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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 116-322 DRI_Approach denotes Activation of the FOXO transcription factor DAF-16 by reduced insulin/IGF signaling (IIS) is considered to be beneficial in C. elegans due to its ability to extend lifespan and to enhance stress resistance.
T2 437-449 DRI_Background denotes In contrast,
T3 468-614 DRI_Background denotes causes a tumorous germline phenotype characterized by hyperproliferation of the germline stem cells and rupture of the adjacent basement membrane.
T4 615-702 DRI_Outcome denotes Here we show that cross-talk between DAF-16 and the transforming growth factor ß (TGFß)
T5 720-831 DRI_Outcome denotes protein (BMP) signaling pathway causes germline hyperplasia and results in disruption of the basement membrane.
T6 832-1020 DRI_Outcome denotes In addition to activating MADM/NRBP/hpo-11 gene alone, DAF-16 also directly interacts with both R-SMAD proteins SMA-2 and SMA-3 in the nucleus to regulate the expression of mTORC1 pathway.
T7 1021-1252 DRI_Background denotes Knocking-down of BMP genes or each of the four target genes in the hypodermis was sufficient to inhibit germline proliferation, indicating a cell-non-autonomously controlled regulation of stem cell proliferation by somatic tissues.
T8 1253-1394 DRI_Approach denotes We propose the existence of two antagonistic DAF-16/FOXO functions, a cell-proliferative somatic and an anti-proliferative germline activity.
T9 1395-1457 DRI_Background denotes Whereas germline hyperplasia under reduced IIS is inhibited by
T10 1482-1625 DRI_Background denotes , activation of somatic DAF-16 in the presence of active IIS promotes germline proliferation and eventually induces tumor-like germline growth.
T11 1626-1800 DRI_Outcome denotes In summary, our results suggest a novel pathway crosstalk of DAF-16 and TGF-ß/BMP that can modulate mTORC1 at the transcriptional level to cause stem-cell hyperproliferation.
T12 1801-1967 DRI_Challenge denotes Such cell-type specific differences may help explaining why human FOXO activity is considered to be tumor-suppressive in most contexts, but may become oncogenic, e.g.
T13 1968-2006 DRI_Background denotes in chronic and acute myeloid leukemia.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 0-1 CVCL_S361|Finite_cell_line|Mus musculus denotes C
T2 42-43 CVCL_7027|Cancer_cell_line|Homo sapiens denotes ß
T3 104-114 CVCL_C410|Hybridoma|Mus musculus denotes activation
T4 116-126 CVCL_C410|Hybridoma|Mus musculus denotes Activation
T5 240-241 CVCL_S361|Finite_cell_line|Mus musculus denotes C
T6 363-371 CVCL_C410|Hybridoma|Mus musculus denotes activity
T7 475-476 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T8 620-622 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes we
T9 694-695 CVCL_7027|Cancer_cell_line|Homo sapiens denotes ß
T10 703-707 CVCL_D953|Induced_pluripotent_stem_cell|Homo sapiens denotes bone
T11 847-857 CVCL_C410|Hybridoma|Mus musculus denotes activating
T12 872-874 CVCL_5986|Cancer_cell_line|Homo sapiens denotes 11
T13 944-949 CVCL_UB67|Induced_pluripotent_stem_cell|Homo sapiens denotes SMA-2
T14 944-949 CVCL_WB08|Transformed_cell_line|Homo sapiens denotes SMA-2
T15 954-959 CVCL_UB68|Induced_pluripotent_stem_cell|Homo sapiens denotes SMA-3
T16 954-959 CVCL_WB09|Transformed_cell_line|Homo sapiens denotes SMA-3
T17 1160-1161 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T18 1253-1255 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes We
T19 1321-1322 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T20 1354-1356 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T21 1354-1356 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T22 1385-1393 CVCL_C410|Hybridoma|Mus musculus denotes activity
T23 1484-1494 CVCL_C410|Hybridoma|Mus musculus denotes activation
T24 1532-1538 CVCL_C410|Hybridoma|Mus musculus denotes active
T25 1658-1659 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T26 1702-1703 CVCL_7027|Cancer_cell_line|Homo sapiens denotes ß
T27 1837-1840 CVCL_E773|Transformed_cell_line|Homo sapiens denotes may
T28 1872-1880 CVCL_C410|Hybridoma|Mus musculus denotes activity
T29 1941-1944 CVCL_E773|Transformed_cell_line|Homo sapiens denotes may

GoldHamster

Id Subject Object Predicate Lexical cue
T4 11-17 PR:O16850 denotes DAF-16
T5 18-22 O16850 denotes FOXO
T6 18-22 PR:Q95V55 denotes FOXO
T8 44-47 PR:000000034 denotes BMP
T9 44-47 P35855 denotes BMP
T7 44-47 CHEBI:60815 denotes BMP
T10 48-57 GO:0023052 denotes signaling
T11 77-82 D009369 denotes tumor
T12 77-82 D009369 denotes tumor
T13 83-92 GO:0009058 denotes formation
T15 97-103 D000076222 denotes mTORC1
T14 97-103 GO:0031931 denotes mTORC1
T16 134-138 O16850 denotes FOXO
T17 134-138 PR:Q95V55 denotes FOXO
T18 139-152 GO:0006351 denotes transcription
T19 139-159 GO:0000981 denotes transcription factor
T23 160-166 PR:O16850 denotes DAF-16
T24 178-185 P51463 denotes insulin
T25 178-185 Q91XI3 denotes insulin
T26 178-185 P01308 denotes insulin
T27 178-185 P01340 denotes insulin
T28 178-185 P07453 denotes insulin
T29 178-185 P68988 denotes insulin
T30 178-185 P21563 denotes insulin
T31 178-185 P68245 denotes insulin
T32 178-185 P68990 denotes insulin
T34 178-185 P09476 denotes insulin
T35 178-185 P69047 denotes insulin
T36 178-185 Q8HXV2 denotes insulin
T37 178-185 P12705 denotes insulin
T38 178-185 P68987 denotes insulin
T40 178-185 Q9NDE7 denotes insulin
T41 178-185 P13190 denotes insulin
T42 178-185 P01321 denotes insulin
T43 178-185 C0HJT9 denotes insulin
T44 178-185 P81423 denotes insulin
T45 178-185 P01327 denotes insulin
T46 178-185 P41522 denotes insulin
T47 178-185 C0HJI1 denotes insulin
T48 178-185 P01336 denotes insulin
T49 178-185 P67974 denotes insulin
T50 178-185 P69046 denotes insulin
T51 178-185 P12704 denotes insulin
T52 178-185 P42633 denotes insulin
T53 178-185 P67968 denotes insulin
T54 178-185 P01334 denotes insulin
T55 178-185 P67973 denotes insulin
T56 178-185 P01328 denotes insulin
T57 178-185 P81881 denotes insulin
T58 178-185 P01330 denotes insulin
T59 178-185 Q9W7R2 denotes insulin
T60 178-185 P09477 denotes insulin
T61 178-185 P01311 denotes insulin
T62 178-185 P01315 denotes insulin
T63 178-185 P06306 denotes insulin
T64 178-185 P01319 denotes insulin
T65 178-185 Q6YK33 denotes insulin
T66 178-185 P67971 denotes insulin
T67 178-185 Q62587 denotes insulin
T68 178-185 P68991 denotes insulin
T69 178-185 P12708 denotes insulin
T70 178-185 P04667 denotes insulin
T72 178-185 P68989 denotes insulin
T73 178-185 P01333 denotes insulin
T74 178-185 PR:000009054 denotes insulin
T75 178-185 P30410 denotes insulin
T76 178-185 P01331 denotes insulin
T77 178-185 P01314 denotes insulin
T78 178-185 P01320 denotes insulin
T79 178-185 P01318 denotes insulin
T80 178-185 P12703 denotes insulin
T81 178-185 C0HJI4 denotes insulin
T82 178-185 P30406 denotes insulin
T83 178-185 C0HJU0 denotes insulin
T84 178-185 P68992 denotes insulin
T85 178-185 P67970 denotes insulin
T86 178-185 P18109 denotes insulin
T87 178-185 Q9TQY7 denotes insulin
T88 178-185 O73727 denotes insulin
T89 178-185 P01329 denotes insulin
T90 178-185 P01324 denotes insulin
T92 178-185 P01335 denotes insulin
T93 178-185 P68243 denotes insulin
T94 178-185 P67972 denotes insulin
T95 178-185 P29335 denotes insulin
T96 178-185 P01342 denotes insulin
T97 178-185 P69048 denotes insulin
T98 178-185 P01313 denotes insulin
T99 178-185 P01316 denotes insulin
T100 178-185 P17715 denotes insulin
T101 178-185 P30407 denotes insulin
T102 178-185 P01339 denotes insulin
T104 178-185 P81025 denotes insulin
T105 178-185 P69045 denotes insulin
T106 178-185 P01317 denotes insulin
T107 178-185 P01310 denotes insulin
T108 178-185 Q98TA8 denotes insulin
T109 178-185 P67969 denotes insulin
T110 178-185 P0C236 denotes insulin
T33 178-185 CHEBI:5931 denotes insulin
T39 178-185 D007328 denotes insulin
T71 178-185 CHEBI:145810 denotes insulin
T91 178-185 D007328 denotes insulin
T103 178-185 GO:0016088 denotes insulin
T111 186-189 P22618 denotes IGF
T112 190-199 GO:0023052 denotes signaling
T113 201-204 PR:000014508 denotes IIS
T114 201-204 Q6XE38 denotes IIS
T115 280-288 UBERON:0000104 denotes lifespan
T119 356-362 PR:O16850 denotes DAF-16
T120 381-390 CL:0000034 denotes stem cell
T121 381-404 GO:0072089 denotes stem cell proliferation
T123 391-404 UBERON:2000098 denotes proliferation
T124 418-423 D009369 denotes tumor
T125 418-423 D009369 denotes tumor
T129 461-467 PR:O16850 denotes DAF-16
T130 572-579 D012421 denotes rupture
T131 572-579 D012421 denotes rupture
T133 596-613 UBERON:0005769 denotes basement membrane
T132 596-613 GO:0005604 denotes basement membrane
T140 652-658 PR:O16850 denotes DAF-16
T141 667-693 D015291 denotes transforming growth factor
T142 667-693 D015291 denotes transforming growth factor
T143 680-693 P08441 denotes growth factor
T144 680-693 P08072 denotes growth factor
T145 680-693 Q776B5 denotes growth factor
T146 680-693 Q6RZT5 denotes growth factor
T147 680-693 Q8V307 denotes growth factor
T148 703-707 UBERON:0001474 denotes bone
T149 703-707 UBERON:0002481 denotes bone
T154 720-727 SO:0000104 denotes protein
T153 720-727 PR:000000001 denotes protein
T151 720-727 CHEBI:36080 denotes protein
T152 720-727 CHEBI:11122 denotes protein
T150 720-727 GO:0003675 denotes protein
T156 729-732 PR:000000034 denotes BMP
T157 729-732 P35855 denotes BMP
T155 729-732 CHEBI:60815 denotes BMP
T158 729-751 GO:0030509 denotes BMP) signaling pathway
T161 744-751 CHEBI:34922 denotes pathway
T162 768-779 D006965 denotes hyperplasia
T163 768-779 D006965 denotes hyperplasia
T165 813-830 UBERON:0005769 denotes basement membrane
T164 813-830 GO:0005604 denotes basement membrane
T169 858-862 PR:O35598 denotes MADM
T170 858-862 PR:Q9Y0Y6 denotes MADM
T171 858-862 PR:000001278 denotes MADM
T172 858-862 PR:000011418 denotes MADM
T173 858-862 PR:O14672 denotes MADM
T174 858-862 PR:P97297 denotes MADM
T175 858-862 PR:Q10743 denotes MADM
T176 858-862 PR:Q99J45 denotes MADM
T177 863-867 PR:000011418 denotes NRBP
T178 863-867 PR:Q9UHY1 denotes NRBP
T179 863-867 PR:Q99J45 denotes NRBP
T180 868-871 PR:P55789 denotes hpo
T181 868-871 PR:Q8T0S6 denotes hpo
T183 868-871 PR:000007940 denotes hpo
T184 868-871 A6YIH8 denotes hpo
T182 868-871 CHEBI:32363 denotes hpo
T185 875-879 SO:0000704 denotes gene
T189 887-893 PR:O16850 denotes DAF-16
T190 928-943 D051896 denotes R-SMAD proteins
T194 944-949 PR:Q9US26 denotes SMA-2
T197 944-949 PR:Q04658 denotes SMA-2
T198 944-949 PR:Q02330 denotes SMA-2
T193 944-949 CVCL_WB08 denotes SMA-2
T195 944-949 CVCL_UB67 denotes SMA-2
T196 944-949 D014897 denotes SMA-2
T201 954-959 PR:O94261 denotes SMA-3
T202 954-959 PR:P45896 denotes SMA-3
T199 954-959 CVCL_UB68 denotes SMA-3
T203 954-959 CVCL_WB09 denotes SMA-3
T200 954-959 D014897 denotes SMA-3
T206 967-974 GO:0005634 denotes nucleus
T205 967-974 UBERON:0000125 denotes nucleus
T204 967-974 CHEBI:33252 denotes nucleus
T207 1005-1011 GO:0031931 denotes mTORC1
T208 1005-1011 D000076222 denotes mTORC1
T209 1012-1019 CHEBI:34922 denotes pathway
T211 1038-1041 PR:000000034 denotes BMP
T212 1038-1041 P35855 denotes BMP
T210 1038-1041 CHEBI:60815 denotes BMP
T213 1088-1098 UBERON:0002072 denotes hypodermis
T214 1088-1098 UBERON:0007376 denotes hypodermis
T215 1134-1147 UBERON:2000098 denotes proliferation
T217 1195-1232 GO:0072091 denotes regulation of stem cell proliferation
T218 1209-1218 CL:0000034 denotes stem cell
T221 1219-1232 UBERON:2000098 denotes proliferation
T225 1298-1304 PR:O16850 denotes DAF-16
T226 1305-1309 O16850 denotes FOXO
T227 1305-1309 PR:Q95V55 denotes FOXO
T228 1412-1423 D006965 denotes hyperplasia
T229 1412-1423 D006965 denotes hyperplasia
T230 1438-1441 PR:000014508 denotes IIS
T231 1438-1441 Q6XE38 denotes IIS
T235 1458-1464 PR:O16850 denotes DAF-16
T239 1506-1512 PR:O16850 denotes DAF-16
T240 1539-1542 PR:000014508 denotes IIS
T241 1539-1542 Q6XE38 denotes IIS
T242 1561-1574 UBERON:2000098 denotes proliferation
T243 1598-1603 D009369 denotes tumor
T244 1598-1603 D009369 denotes tumor
T245 1666-1673 CHEBI:34922 denotes pathway
T249 1687-1693 PR:O16850 denotes DAF-16
T251 1704-1707 PR:000000034 denotes BMP
T252 1704-1707 P35855 denotes BMP
T250 1704-1707 CHEBI:60815 denotes BMP
T253 1726-1732 GO:0031931 denotes mTORC1
T254 1726-1732 D000076222 denotes mTORC1
T255 1771-1780 CL:0000034 denotes stem-cell
T256 1861-1866 D006801 denotes human
T257 1867-1871 O16850 denotes FOXO
T258 1867-1871 PR:Q95V55 denotes FOXO
T259 1901-1906 D009369 denotes tumor
T260 1901-1906 D009369 denotes tumor
T261 1983-2005 D015470 denotes acute myeloid leukemia
T262 1983-2005 D015470 denotes acute myeloid leukemia