> top > docs > PubMed:28516454 > spans > 805-2438 > annotations

PubMed:28516454 / 805-2438 JSONTXT

Annnotations TAB JSON ListView MergeView

GoldHamster

Id Subject Object Predicate Lexical cue
T26 74-92 D016171 denotes torsade de pointes
T27 74-92 D016171 denotes torsade de pointes
T28 94-97 CHEBI:61377 denotes TdP
T29 94-97 CHEBI:61417 denotes TdP
T30 170-173 CHEBI:61377 denotes TdP
T31 170-173 CHEBI:61417 denotes TdP
T32 177-183 UBERON:0003100 denotes female
T33 184-200 D008133 denotes long-QT syndrome
T34 184-200 D008133 denotes long-QT syndrome
T35 304-311 D006728 denotes hormone
T36 304-311 D006728 denotes hormone
T37 304-311 CHEBI:24621 denotes hormone
T38 378-388 D001145 denotes arrhythmia
T39 378-388 D001145 denotes arrhythmia
T40 515-531 D008133 denotes long-QT syndrome
T41 515-531 D008133 denotes long-QT syndrome
T42 535-539 UBERON:0003101 denotes male
T43 535-539 CHEBI:30780 denotes male
T44 544-550 UBERON:0003100 denotes female
T45 563-568 D006801 denotes human
T46 604-611 D006728 denotes hormone
T47 604-611 D006728 denotes hormone
T48 604-611 CHEBI:24621 denotes hormone
T49 618-622 PR:000000791 denotes hERG
T50 618-622 PR:Q12809 denotes hERG
T51 618-622 PR:P11308 denotes hERG
T53 632-642 49247 denotes dofetilide
T52 632-642 CHEBI:4681 denotes dofetilide
T54 632-642 C063533 denotes dofetilide
T55 632-642 C063533 denotes dofetilide
T56 647-651 PR:000000791 denotes hERG
T57 647-651 PR:Q12809 denotes hERG
T58 647-651 PR:P11308 denotes hERG
T59 670-674 UBERON:0003101 denotes male
T60 670-674 CHEBI:30780 denotes male
T61 681-687 UBERON:0003100 denotes female
T62 785-795 D001145 denotes arrhythmia
T63 785-795 D001145 denotes arrhythmia
T64 825-851 UBERON:0000013 denotes sympathetic nervous system
T65 837-851 D009422 denotes nervous system
T67 837-851 D009422 denotes nervous system
T68 873-882 SO:0000732 denotes predicted
T69 902-912 D001145 denotes arrhythmia
T70 902-912 D001145 denotes arrhythmia
T71 935-961 UBERON:0000013 denotes sympathetic nervous system
T72 947-961 D009422 denotes nervous system
T74 947-961 D009422 denotes nervous system
T75 1031-1047 D008133 denotes long-QT syndrome
T76 1031-1047 D008133 denotes long-QT syndrome
T77 1062-1071 SO:0000732 denotes predicted
T78 1096-1106 D001145 denotes arrhythmia
T79 1096-1106 D001145 denotes arrhythmia
T81 1122-1134 8727 denotes progesterone
T80 1122-1134 D011374 denotes progesterone
T82 1122-1134 CHEBI:17026 denotes progesterone
T83 1122-1134 D011374 denotes progesterone
T87 1184-1196 10379 denotes testosterone
T84 1184-1196 D013739 denotes testosterone
T85 1184-1196 CHEBI:17347 denotes testosterone
T86 1184-1196 D013739 denotes testosterone
T88 1275-1284 CHEBI:50114 denotes oestrogen
T89 1324-1334 D004958 denotes oestradiol
T90 1324-1334 CHEBI:23965 denotes oestradiol
T91 1324-1334 D004958 denotes oestradiol
T92 1352-1356 PR:000000791 denotes hERG
T93 1352-1356 PR:Q12809 denotes hERG
T94 1352-1356 PR:P11308 denotes hERG
T96 1374-1378 UBERON:0008915 denotes pore
T95 1374-1378 GO:0046930 denotes pore
T97 1415-1418 CHEBI:61377 denotes TdP
T98 1415-1418 CHEBI:61417 denotes TdP
T99 1449-1455 UBERON:0002553 denotes cavity
T102 1456-1463 GO:0005488 denotes binding
T103 1456-1468 SO:0001091 denotes binding site
T104 1456-1468 SO:0000409 denotes binding site
T105 1585-1591 UBERON:0003100 denotes female

PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T2 0-1633 ABSTRACT denotes Female sex is a risk factor for inherited and acquired long-QT associated torsade de pointes (TdP) arrhythmias, and sympathetic discharge is a major factor in triggering TdP in female long-QT syndrome patients. We used a combined experimental and computational approach to predict 'the perfect storm' of hormone concentration, IKr block and sympathetic stimulation that induces arrhythmia in females with inherited and acquired long-QT. More specifically, we developed mathematical models of acquired and inherited long-QT syndrome in male and female ventricular human myocytes by combining effects of a hormone and a hERG blocker, dofetilide, or hERG mutations. These 'male' and 'female' model myocytes and tissues then were used to predict how various sex-based differences underlie arrhythmia risk in the setting of acute sympathetic nervous system discharge. The model predicted increased risk for arrhythmia in females when acute sympathetic nervous system discharge was applied in the settings of both inherited and acquired long-QT syndrome. Females were predicted to have protection from arrhythmia induction when progesterone is high. Males were protected by the presence of testosterone. Structural modelling points towards two plausible and distinct mechanisms of oestrogen action enhancing torsadogenic effects: oestradiol interaction with hERG mutations in the pore loop containing G604 or with common TdP-related blockers in the intra-cavity binding site. Our study presents findings that constitute the first evidence linking structure to function mechanisms underlying female dominance of arousal-induced arrhythmias.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T8 14-15 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T9 141-142 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T10 211-213 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes We
T11 219-220 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T12 456-458 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes we
T13 602-603 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T14 616-617 CVCL_6479|Finite_cell_line|Mus musculus denotes a