 denotes EGF
T261 884-887 P07522 denotes EGF
T263 884-887 PR:000006928 denotes EGF
T264 884-887 P26224 denotes EGF
T266 884-887 Q00968 denotes EGF
T254 884-887 CHEBI:140739 denotes EGF
T265 884-887 D004815 denotes EGF
T267 884-887 D004815 denotes EGF
T262 884-887 GO:0005154 denotes EGF
T268 896-910 GO:0016477 denotes cell migration
T269 929-932 UBERON:2001977 denotes PAD
T288 929-933 PR:O24616 denotes PAD2
T289 929-933 PR:Q08642 denotes PAD2
T290 929-933 PR:000012220 denotes PAD2
T291 929-933 PR:P20717 denotes PAD2
T292 929-933 PR:P46309 denotes PAD2
T293 929-933 PR:Q8WR51 denotes PAD2
T294 929-933 PR:Q9Y2J8 denotes PAD2
T295 948-953 D009369 denotes tumor
T296 948-953 D009369 denotes tumor
T297 948-958 CL:0001063 denotes tumor cell
T298 954-968 GO:0016477 denotes cell migration
T299 1003-1006 UBERON:2001977 denotes PAD
T318 1003-1007 PR:O24616 denotes PAD2
T319 1003-1007 PR:Q08642 denotes PAD2
T320 1003-1007 PR:000012220 denotes PAD2
T321 1003-1007 PR:P20717 denotes PAD2
T322 1003-1007 PR:P46309 denotes PAD2
T323 1003-1007 PR:Q8WR51 denotes PAD2
T324 1003-1007 PR:Q9Y2J8 denotes PAD2
T325 1048-1062 GO:0016477 denotes cell migration
T328 1076-1089 CVCL_5552 denotes MCF10DCIS.com
T329 1081-1085 D002285 denotes DCIS
T331 1081-1085 D002285 denotes DCIS
T333 1086-1089 CHEBI:17905 denotes com
T334 1100-1106 D009369 denotes tumors
T335 1100-1106 D009369 denotes tumors
T336 1145-1148 UBERON:2001977 denotes PAD
T355 1145-1149 PR:O24616 denotes PAD2
T356 1145-1149 PR:Q08642 denotes PAD2
T357 1145-1149 PR:000012220 denotes PAD2
T358 1145-1149 PR:P20717 denotes PAD2
T359 1145-1149 PR:P46309 denotes PAD2
T360 1145-1149 PR:Q8WR51 denotes PAD2
T361 1145-1149 PR:Q9Y2J8 denotes PAD2
T362 1164-1167 Q95ND4 denotes EGF
T364 1164-1167 PR:P01133 denotes EGF
T365 1164-1167 P01133 denotes EGF
T366 1164-1167 PR:P07522 denotes EGF
T367 1164-1167 PR:P01132 denotes EGF
T368 1164-1167 Q9BEA0 denotes EGF
T369 1164-1167 P01132 denotes EGF
T370 1164-1167 P07522 denotes EGF
T372 1164-1167 PR:000006928 denotes EGF
T373 1164-1167 P26224 denotes EGF
T375 1164-1167 Q00968 denotes EGF
T363 1164-1167 CHEBI:140739 denotes EGF
T374 1164-1167 D004815 denotes EGF
T376 1164-1167 D004815 denotes EGF
T371 1164-1167 GO:0005154 denotes EGF
T377 1218-1223 10090 denotes mouse
T378 1218-1223 D051379 denotes mouse
T379 1259-1269 SO:0000781 denotes transgenic
T380 1259-1275 D008822 denotes transgenic mouse
T383 1314-1317 UBERON:2001977 denotes PAD
T402 1314-1318 PR:O24616 denotes PAD2
T403 1314-1318 PR:Q08642 denotes PAD2
T404 1314-1318 PR:000012220 denotes PAD2
T405 1314-1318 PR:P20717 denotes PAD2
T406 1314-1318 PR:P46309 denotes PAD2
T407 1314-1318 PR:Q8WR51 denotes PAD2
T408 1314-1318 PR:Q9Y2J8 denotes PAD2
T409 1337-1350 UBERON:0001911 denotes mammary gland
T410 1337-1350 UBERON:0005200 denotes mammary gland
T411 1337-1362 GO:0030879 denotes mammary gland development
T414 1399-1402 UBERON:2001977 denotes PAD
T433 1399-1403 PR:O24616 denotes PAD2
T434 1399-1403 PR:Q08642 denotes PAD2
T435 1399-1403 PR:000012220 denotes PAD2
T436 1399-1403 PR:P20717 denotes PAD2
T437 1399-1403 PR:P46309 denotes PAD2
T438 1399-1403 PR:Q8WR51 denotes PAD2
T439 1399-1403 PR:Q9Y2J8 denotes PAD2
T440 1439-1453 GO:0016477 denotes cell migration
T443 1483-1496 CVCL_5552 denotes MCF10DCIS.com
T444 1488-1492 D002285 denotes DCIS
T446 1488-1492 D002285 denotes DCIS
T448 1493-1496 CHEBI:17905 denotes com
T449 1531-1534 UBERON:2001977 denotes PAD
T468 1531-1535 PR:O24616 denotes PAD2
T469 1531-1535 PR:Q08642 denotes PAD2
T470 1531-1535 PR:000012220 denotes PAD2
T471 1531-1535 PR:P20717 denotes PAD2
T472 1531-1535 PR:P46309 denotes PAD2
T473 1531-1535 PR:Q8WR51 denotes PAD2
T474 1531-1535 PR:Q9Y2J8 denotes PAD2
T475 1603-1611 CHEBI:36080 denotes proteins
T476 1612-1616 PR:Q22038 denotes RhoA
T477 1612-1616 PR:000000176 denotes RhoA
T478 1612-1616 PR:Q9QUI0 denotes RhoA
T479 1612-1616 PR:P61589 denotes RhoA
T480 1612-1616 PR:P61585 denotes RhoA
T481 1612-1616 PR:P61586 denotes RhoA
T485 1618-1622 PR:000013660 denotes Rac1
T486 1618-1622 PR:Q03206 denotes Rac1
T487 1618-1622 PR:Q38912 denotes Rac1
T488 1618-1622 PR:P63001 denotes Rac1
T489 1618-1622 PR:P40792 denotes Rac1
T490 1618-1622 PR:Q6RUV5 denotes Rac1
T491 1618-1622 PR:P63000 denotes Rac1
T492 1628-1631 CL:0000990 denotes Cdc
T493 1628-1633 PR:P19073 denotes Cdc42
T494 1628-1633 PR:P60953 denotes Cdc42
T495 1628-1633 PR:Q01112 denotes Cdc42
T496 1628-1633 PR:P60766 denotes Cdc42
T497 1628-1633 PR:P40793 denotes Cdc42
T498 1628-1633 PR:Q90694 denotes Cdc42
T499 1628-1633 PR:Q05062 denotes Cdc42
T500 1628-1633 PR:000005204 denotes Cdc42
T501 1628-1633 PR:Q8CFN2 denotes Cdc42
T502 1628-1633 PR:P0CY33 denotes Cdc42
T503 1685-1695 SO:1000009 denotes transition
T504 1699-1704 D009369 denotes tumor
T505 1699-1704 D009369 denotes tumor
T506 1746-1759 GO:0007155 denotes cell adhesion
T507 1768-1778 P08641 denotes E-cadherin
T508 1768-1778 P30944 denotes E-cadherin
T509 1768-1778 Q6R8F2 denotes E-cadherin
T510 1768-1778 PR:Q24298 denotes E-cadherin
T511 1768-1778 F1PAA9 denotes E-cadherin
T512 1768-1778 P09803 denotes E-cadherin
T514 1768-1778 PR:000001447 denotes E-cadherin
T516 1768-1778 P12830 denotes E-cadherin
T517 1768-1778 Q5RAX1 denotes E-cadherin
T518 1768-1778 Q9R0T4 denotes E-cadherin
T513 1768-1778 D015820 denotes E-cadherin
T515 1768-1778 D015820 denotes E-cadherin
T519 1770-1778 GO:0008014 denotes cadherin
T521 1784-1797 UBERON:0001911 denotes mammary gland
T522 1784-1797 UBERON:0005200 denotes mammary gland
T524 1838-1841 UBERON:2001977 denotes PAD
T543 1838-1842 PR:O24616 denotes PAD2
T544 1838-1842 PR:Q08642 denotes PAD2
T545 1838-1842 PR:000012220 denotes PAD2
T546 1838-1842 PR:P20717 denotes PAD2
T547 1838-1842 PR:P46309 denotes PAD2
T548 1838-1842 PR:Q8WR51 denotes PAD2
T549 1838-1842 PR:Q9Y2J8 denotes PAD2
T550 1863-1866 Q95ND4 denotes EGF
T552 1863-1866 PR:P01133 denotes EGF
T553 1863-1866 P01133 denotes EGF
T554 1863-1866 PR:P07522 denotes EGF
T555 1863-1866 PR:P01132 denotes EGF
T556 1863-1866 Q9BEA0 denotes EGF
T557 1863-1866 P01132 denotes EGF
T558 1863-1866 P07522 denotes EGF
T560 1863-1866 PR:000006928 denotes EGF
T561 1863-1866 P26224 denotes EGF
T563 1863-1866 Q00968 denotes EGF
T551 1863-1866 CHEBI:140739 denotes EGF
T562 1863-1866 D004815 denotes EGF
T564 1863-1866 D004815 denotes EGF
T559 1863-1866 GO:0005154 denotes EGF
T565 1915-1918 UBERON:2001977 denotes PAD
T584 1915-1919 PR:O24616 denotes PAD2
T585 1915-1919 PR:Q08642 denotes PAD2
T586 1915-1919 PR:000012220 denotes PAD2
T587 1915-1919 PR:P20717 denotes PAD2
T588 1915-1919 PR:P46309 denotes PAD2
T589 1915-1919 PR:Q8WR51 denotes PAD2
T590 1915-1919 PR:Q9Y2J8 denotes PAD2
T591 1975-1988 UBERON:0001911 denotes mammary gland
T592 1975-1988 UBERON:0005200 denotes mammary gland
T594 2039-2042 UBERON:2001977 denotes PAD
T613 2039-2043 PR:O24616 denotes PAD2
T614 2039-2043 PR:Q08642 denotes PAD2
T615 2039-2043 PR:000012220 denotes PAD2
T616 2039-2043 PR:P20717 denotes PAD2
T617 2039-2043 PR:P46309 denotes PAD2
T618 2039-2043 PR:Q8WR51 denotes PAD2
T619 2039-2043 PR:Q9Y2J8 denotes PAD2
T620 2069-2075 UBERON:0000310 denotes breast
T621 2069-2082 D001943 denotes breast cancer
T622 2069-2082 D001943 denotes breast cancer
T623 2076-2087 CL:0001064 denotes cancer cell
T624 2083-2097 GO:0016477 denotes cell migration
T625 2117-2120 Q95ND4 denotes EGF
T627 2117-2120 PR:P01133 denotes EGF
T628 2117-2120 P01133 denotes EGF
T629 2117-2120 PR:P07522 denotes EGF
T630 2117-2120 PR:P01132 denotes EGF
T631 2117-2120 Q9BEA0 denotes EGF
T632 2117-2120 P01132 denotes EGF
T633 2117-2120 P07522 denotes EGF
T635 2117-2120 PR:000006928 denotes EGF
T636 2117-2120 P26224 denotes EGF
T638 2117-2120 Q00968 denotes EGF
T626 2117-2120 CHEBI:140739 denotes EGF
T637 2117-2120 D004815 denotes EGF
T639 2117-2120 D004815 denotes EGF
T634 2117-2120 GO:0005154 denotes EGF
T644 2141-2148 SO:0000104 denotes protein
T643 2141-2148 PR:000000001 denotes protein
T641 2141-2148 CHEBI:36080 denotes protein
T642 2141-2148 CHEBI:11122 denotes protein
T640 2141-2148 GO:0003675 denotes protein
T645 2141-2163 GO:0018101 denotes protein citrullination
T646 2173-2176 UBERON:2001977 denotes PAD
T665 2173-2177 PR:O24616 denotes PAD2
T666 2173-2177 PR:Q08642 denotes PAD2
T667 2173-2177 PR:000012220 denotes PAD2
T668 2173-2177 PR:P20717 denotes PAD2
T669 2173-2177 PR:P46309 denotes PAD2
T670 2173-2177 PR:Q8WR51 denotes PAD2
T671 2173-2177 PR:Q9Y2J8 denotes PAD2
T672 2196-2199 Q95ND4 denotes EGF
T674 2196-2199 PR:P01133 denotes EGF
T675 2196-2199 P01133 denotes EGF
T676 2196-2199 PR:P07522 denotes EGF
T677 2196-2199 PR:P01132 denotes EGF
T678 2196-2199 Q9BEA0 denotes EGF
T679 2196-2199 P01132 denotes EGF
T680 2196-2199 P07522 denotes EGF
T682 2196-2199 PR:000006928 denotes EGF
T683 2196-2199 P26224 denotes EGF
T685 2196-2199 Q00968 denotes EGF
T673 2196-2199 CHEBI:140739 denotes EGF
T684 2196-2199 D004815 denotes EGF
T686 2196-2199 D004815 denotes EGF
T681 2196-2199 GO:0005154 denotes EGF
T687 2208-2222 GO:0016477 denotes cell migration
T688 2236-2239 UBERON:2001977 denotes PAD
T707 2236-2240 PR:O24616 denotes PAD2
T708 2236-2240 PR:Q08642 denotes PAD2
T709 2236-2240 PR:000012220 denotes PAD2
T710 2236-2240 PR:P20717 denotes PAD2
T711 2236-2240 PR:P46309 denotes PAD2
T712 2236-2240 PR:Q8WR51 denotes PAD2
T713 2236-2240 PR:Q9Y2J8 denotes PAD2
T714 2269-2272 Q95ND4 denotes EGF
T716 2269-2272 PR:P01133 denotes EGF
T717 2269-2272 P01133 denotes EGF
T718 2269-2272 PR:P07522 denotes EGF
T719 2269-2272 PR:P01132 denotes EGF
T720 2269-2272 Q9BEA0 denotes EGF
T721 2269-2272 P01132 denotes EGF
T722 2269-2272 P07522 denotes EGF
T724 2269-2272 PR:000006928 denotes EGF
T725 2269-2272 P26224 denotes EGF
T727 2269-2272 Q00968 denotes EGF
T715 2269-2272 CHEBI:140739 denotes EGF
T726 2269-2272 D004815 denotes EGF
T728 2269-2272 D004815 denotes EGF
T723 2269-2272 GO:0005154 denotes EGF
T730 2273-2290 GO:0007165 denotes signaling pathway
T731 2283-2290 CHEBI:34922 denotes pathway
T732 2302-2316 GO:0016477 denotes cell migration

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-7 DRI_Background denotes Role of
T2 8-34 Token_Label.OUTSIDE denotes peptidylarginine deiminase
T3 35-80 DRI_Background denotes 2 (PAD2) in mammary carcinoma cell migration.
T4 93-202 DRI_Approach denotes Penetration of the mammary gland basement membrane by cancer cells is a crucial first step in tumor invasion.
T5 203-290 DRI_Background denotes Using a mouse model of ductal carcinoma in situ, we previously found that inhibition of
T6 291-317 Token_Label.OUTSIDE denotes peptidylarginine deiminase
T7 318-415 DRI_Background denotes 2 (PAD2, aka PADI2) activity appears to maintain basement membrane integrity in xenograft tumors.
T8 416-523 DRI_Challenge denotes The goal of this investigation was to gain insight into the mechanisms by which PAD2 mediates this process.
T9 533-611 DRI_Outcome denotes For our study, we modulated PAD2 activity in mammary ductal carcinoma cells by
T10 612-637 Token_Label.OUTSIDE denotes lentiviral shRNA-mediated
T11 638-648 DRI_Outcome denotes depletion,
T12 649-673 Token_Label.OUTSIDE denotes lentiviral-mediated PAD2
T13 674-802 DRI_Outcome denotes overexpression, or PAD inhibition and explored the effects of these treatments on changes in cell migration and cell morphology.
T14 803-911 DRI_Approach denotes We also used these PAD2-modulated cells to test whether PAD2 may be required for EGF-induced cell migration.
T15 912-1107 DRI_Challenge denotes To determine how PAD2 might promote tumor cell migration in vivo, we tested the effects of PAD2 inhibition on the expression of several cell migration mediators in MCF10DCIS.com xenograft tumors.
T16 1108-1242 DRI_Outcome denotes In addition, we tested the effect of PAD2 inhibition on EGF-induced ductal invasion and elongation in primary mouse mammary organoids.
T17 1243-1363 DRI_Approach denotes Lastly, using a transgenic mouse model, we investigated the effects of PAD2 overexpression on mammary gland development.
T18 1373-1503 DRI_Outcome denotes Our results indicate that PAD2 depletion or inhibition suppresses cell migration and alters the morphology of MCF10DCIS.com cells.
T19 1504-1779 DRI_Outcome denotes In addition, we found that PAD2 depletion suppresses the expression of the cytoskeletal regulatory proteins RhoA, Rac1, and Cdc42 and also promotes a mesenchymal to epithelial-like transition in tumor cells with an associated increase in the cell adhesion marker, E-cadherin.
T20 1780-1891 DRI_Outcome denotes Our mammary gland organoid study found that inhibition of PAD2 activity suppresses EGF-induced ductal invasion.
T21 1892-1989 DRI_Outcome denotes In vivo, we found that PAD2 overexpression causes hyperbranching in the developing mammary gland.
T22 2002-2098 DRI_Approach denotes Together, these results suggest that PAD2 plays a critical role in breast cancer cell migration.
T23 2099-2317 DRI_Outcome denotes Our findings that EGF treatment increases protein citrullination and that PAD2 inhibition blocks EGF-induced cell migration suggest that PAD2 likely functions within the EGF signaling pathway to mediate cell migration.