PubMed:28511649 JSONTXT

{"project":"GoldHamster","denotations":[{"id":"T1","span":{"begin":0,"end":5},"obj":"PR:000001471"},{"id":"T2","span":{"begin":0,"end":5},"obj":"Q29408"},{"id":"T3","span":{"begin":0,"end":5},"obj":"P18893"},{"id":"T4","span":{"begin":0,"end":5},"obj":"PR:Q6A2H4"},{"id":"T5","span":{"begin":0,"end":5},"obj":"Q25BC1"},{"id":"T6","span":{"begin":0,"end":5},"obj":"Q9TSJ4"},{"id":"T7","span":{"begin":0,"end":5},"obj":"O97798"},{"id":"T8","span":{"begin":0,"end":5},"obj":"P46651"},{"id":"T9","span":{"begin":0,"end":5},"obj":"P51497"},{"id":"T10","span":{"begin":0,"end":5},"obj":"O46673"},{"id":"T11","span":{"begin":0,"end":5},"obj":"P29456"},{"id":"T12","span":{"begin":0,"end":5},"obj":"Q8MKG9"},{"id":"T13","span":{"begin":0,"end":5},"obj":"Q6A2H4"},{"id":"T14","span":{"begin":0,"end":5},"obj":"P79338"},{"id":"T16","span":{"begin":0,"end":5},"obj":"Q29055"},{"id":"T17","span":{"begin":0,"end":5},"obj":"P48411"},{"id":"T18","span":{"begin":0,"end":5},"obj":"PR:P29456"},{"id":"T19","span":{"begin":0,"end":5},"obj":"Q2PE73"},{"id":"T20","span":{"begin":0,"end":5},"obj":"A2T6Z6"},{"id":"T21","span":{"begin":0,"end":5},"obj":"PR:P22301"},{"id":"T22","span":{"begin":0,"end":5},"obj":"Q865X4"},{"id":"T23","span":{"begin":0,"end":5},"obj":"Q5Q0V6"},{"id":"T24","span":{"begin":0,"end":5},"obj":"Q9Z1Y5"},{"id":"T25","span":{"begin":0,"end":5},"obj":"PR:P18893"},{"id":"T26","span":{"begin":0,"end":5},"obj":"P55029"},{"id":"T27","span":{"begin":0,"end":5},"obj":"P43480"},{"id":"T28","span":{"begin":0,"end":5},"obj":"P47965"},{"id":"T29","span":{"begin":0,"end":5},"obj":"P22301"},{"id":"T31","span":{"begin":0,"end":5},"obj":"Q9JHK7"},{"id":"T32","span":{"begin":0,"end":5},"obj":"Q0Z972"},{"id":"T34","span":{"begin":0,"end":5},"obj":"P51746"},{"id":"T35","span":{"begin":0,"end":5},"obj":"Q28374"},{"id":"T36","span":{"begin":0,"end":5},"obj":"P51496"},{"id":"T15","span":{"begin":0,"end":5},"obj":"D016753"},{"id":"T30","span":{"begin":0,"end":5},"obj":"D016753"},{"id":"T33","span":{"begin":0,"end":5},"obj":"GO:0005141"},{"id":"T37","span":{"begin":18,"end":21},"obj":"PR:P01375"},{"id":"T38","span":{"begin":18,"end":21},"obj":"PR:P06804"},{"id":"T39","span":{"begin":18,"end":21},"obj":"PR:000000134"},{"id":"T40","span":{"begin":18,"end":21},"obj":"PR:P16599"},{"id":"T41","span":{"begin":32,"end":40},"obj":"UBERON:0000387"},{"id":"T42","span":{"begin":73,"end":79},"obj":"UBERON:0000479"},{"id":"T43","span":{"begin":108,"end":120},"obj":"GO:0006954"},{"id":"T44","span":{"begin":108,"end":120},"obj":"D007249"},{"id":"T45","span":{"begin":108,"end":120},"obj":"D007249"},{"id":"T46","span":{"begin":128,"end":136},"obj":"UBERON:0000387"},{"id":"T47","span":{"begin":184,"end":192},"obj":"UBERON:0000387"},{"id":"T49","span":{"begin":205,"end":225},"obj":"GO:0031012"},{"id":"T50","span":{"begin":219,"end":225},"obj":"UBERON:0027368"},{"id":"T51","span":{"begin":226,"end":237},"obj":"GO:0009056"},{"id":"T52","span":{"begin":271,"end":281},"obj":"GO:0008219"},{"id":"T55","span":{"begin":346,"end":360},"obj":"PR:000001471"},{"id":"T56","span":{"begin":346,"end":360},"obj":"Q29408"},{"id":"T57","span":{"begin":346,"end":360},"obj":"P18893"},{"id":"T58","span":{"begin":346,"end":360},"obj":"Q25BC1"},{"id":"T59","span":{"begin":346,"end":360},"obj":"Q9TSJ4"},{"id":"T60","span":{"begin":346,"end":360},"obj":"O97798"},{"id":"T61","span":{"begin":346,"end":360},"obj":"P46651"},{"id":"T62","span":{"begin":346,"end":360},"obj":"P51497"},{"id":"T63","span":{"begin":346,"end":360},"obj":"O46673"},{"id":"T64","span":{"begin":346,"end":360},"obj":"P29456"},{"id":"T65","span":{"begin":346,"end":360},"obj":"Q8MKG9"},{"id":"T66","span":{"begin":346,"end":360},"obj":"Q6A2H4"},{"id":"T67","span":{"begin":346,"end":360},"obj":"P79338"},{"id":"T69","span":{"begin":346,"end":360},"obj":"Q29055"},{"id":"T70","span":{"begin":346,"end":360},"obj":"P48411"},{"id":"T71","span":{"begin":346,"end":360},"obj":"Q2PE73"},{"id":"T72","span":{"begin":346,"end":360},"obj":"A2T6Z6"},{"id":"T73","span":{"begin":346,"end":360},"obj":"Q865X4"},{"id":"T74","span":{"begin":346,"end":360},"obj":"Q5Q0V6"},{"id":"T75","span":{"begin":346,"end":360},"obj":"Q9Z1Y5"},{"id":"T76","span":{"begin":346,"end":360},"obj":"P55029"},{"id":"T77","span":{"begin":346,"end":360},"obj":"P43480"},{"id":"T78","span":{"begin":346,"end":360},"obj":"P47965"},{"id":"T79","span":{"begin":346,"end":360},"obj":"P22301"},{"id":"T81","span":{"begin":346,"end":360},"obj":"Q9JHK7"},{"id":"T82","span":{"begin":346,"end":360},"obj":"Q0Z972"},{"id":"T83","span":{"begin":346,"end":360},"obj":"P51746"},{"id":"T84","span":{"begin":346,"end":360},"obj":"Q28374"},{"id":"T85","span":{"begin":346,"end":360},"obj":"P51496"},{"id":"T68","span":{"begin":346,"end":360},"obj":"D016753"},{"id":"T80","span":{"begin":346,"end":360},"obj":"D016753"},{"id":"T86","span":{"begin":411,"end":414},"obj":"PR:P01375"},{"id":"T87","span":{"begin":411,"end":414},"obj":"PR:P06804"},{"id":"T88","span":{"begin":411,"end":414},"obj":"PR:000000134"},{"id":"T89","span":{"begin":411,"end":414},"obj":"PR:P16599"},{"id":"T90","span":{"begin":425,"end":433},"obj":"UBERON:0000387"},{"id":"T91","span":{"begin":457,"end":465},"obj":"UBERON:0000387"},{"id":"T92","span":{"begin":466,"end":472},"obj":"UBERON:0000479"},{"id":"T93","span":{"begin":505,"end":510},"obj":"UBERON:0007023"},{"id":"T94","span":{"begin":585,"end":591},"obj":"9913"},{"id":"T95","span":{"begin":592,"end":595},"obj":"PR:P01375"},{"id":"T96","span":{"begin":592,"end":595},"obj":"PR:P06804"},{"id":"T97","span":{"begin":592,"end":595},"obj":"PR:000000134"},{"id":"T98","span":{"begin":592,"end":595},"obj":"PR:P16599"},{"id":"T99","span":{"begin":602,"end":607},"obj":"PR:000001471"},{"id":"T100","span":{"begin":602,"end":607},"obj":"Q29408"},{"id":"T101","span":{"begin":602,"end":607},"obj":"P18893"},{"id":"T102","span":{"begin":602,"end":607},"obj":"PR:Q6A2H4"},{"id":"T103","span":{"begin":602,"end":607},"obj":"Q25BC1"},{"id":"T104","span":{"begin":602,"end":607},"obj":"Q9TSJ4"},{"id":"T105","span":{"begin":602,"end":607},"obj":"O97798"},{"id":"T106","span":{"begin":602,"end":607},"obj":"P46651"},{"id":"T107","span":{"begin":602,"end":607},"obj":"P51497"},{"id":"T108","span":{"begin":602,"end":607},"obj":"O46673"},{"id":"T109","span":{"begin":602,"end":607},"obj":"P29456"},{"id":"T110","span":{"begin":602,"end":607},"obj":"Q8MKG9"},{"id":"T111","span":{"begin":602,"end":607},"obj":"Q6A2H4"},{"id":"T112","span":{"begin":602,"end":607},"obj":"P79338"},{"id":"T114","span":{"begin":602,"end":607},"obj":"Q29055"},{"id":"T115","span":{"begin":602,"end":607},"obj":"P48411"},{"id":"T116","span":{"begin":602,"end":607},"obj":"PR:P29456"},{"id":"T117","span":{"begin":602,"end":607},"obj":"Q2PE73"},{"id":"T118","span":{"begin":602,"end":607},"obj":"A2T6Z6"},{"id":"T119","span":{"begin":602,"end":607},"obj":"PR:P22301"},{"id":"T120","span":{"begin":602,"end":607},"obj":"Q865X4"},{"id":"T121","span":{"begin":602,"end":607},"obj":"Q5Q0V6"},{"id":"T122","span":{"begin":602,"end":607},"obj":"Q9Z1Y5"},{"id":"T123","span":{"begin":602,"end":607},"obj":"PR:P18893"},{"id":"T124","span":{"begin":602,"end":607},"obj":"P55029"},{"id":"T125","span":{"begin":602,"end":607},"obj":"P43480"},{"id":"T126","span":{"begin":602,"end":607},"obj":"P47965"},{"id":"T127","span":{"begin":602,"end":607},"obj":"P22301"},{"id":"T129","span":{"begin":602,"end":607},"obj":"Q9JHK7"},{"id":"T130","span":{"begin":602,"end":607},"obj":"Q0Z972"},{"id":"T132","span":{"begin":602,"end":607},"obj":"P51746"},{"id":"T133","span":{"begin":602,"end":607},"obj":"Q28374"},{"id":"T134","span":{"begin":602,"end":607},"obj":"P51496"},{"id":"T113","span":{"begin":602,"end":607},"obj":"D016753"},{"id":"T128","span":{"begin":602,"end":607},"obj":"D016753"},{"id":"T131","span":{"begin":602,"end":607},"obj":"GO:0005141"},{"id":"T135","span":{"begin":640,"end":646},"obj":"CL:0002674"},{"id":"T136","span":{"begin":642,"end":652},"obj":"GO:0008219"},{"id":"T137","span":{"begin":697,"end":705},"obj":"GO:0032060"},{"id":"T138","span":{"begin":726,"end":744},"obj":"CHEBI:18085"},{"id":"T139","span":{"begin":726,"end":744},"obj":"D006025"},{"id":"T140","span":{"begin":726,"end":744},"obj":"D006025"},{"id":"T144","span":{"begin":746,"end":749},"obj":"1498292"},{"id":"T142","span":{"begin":746,"end":749},"obj":"PR:P21330"},{"id":"T143","span":{"begin":746,"end":749},"obj":"PR:Q967S7"},{"id":"T145","span":{"begin":746,"end":749},"obj":"PR:Q8I7Q0"},{"id":"T147","span":{"begin":746,"end":749},"obj":"PR:P20828"},{"id":"T148","span":{"begin":746,"end":749},"obj":"PR:P10405"},{"id":"T149","span":{"begin":746,"end":749},"obj":"PR:P04282"},{"id":"T141","span":{"begin":746,"end":749},"obj":"103820"},{"id":"T146","span":{"begin":746,"end":749},"obj":"CHEBI:143889"},{"id":"T150","span":{"begin":751,"end":755},"obj":"C435946"},{"id":"T151","span":{"begin":751,"end":755},"obj":"C435946"},{"id":"T155","span":{"begin":767,"end":779},"obj":"7442"},{"id":"T152","span":{"begin":767,"end":779},"obj":"CHEBI:16480"},{"id":"T153","span":{"begin":767,"end":779},"obj":"D009569"},{"id":"T154","span":{"begin":767,"end":779},"obj":"D009569"},{"id":"T158","span":{"begin":785,"end":799},"obj":"C095000"},{"id":"T159","span":{"begin":785,"end":799},"obj":"C095000"},{"id":"T160","span":{"begin":792,"end":799},"obj":"SO:0000695"},{"id":"T164","span":{"begin":838,"end":842},"obj":"SO:0000234"},{"id":"T162","span":{"begin":838,"end":842},"obj":"D012333"},{"id":"T163","span":{"begin":838,"end":842},"obj":"CHEBI:33699"},{"id":"T165","span":{"begin":847,"end":853},"obj":"UBERON:0027368"},{"id":"T167","span":{"begin":873,"end":881},"obj":"2714"},{"id":"T166","span":{"begin":873,"end":881},"obj":"GO:0005202"},{"id":"T170","span":{"begin":873,"end":888},"obj":"CHEBI:3822"},{"id":"T171","span":{"begin":873,"end":888},"obj":"D024121"},{"id":"T174","span":{"begin":890,"end":895},"obj":"CVCL_4604"},{"id":"T177","span":{"begin":890,"end":897},"obj":"PR:000005693"},{"id":"T178","span":{"begin":890,"end":897},"obj":"PR:P08125"},{"id":"T179","span":{"begin":890,"end":897},"obj":"PR:Q03692"},{"id":"T180","span":{"begin":890,"end":897},"obj":"PR:Q05306"},{"id":"T182","span":{"begin":893,"end":896},"obj":"CVCL_IR40"},{"id":"T186","span":{"begin":903,"end":915},"obj":"7442"},{"id":"T187","span":{"begin":903,"end":926},"obj":"D019001"},{"id":"T198","span":{"begin":930,"end":934},"obj":"PR:000001901"},{"id":"T199","span":{"begin":930,"end":934},"obj":"PR:P29477"},{"id":"T200","span":{"begin":930,"end":934},"obj":"PR:Q06518"},{"id":"T201","span":{"begin":930,"end":934},"obj":"PR:P35228"},{"id":"T202","span":{"begin":930,"end":934},"obj":"PR:P60321"},{"id":"T203","span":{"begin":930,"end":934},"obj":"P60322"},{"id":"T205","span":{"begin":930,"end":934},"obj":"PR:000010971"},{"id":"T206","span":{"begin":930,"end":934},"obj":"PR:Q90703"},{"id":"T207","span":{"begin":930,"end":934},"obj":"P60321"},{"id":"T208","span":{"begin":930,"end":934},"obj":"PR:P60322"},{"id":"T204","span":{"begin":930,"end":934},"obj":"CVCL_T747"},{"id":"T209","span":{"begin":930,"end":934},"obj":"CVCL_3351"},{"id":"T210","span":{"begin":976,"end":979},"obj":"Q41249"},{"id":"T211","span":{"begin":976,"end":979},"obj":"O66148"},{"id":"T212","span":{"begin":976,"end":979},"obj":"Q59987"},{"id":"T213","span":{"begin":976,"end":979},"obj":"Q01289"},{"id":"T214","span":{"begin":976,"end":979},"obj":"O80333"},{"id":"T215","span":{"begin":976,"end":979},"obj":"P15904"},{"id":"T216","span":{"begin":976,"end":979},"obj":"Q9SDT1"},{"id":"T217","span":{"begin":976,"end":979},"obj":"Q39617"},{"id":"T218","span":{"begin":981,"end":984},"obj":"PR:P01375"},{"id":"T219","span":{"begin":981,"end":984},"obj":"PR:P06804"},{"id":"T220","span":{"begin":981,"end":984},"obj":"PR:000000134"},{"id":"T221","span":{"begin":981,"end":984},"obj":"PR:P16599"},{"id":"T222","span":{"begin":997,"end":1006},"obj":"GO:0009058"},{"id":"T223","span":{"begin":1014,"end":1025},"obj":"C083641"},{"id":"T224","span":{"begin":1035,"end":1043},"obj":"D053674"},{"id":"T225","span":{"begin":1035,"end":1043},"obj":"D053674"},{"id":"T226","span":{"begin":1055,"end":1061},"obj":"C083641"},{"id":"T227","span":{"begin":1155,"end":1160},"obj":"PR:Q9UNW9"},{"id":"T228","span":{"begin":1155,"end":1160},"obj":"PR:000011340"},{"id":"T229","span":{"begin":1184,"end":1187},"obj":"P18056"},{"id":"T230","span":{"begin":1221,"end":1226},"obj":"PR:000001471"},{"id":"T231","span":{"begin":1221,"end":1226},"obj":"Q29408"},{"id":"T232","span":{"begin":1221,"end":1226},"obj":"P18893"},{"id":"T233","span":{"begin":1221,"end":1226},"obj":"PR:Q6A2H4"},{"id":"T234","span":{"begin":1221,"end":1226},"obj":"Q25BC1"},{"id":"T235","span":{"begin":1221,"end":1226},"obj":"Q9TSJ4"},{"id":"T236","span":{"begin":1221,"end":1226},"obj":"O97798"},{"id":"T237","span":{"begin":1221,"end":1226},"obj":"P46651"},{"id":"T238","span":{"begin":1221,"end":1226},"obj":"P51497"},{"id":"T239","span":{"begin":1221,"end":1226},"obj":"O46673"},{"id":"T240","span":{"begin":1221,"end":1226},"obj":"P29456"},{"id":"T241","span":{"begin":1221,"end":1226},"obj":"Q8MKG9"},{"id":"T242","span":{"begin":1221,"end":1226},"obj":"Q6A2H4"},{"id":"T243","span":{"begin":1221,"end":1226},"obj":"P79338"},{"id":"T245","span":{"begin":1221,"end":1226},"obj":"Q29055"},{"id":"T246","span":{"begin":1221,"end":1226},"obj":"P48411"},{"id":"T247","span":{"begin":1221,"end":1226},"obj":"PR:P29456"},{"id":"T248","span":{"begin":1221,"end":1226},"obj":"Q2PE73"},{"id":"T249","span":{"begin":1221,"end":1226},"obj":"A2T6Z6"},{"id":"T250","span":{"begin":1221,"end":1226},"obj":"PR:P22301"},{"id":"T251","span":{"begin":1221,"end":1226},"obj":"Q865X4"},{"id":"T252","span":{"begin":1221,"end":1226},"obj":"Q5Q0V6"},{"id":"T253","span":{"begin":1221,"end":1226},"obj":"Q9Z1Y5"},{"id":"T254","span":{"begin":1221,"end":1226},"obj":"PR:P18893"},{"id":"T255","span":{"begin":1221,"end":1226},"obj":"P55029"},{"id":"T256","span":{"begin":1221,"end":1226},"obj":"P43480"},{"id":"T257","span":{"begin":1221,"end":1226},"obj":"P47965"},{"id":"T258","span":{"begin":1221,"end":1226},"obj":"P22301"},{"id":"T260","span":{"begin":1221,"end":1226},"obj":"Q9JHK7"},{"id":"T261","span":{"begin":1221,"end":1226},"obj":"Q0Z972"},{"id":"T263","span":{"begin":1221,"end":1226},"obj":"P51746"},{"id":"T264","span":{"begin":1221,"end":1226},"obj":"Q28374"},{"id":"T265","span":{"begin":1221,"end":1226},"obj":"P51496"},{"id":"T244","span":{"begin":1221,"end":1226},"obj":"D016753"},{"id":"T259","span":{"begin":1221,"end":1226},"obj":"D016753"},{"id":"T262","span":{"begin":1221,"end":1226},"obj":"GO:0005141"},{"id":"T266","span":{"begin":1255,"end":1258},"obj":"PR:P01375"},{"id":"T267","span":{"begin":1255,"end":1258},"obj":"PR:P06804"},{"id":"T268","span":{"begin":1255,"end":1258},"obj":"PR:000000134"},{"id":"T269","span":{"begin":1255,"end":1258},"obj":"PR:P16599"},{"id":"T270","span":{"begin":1269,"end":1279},"obj":"GO:0008219"},{"id":"T271","span":{"begin":1281,"end":1287},"obj":"CVCL_JT24"},{"id":"T279","span":{"begin":1317,"end":1321},"obj":"PR:000001901"},{"id":"T280","span":{"begin":1317,"end":1321},"obj":"PR:P29477"},{"id":"T281","span":{"begin":1317,"end":1321},"obj":"PR:Q06518"},{"id":"T282","span":{"begin":1317,"end":1321},"obj":"PR:P35228"},{"id":"T283","span":{"begin":1317,"end":1321},"obj":"PR:P60321"},{"id":"T284","span":{"begin":1317,"end":1321},"obj":"P60322"},{"id":"T286","span":{"begin":1317,"end":1321},"obj":"PR:000010971"},{"id":"T287","span":{"begin":1317,"end":1321},"obj":"PR:Q90703"},{"id":"T288","span":{"begin":1317,"end":1321},"obj":"P60321"},{"id":"T289","span":{"begin":1317,"end":1321},"obj":"PR:P60322"},{"id":"T285","span":{"begin":1317,"end":1321},"obj":"CVCL_T747"},{"id":"T290","span":{"begin":1317,"end":1321},"obj":"CVCL_3351"},{"id":"T294","span":{"begin":1353,"end":1356},"obj":"1498292"},{"id":"T292","span":{"begin":1353,"end":1356},"obj":"PR:P21330"},{"id":"T293","span":{"begin":1353,"end":1356},"obj":"PR:Q967S7"},{"id":"T295","span":{"begin":1353,"end":1356},"obj":"PR:Q8I7Q0"},{"id":"T297","span":{"begin":1353,"end":1356},"obj":"PR:P20828"},{"id":"T298","span":{"begin":1353,"end":1356},"obj":"PR:P10405"},{"id":"T299","span":{"begin":1353,"end":1356},"obj":"PR:P04282"},{"id":"T291","span":{"begin":1353,"end":1356},"obj":"103820"},{"id":"T296","span":{"begin":1353,"end":1356},"obj":"CHEBI:143889"},{"id":"T300","span":{"begin":1368,"end":1374},"obj":"CVCL_JT24"},{"id":"T301","span":{"begin":1377,"end":1383},"obj":"C083641"},{"id":"T302","span":{"begin":1384,"end":1393},"obj":"GO:0009058"},{"id":"T303","span":{"begin":1412,"end":1415},"obj":"CHEBI:340824"},{"id":"T306","span":{"begin":1412,"end":1415},"obj":"CHEBI:59761"},{"id":"T307","span":{"begin":1412,"end":1416},"obj":"P28863"},{"id":"T308","span":{"begin":1412,"end":1416},"obj":"P08254"},{"id":"T309","span":{"begin":1412,"end":1416},"obj":"Q28397"},{"id":"T310","span":{"begin":1412,"end":1416},"obj":"PR:P08254"},{"id":"T311","span":{"begin":1412,"end":1416},"obj":"PR:P03957"},{"id":"T312","span":{"begin":1412,"end":1416},"obj":"Q6Y4Q5"},{"id":"T313","span":{"begin":1412,"end":1416},"obj":"P28862"},{"id":"T315","span":{"begin":1412,"end":1416},"obj":"PR:000010488"},{"id":"T316","span":{"begin":1412,"end":1416},"obj":"PR:P28862"},{"id":"T317","span":{"begin":1412,"end":1416},"obj":"P03957"},{"id":"T314","span":{"begin":1412,"end":1416},"obj":"GO:0004248"},{"id":"T318","span":{"begin":1443,"end":1450},"obj":"Q9TT93"},{"id":"T319","span":{"begin":1443,"end":1450},"obj":"Q8BNJ2"},{"id":"T320","span":{"begin":1443,"end":1450},"obj":"O75173"},{"id":"T321","span":{"begin":1443,"end":1450},"obj":"PR:O75173"},{"id":"T322","span":{"begin":1443,"end":1450},"obj":"Q9ESP7"},{"id":"T323","span":{"begin":1443,"end":1450},"obj":"Q5RFQ8"},{"id":"T324","span":{"begin":1443,"end":1450},"obj":"PR:Q8BNJ2"},{"id":"T325","span":{"begin":1443,"end":1450},"obj":"PR:Q9TT93"},{"id":"T326","span":{"begin":1443,"end":1450},"obj":"PR:000003733"},{"id":"T327","span":{"begin":1452,"end":1458},"obj":"CVCL_JT24"},{"id":"T328","span":{"begin":1492,"end":1495},"obj":"PR:P01375"},{"id":"T329","span":{"begin":1492,"end":1495},"obj":"PR:P06804"},{"id":"T330","span":{"begin":1492,"end":1495},"obj":"PR:000000134"},{"id":"T331","span":{"begin":1492,"end":1495},"obj":"PR:P16599"},{"id":"T334","span":{"begin":1520,"end":1525},"obj":"CVCL_4604"},{"id":"T337","span":{"begin":1520,"end":1527},"obj":"PR:000005693"},{"id":"T338","span":{"begin":1520,"end":1527},"obj":"PR:P08125"},{"id":"T339","span":{"begin":1520,"end":1527},"obj":"PR:Q03692"},{"id":"T340","span":{"begin":1520,"end":1527},"obj":"PR:Q05306"},{"id":"T342","span":{"begin":1523,"end":1526},"obj":"CVCL_IR40"},{"id":"T343","span":{"begin":1563,"end":1568},"obj":"PR:000001471"},{"id":"T344","span":{"begin":1563,"end":1568},"obj":"Q29408"},{"id":"T345","span":{"begin":1563,"end":1568},"obj":"P18893"},{"id":"T346","span":{"begin":1563,"end":1568},"obj":"PR:Q6A2H4"},{"id":"T347","span":{"begin":1563,"end":1568},"obj":"Q25BC1"},{"id":"T348","span":{"begin":1563,"end":1568},"obj":"Q9TSJ4"},{"id":"T349","span":{"begin":1563,"end":1568},"obj":"O97798"},{"id":"T350","span":{"begin":1563,"end":1568},"obj":"P46651"},{"id":"T351","span":{"begin":1563,"end":1568},"obj":"P51497"},{"id":"T352","span":{"begin":1563,"end":1568},"obj":"O46673"},{"id":"T353","span":{"begin":1563,"end":1568},"obj":"P29456"},{"id":"T354","span":{"begin":1563,"end":1568},"obj":"Q8MKG9"},{"id":"T355","span":{"begin":1563,"end":1568},"obj":"Q6A2H4"},{"id":"T356","span":{"begin":1563,"end":1568},"obj":"P79338"},{"id":"T358","span":{"begin":1563,"end":1568},"obj":"Q29055"},{"id":"T359","span":{"begin":1563,"end":1568},"obj":"P48411"},{"id":"T360","span":{"begin":1563,"end":1568},"obj":"PR:P29456"},{"id":"T361","span":{"begin":1563,"end":1568},"obj":"Q2PE73"},{"id":"T362","span":{"begin":1563,"end":1568},"obj":"A2T6Z6"},{"id":"T363","span":{"begin":1563,"end":1568},"obj":"PR:P22301"},{"id":"T364","span":{"begin":1563,"end":1568},"obj":"Q865X4"},{"id":"T365","span":{"begin":1563,"end":1568},"obj":"Q5Q0V6"},{"id":"T366","span":{"begin":1563,"end":1568},"obj":"Q9Z1Y5"},{"id":"T367","span":{"begin":1563,"end":1568},"obj":"PR:P18893"},{"id":"T368","span":{"begin":1563,"end":1568},"obj":"P55029"},{"id":"T369","span":{"begin":1563,"end":1568},"obj":"P43480"},{"id":"T370","span":{"begin":1563,"end":1568},"obj":"P47965"},{"id":"T371","span":{"begin":1563,"end":1568},"obj":"P22301"},{"id":"T373","span":{"begin":1563,"end":1568},"obj":"Q9JHK7"},{"id":"T374","span":{"begin":1563,"end":1568},"obj":"Q0Z972"},{"id":"T376","span":{"begin":1563,"end":1568},"obj":"P51746"},{"id":"T377","span":{"begin":1563,"end":1568},"obj":"Q28374"},{"id":"T378","span":{"begin":1563,"end":1568},"obj":"P51496"},{"id":"T357","span":{"begin":1563,"end":1568},"obj":"D016753"},{"id":"T372","span":{"begin":1563,"end":1568},"obj":"D016753"},{"id":"T375","span":{"begin":1563,"end":1568},"obj":"GO:0005141"},{"id":"T379","span":{"begin":1590,"end":1595},"obj":"PR:000001471"},{"id":"T380","span":{"begin":1590,"end":1595},"obj":"Q29408"},{"id":"T381","span":{"begin":1590,"end":1595},"obj":"P18893"},{"id":"T382","span":{"begin":1590,"end":1595},"obj":"PR:Q6A2H4"},{"id":"T383","span":{"begin":1590,"end":1595},"obj":"Q25BC1"},{"id":"T384","span":{"begin":1590,"end":1595},"obj":"Q9TSJ4"},{"id":"T385","span":{"begin":1590,"end":1595},"obj":"O97798"},{"id":"T386","span":{"begin":1590,"end":1595},"obj":"P46651"},{"id":"T387","span":{"begin":1590,"end":1595},"obj":"P51497"},{"id":"T388","span":{"begin":1590,"end":1595},"obj":"O46673"},{"id":"T389","span":{"begin":1590,"end":1595},"obj":"P29456"},{"id":"T390","span":{"begin":1590,"end":1595},"obj":"Q8MKG9"},{"id":"T391","span":{"begin":1590,"end":1595},"obj":"Q6A2H4"},{"id":"T392","span":{"begin":1590,"end":1595},"obj":"P79338"},{"id":"T394","span":{"begin":1590,"end":1595},"obj":"Q29055"},{"id":"T395","span":{"begin":1590,"end":1595},"obj":"P48411"},{"id":"T396","span":{"begin":1590,"end":1595},"obj":"PR:P29456"},{"id":"T397","span":{"begin":1590,"end":1595},"obj":"Q2PE73"},{"id":"T398","span":{"begin":1590,"end":1595},"obj":"A2T6Z6"},{"id":"T399","span":{"begin":1590,"end":1595},"obj":"PR:P22301"},{"id":"T400","span":{"begin":1590,"end":1595},"obj":"Q865X4"},{"id":"T401","span":{"begin":1590,"end":1595},"obj":"Q5Q0V6"},{"id":"T402","span":{"begin":1590,"end":1595},"obj":"Q9Z1Y5"},{"id":"T403","span":{"begin":1590,"end":1595},"obj":"PR:P18893"},{"id":"T404","span":{"begin":1590,"end":1595},"obj":"P55029"},{"id":"T405","span":{"begin":1590,"end":1595},"obj":"P43480"},{"id":"T406","span":{"begin":1590,"end":1595},"obj":"P47965"},{"id":"T407","span":{"begin":1590,"end":1595},"obj":"P22301"},{"id":"T409","span":{"begin":1590,"end":1595},"obj":"Q9JHK7"},{"id":"T410","span":{"begin":1590,"end":1595},"obj":"Q0Z972"},{"id":"T412","span":{"begin":1590,"end":1595},"obj":"P51746"},{"id":"T413","span":{"begin":1590,"end":1595},"obj":"Q28374"},{"id":"T414","span":{"begin":1590,"end":1595},"obj":"P51496"},{"id":"T393","span":{"begin":1590,"end":1595},"obj":"D016753"},{"id":"T408","span":{"begin":1590,"end":1595},"obj":"D016753"},{"id":"T411","span":{"begin":1590,"end":1595},"obj":"GO:0005141"},{"id":"T415","span":{"begin":1683,"end":1686},"obj":"PR:P01375"},{"id":"T416","span":{"begin":1683,"end":1686},"obj":"PR:P06804"},{"id":"T417","span":{"begin":1683,"end":1686},"obj":"PR:000000134"},{"id":"T418","span":{"begin":1683,"end":1686},"obj":"PR:P16599"},{"id":"T419","span":{"begin":1708,"end":1713},"obj":"PR:000001471"},{"id":"T420","span":{"begin":1708,"end":1713},"obj":"Q29408"},{"id":"T421","span":{"begin":1708,"end":1713},"obj":"P18893"},{"id":"T422","span":{"begin":1708,"end":1713},"obj":"PR:Q6A2H4"},{"id":"T423","span":{"begin":1708,"end":1713},"obj":"Q25BC1"},{"id":"T424","span":{"begin":1708,"end":1713},"obj":"Q9TSJ4"},{"id":"T425","span":{"begin":1708,"end":1713},"obj":"O97798"},{"id":"T426","span":{"begin":1708,"end":1713},"obj":"P46651"},{"id":"T427","span":{"begin":1708,"end":1713},"obj":"P51497"},{"id":"T428","span":{"begin":1708,"end":1713},"obj":"O46673"},{"id":"T429","span":{"begin":1708,"end":1713},"obj":"P29456"},{"id":"T430","span":{"begin":1708,"end":1713},"obj":"Q8MKG9"},{"id":"T431","span":{"begin":1708,"end":1713},"obj":"Q6A2H4"},{"id":"T432","span":{"begin":1708,"end":1713},"obj":"P79338"},{"id":"T434","span":{"begin":1708,"end":1713},"obj":"Q29055"},{"id":"T435","span":{"begin":1708,"end":1713},"obj":"P48411"},{"id":"T436","span":{"begin":1708,"end":1713},"obj":"PR:P29456"},{"id":"T437","span":{"begin":1708,"end":1713},"obj":"Q2PE73"},{"id":"T438","span":{"begin":1708,"end":1713},"obj":"A2T6Z6"},{"id":"T439","span":{"begin":1708,"end":1713},"obj":"PR:P22301"},{"id":"T440","span":{"begin":1708,"end":1713},"obj":"Q865X4"},{"id":"T441","span":{"begin":1708,"end":1713},"obj":"Q5Q0V6"},{"id":"T442","span":{"begin":1708,"end":1713},"obj":"Q9Z1Y5"},{"id":"T443","span":{"begin":1708,"end":1713},"obj":"PR:P18893"},{"id":"T444","span":{"begin":1708,"end":1713},"obj":"P55029"},{"id":"T445","span":{"begin":1708,"end":1713},"obj":"P43480"},{"id":"T446","span":{"begin":1708,"end":1713},"obj":"P47965"},{"id":"T447","span":{"begin":1708,"end":1713},"obj":"P22301"},{"id":"T449","span":{"begin":1708,"end":1713},"obj":"Q9JHK7"},{"id":"T450","span":{"begin":1708,"end":1713},"obj":"Q0Z972"},{"id":"T452","span":{"begin":1708,"end":1713},"obj":"P51746"},{"id":"T453","span":{"begin":1708,"end":1713},"obj":"Q28374"},{"id":"T454","span":{"begin":1708,"end":1713},"obj":"P51496"},{"id":"T433","span":{"begin":1708,"end":1713},"obj":"D016753"},{"id":"T448","span":{"begin":1708,"end":1713},"obj":"D016753"},{"id":"T451","span":{"begin":1708,"end":1713},"obj":"GO:0005141"},{"id":"T455","span":{"begin":1743,"end":1755},"obj":"GO:0031099"},{"id":"T456","span":{"begin":1805,"end":1813},"obj":"UBERON:0000387"},{"id":"T457","span":{"begin":1859,"end":1874},"obj":"D001265"},{"id":"T458","span":{"begin":1859,"end":1874},"obj":"D001265"}],"text":"IL-10 ameliorates TNF-α induced meniscus degeneration in mature meniscal tissue in vitro.\nBACKGROUND: Joint inflammation causes meniscus degeneration and can exacerbate post-traumatic meniscus injuries by extracellular matrix degradation, cellular de-differentiation and cell death. The aim of this study was to examine whether anti-inflammatory interleukin-10 exerts protective effects in an in vitro model of TNF-α-induced meniscus degeneration.\nMETHODS: Meniscus tissue was harvested from the knees of adult cows. After 24 h of equilibrium explants were simultaneously treated with bovine TNF-α and IL-10. After an incubation time of 72 h cell death was measured histomorphometrically (nuclear blebbing, NB) and release of glycosaminoglycans (GAG, DMMB assay) and nitric oxide (NO, Griess-reagent) were analysed. Transcription levels (mRNA) of matrix degrading enzymes, collagen type X (COL10A1) and nitric oxide synthetase 2 (NOS2) were measured by quantitative real time PCR. TNF-α-dependent formation of the aggrecanase-specific aggrecan neoepitope NITEGE was visualised by immunostaining. Differences between groups were calculated using a one-way ANOVA with a Bonferroni post hoc test.\nRESULTS: Administration of IL-10 significantly prevented the TNF-α-related cell death (P .001), release of NO (P .003) and NOS2 expression (P .04). Release of GAG fragments (P .001), NITEGE formation and expression of MMP3 (P .007), -13 (P .02) and ADAMTS4 (P .001) were significantly reduced. The TNF-α-dependent increase in COL10A1 expression was also antagonized by IL-10 (P .02).\nCONCLUSION: IL-10 prevented crucial mechanisms of meniscal degeneration induced by a key cytokine of OA, TNF-α. Administration of IL-10 might improve the biological regeneration and provide a treatment approach in degenerative meniscus injuries and in conditions of post-traumatic sports injuries."}

{"project":"PubMed_Structured_Abstracts","denotations":[{"id":"T1","span":{"begin":102,"end":447},"obj":"BACKGROUND"},{"id":"T2","span":{"begin":457,"end":1193},"obj":"METHODS"},{"id":"T3","span":{"begin":1203,"end":1577},"obj":"RESULTS"},{"id":"T4","span":{"begin":1590,"end":1875},"obj":"CONCLUSION"}],"text":"IL-10 ameliorates TNF-α induced meniscus degeneration in mature meniscal tissue in vitro.\nBACKGROUND: Joint inflammation causes meniscus degeneration and can exacerbate post-traumatic meniscus injuries by extracellular matrix degradation, cellular de-differentiation and cell death. The aim of this study was to examine whether anti-inflammatory interleukin-10 exerts protective effects in an in vitro model of TNF-α-induced meniscus degeneration.\nMETHODS: Meniscus tissue was harvested from the knees of adult cows. After 24 h of equilibrium explants were simultaneously treated with bovine TNF-α and IL-10. After an incubation time of 72 h cell death was measured histomorphometrically (nuclear blebbing, NB) and release of glycosaminoglycans (GAG, DMMB assay) and nitric oxide (NO, Griess-reagent) were analysed. Transcription levels (mRNA) of matrix degrading enzymes, collagen type X (COL10A1) and nitric oxide synthetase 2 (NOS2) were measured by quantitative real time PCR. TNF-α-dependent formation of the aggrecanase-specific aggrecan neoepitope NITEGE was visualised by immunostaining. Differences between groups were calculated using a one-way ANOVA with a Bonferroni post hoc test.\nRESULTS: Administration of IL-10 significantly prevented the TNF-α-related cell death (P .001), release of NO (P .003) and NOS2 expression (P .04). Release of GAG fragments (P .001), NITEGE formation and expression of MMP3 (P .007), -13 (P .02) and ADAMTS4 (P .001) were significantly reduced. The TNF-α-dependent increase in COL10A1 expression was also antagonized by IL-10 (P .02).\nCONCLUSION: IL-10 prevented crucial mechanisms of meniscal degeneration induced by a key cytokine of OA, TNF-α. Administration of IL-10 might improve the biological regeneration and provide a treatment approach in degenerative meniscus injuries and in conditions of post-traumatic sports injuries."}

{"project":"Goldhamster2_Cellosaurus","denotations":[{"id":"T1","span":{"begin":390,"end":392},"obj":"CVCL_8754|Cancer_cell_line|Homo sapiens"},{"id":"T2","span":{"begin":390,"end":392},"obj":"CVCL_H241|Cancer_cell_line|Homo sapiens"},{"id":"T3","span":{"begin":523,"end":527},"obj":"CVCL_8262|Cancer_cell_line|Homo sapiens"},{"id":"T4","span":{"begin":615,"end":617},"obj":"CVCL_8754|Cancer_cell_line|Homo sapiens"},{"id":"T5","span":{"begin":615,"end":617},"obj":"CVCL_H241|Cancer_cell_line|Homo sapiens"},{"id":"T6","span":{"begin":629,"end":633},"obj":"CVCL_0047|Telomerase_immortalized_cell_line|Homo sapiens"},{"id":"T7","span":{"begin":930,"end":934},"obj":"CVCL_3351|Cancer_cell_line|Homo sapiens"},{"id":"T8","span":{"begin":930,"end":934},"obj":"CVCL_T747|Cancer_cell_line|Homo sapiens"},{"id":"T9","span":{"begin":971,"end":975},"obj":"CVCL_0047|Telomerase_immortalized_cell_line|Homo sapiens"},{"id":"T10","span":{"begin":1145,"end":1146},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"},{"id":"T11","span":{"begin":1147,"end":1150},"obj":"CVCL_Z424|Spontaneously_immortalized_cell_line|Ostrinia nubilalis"},{"id":"T12","span":{"begin":1166,"end":1167},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"},{"id":"T13","span":{"begin":1281,"end":1287},"obj":"CVCL_JT24|Induced_pluripotent_stem_cell|Homo sapiens"},{"id":"T14","span":{"begin":1317,"end":1321},"obj":"CVCL_3351|Cancer_cell_line|Homo sapiens"},{"id":"T15","span":{"begin":1317,"end":1321},"obj":"CVCL_T747|Cancer_cell_line|Homo sapiens"},{"id":"T16","span":{"begin":1368,"end":1374},"obj":"CVCL_JT24|Induced_pluripotent_stem_cell|Homo sapiens"},{"id":"T17","span":{"begin":1452,"end":1458},"obj":"CVCL_JT24|Induced_pluripotent_stem_cell|Homo sapiens"},{"id":"T18","span":{"begin":1661,"end":1662},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"},{"id":"T19","span":{"begin":1768,"end":1769},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"}],"text":"IL-10 ameliorates TNF-α induced meniscus degeneration in mature meniscal tissue in vitro.\nBACKGROUND: Joint inflammation causes meniscus degeneration and can exacerbate post-traumatic meniscus injuries by extracellular matrix degradation, cellular de-differentiation and cell death. The aim of this study was to examine whether anti-inflammatory interleukin-10 exerts protective effects in an in vitro model of TNF-α-induced meniscus degeneration.\nMETHODS: Meniscus tissue was harvested from the knees of adult cows. After 24 h of equilibrium explants were simultaneously treated with bovine TNF-α and IL-10. After an incubation time of 72 h cell death was measured histomorphometrically (nuclear blebbing, NB) and release of glycosaminoglycans (GAG, DMMB assay) and nitric oxide (NO, Griess-reagent) were analysed. Transcription levels (mRNA) of matrix degrading enzymes, collagen type X (COL10A1) and nitric oxide synthetase 2 (NOS2) were measured by quantitative real time PCR. TNF-α-dependent formation of the aggrecanase-specific aggrecan neoepitope NITEGE was visualised by immunostaining. Differences between groups were calculated using a one-way ANOVA with a Bonferroni post hoc test.\nRESULTS: Administration of IL-10 significantly prevented the TNF-α-related cell death (P .001), release of NO (P .003) and NOS2 expression (P .04). Release of GAG fragments (P .001), NITEGE formation and expression of MMP3 (P .007), -13 (P .02) and ADAMTS4 (P .001) were significantly reduced. The TNF-α-dependent increase in COL10A1 expression was also antagonized by IL-10 (P .02).\nCONCLUSION: IL-10 prevented crucial mechanisms of meniscal degeneration induced by a key cytokine of OA, TNF-α. Administration of IL-10 might improve the biological regeneration and provide a treatment approach in degenerative meniscus injuries and in conditions of post-traumatic sports injuries."}

{"project":"Inflammaging","denotations":[{"id":"T1","span":{"begin":0,"end":89},"obj":"Sentence"},{"id":"T2","span":{"begin":90,"end":101},"obj":"Sentence"},{"id":"T3","span":{"begin":102,"end":282},"obj":"Sentence"},{"id":"T4","span":{"begin":283,"end":447},"obj":"Sentence"},{"id":"T5","span":{"begin":448,"end":456},"obj":"Sentence"},{"id":"T6","span":{"begin":457,"end":516},"obj":"Sentence"},{"id":"T7","span":{"begin":517,"end":608},"obj":"Sentence"},{"id":"T8","span":{"begin":609,"end":815},"obj":"Sentence"},{"id":"T9","span":{"begin":816,"end":980},"obj":"Sentence"},{"id":"T10","span":{"begin":981,"end":1095},"obj":"Sentence"},{"id":"T11","span":{"begin":1096,"end":1193},"obj":"Sentence"},{"id":"T12","span":{"begin":1194,"end":1202},"obj":"Sentence"},{"id":"T13","span":{"begin":1203,"end":1341},"obj":"Sentence"},{"id":"T14","span":{"begin":1342,"end":1487},"obj":"Sentence"},{"id":"T15","span":{"begin":1488,"end":1577},"obj":"Sentence"},{"id":"T16","span":{"begin":1578,"end":1689},"obj":"Sentence"},{"id":"T17","span":{"begin":1690,"end":1875},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":89},"obj":"Sentence"},{"id":"T2","span":{"begin":90,"end":101},"obj":"Sentence"},{"id":"T3","span":{"begin":102,"end":282},"obj":"Sentence"},{"id":"T4","span":{"begin":283,"end":447},"obj":"Sentence"},{"id":"T5","span":{"begin":448,"end":456},"obj":"Sentence"},{"id":"T6","span":{"begin":457,"end":516},"obj":"Sentence"},{"id":"T7","span":{"begin":517,"end":608},"obj":"Sentence"},{"id":"T8","span":{"begin":609,"end":815},"obj":"Sentence"},{"id":"T9","span":{"begin":816,"end":980},"obj":"Sentence"},{"id":"T10","span":{"begin":981,"end":1095},"obj":"Sentence"},{"id":"T11","span":{"begin":1096,"end":1193},"obj":"Sentence"},{"id":"T12","span":{"begin":1194,"end":1202},"obj":"Sentence"},{"id":"T13","span":{"begin":1203,"end":1341},"obj":"Sentence"},{"id":"T14","span":{"begin":1342,"end":1487},"obj":"Sentence"},{"id":"T15","span":{"begin":1488,"end":1577},"obj":"Sentence"},{"id":"T16","span":{"begin":1578,"end":1689},"obj":"Sentence"},{"id":"T17","span":{"begin":1690,"end":1875},"obj":"Sentence"}],"text":"IL-10 ameliorates TNF-α induced meniscus degeneration in mature meniscal tissue in vitro.\nBACKGROUND: Joint inflammation causes meniscus degeneration and can exacerbate post-traumatic meniscus injuries by extracellular matrix degradation, cellular de-differentiation and cell death. The aim of this study was to examine whether anti-inflammatory interleukin-10 exerts protective effects in an in vitro model of TNF-α-induced meniscus degeneration.\nMETHODS: Meniscus tissue was harvested from the knees of adult cows. After 24 h of equilibrium explants were simultaneously treated with bovine TNF-α and IL-10. After an incubation time of 72 h cell death was measured histomorphometrically (nuclear blebbing, NB) and release of glycosaminoglycans (GAG, DMMB assay) and nitric oxide (NO, Griess-reagent) were analysed. Transcription levels (mRNA) of matrix degrading enzymes, collagen type X (COL10A1) and nitric oxide synthetase 2 (NOS2) were measured by quantitative real time PCR. TNF-α-dependent formation of the aggrecanase-specific aggrecan neoepitope NITEGE was visualised by immunostaining. Differences between groups were calculated using a one-way ANOVA with a Bonferroni post hoc test.\nRESULTS: Administration of IL-10 significantly prevented the TNF-α-related cell death (P .001), release of NO (P .003) and NOS2 expression (P .04). Release of GAG fragments (P .001), NITEGE formation and expression of MMP3 (P .007), -13 (P .02) and ADAMTS4 (P .001) were significantly reduced. The TNF-α-dependent increase in COL10A1 expression was also antagonized by IL-10 (P .02).\nCONCLUSION: IL-10 prevented crucial mechanisms of meniscal degeneration induced by a key cytokine of OA, TNF-α. Administration of IL-10 might improve the biological regeneration and provide a treatment approach in degenerative meniscus injuries and in conditions of post-traumatic sports injuries."}