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sentences

Id Subject Object Predicate Lexical cue
T1 0-113 Sentence denotes An engineered cyclic peptide alleviates symptoms of inflammation in a murine model of inflammatory bowel disease.
T2 114-241 Sentence denotes Inflammatory bowel diseases (IBDs) are a set of complex and debilitating diseases for which there is no satisfactory treatment.
T3 242-344 Sentence denotes Recent studies have shown that small peptides show promise for reducing inflammation in models of IBD.
T4 345-528 Sentence denotes However, these small peptides are likely to be unstable and rapidly cleared from the circulation, and therefore, if not modified for better stability, represent non-viable drug leads.
T5 529-687 Sentence denotes We hypothesized that improving the stability of these peptides by grafting them into a stable cyclic peptide scaffold may enhance their therapeutic potential.
T6 688-877 Sentence denotes Using this approach, we have designed a novel cyclic peptide that comprises a small bioactive peptide from the annexin A1 protein grafted into a sunflower trypsin inhibitor cyclic scaffold.
T7 878-952 Sentence denotes We used native chemical ligation to synthesize the grafted cyclic peptide.
T8 953-1212 Sentence denotes This engineered cyclic peptide maintained the overall fold of the naturally occurring cyclic peptide, was more effective at reducing inflammation in a mouse model of acute colitis than the bioactive peptide alone, and showed enhanced stability in human serum.
T9 1213-1397 Sentence denotes Our findings suggest that the use of cyclic peptides as structural backbones offers a promising approach for the treatment of IBD and potentially other chronic inflammatory conditions.

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-113 Sentence denotes An engineered cyclic peptide alleviates symptoms of inflammation in a murine model of inflammatory bowel disease.
T2 114-241 Sentence denotes Inflammatory bowel diseases (IBDs) are a set of complex and debilitating diseases for which there is no satisfactory treatment.
T3 242-344 Sentence denotes Recent studies have shown that small peptides show promise for reducing inflammation in models of IBD.
T4 345-528 Sentence denotes However, these small peptides are likely to be unstable and rapidly cleared from the circulation, and therefore, if not modified for better stability, represent non-viable drug leads.
T5 529-687 Sentence denotes We hypothesized that improving the stability of these peptides by grafting them into a stable cyclic peptide scaffold may enhance their therapeutic potential.
T6 688-877 Sentence denotes Using this approach, we have designed a novel cyclic peptide that comprises a small bioactive peptide from the annexin A1 protein grafted into a sunflower trypsin inhibitor cyclic scaffold.
T7 878-952 Sentence denotes We used native chemical ligation to synthesize the grafted cyclic peptide.
T8 953-1212 Sentence denotes This engineered cyclic peptide maintained the overall fold of the naturally occurring cyclic peptide, was more effective at reducing inflammation in a mouse model of acute colitis than the bioactive peptide alone, and showed enhanced stability in human serum.
T9 1213-1397 Sentence denotes Our findings suggest that the use of cyclic peptides as structural backbones offers a promising approach for the treatment of IBD and potentially other chronic inflammatory conditions.
T1 0-113 Sentence denotes An engineered cyclic peptide alleviates symptoms of inflammation in a murine model of inflammatory bowel disease.
T2 114-241 Sentence denotes Inflammatory bowel diseases (IBDs) are a set of complex and debilitating diseases for which there is no satisfactory treatment.
T3 242-344 Sentence denotes Recent studies have shown that small peptides show promise for reducing inflammation in models of IBD.
T4 345-528 Sentence denotes However, these small peptides are likely to be unstable and rapidly cleared from the circulation, and therefore, if not modified for better stability, represent non-viable drug leads.
T5 529-687 Sentence denotes We hypothesized that improving the stability of these peptides by grafting them into a stable cyclic peptide scaffold may enhance their therapeutic potential.
T6 688-877 Sentence denotes Using this approach, we have designed a novel cyclic peptide that comprises a small bioactive peptide from the annexin A1 protein grafted into a sunflower trypsin inhibitor cyclic scaffold.
T7 878-952 Sentence denotes We used native chemical ligation to synthesize the grafted cyclic peptide.
T8 953-1212 Sentence denotes This engineered cyclic peptide maintained the overall fold of the naturally occurring cyclic peptide, was more effective at reducing inflammation in a mouse model of acute colitis than the bioactive peptide alone, and showed enhanced stability in human serum.
T9 1213-1397 Sentence denotes Our findings suggest that the use of cyclic peptides as structural backbones offers a promising approach for the treatment of IBD and potentially other chronic inflammatory conditions.

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 52-64 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T2 86-112 Disease denotes inflammatory bowel disease http://purl.obolibrary.org/obo/MONDO_0005265
T3 114-141 Disease denotes Inflammatory bowel diseases http://purl.obolibrary.org/obo/MONDO_0005265
T4 143-147 Disease denotes IBDs http://purl.obolibrary.org/obo/MONDO_0005265
T5 314-326 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T6 340-343 Disease denotes IBD http://purl.obolibrary.org/obo/MONDO_0005052|http://purl.obolibrary.org/obo/MONDO_0005265
T8 1086-1098 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T9 1125-1132 Disease denotes colitis http://purl.obolibrary.org/obo/MONDO_0005292
T10 1339-1342 Disease denotes IBD http://purl.obolibrary.org/obo/MONDO_0005052|http://purl.obolibrary.org/obo/MONDO_0005265

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 86-112 Phenotype denotes inflammatory bowel disease HP:0002037
T2 114-141 Phenotype denotes Inflammatory bowel diseases HP:0002037
T3 143-147 Phenotype denotes IBDs HP:0002037
T4 1119-1132 Phenotype denotes acute colitis HP:0100282

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1104-1109 OrganismTaxon denotes mouse 10088|10090
T3 1200-1205 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 99-104 Body_part denotes bowel http://purl.obolibrary.org/obo/UBERON_0000160
T2 127-132 Body_part denotes bowel http://purl.obolibrary.org/obo/UBERON_0000160
T3 1280-1289 Body_part denotes backbones http://purl.obolibrary.org/obo/UBERON_0001130