PubMed:28516454 / 144-794 JSONTXT

{"project":"GoldHamster","denotations":[{"id":"T2","span":{"begin":174,"end":178},"obj":"CHEBI:23888"},{"id":"T3","span":{"begin":265,"end":270},"obj":"CHEBI:23888"},{"id":"T4","span":{"begin":411,"end":414},"obj":"PR:Q02280"},{"id":"T5","span":{"begin":411,"end":414},"obj":"PR:O95259"},{"id":"T6","span":{"begin":411,"end":414},"obj":"PR:Q63472"},{"id":"T7","span":{"begin":411,"end":414},"obj":"PR:Q60603"},{"id":"T8","span":{"begin":411,"end":414},"obj":"PR:000000790"},{"id":"T9","span":{"begin":483,"end":492},"obj":"CHEBI:50114"},{"id":"T10","span":{"begin":502,"end":506},"obj":"GO:0046930"},{"id":"T11","span":{"begin":502,"end":506},"obj":"UBERON:0008915"},{"id":"T12","span":{"begin":512,"end":516},"obj":"PR:000000791"},{"id":"T13","span":{"begin":512,"end":516},"obj":"PR:Q12809"},{"id":"T14","span":{"begin":512,"end":516},"obj":"PR:P11308"},{"id":"T15","span":{"begin":517,"end":525},"obj":"SO:0000109"},{"id":"T16","span":{"begin":565,"end":574},"obj":"CHEBI:50114"},{"id":"T18","span":{"begin":579,"end":589},"obj":"49247"},{"id":"T17","span":{"begin":579,"end":589},"obj":"CHEBI:4681"},{"id":"T19","span":{"begin":579,"end":589},"obj":"C063533"},{"id":"T20","span":{"begin":579,"end":589},"obj":"C063533"},{"id":"T21","span":{"begin":632,"end":636},"obj":"PR:000000791"},{"id":"T22","span":{"begin":632,"end":636},"obj":"PR:Q12809"},{"id":"T23","span":{"begin":632,"end":636},"obj":"PR:P11308"},{"id":"T25","span":{"begin":645,"end":649},"obj":"UBERON:0008915"},{"id":"T24","span":{"begin":645,"end":649},"obj":"GO:0046930"}],"text":"This study represents a first step toward predicting mechanisms of sex-based arrhythmias that may lead to important developments in risk stratification and may inform future drug design and screening. We undertook simulations to reveal the conditions (i.e. pacing, drugs, sympathetic stimulation) required for triggering and sustaining reentrant arrhythmias. Using the recently solved cryo-EM structure for the Eag-family channel as a template, we revealed potential interactions of oestrogen with the pore loop hERG mutation (G604S). Molecular models suggest that oestrogen and dofetilide blockade can concur simultaneously in the hERG channel pore."}

{"project":"PubMed_Structured_Abstracts","denotations":[{"id":"T1","span":{"begin":0,"end":650},"obj":"KEY POINTS"}],"text":"This study represents a first step toward predicting mechanisms of sex-based arrhythmias that may lead to important developments in risk stratification and may inform future drug design and screening. We undertook simulations to reveal the conditions (i.e. pacing, drugs, sympathetic stimulation) required for triggering and sustaining reentrant arrhythmias. Using the recently solved cryo-EM structure for the Eag-family channel as a template, we revealed potential interactions of oestrogen with the pore loop hERG mutation (G604S). Molecular models suggest that oestrogen and dofetilide blockade can concur simultaneously in the hERG channel pore."}

{"project":"Goldhamster2_Cellosaurus","denotations":[{"id":"T2","span":{"begin":22,"end":23},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"},{"id":"T3","span":{"begin":94,"end":97},"obj":"CVCL_E773|Transformed_cell_line|Homo sapiens"},{"id":"T4","span":{"begin":156,"end":159},"obj":"CVCL_E773|Transformed_cell_line|Homo sapiens"},{"id":"T5","span":{"begin":201,"end":203},"obj":"CVCL_5M23|Cancer_cell_line|Mesocricetus auratus"},{"id":"T6","span":{"begin":433,"end":434},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"},{"id":"T7","span":{"begin":445,"end":447},"obj":"CVCL_5M23|Cancer_cell_line|Mesocricetus auratus"}],"text":"This study represents a first step toward predicting mechanisms of sex-based arrhythmias that may lead to important developments in risk stratification and may inform future drug design and screening. We undertook simulations to reveal the conditions (i.e. pacing, drugs, sympathetic stimulation) required for triggering and sustaining reentrant arrhythmias. Using the recently solved cryo-EM structure for the Eag-family channel as a template, we revealed potential interactions of oestrogen with the pore loop hERG mutation (G604S). Molecular models suggest that oestrogen and dofetilide blockade can concur simultaneously in the hERG channel pore."}