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PubMed:28473453 JSONTXT

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GoldHamster

Id Subject Object Predicate Lexical cue
T1 57-61 D013987 denotes tick
T2 62-68 UBERON:0001836 denotes saliva
T3 78-87 D035683 denotes microRNAs
T4 155-165 D014714 denotes vertebrate
T5 187-196 D026863 denotes hard tick
T12 197-211 D018884 denotes Ixodes ricinus
T13 197-211 34613 denotes Ixodes ricinus
T15 228-235 D004194 denotes disease
T16 228-235 D004194 denotes disease
T17 236-242 SO:0000440 denotes vector
T18 302-312 D014714 denotes vertebrate
T19 383-393 SO:0001633 denotes downstream
T20 425-434 D035683 denotes microRNAs
T21 436-442 D035683 denotes miRNAs
T22 460-467 D012278 denotes ricinus
T23 488-494 UBERON:0001836 denotes saliva
T24 503-507 D013987 denotes tick
T25 609-613 CVCL_E494 denotes bona
T26 619-625 D035683 denotes miRNAs
T27 725-734 D035683 denotes microRNAs
T28 738-742 D013987 denotes tick
T29 743-749 UBERON:0001836 denotes saliva
T30 851-860 D035683 denotes microRNAs
T31 904-910 UBERON:0001836 denotes saliva
T32 940-949 D035683 denotes microRNAs
T33 1199-1211 GO:0006954 denotes inflammation
T34 1199-1211 D007249 denotes inflammation
T35 1199-1211 D007249 denotes inflammation
T36 1216-1220 PR:Q9W0Y6 denotes pain
T37 1263-1272 D035683 denotes microRNAs
T38 1281-1287 UBERON:0001836 denotes saliva
T39 1416-1422 D035683 denotes miRNAs
T40 1428-1432 PR:Q8FYW3 denotes pure
T41 1428-1432 PR:Q54QE4 denotes pure
T42 1428-1432 PR:P52558 denotes pure
T43 1428-1432 PR:P0AG18 denotes pure
T45 1428-1432 PR:000023640 denotes pure
T44 1428-1432 GO:0034023 denotes pure
T46 1433-1437 D013987 denotes tick
T47 1438-1444 UBERON:0001836 denotes saliva
T48 1483-1487 D013987 denotes tick
T49 1488-1494 UBERON:0001836 denotes saliva
T50 1495-1501 D035683 denotes miRNAs
T51 1515-1525 D014714 denotes vertebrate
T52 1531-1542 GO:0042592 denotes homeostasis
T53 1587-1591 D013987 denotes tick
T55 1592-1597 SO:0000276 denotes miRNA
T54 1592-1597 D035683 denotes miRNA
T56 1607-1617 GO:0065007 denotes regulation
T57 1621-1631 D014714 denotes vertebrate
T58 1637-1641 SO:0000704 denotes gene
T59 1637-1652 GO:0010467 denotes gene expression
T60 1660-1664 D013987 denotes tick
T61 1711-1717 D035683 denotes miRNAs
T62 1737-1741 CHEBI:23888 denotes drug
T63 1822-1831 SO:0000732 denotes predicted
T64 1857-1867 D014714 denotes vertebrate

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 183-337 DRI_Challenge denotes The hard tick Ixodes ricinus is an important disease vector whose salivary secretions mediate blood-feeding success on vertebrate hosts, including humans.
T2 338-495 DRI_Approach denotes Here we describe the expression profiles and downstream analysis of de novo-discovered microRNAs (miRNAs) expressed in I. ricinus salivary glands and saliva.
T3 496-578 DRI_Approach denotes Eleven tick-derived libraries were sequenced to produce 67,375,557 Illumina reads.
T4 579-679 DRI_Background denotes De novo prediction yielded 67 bona fide miRNAs out of which 35 are currently not present in miRBase.
T5 680-833 DRI_Outcome denotes We report for the first time the presence of microRNAs in tick saliva, obtaining furthermore molecular indicators that those might be of exosomal origin.
T6 834-911 DRI_Approach denotes Ten out of these microRNAs are at least 100 times more represented in saliva.
T7 912-1086 DRI_Outcome denotes For the four most expressed microRNAs from this subset, we analyzed their combinatorial effects upon their host transcriptome using a novel in silico target network approach.
T8 1087-1229 DRI_Outcome denotes We show that only the inclusion of combinatorial effects reveals the functions in important pathways related to inflammation and pain sensing.
T9 1230-1388 DRI_Background denotes A control set of highly abundant microRNAs in both saliva and salivary glands indicates no significant pathways and a far lower number of shared target genes.
T10 1389-1680 DRI_Outcome denotes Therefore, the analysis of miRNAs from pure tick saliva strongly supports the hypothesis that tick saliva miRNAs can modulate vertebrate host homeostasis and represents the first direct evidence of tick miRNA-mediated regulation of vertebrate host gene expression at the tick-host interface.
T11 1681-1873 DRI_Outcome denotes As such, the herein described miRNAs may support future drug discovery and development projects that will also experimentally question their predicted molecular targets in the vertebrate host.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 215-217 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T2 215-217 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T3 343-345 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes we
T4 609-613 CVCL_E494|Transformed_cell_line|Homo sapiens denotes bona
T5 639-641 CVCL_4630|Cancer_cell_line|Rattus norvegicus denotes 35
T6 680-682 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes We
T7 704-708 CVCL_0047|Telomerase_immortalized_cell_line|Homo sapiens denotes time
T8 834-837 CVCL_E063|Cancer_cell_line|Homo sapiens denotes Ten
T9 878-883 CVCL_0047|Telomerase_immortalized_cell_line|Homo sapiens denotes times
T10 968-970 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes we
T11 1044-1045 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T12 1087-1089 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes We
T13 1230-1231 CVCL_6479|Finite_cell_line|Mus musculus denotes A
T14 1240-1243 CVCL_WY71|Spontaneously_immortalized_cell_line|Oncorhynchus keta denotes set
T15 1346-1347 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T16 1718-1721 CVCL_E773|Transformed_cell_line|Homo sapiens denotes may

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-182 Sentence denotes In silico target network analysis of de novo-discovered, tick saliva-specific microRNAs reveals important combinatorial effects in their interference with vertebrate host physiology.
T2 183-337 Sentence denotes The hard tick Ixodes ricinus is an important disease vector whose salivary secretions mediate blood-feeding success on vertebrate hosts, including humans.
T3 338-495 Sentence denotes Here we describe the expression profiles and downstream analysis of de novo-discovered microRNAs (miRNAs) expressed in I. ricinus salivary glands and saliva.
T4 496-578 Sentence denotes Eleven tick-derived libraries were sequenced to produce 67,375,557 Illumina reads.
T5 579-679 Sentence denotes De novo prediction yielded 67 bona fide miRNAs out of which 35 are currently not present in miRBase.
T6 680-833 Sentence denotes We report for the first time the presence of microRNAs in tick saliva, obtaining furthermore molecular indicators that those might be of exosomal origin.
T7 834-911 Sentence denotes Ten out of these microRNAs are at least 100 times more represented in saliva.
T8 912-1086 Sentence denotes For the four most expressed microRNAs from this subset, we analyzed their combinatorial effects upon their host transcriptome using a novel in silico target network approach.
T9 1087-1229 Sentence denotes We show that only the inclusion of combinatorial effects reveals the functions in important pathways related to inflammation and pain sensing.
T10 1230-1388 Sentence denotes A control set of highly abundant microRNAs in both saliva and salivary glands indicates no significant pathways and a far lower number of shared target genes.
T11 1389-1680 Sentence denotes Therefore, the analysis of miRNAs from pure tick saliva strongly supports the hypothesis that tick saliva miRNAs can modulate vertebrate host homeostasis and represents the first direct evidence of tick miRNA-mediated regulation of vertebrate host gene expression at the tick-host interface.
T12 1681-1873 Sentence denotes As such, the herein described miRNAs may support future drug discovery and development projects that will also experimentally question their predicted molecular targets in the vertebrate host.
T1 0-182 Sentence denotes In silico target network analysis of de novo-discovered, tick saliva-specific microRNAs reveals important combinatorial effects in their interference with vertebrate host physiology.
T2 183-337 Sentence denotes The hard tick Ixodes ricinus is an important disease vector whose salivary secretions mediate blood-feeding success on vertebrate hosts, including humans.
T3 338-495 Sentence denotes Here we describe the expression profiles and downstream analysis of de novo-discovered microRNAs (miRNAs) expressed in I. ricinus salivary glands and saliva.
T4 496-578 Sentence denotes Eleven tick-derived libraries were sequenced to produce 67,375,557 Illumina reads.
T5 579-679 Sentence denotes De novo prediction yielded 67 bona fide miRNAs out of which 35 are currently not present in miRBase.
T6 680-833 Sentence denotes We report for the first time the presence of microRNAs in tick saliva, obtaining furthermore molecular indicators that those might be of exosomal origin.
T7 834-911 Sentence denotes Ten out of these microRNAs are at least 100 times more represented in saliva.
T8 912-1086 Sentence denotes For the four most expressed microRNAs from this subset, we analyzed their combinatorial effects upon their host transcriptome using a novel in silico target network approach.
T9 1087-1229 Sentence denotes We show that only the inclusion of combinatorial effects reveals the functions in important pathways related to inflammation and pain sensing.
T10 1230-1388 Sentence denotes A control set of highly abundant microRNAs in both saliva and salivary glands indicates no significant pathways and a far lower number of shared target genes.
T11 1389-1680 Sentence denotes Therefore, the analysis of miRNAs from pure tick saliva strongly supports the hypothesis that tick saliva miRNAs can modulate vertebrate host homeostasis and represents the first direct evidence of tick miRNA-mediated regulation of vertebrate host gene expression at the tick-host interface.
T12 1681-1873 Sentence denotes As such, the herein described miRNAs may support future drug discovery and development projects that will also experimentally question their predicted molecular targets in the vertebrate host.