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PubMed:28543872 JSONTXT

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kaiyin_test

Id Subject Object Predicate Lexical cue
T1 122-127 Gene denotes PAI-1
T3 145-153 Var denotes variants
T4 154-161 PosReg denotes promote
T5 162-177 CPA denotes airway fibrosis
T6 186-201 Reg denotes associated with
T7 202-208 Disease denotes asthma
R1 T3 T4 CauseOf variants,promote
R2 T5 T4 ThemeOf airway fibrosis,promote
R3 T1 T3 ThemeOf PAI-1,variants
R4 T3 T6 CauseOf variants,associated with
R5 T7 T6 ThemeOf asthma,associated with

name_no

Id Subject Object Predicate Lexical cue
T1 122-127 Gene denotes PAI-1
T3 145-153 Var denotes variants
T4 154-161 PosReg denotes promote
T5 162-177 CPA denotes airway fibrosis
T6 186-201 Reg denotes associated with
T7 202-208 Disease denotes asthma
R1 T3 T4 CauseOf variants,promote
R2 T5 T4 ThemeOf airway fibrosis,promote
R3 T1 T3 ThemeOf PAI-1,variants
R4 T3 T6 CauseOf variants,associated with
R5 T7 T6 ThemeOf asthma,associated with

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-89 Sentence denotes PAI-1 gain-of-function genotype, factors increasing PAI-1 levels, and airway obstruction:
T2 90-109 Sentence denotes The GALA II Cohort.
T3 110-262 Sentence denotes BACKGROUND: PAI-1 gain-of-function variants promote airway fibrosis and are associated with asthma and with worse lung function in subjects with asthma.
T4 263-273 Sentence denotes OBJECTIVE:
T5 274-560 Sentence denotes We sought to determine whether the association of a gain-of-function polymorphism in plasminogen activator inhibitor-1 (PAI-1) with airway obstruction is modified by asthma status, and whether any genotype effect persists after accounting for common exposures that increase PAI-1 level.
T6 561-569 Sentence denotes METHODS:
T7 570-677 Sentence denotes We studied 2070 Latino children (8-21y) with genotypic and pulmonary function data from the GALA II cohort.
T8 678-810 Sentence denotes We estimated the relationship of the PAI-1 risk allele with FEV1/FVC by multivariate linear regression, stratified by asthma status.
T9 811-949 Sentence denotes We examined the association of the polymorphism with asthma and airway obstruction within asthmatics via multivariate logistic regression.
T10 950-1030 Sentence denotes We replicated associations in the SAPPHIRE cohort of African Americans (n=1056).
T11 1031-1134 Sentence denotes Secondary analysis included the effect of the at-risk polymorphism on postbronchodilator lung function.
T12 1135-1143 Sentence denotes RESULTS:
T13 1144-1239 Sentence denotes There was an interaction between asthma status and the PAI-1 polymorphism on FEV1 /FVC (P=.03).
T14 1240-1407 Sentence denotes The gain-of-function variants, genotypes (AA/AG), were associated with lower FEV1 /FVC in subjects with asthma (β=-1.25, CI: -2.14,-0.35, P=.006), but not in controls.
T15 1408-1493 Sentence denotes Subjects with asthma and the AA/AG genotypes had a 5% decrease in FEV1 /FVC (P<.001).
T16 1494-1633 Sentence denotes In asthmatics, the risk genotype (AA/AG) was associated with a 39% increase in risk of clinically relevant airway obstruction (OR=1.39, CI:
T17 1634-1653 Sentence denotes 1.01, 1.92, P=.04).
T18 1654-1769 Sentence denotes These associations persisted after exclusion of factors that increase PAI-1 including tobacco exposure and obesity.
T19 1770-1805 Sentence denotes CONCLUSIONS AND CLINICAL RELEVANCE:
T20 1806-1906 Sentence denotes The decrease in the FEV1 /FVC ratio associated with the risk genotype was modified by asthma status.
T21 1907-1991 Sentence denotes The genotype increased the odds of airway obstruction by 75% within asthmatics only.
T22 1992-2170 Sentence denotes As exposures known to increase PAI-1 levels did not mitigate this association, PAI-1 may contribute to airway obstruction in the context of chronic asthmatic airway inflammation.
T1 0-89 Sentence denotes PAI-1 gain-of-function genotype, factors increasing PAI-1 levels, and airway obstruction:
T2 90-109 Sentence denotes The GALA II Cohort.
T3 110-262 Sentence denotes BACKGROUND: PAI-1 gain-of-function variants promote airway fibrosis and are associated with asthma and with worse lung function in subjects with asthma.
T4 263-273 Sentence denotes OBJECTIVE:
T5 274-560 Sentence denotes We sought to determine whether the association of a gain-of-function polymorphism in plasminogen activator inhibitor-1 (PAI-1) with airway obstruction is modified by asthma status, and whether any genotype effect persists after accounting for common exposures that increase PAI-1 level.
T6 561-569 Sentence denotes METHODS:
T7 570-677 Sentence denotes We studied 2070 Latino children (8-21y) with genotypic and pulmonary function data from the GALA II cohort.
T8 678-810 Sentence denotes We estimated the relationship of the PAI-1 risk allele with FEV1/FVC by multivariate linear regression, stratified by asthma status.
T9 811-949 Sentence denotes We examined the association of the polymorphism with asthma and airway obstruction within asthmatics via multivariate logistic regression.
T10 950-1030 Sentence denotes We replicated associations in the SAPPHIRE cohort of African Americans (n=1056).
T11 1031-1134 Sentence denotes Secondary analysis included the effect of the at-risk polymorphism on postbronchodilator lung function.
T12 1135-1143 Sentence denotes RESULTS:
T13 1144-1239 Sentence denotes There was an interaction between asthma status and the PAI-1 polymorphism on FEV1 /FVC (P=.03).
T14 1240-1407 Sentence denotes The gain-of-function variants, genotypes (AA/AG), were associated with lower FEV1 /FVC in subjects with asthma (β=-1.25, CI: -2.14,-0.35, P=.006), but not in controls.
T15 1408-1493 Sentence denotes Subjects with asthma and the AA/AG genotypes had a 5% decrease in FEV1 /FVC (P<.001).
T16 1494-1633 Sentence denotes In asthmatics, the risk genotype (AA/AG) was associated with a 39% increase in risk of clinically relevant airway obstruction (OR=1.39, CI:
T17 1634-1653 Sentence denotes 1.01, 1.92, P=.04).
T18 1654-1769 Sentence denotes These associations persisted after exclusion of factors that increase PAI-1 including tobacco exposure and obesity.
T19 1770-1805 Sentence denotes CONCLUSIONS AND CLINICAL RELEVANCE:
T20 1806-1906 Sentence denotes The decrease in the FEV1 /FVC ratio associated with the risk genotype was modified by asthma status.
T21 1907-1991 Sentence denotes The genotype increased the odds of airway obstruction by 75% within asthmatics only.
T22 1992-2170 Sentence denotes As exposures known to increase PAI-1 levels did not mitigate this association, PAI-1 may contribute to airway obstruction in the context of chronic asthmatic airway inflammation.