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sentences

Id Subject Object Predicate Lexical cue
T1 0-131 Sentence denotes Inflammatory cytokines down-regulate the barrier-protective prostasin-matriptase proteolytic cascade early in experimental colitis.
T2 132-356 Sentence denotes Compromised gastrointestinal barrier function is strongly associated with the progressive and destructive pathologies of the two main forms of irritable bowel disease (IBD), ulcerative colitis (UC), and Crohn's disease (CD).
T3 357-533 Sentence denotes Matriptase is a membrane-anchored serine protease encoded by suppression of tumorigenicity-14 (ST14) gene, which is critical for epithelial barrier development and homeostasis.
T4 534-718 Sentence denotes Matriptase barrier-protective activity is linked with the glycosylphosphatidylinositol (GPI)-anchored serine protease prostasin, which is a co-factor for matriptase zymogen activation.
T5 719-1090 Sentence denotes Here we show that mRNA and protein expression of both matriptase and prostasin are rapidly down-regulated in the initiating inflammatory phases of dextran sulfate sodium (DSS)-induced experimental colitis in mice, and, significantly, the loss of these proteases precedes the appearance of clinical symptoms, suggesting their loss may contribute to disease susceptibility.
T6 1091-1262 Sentence denotes We used heterozygous St14 hypomorphic mice expressing a promoter-linked β-gal reporter to show that inflammatory colitis suppresses the activity of the St14 gene promoter.
T7 1263-1659 Sentence denotes Studies in colonic T84 cell monolayers revealed that barrier disruption by the colitis-associated Th2-type cytokines, IL-4 and IL-13, down-regulates matriptase as well as prostasin through phosphorylation of the transcriptional regulator STAT6 and that inhibition of STAT6 with suberoylanilide hydroxamic acid (SAHA) restores protease expression and reverses cytokine-induced barrier dysfunction.
T8 1660-1925 Sentence denotes Both matriptase and prostasin are significantly down-regulated in colonic tissues from human subjects with active ulcerative colitis or Crohn's disease, implicating the loss of this barrier-protective protease pathway in the pathogenesis of irritable bowel disease.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1274-1281 http://purl.obolibrary.org/obo/MAT_0000526 denotes colonic
T2 1726-1733 http://purl.obolibrary.org/obo/MAT_0000526 denotes colonic

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-131 Sentence denotes Inflammatory cytokines down-regulate the barrier-protective prostasin-matriptase proteolytic cascade early in experimental colitis.
T2 132-356 Sentence denotes Compromised gastrointestinal barrier function is strongly associated with the progressive and destructive pathologies of the two main forms of irritable bowel disease (IBD), ulcerative colitis (UC), and Crohn's disease (CD).
T3 357-533 Sentence denotes Matriptase is a membrane-anchored serine protease encoded by suppression of tumorigenicity-14 (ST14) gene, which is critical for epithelial barrier development and homeostasis.
T4 534-718 Sentence denotes Matriptase barrier-protective activity is linked with the glycosylphosphatidylinositol (GPI)-anchored serine protease prostasin, which is a co-factor for matriptase zymogen activation.
T5 719-1090 Sentence denotes Here we show that mRNA and protein expression of both matriptase and prostasin are rapidly down-regulated in the initiating inflammatory phases of dextran sulfate sodium (DSS)-induced experimental colitis in mice, and, significantly, the loss of these proteases precedes the appearance of clinical symptoms, suggesting their loss may contribute to disease susceptibility.
T6 1091-1262 Sentence denotes We used heterozygous St14 hypomorphic mice expressing a promoter-linked β-gal reporter to show that inflammatory colitis suppresses the activity of the St14 gene promoter.
T7 1263-1659 Sentence denotes Studies in colonic T84 cell monolayers revealed that barrier disruption by the colitis-associated Th2-type cytokines, IL-4 and IL-13, down-regulates matriptase as well as prostasin through phosphorylation of the transcriptional regulator STAT6 and that inhibition of STAT6 with suberoylanilide hydroxamic acid (SAHA) restores protease expression and reverses cytokine-induced barrier dysfunction.
T8 1660-1925 Sentence denotes Both matriptase and prostasin are significantly down-regulated in colonic tissues from human subjects with active ulcerative colitis or Crohn's disease, implicating the loss of this barrier-protective protease pathway in the pathogenesis of irritable bowel disease.
T1 0-131 Sentence denotes Inflammatory cytokines down-regulate the barrier-protective prostasin-matriptase proteolytic cascade early in experimental colitis.
T2 132-356 Sentence denotes Compromised gastrointestinal barrier function is strongly associated with the progressive and destructive pathologies of the two main forms of irritable bowel disease (IBD), ulcerative colitis (UC), and Crohn's disease (CD).
T3 357-533 Sentence denotes Matriptase is a membrane-anchored serine protease encoded by suppression of tumorigenicity-14 (ST14) gene, which is critical for epithelial barrier development and homeostasis.
T4 534-718 Sentence denotes Matriptase barrier-protective activity is linked with the glycosylphosphatidylinositol (GPI)-anchored serine protease prostasin, which is a co-factor for matriptase zymogen activation.
T5 719-1090 Sentence denotes Here we show that mRNA and protein expression of both matriptase and prostasin are rapidly down-regulated in the initiating inflammatory phases of dextran sulfate sodium (DSS)-induced experimental colitis in mice, and, significantly, the loss of these proteases precedes the appearance of clinical symptoms, suggesting their loss may contribute to disease susceptibility.
T6 1091-1262 Sentence denotes We used heterozygous St14 hypomorphic mice expressing a promoter-linked β-gal reporter to show that inflammatory colitis suppresses the activity of the St14 gene promoter.
T7 1263-1659 Sentence denotes Studies in colonic T84 cell monolayers revealed that barrier disruption by the colitis-associated Th2-type cytokines, IL-4 and IL-13, down-regulates matriptase as well as prostasin through phosphorylation of the transcriptional regulator STAT6 and that inhibition of STAT6 with suberoylanilide hydroxamic acid (SAHA) restores protease expression and reverses cytokine-induced barrier dysfunction.
T8 1660-1925 Sentence denotes Both matriptase and prostasin are significantly down-regulated in colonic tissues from human subjects with active ulcerative colitis or Crohn's disease, implicating the loss of this barrier-protective protease pathway in the pathogenesis of irritable bowel disease.

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 123-130 Disease denotes colitis http://purl.obolibrary.org/obo/MONDO_0005292
T2 300-303 Disease denotes IBD http://purl.obolibrary.org/obo/MONDO_0005052|http://purl.obolibrary.org/obo/MONDO_0005265
T4 306-324 Disease denotes ulcerative colitis http://purl.obolibrary.org/obo/MONDO_0005101|http://purl.obolibrary.org/obo/MONDO_0009960
T6 326-328 Disease denotes UC http://purl.obolibrary.org/obo/MONDO_0005101
T7 335-350 Disease denotes Crohn's disease http://purl.obolibrary.org/obo/MONDO_0005011
T8 352-354 Disease denotes CD http://purl.obolibrary.org/obo/MONDO_0005011
T9 890-893 Disease denotes DSS http://purl.obolibrary.org/obo/MONDO_0000248
T10 916-923 Disease denotes colitis http://purl.obolibrary.org/obo/MONDO_0005292
T11 1204-1211 Disease denotes colitis http://purl.obolibrary.org/obo/MONDO_0005292
T12 1342-1349 Disease denotes colitis http://purl.obolibrary.org/obo/MONDO_0005292
T13 1774-1792 Disease denotes ulcerative colitis http://purl.obolibrary.org/obo/MONDO_0005101|http://purl.obolibrary.org/obo/MONDO_0009960
T15 1796-1811 Disease denotes Crohn's disease http://purl.obolibrary.org/obo/MONDO_0005011

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 123-130 Phenotype denotes colitis HP:0002583
T2 275-284 Phenotype denotes irritable HP:0000737
T3 306-324 Phenotype denotes ulcerative colitis HP:0100279
T4 326-328 Phenotype denotes UC HP:0100279
T5 335-350 Phenotype denotes Crohn's disease HP:0100280
T6 352-354 Phenotype denotes CD HP:0100280
T7 916-923 Phenotype denotes colitis HP:0002583
T8 1204-1211 Phenotype denotes colitis HP:0002583
T9 1342-1349 Phenotype denotes colitis HP:0002583
T10 1774-1792 Phenotype denotes ulcerative colitis HP:0100279
T11 1796-1811 Phenotype denotes Crohn's disease HP:0100280
T12 1901-1910 Phenotype denotes irritable HP:0000737

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 927-931 OrganismTaxon denotes mice 10088
T2 1129-1133 OrganismTaxon denotes mice 10088
T3 1747-1752 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 285-290 Body_part denotes bowel http://purl.obolibrary.org/obo/UBERON_0000160
T2 373-381 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T5 1911-1916 Body_part denotes bowel http://purl.obolibrary.org/obo/UBERON_0000160

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1274-1281 Body_part denotes colonic http://purl.obolibrary.org/obo/MAT_0000526
T2 1726-1733 Body_part denotes colonic http://purl.obolibrary.org/obo/MAT_0000526