PubMed:28472682 JSONTXT

{"project":"GoldHamster","denotations":[{"id":"T1","span":{"begin":0,"end":7},"obj":"P51463"},{"id":"T2","span":{"begin":0,"end":7},"obj":"Q91XI3"},{"id":"T3","span":{"begin":0,"end":7},"obj":"P01308"},{"id":"T4","span":{"begin":0,"end":7},"obj":"P01340"},{"id":"T5","span":{"begin":0,"end":7},"obj":"P07453"},{"id":"T6","span":{"begin":0,"end":7},"obj":"P68988"},{"id":"T7","span":{"begin":0,"end":7},"obj":"P21563"},{"id":"T8","span":{"begin":0,"end":7},"obj":"P68245"},{"id":"T9","span":{"begin":0,"end":7},"obj":"P68990"},{"id":"T11","span":{"begin":0,"end":7},"obj":"P09476"},{"id":"T12","span":{"begin":0,"end":7},"obj":"P69047"},{"id":"T13","span":{"begin":0,"end":7},"obj":"Q8HXV2"},{"id":"T14","span":{"begin":0,"end":7},"obj":"P12705"},{"id":"T15","span":{"begin":0,"end":7},"obj":"P68987"},{"id":"T17","span":{"begin":0,"end":7},"obj":"Q9NDE7"},{"id":"T18","span":{"begin":0,"end":7},"obj":"P13190"},{"id":"T19","span":{"begin":0,"end":7},"obj":"P01321"},{"id":"T20","span":{"begin":0,"end":7},"obj":"C0HJT9"},{"id":"T21","span":{"begin":0,"end":7},"obj":"P81423"},{"id":"T22","span":{"begin":0,"end":7},"obj":"P01327"},{"id":"T23","span":{"begin":0,"end":7},"obj":"P41522"},{"id":"T24","span":{"begin":0,"end":7},"obj":"C0HJI1"},{"id":"T25","span":{"begin":0,"end":7},"obj":"P01336"},{"id":"T26","span":{"begin":0,"end":7},"obj":"P67974"},{"id":"T27","span":{"begin":0,"end":7},"obj":"P69046"},{"id":"T28","span":{"begin":0,"end":7},"obj":"P12704"},{"id":"T29","span":{"begin":0,"end":7},"obj":"P42633"},{"id":"T30","span":{"begin":0,"end":7},"obj":"P67968"},{"id":"T31","span":{"begin":0,"end":7},"obj":"P01334"},{"id":"T32","span":{"begin":0,"end":7},"obj":"P67973"},{"id":"T33","span":{"begin":0,"end":7},"obj":"P01328"},{"id":"T34","span":{"begin":0,"end":7},"obj":"P81881"},{"id":"T35","span":{"begin":0,"end":7},"obj":"P01330"},{"id":"T36","span":{"begin":0,"end":7},"obj":"Q9W7R2"},{"id":"T37","span":{"begin":0,"end":7},"obj":"P09477"},{"id":"T38","span":{"begin":0,"end":7},"obj":"P01311"},{"id":"T39","span":{"begin":0,"end":7},"obj":"P01315"},{"id":"T40","span":{"begin":0,"end":7},"obj":"P06306"},{"id":"T41","span":{"begin":0,"end":7},"obj":"P01319"},{"id":"T42","span":{"begin":0,"end":7},"obj":"Q6YK33"},{"id":"T43","span":{"begin":0,"end":7},"obj":"P67971"},{"id":"T44","span":{"begin":0,"end":7},"obj":"Q62587"},{"id":"T45","span":{"begin":0,"end":7},"obj":"P68991"},{"id":"T46","span":{"begin":0,"end":7},"obj":"P12708"},{"id":"T47","span":{"begin":0,"end":7},"obj":"P04667"},{"id":"T49","span":{"begin":0,"end":7},"obj":"P68989"},{"id":"T50","span":{"begin":0,"end":7},"obj":"P01333"},{"id":"T51","span":{"begin":0,"end":7},"obj":"PR:000009054"},{"id":"T52","span":{"begin":0,"end":7},"obj":"P30410"},{"id":"T53","span":{"begin":0,"end":7},"obj":"P01331"},{"id":"T54","span":{"begin":0,"end":7},"obj":"P01314"},{"id":"T55","span":{"begin":0,"end":7},"obj":"P01320"},{"id":"T56","span":{"begin":0,"end":7},"obj":"P01318"},{"id":"T57","span":{"begin":0,"end":7},"obj":"P12703"},{"id":"T58","span":{"begin":0,"end":7},"obj":"C0HJI4"},{"id":"T59","span":{"begin":0,"end":7},"obj":"P30406"},{"id":"T60","span":{"begin":0,"end":7},"obj":"C0HJU0"},{"id":"T61","span":{"begin":0,"end":7},"obj":"P68992"},{"id":"T62","span":{"begin":0,"end":7},"obj":"P67970"},{"id":"T63","span":{"begin":0,"end":7},"obj":"P18109"},{"id":"T64","span":{"begin":0,"end":7},"obj":"Q9TQY7"},{"id":"T65","span":{"begin":0,"end":7},"obj":"O73727"},{"id":"T66","span":{"begin":0,"end":7},"obj":"P01329"},{"id":"T67","span":{"begin":0,"end":7},"obj":"P01324"},{"id":"T69","span":{"begin":0,"end":7},"obj":"P01335"},{"id":"T70","span":{"begin":0,"end":7},"obj":"P68243"},{"id":"T71","span":{"begin":0,"end":7},"obj":"P67972"},{"id":"T72","span":{"begin":0,"end":7},"obj":"P29335"},{"id":"T73","span":{"begin":0,"end":7},"obj":"P01342"},{"id":"T74","span":{"begin":0,"end":7},"obj":"P69048"},{"id":"T75","span":{"begin":0,"end":7},"obj":"P01313"},{"id":"T76","span":{"begin":0,"end":7},"obj":"P01316"},{"id":"T77","span":{"begin":0,"end":7},"obj":"P17715"},{"id":"T78","span":{"begin":0,"end":7},"obj":"P30407"},{"id":"T79","span":{"begin":0,"end":7},"obj":"P01339"},{"id":"T81","span":{"begin":0,"end":7},"obj":"P81025"},{"id":"T82","span":{"begin":0,"end":7},"obj":"P69045"},{"id":"T83","span":{"begin":0,"end":7},"obj":"P01317"},{"id":"T84","span":{"begin":0,"end":7},"obj":"P01310"},{"id":"T85","span":{"begin":0,"end":7},"obj":"Q98TA8"},{"id":"T86","span":{"begin":0,"end":7},"obj":"P67969"},{"id":"T87","span":{"begin":0,"end":7},"obj":"P0C236"},{"id":"T10","span":{"begin":0,"end":7},"obj":"CHEBI:5931"},{"id":"T16","span":{"begin":0,"end":7},"obj":"D007328"},{"id":"T48","span":{"begin":0,"end":7},"obj":"CHEBI:145810"},{"id":"T68","span":{"begin":0,"end":7},"obj":"D007328"},{"id":"T80","span":{"begin":0,"end":7},"obj":"GO:0016088"},{"id":"T102","span":{"begin":21,"end":31},"obj":"1600930"},{"id":"T88","span":{"begin":21,"end":31},"obj":"P15984"},{"id":"T89","span":{"begin":21,"end":31},"obj":"Q9SCX8"},{"id":"T90","span":{"begin":21,"end":31},"obj":"P85957"},{"id":"T91","span":{"begin":21,"end":31},"obj":"Q01603"},{"id":"T92","span":{"begin":21,"end":31},"obj":"Q55080"},{"id":"T93","span":{"begin":21,"end":31},"obj":"P85317"},{"id":"T94","span":{"begin":21,"end":31},"obj":"Q05855"},{"id":"T95","span":{"begin":21,"end":31},"obj":"A8NK72"},{"id":"T96","span":{"begin":21,"end":31},"obj":"P84714"},{"id":"T99","span":{"begin":21,"end":31},"obj":"P28313"},{"id":"T100","span":{"begin":21,"end":31},"obj":"P28314"},{"id":"T101","span":{"begin":21,"end":31},"obj":"P16147"},{"id":"T103","span":{"begin":21,"end":31},"obj":"B3EWG7"},{"id":"T97","span":{"begin":21,"end":31},"obj":"D009195"},{"id":"T98","span":{"begin":21,"end":31},"obj":"CHEBI:8027"},{"id":"T104","span":{"begin":21,"end":40},"obj":"GO:0004601"},{"id":"T106","span":{"begin":44,"end":48},"obj":"PR:Q54DF9"},{"id":"T110","span":{"begin":44,"end":48},"obj":"PR:Q2FXA3"},{"id":"T111","span":{"begin":44,"end":48},"obj":"PR:P29680"},{"id":"T105","span":{"begin":44,"end":48},"obj":"CHEBI:17627"},{"id":"T107","span":{"begin":44,"end":48},"obj":"CHEBI:30413"},{"id":"T108","span":{"begin":44,"end":48},"obj":"D006418"},{"id":"T109","span":{"begin":44,"end":48},"obj":"CHEBI:26355"},{"id":"T112","span":{"begin":44,"end":48},"obj":"D006418"},{"id":"T114","span":{"begin":60,"end":64},"obj":"PR:Q54DF9"},{"id":"T118","span":{"begin":60,"end":64},"obj":"PR:Q2FXA3"},{"id":"T119","span":{"begin":60,"end":64},"obj":"PR:P29680"},{"id":"T113","span":{"begin":60,"end":64},"obj":"CHEBI:17627"},{"id":"T115","span":{"begin":60,"end":64},"obj":"CHEBI:30413"},{"id":"T116","span":{"begin":60,"end":64},"obj":"D006418"},{"id":"T117","span":{"begin":60,"end":64},"obj":"CHEBI:26355"},{"id":"T120","span":{"begin":60,"end":64},"obj":"D006418"},{"id":"T121","span":{"begin":65,"end":72},"obj":"P51463"},{"id":"T122","span":{"begin":65,"end":72},"obj":"Q91XI3"},{"id":"T123","span":{"begin":65,"end":72},"obj":"P01308"},{"id":"T124","span":{"begin":65,"end":72},"obj":"P01340"},{"id":"T125","span":{"begin":65,"end":72},"obj":"P07453"},{"id":"T126","span":{"begin":65,"end":72},"obj":"P68988"},{"id":"T127","span":{"begin":65,"end":72},"obj":"P21563"},{"id":"T128","span":{"begin":65,"end":72},"obj":"P68245"},{"id":"T129","span":{"begin":65,"end":72},"obj":"P68990"},{"id":"T131","span":{"begin":65,"end":72},"obj":"P09476"},{"id":"T132","span":{"begin":65,"end":72},"obj":"P69047"},{"id":"T133","span":{"begin":65,"end":72},"obj":"Q8HXV2"},{"id":"T134","span":{"begin":65,"end":72},"obj":"P12705"},{"id":"T135","span":{"begin":65,"end":72},"obj":"P68987"},{"id":"T137","span":{"begin":65,"end":72},"obj":"Q9NDE7"},{"id":"T138","span":{"begin":65,"end":72},"obj":"P13190"},{"id":"T139","span":{"begin":65,"end":72},"obj":"P01321"},{"id":"T140","span":{"begin":65,"end":72},"obj":"C0HJT9"},{"id":"T141","span":{"begin":65,"end":72},"obj":"P81423"},{"id":"T142","span":{"begin":65,"end":72},"obj":"P01327"},{"id":"T143","span":{"begin":65,"end":72},"obj":"P41522"},{"id":"T144","span":{"begin":65,"end":72},"obj":"C0HJI1"},{"id":"T145","span":{"begin":65,"end":72},"obj":"P01336"},{"id":"T146","span":{"begin":65,"end":72},"obj":"P67974"},{"id":"T147","span":{"begin":65,"end":72},"obj":"P69046"},{"id":"T148","span":{"begin":65,"end":72},"obj":"P12704"},{"id":"T149","span":{"begin":65,"end":72},"obj":"P42633"},{"id":"T150","span":{"begin":65,"end":72},"obj":"P67968"},{"id":"T151","span":{"begin":65,"end":72},"obj":"P01334"},{"id":"T152","span":{"begin":65,"end":72},"obj":"P67973"},{"id":"T153","span":{"begin":65,"end":72},"obj":"P01328"},{"id":"T154","span":{"begin":65,"end":72},"obj":"P81881"},{"id":"T155","span":{"begin":65,"end":72},"obj":"P01330"},{"id":"T156","span":{"begin":65,"end":72},"obj":"Q9W7R2"},{"id":"T157","span":{"begin":65,"end":72},"obj":"P09477"},{"id":"T158","span":{"begin":65,"end":72},"obj":"P01311"},{"id":"T159","span":{"begin":65,"end":72},"obj":"P01315"},{"id":"T160","span":{"begin":65,"end":72},"obj":"P06306"},{"id":"T161","span":{"begin":65,"end":72},"obj":"P01319"},{"id":"T162","span":{"begin":65,"end":72},"obj":"Q6YK33"},{"id":"T163","span":{"begin":65,"end":72},"obj":"P67971"},{"id":"T164","span":{"begin":65,"end":72},"obj":"Q62587"},{"id":"T165","span":{"begin":65,"end":72},"obj":"P68991"},{"id":"T166","span":{"begin":65,"end":72},"obj":"P12708"},{"id":"T167","span":{"begin":65,"end":72},"obj":"P04667"},{"id":"T169","span":{"begin":65,"end":72},"obj":"P68989"},{"id":"T170","span":{"begin":65,"end":72},"obj":"P01333"},{"id":"T171","span":{"begin":65,"end":72},"obj":"PR:000009054"},{"id":"T172","span":{"begin":65,"end":72},"obj":"P30410"},{"id":"T173","span":{"begin":65,"end":72},"obj":"P01331"},{"id":"T174","span":{"begin":65,"end":72},"obj":"P01314"},{"id":"T175","span":{"begin":65,"end":72},"obj":"P01320"},{"id":"T176","span":{"begin":65,"end":72},"obj":"P01318"},{"id":"T177","span":{"begin":65,"end":72},"obj":"P12703"},{"id":"T178","span":{"begin":65,"end":72},"obj":"C0HJI4"},{"id":"T179","span":{"begin":65,"end":72},"obj":"P30406"},{"id":"T180","span":{"begin":65,"end":72},"obj":"C0HJU0"},{"id":"T181","span":{"begin":65,"end":72},"obj":"P68992"},{"id":"T182","span":{"begin":65,"end":72},"obj":"P67970"},{"id":"T183","span":{"begin":65,"end":72},"obj":"P18109"},{"id":"T184","span":{"begin":65,"end":72},"obj":"Q9TQY7"},{"id":"T185","span":{"begin":65,"end":72},"obj":"O73727"},{"id":"T186","span":{"begin":65,"end":72},"obj":"P01329"},{"id":"T187","span":{"begin":65,"end":72},"obj":"P01324"},{"id":"T189","span":{"begin":65,"end":72},"obj":"P01335"},{"id":"T190","span":{"begin":65,"end":72},"obj":"P68243"},{"id":"T191","span":{"begin":65,"end":72},"obj":"P67972"},{"id":"T192","span":{"begin":65,"end":72},"obj":"P29335"},{"id":"T193","span":{"begin":65,"end":72},"obj":"P01342"},{"id":"T194","span":{"begin":65,"end":72},"obj":"P69048"},{"id":"T195","span":{"begin":65,"end":72},"obj":"P01313"},{"id":"T196","span":{"begin":65,"end":72},"obj":"P01316"},{"id":"T197","span":{"begin":65,"end":72},"obj":"P17715"},{"id":"T198","span":{"begin":65,"end":72},"obj":"P30407"},{"id":"T199","span":{"begin":65,"end":72},"obj":"P01339"},{"id":"T201","span":{"begin":65,"end":72},"obj":"P81025"},{"id":"T202","span":{"begin":65,"end":72},"obj":"P69045"},{"id":"T203","span":{"begin":65,"end":72},"obj":"P01317"},{"id":"T204","span":{"begin":65,"end":72},"obj":"P01310"},{"id":"T205","span":{"begin":65,"end":72},"obj":"Q98TA8"},{"id":"T206","span":{"begin":65,"end":72},"obj":"P67969"},{"id":"T207","span":{"begin":65,"end":72},"obj":"P0C236"},{"id":"T130","span":{"begin":65,"end":72},"obj":"CHEBI:5931"},{"id":"T136","span":{"begin":65,"end":72},"obj":"D007328"},{"id":"T168","span":{"begin":65,"end":72},"obj":"CHEBI:145810"},{"id":"T188","span":{"begin":65,"end":72},"obj":"D007328"},{"id":"T200","span":{"begin":65,"end":72},"obj":"GO:0016088"},{"id":"T210","span":{"begin":95,"end":119},"obj":"D003924"},{"id":"T211","span":{"begin":95,"end":119},"obj":"D003924"},{"id":"T215","span":{"begin":166,"end":170},"obj":"PR:Q54DF9"},{"id":"T219","span":{"begin":166,"end":170},"obj":"PR:Q2FXA3"},{"id":"T220","span":{"begin":166,"end":170},"obj":"PR:P29680"},{"id":"T214","span":{"begin":166,"end":170},"obj":"CHEBI:17627"},{"id":"T216","span":{"begin":166,"end":170},"obj":"CHEBI:30413"},{"id":"T217","span":{"begin":166,"end":170},"obj":"D006418"},{"id":"T218","span":{"begin":166,"end":170},"obj":"CHEBI:26355"},{"id":"T221","span":{"begin":166,"end":170},"obj":"D006418"},{"id":"T224","span":{"begin":178,"end":202},"obj":"D003924"},{"id":"T225","span":{"begin":178,"end":202},"obj":"D003924"},{"id":"T228","span":{"begin":210,"end":222},"obj":"GO:0009405"},{"id":"T230","span":{"begin":263,"end":267},"obj":"PR:Q54DF9"},{"id":"T234","span":{"begin":263,"end":267},"obj":"PR:Q2FXA3"},{"id":"T235","span":{"begin":263,"end":267},"obj":"PR:P29680"},{"id":"T229","span":{"begin":263,"end":267},"obj":"CHEBI:17627"},{"id":"T231","span":{"begin":263,"end":267},"obj":"CHEBI:30413"},{"id":"T232","span":{"begin":263,"end":267},"obj":"D006418"},{"id":"T233","span":{"begin":263,"end":267},"obj":"CHEBI:26355"},{"id":"T236","span":{"begin":263,"end":267},"obj":"D006418"},{"id":"T238","span":{"begin":362,"end":366},"obj":"PR:Q54DF9"},{"id":"T242","span":{"begin":362,"end":366},"obj":"PR:Q2FXA3"},{"id":"T243","span":{"begin":362,"end":366},"obj":"PR:P29680"},{"id":"T237","span":{"begin":362,"end":366},"obj":"CHEBI:17627"},{"id":"T239","span":{"begin":362,"end":366},"obj":"CHEBI:30413"},{"id":"T240","span":{"begin":362,"end":366},"obj":"D006418"},{"id":"T241","span":{"begin":362,"end":366},"obj":"CHEBI:26355"},{"id":"T244","span":{"begin":362,"end":366},"obj":"D006418"},{"id":"T245","span":{"begin":368,"end":375},"obj":"P51463"},{"id":"T246","span":{"begin":368,"end":375},"obj":"Q91XI3"},{"id":"T247","span":{"begin":368,"end":375},"obj":"P01308"},{"id":"T248","span":{"begin":368,"end":375},"obj":"P01340"},{"id":"T249","span":{"begin":368,"end":375},"obj":"P07453"},{"id":"T250","span":{"begin":368,"end":375},"obj":"P68988"},{"id":"T251","span":{"begin":368,"end":375},"obj":"P21563"},{"id":"T252","span":{"begin":368,"end":375},"obj":"P68245"},{"id":"T253","span":{"begin":368,"end":375},"obj":"P68990"},{"id":"T255","span":{"begin":368,"end":375},"obj":"P09476"},{"id":"T256","span":{"begin":368,"end":375},"obj":"P69047"},{"id":"T257","span":{"begin":368,"end":375},"obj":"Q8HXV2"},{"id":"T258","span":{"begin":368,"end":375},"obj":"P12705"},{"id":"T259","span":{"begin":368,"end":375},"obj":"P68987"},{"id":"T261","span":{"begin":368,"end":375},"obj":"Q9NDE7"},{"id":"T262","span":{"begin":368,"end":375},"obj":"P13190"},{"id":"T263","span":{"begin":368,"end":375},"obj":"P01321"},{"id":"T264","span":{"begin":368,"end":375},"obj":"C0HJT9"},{"id":"T265","span":{"begin":368,"end":375},"obj":"P81423"},{"id":"T266","span":{"begin":368,"end":375},"obj":"P01327"},{"id":"T267","span":{"begin":368,"end":375},"obj":"P41522"},{"id":"T268","span":{"begin":368,"end":375},"obj":"C0HJI1"},{"id":"T269","span":{"begin":368,"end":375},"obj":"P01336"},{"id":"T270","span":{"begin":368,"end":375},"obj":"P67974"},{"id":"T271","span":{"begin":368,"end":375},"obj":"P69046"},{"id":"T272","span":{"begin":368,"end":375},"obj":"P12704"},{"id":"T273","span":{"begin":368,"end":375},"obj":"P42633"},{"id":"T274","span":{"begin":368,"end":375},"obj":"P67968"},{"id":"T275","span":{"begin":368,"end":375},"obj":"P01334"},{"id":"T276","span":{"begin":368,"end":375},"obj":"P67973"},{"id":"T277","span":{"begin":368,"end":375},"obj":"P01328"},{"id":"T278","span":{"begin":368,"end":375},"obj":"P81881"},{"id":"T279","span":{"begin":368,"end":375},"obj":"P01330"},{"id":"T280","span":{"begin":368,"end":375},"obj":"Q9W7R2"},{"id":"T281","span":{"begin":368,"end":375},"obj":"P09477"},{"id":"T282","span":{"begin":368,"end":375},"obj":"P01311"},{"id":"T283","span":{"begin":368,"end":375},"obj":"P01315"},{"id":"T284","span":{"begin":368,"end":375},"obj":"P06306"},{"id":"T285","span":{"begin":368,"end":375},"obj":"P01319"},{"id":"T286","span":{"begin":368,"end":375},"obj":"Q6YK33"},{"id":"T287","span":{"begin":368,"end":375},"obj":"P67971"},{"id":"T288","span":{"begin":368,"end":375},"obj":"Q62587"},{"id":"T289","span":{"begin":368,"end":375},"obj":"P68991"},{"id":"T290","span":{"begin":368,"end":375},"obj":"P12708"},{"id":"T291","span":{"begin":368,"end":375},"obj":"P04667"},{"id":"T293","span":{"begin":368,"end":375},"obj":"P68989"},{"id":"T294","span":{"begin":368,"end":375},"obj":"P01333"},{"id":"T295","span":{"begin":368,"end":375},"obj":"PR:000009054"},{"id":"T296","span":{"begin":368,"end":375},"obj":"P30410"},{"id":"T297","span":{"begin":368,"end":375},"obj":"P01331"},{"id":"T298","span":{"begin":368,"end":375},"obj":"P01314"},{"id":"T299","span":{"begin":368,"end":375},"obj":"P01320"},{"id":"T300","span":{"begin":368,"end":375},"obj":"P01318"},{"id":"T301","span":{"begin":368,"end":375},"obj":"P12703"},{"id":"T302","span":{"begin":368,"end":375},"obj":"C0HJI4"},{"id":"T303","span":{"begin":368,"end":375},"obj":"P30406"},{"id":"T304","span":{"begin":368,"end":375},"obj":"C0HJU0"},{"id":"T305","span":{"begin":368,"end":375},"obj":"P68992"},{"id":"T306","span":{"begin":368,"end":375},"obj":"P67970"},{"id":"T307","span":{"begin":368,"end":375},"obj":"P18109"},{"id":"T308","span":{"begin":368,"end":375},"obj":"Q9TQY7"},{"id":"T309","span":{"begin":368,"end":375},"obj":"O73727"},{"id":"T310","span":{"begin":368,"end":375},"obj":"P01329"},{"id":"T311","span":{"begin":368,"end":375},"obj":"P01324"},{"id":"T313","span":{"begin":368,"end":375},"obj":"P01335"},{"id":"T314","span":{"begin":368,"end":375},"obj":"P68243"},{"id":"T315","span":{"begin":368,"end":375},"obj":"P67972"},{"id":"T316","span":{"begin":368,"end":375},"obj":"P29335"},{"id":"T317","span":{"begin":368,"end":375},"obj":"P01342"},{"id":"T318","span":{"begin":368,"end":375},"obj":"P69048"},{"id":"T319","span":{"begin":368,"end":375},"obj":"P01313"},{"id":"T320","span":{"begin":368,"end":375},"obj":"P01316"},{"id":"T321","span":{"begin":368,"end":375},"obj":"P17715"},{"id":"T322","span":{"begin":368,"end":375},"obj":"P30407"},{"id":"T323","span":{"begin":368,"end":375},"obj":"P01339"},{"id":"T325","span":{"begin":368,"end":375},"obj":"P81025"},{"id":"T326","span":{"begin":368,"end":375},"obj":"P69045"},{"id":"T327","span":{"begin":368,"end":375},"obj":"P01317"},{"id":"T328","span":{"begin":368,"end":375},"obj":"P01310"},{"id":"T329","span":{"begin":368,"end":375},"obj":"Q98TA8"},{"id":"T330","span":{"begin":368,"end":375},"obj":"P67969"},{"id":"T331","span":{"begin":368,"end":375},"obj":"P0C236"},{"id":"T254","span":{"begin":368,"end":375},"obj":"CHEBI:5931"},{"id":"T260","span":{"begin":368,"end":375},"obj":"D007328"},{"id":"T292","span":{"begin":368,"end":375},"obj":"CHEBI:145810"},{"id":"T312","span":{"begin":368,"end":375},"obj":"D007328"},{"id":"T324","span":{"begin":368,"end":375},"obj":"GO:0016088"},{"id":"T332","span":{"begin":419,"end":428},"obj":"GO:0009058"},{"id":"T334","span":{"begin":432,"end":436},"obj":"PR:Q54DF9"},{"id":"T338","span":{"begin":432,"end":436},"obj":"PR:Q2FXA3"},{"id":"T339","span":{"begin":432,"end":436},"obj":"PR:P29680"},{"id":"T333","span":{"begin":432,"end":436},"obj":"CHEBI:17627"},{"id":"T335","span":{"begin":432,"end":436},"obj":"CHEBI:30413"},{"id":"T336","span":{"begin":432,"end":436},"obj":"D006418"},{"id":"T337","span":{"begin":432,"end":436},"obj":"CHEBI:26355"},{"id":"T340","span":{"begin":432,"end":436},"obj":"D006418"},{"id":"T341","span":{"begin":437,"end":444},"obj":"P51463"},{"id":"T342","span":{"begin":437,"end":444},"obj":"Q91XI3"},{"id":"T343","span":{"begin":437,"end":444},"obj":"P01308"},{"id":"T344","span":{"begin":437,"end":444},"obj":"P01340"},{"id":"T345","span":{"begin":437,"end":444},"obj":"P07453"},{"id":"T346","span":{"begin":437,"end":444},"obj":"P68988"},{"id":"T347","span":{"begin":437,"end":444},"obj":"P21563"},{"id":"T348","span":{"begin":437,"end":444},"obj":"P68245"},{"id":"T349","span":{"begin":437,"end":444},"obj":"P68990"},{"id":"T351","span":{"begin":437,"end":444},"obj":"P09476"},{"id":"T352","span":{"begin":437,"end":444},"obj":"P69047"},{"id":"T353","span":{"begin":437,"end":444},"obj":"Q8HXV2"},{"id":"T354","span":{"begin":437,"end":444},"obj":"P12705"},{"id":"T355","span":{"begin":437,"end":444},"obj":"P68987"},{"id":"T357","span":{"begin":437,"end":444},"obj":"Q9NDE7"},{"id":"T358","span":{"begin":437,"end":444},"obj":"P13190"},{"id":"T359","span":{"begin":437,"end":444},"obj":"P01321"},{"id":"T360","span":{"begin":437,"end":444},"obj":"C0HJT9"},{"id":"T361","span":{"begin":437,"end":444},"obj":"P81423"},{"id":"T362","span":{"begin":437,"end":444},"obj":"P01327"},{"id":"T363","span":{"begin":437,"end":444},"obj":"P41522"},{"id":"T364","span":{"begin":437,"end":444},"obj":"C0HJI1"},{"id":"T365","span":{"begin":437,"end":444},"obj":"P01336"},{"id":"T366","span":{"begin":437,"end":444},"obj":"P67974"},{"id":"T367","span":{"begin":437,"end":444},"obj":"P69046"},{"id":"T368","span":{"begin":437,"end":444},"obj":"P12704"},{"id":"T369","span":{"begin":437,"end":444},"obj":"P42633"},{"id":"T370","span":{"begin":437,"end":444},"obj":"P67968"},{"id":"T371","span":{"begin":437,"end":444},"obj":"P01334"},{"id":"T372","span":{"begin":437,"end":444},"obj":"P67973"},{"id":"T373","span":{"begin":437,"end":444},"obj":"P01328"},{"id":"T374","span":{"begin":437,"end":444},"obj":"P81881"},{"id":"T375","span":{"begin":437,"end":444},"obj":"P01330"},{"id":"T376","span":{"begin":437,"end":444},"obj":"Q9W7R2"},{"id":"T377","span":{"begin":437,"end":444},"obj":"P09477"},{"id":"T378","span":{"begin":437,"end":444},"obj":"P01311"},{"id":"T379","span":{"begin":437,"end":444},"obj":"P01315"},{"id":"T380","span":{"begin":437,"end":444},"obj":"P06306"},{"id":"T381","span":{"begin":437,"end":444},"obj":"P01319"},{"id":"T382","span":{"begin":437,"end":444},"obj":"Q6YK33"},{"id":"T383","span":{"begin":437,"end":444},"obj":"P67971"},{"id":"T384","span":{"begin":437,"end":444},"obj":"Q62587"},{"id":"T385","span":{"begin":437,"end":444},"obj":"P68991"},{"id":"T386","span":{"begin":437,"end":444},"obj":"P12708"},{"id":"T387","span":{"begin":437,"end":444},"obj":"P04667"},{"id":"T389","span":{"begin":437,"end":444},"obj":"P68989"},{"id":"T390","span":{"begin":437,"end":444},"obj":"P01333"},{"id":"T391","span":{"begin":437,"end":444},"obj":"PR:000009054"},{"id":"T392","span":{"begin":437,"end":444},"obj":"P30410"},{"id":"T393","span":{"begin":437,"end":444},"obj":"P01331"},{"id":"T394","span":{"begin":437,"end":444},"obj":"P01314"},{"id":"T395","span":{"begin":437,"end":444},"obj":"P01320"},{"id":"T396","span":{"begin":437,"end":444},"obj":"P01318"},{"id":"T397","span":{"begin":437,"end":444},"obj":"P12703"},{"id":"T398","span":{"begin":437,"end":444},"obj":"C0HJI4"},{"id":"T399","span":{"begin":437,"end":444},"obj":"P30406"},{"id":"T400","span":{"begin":437,"end":444},"obj":"C0HJU0"},{"id":"T401","span":{"begin":437,"end":444},"obj":"P68992"},{"id":"T402","span":{"begin":437,"end":444},"obj":"P67970"},{"id":"T403","span":{"begin":437,"end":444},"obj":"P18109"},{"id":"T404","span":{"begin":437,"end":444},"obj":"Q9TQY7"},{"id":"T405","span":{"begin":437,"end":444},"obj":"O73727"},{"id":"T406","span":{"begin":437,"end":444},"obj":"P01329"},{"id":"T407","span":{"begin":437,"end":444},"obj":"P01324"},{"id":"T409","span":{"begin":437,"end":444},"obj":"P01335"},{"id":"T410","span":{"begin":437,"end":444},"obj":"P68243"},{"id":"T411","span":{"begin":437,"end":444},"obj":"P67972"},{"id":"T412","span":{"begin":437,"end":444},"obj":"P29335"},{"id":"T413","span":{"begin":437,"end":444},"obj":"P01342"},{"id":"T414","span":{"begin":437,"end":444},"obj":"P69048"},{"id":"T415","span":{"begin":437,"end":444},"obj":"P01313"},{"id":"T416","span":{"begin":437,"end":444},"obj":"P01316"},{"id":"T417","span":{"begin":437,"end":444},"obj":"P17715"},{"id":"T418","span":{"begin":437,"end":444},"obj":"P30407"},{"id":"T419","span":{"begin":437,"end":444},"obj":"P01339"},{"id":"T421","span":{"begin":437,"end":444},"obj":"P81025"},{"id":"T422","span":{"begin":437,"end":444},"obj":"P69045"},{"id":"T423","span":{"begin":437,"end":444},"obj":"P01317"},{"id":"T424","span":{"begin":437,"end":444},"obj":"P01310"},{"id":"T425","span":{"begin":437,"end":444},"obj":"Q98TA8"},{"id":"T426","span":{"begin":437,"end":444},"obj":"P67969"},{"id":"T427","span":{"begin":437,"end":444},"obj":"P0C236"},{"id":"T350","span":{"begin":437,"end":444},"obj":"CHEBI:5931"},{"id":"T356","span":{"begin":437,"end":444},"obj":"D007328"},{"id":"T388","span":{"begin":437,"end":444},"obj":"CHEBI:145810"},{"id":"T408","span":{"begin":437,"end":444},"obj":"D007328"},{"id":"T420","span":{"begin":437,"end":444},"obj":"GO:0016088"},{"id":"T428","span":{"begin":495,"end":504},"obj":"UBERON:0001982"},{"id":"T429","span":{"begin":521,"end":528},"obj":"UBERON:0000209"},{"id":"T431","span":{"begin":570,"end":574},"obj":"PR:Q54DF9"},{"id":"T435","span":{"begin":570,"end":574},"obj":"PR:Q2FXA3"},{"id":"T436","span":{"begin":570,"end":574},"obj":"PR:P29680"},{"id":"T430","span":{"begin":570,"end":574},"obj":"CHEBI:17627"},{"id":"T432","span":{"begin":570,"end":574},"obj":"CHEBI:30413"},{"id":"T433","span":{"begin":570,"end":574},"obj":"D006418"},{"id":"T434","span":{"begin":570,"end":574},"obj":"CHEBI:26355"},{"id":"T437","span":{"begin":570,"end":574},"obj":"D006418"},{"id":"T438","span":{"begin":570,"end":582},"obj":"GO:0020037"},{"id":"T439","span":{"begin":575,"end":582},"obj":"SO:0100018"},{"id":"T440","span":{"begin":575,"end":582},"obj":"SO:0001091"},{"id":"T442","span":{"begin":583,"end":590},"obj":"P51463"},{"id":"T443","span":{"begin":583,"end":590},"obj":"Q91XI3"},{"id":"T444","span":{"begin":583,"end":590},"obj":"P01308"},{"id":"T445","span":{"begin":583,"end":590},"obj":"P01340"},{"id":"T446","span":{"begin":583,"end":590},"obj":"P07453"},{"id":"T447","span":{"begin":583,"end":590},"obj":"P68988"},{"id":"T448","span":{"begin":583,"end":590},"obj":"P21563"},{"id":"T449","span":{"begin":583,"end":590},"obj":"P68245"},{"id":"T450","span":{"begin":583,"end":590},"obj":"P68990"},{"id":"T452","span":{"begin":583,"end":590},"obj":"P09476"},{"id":"T453","span":{"begin":583,"end":590},"obj":"P69047"},{"id":"T454","span":{"begin":583,"end":590},"obj":"Q8HXV2"},{"id":"T455","span":{"begin":583,"end":590},"obj":"P12705"},{"id":"T456","span":{"begin":583,"end":590},"obj":"P68987"},{"id":"T458","span":{"begin":583,"end":590},"obj":"Q9NDE7"},{"id":"T459","span":{"begin":583,"end":590},"obj":"P13190"},{"id":"T460","span":{"begin":583,"end":590},"obj":"P01321"},{"id":"T461","span":{"begin":583,"end":590},"obj":"C0HJT9"},{"id":"T462","span":{"begin":583,"end":590},"obj":"P81423"},{"id":"T463","span":{"begin":583,"end":590},"obj":"P01327"},{"id":"T464","span":{"begin":583,"end":590},"obj":"P41522"},{"id":"T465","span":{"begin":583,"end":590},"obj":"C0HJI1"},{"id":"T466","span":{"begin":583,"end":590},"obj":"P01336"},{"id":"T467","span":{"begin":583,"end":590},"obj":"P67974"},{"id":"T468","span":{"begin":583,"end":590},"obj":"P69046"},{"id":"T469","span":{"begin":583,"end":590},"obj":"P12704"},{"id":"T470","span":{"begin":583,"end":590},"obj":"P42633"},{"id":"T471","span":{"begin":583,"end":590},"obj":"P67968"},{"id":"T472","span":{"begin":583,"end":590},"obj":"P01334"},{"id":"T473","span":{"begin":583,"end":590},"obj":"P67973"},{"id":"T474","span":{"begin":583,"end":590},"obj":"P01328"},{"id":"T475","span":{"begin":583,"end":590},"obj":"P81881"},{"id":"T476","span":{"begin":583,"end":590},"obj":"P01330"},{"id":"T477","span":{"begin":583,"end":590},"obj":"Q9W7R2"},{"id":"T478","span":{"begin":583,"end":590},"obj":"P09477"},{"id":"T479","span":{"begin":583,"end":590},"obj":"P01311"},{"id":"T480","span":{"begin":583,"end":590},"obj":"P01315"},{"id":"T481","span":{"begin":583,"end":590},"obj":"P06306"},{"id":"T482","span":{"begin":583,"end":590},"obj":"P01319"},{"id":"T483","span":{"begin":583,"end":590},"obj":"Q6YK33"},{"id":"T484","span":{"begin":583,"end":590},"obj":"P67971"},{"id":"T485","span":{"begin":583,"end":590},"obj":"Q62587"},{"id":"T486","span":{"begin":583,"end":590},"obj":"P68991"},{"id":"T487","span":{"begin":583,"end":590},"obj":"P12708"},{"id":"T488","span":{"begin":583,"end":590},"obj":"P04667"},{"id":"T490","span":{"begin":583,"end":590},"obj":"P68989"},{"id":"T491","span":{"begin":583,"end":590},"obj":"P01333"},{"id":"T492","span":{"begin":583,"end":590},"obj":"PR:000009054"},{"id":"T493","span":{"begin":583,"end":590},"obj":"P30410"},{"id":"T494","span":{"begin":583,"end":590},"obj":"P01331"},{"id":"T495","span":{"begin":583,"end":590},"obj":"P01314"},{"id":"T496","span":{"begin":583,"end":590},"obj":"P01320"},{"id":"T497","span":{"begin":583,"end":590},"obj":"P01318"},{"id":"T498","span":{"begin":583,"end":590},"obj":"P12703"},{"id":"T499","span":{"begin":583,"end":590},"obj":"C0HJI4"},{"id":"T500","span":{"begin":583,"end":590},"obj":"P30406"},{"id":"T501","span":{"begin":583,"end":590},"obj":"C0HJU0"},{"id":"T502","span":{"begin":583,"end":590},"obj":"P68992"},{"id":"T503","span":{"begin":583,"end":590},"obj":"P67970"},{"id":"T504","span":{"begin":583,"end":590},"obj":"P18109"},{"id":"T505","span":{"begin":583,"end":590},"obj":"Q9TQY7"},{"id":"T506","span":{"begin":583,"end":590},"obj":"O73727"},{"id":"T507","span":{"begin":583,"end":590},"obj":"P01329"},{"id":"T508","span":{"begin":583,"end":590},"obj":"P01324"},{"id":"T510","span":{"begin":583,"end":590},"obj":"P01335"},{"id":"T511","span":{"begin":583,"end":590},"obj":"P68243"},{"id":"T512","span":{"begin":583,"end":590},"obj":"P67972"},{"id":"T513","span":{"begin":583,"end":590},"obj":"P29335"},{"id":"T514","span":{"begin":583,"end":590},"obj":"P01342"},{"id":"T515","span":{"begin":583,"end":590},"obj":"P69048"},{"id":"T516","span":{"begin":583,"end":590},"obj":"P01313"},{"id":"T517","span":{"begin":583,"end":590},"obj":"P01316"},{"id":"T518","span":{"begin":583,"end":590},"obj":"P17715"},{"id":"T519","span":{"begin":583,"end":590},"obj":"P30407"},{"id":"T520","span":{"begin":583,"end":590},"obj":"P01339"},{"id":"T522","span":{"begin":583,"end":590},"obj":"P81025"},{"id":"T523","span":{"begin":583,"end":590},"obj":"P69045"},{"id":"T524","span":{"begin":583,"end":590},"obj":"P01317"},{"id":"T525","span":{"begin":583,"end":590},"obj":"P01310"},{"id":"T526","span":{"begin":583,"end":590},"obj":"Q98TA8"},{"id":"T527","span":{"begin":583,"end":590},"obj":"P67969"},{"id":"T528","span":{"begin":583,"end":590},"obj":"P0C236"},{"id":"T451","span":{"begin":583,"end":590},"obj":"CHEBI:5931"},{"id":"T457","span":{"begin":583,"end":590},"obj":"D007328"},{"id":"T489","span":{"begin":583,"end":590},"obj":"CHEBI:145810"},{"id":"T509","span":{"begin":583,"end":590},"obj":"D007328"},{"id":"T521","span":{"begin":583,"end":590},"obj":"GO:0016088"},{"id":"T530","span":{"begin":595,"end":598},"obj":"PR:O95817"},{"id":"T531","span":{"begin":595,"end":598},"obj":"PR:000004621"},{"id":"T532","span":{"begin":595,"end":598},"obj":"PR:Q9JLV1"},{"id":"T529","span":{"begin":595,"end":598},"obj":"GO:0033815"},{"id":"T536","span":{"begin":599,"end":608},"obj":"SO:0001452"},{"id":"T537","span":{"begin":599,"end":608},"obj":"5340"},{"id":"T533","span":{"begin":599,"end":608},"obj":"D006639"},{"id":"T534","span":{"begin":599,"end":608},"obj":"CHEBI:15971"},{"id":"T535","span":{"begin":599,"end":608},"obj":"D006639"},{"id":"T538","span":{"begin":599,"end":608},"obj":"CHEBI:27570"},{"id":"T539","span":{"begin":654,"end":661},"obj":"P51463"},{"id":"T540","span":{"begin":654,"end":661},"obj":"Q91XI3"},{"id":"T541","span":{"begin":654,"end":661},"obj":"P01308"},{"id":"T542","span":{"begin":654,"end":661},"obj":"P01340"},{"id":"T543","span":{"begin":654,"end":661},"obj":"P07453"},{"id":"T544","span":{"begin":654,"end":661},"obj":"P68988"},{"id":"T545","span":{"begin":654,"end":661},"obj":"P21563"},{"id":"T546","span":{"begin":654,"end":661},"obj":"P68245"},{"id":"T547","span":{"begin":654,"end":661},"obj":"P68990"},{"id":"T549","span":{"begin":654,"end":661},"obj":"P09476"},{"id":"T550","span":{"begin":654,"end":661},"obj":"P69047"},{"id":"T551","span":{"begin":654,"end":661},"obj":"Q8HXV2"},{"id":"T552","span":{"begin":654,"end":661},"obj":"P12705"},{"id":"T553","span":{"begin":654,"end":661},"obj":"P68987"},{"id":"T555","span":{"begin":654,"end":661},"obj":"Q9NDE7"},{"id":"T556","span":{"begin":654,"end":661},"obj":"P13190"},{"id":"T557","span":{"begin":654,"end":661},"obj":"P01321"},{"id":"T558","span":{"begin":654,"end":661},"obj":"C0HJT9"},{"id":"T559","span":{"begin":654,"end":661},"obj":"P81423"},{"id":"T560","span":{"begin":654,"end":661},"obj":"P01327"},{"id":"T561","span":{"begin":654,"end":661},"obj":"P41522"},{"id":"T562","span":{"begin":654,"end":661},"obj":"C0HJI1"},{"id":"T563","span":{"begin":654,"end":661},"obj":"P01336"},{"id":"T564","span":{"begin":654,"end":661},"obj":"P67974"},{"id":"T565","span":{"begin":654,"end":661},"obj":"P69046"},{"id":"T566","span":{"begin":654,"end":661},"obj":"P12704"},{"id":"T567","span":{"begin":654,"end":661},"obj":"P42633"},{"id":"T568","span":{"begin":654,"end":661},"obj":"P67968"},{"id":"T569","span":{"begin":654,"end":661},"obj":"P01334"},{"id":"T570","span":{"begin":654,"end":661},"obj":"P67973"},{"id":"T571","span":{"begin":654,"end":661},"obj":"P01328"},{"id":"T572","span":{"begin":654,"end":661},"obj":"P81881"},{"id":"T573","span":{"begin":654,"end":661},"obj":"P01330"},{"id":"T574","span":{"begin":654,"end":661},"obj":"Q9W7R2"},{"id":"T575","span":{"begin":654,"end":661},"obj":"P09477"},{"id":"T576","span":{"begin":654,"end":661},"obj":"P01311"},{"id":"T577","span":{"begin":654,"end":661},"obj":"P01315"},{"id":"T578","span":{"begin":654,"end":661},"obj":"P06306"},{"id":"T579","span":{"begin":654,"end":661},"obj":"P01319"},{"id":"T580","span":{"begin":654,"end":661},"obj":"Q6YK33"},{"id":"T581","span":{"begin":654,"end":661},"obj":"P67971"},{"id":"T582","span":{"begin":654,"end":661},"obj":"Q62587"},{"id":"T583","span":{"begin":654,"end":661},"obj":"P68991"},{"id":"T584","span":{"begin":654,"end":661},"obj":"P12708"},{"id":"T585","span":{"begin":654,"end":661},"obj":"P04667"},{"id":"T587","span":{"begin":654,"end":661},"obj":"P68989"},{"id":"T588","span":{"begin":654,"end":661},"obj":"P01333"},{"id":"T589","span":{"begin":654,"end":661},"obj":"PR:000009054"},{"id":"T590","span":{"begin":654,"end":661},"obj":"P30410"},{"id":"T591","span":{"begin":654,"end":661},"obj":"P01331"},{"id":"T592","span":{"begin":654,"end":661},"obj":"P01314"},{"id":"T593","span":{"begin":654,"end":661},"obj":"P01320"},{"id":"T594","span":{"begin":654,"end":661},"obj":"P01318"},{"id":"T595","span":{"begin":654,"end":661},"obj":"P12703"},{"id":"T596","span":{"begin":654,"end":661},"obj":"C0HJI4"},{"id":"T597","span":{"begin":654,"end":661},"obj":"P30406"},{"id":"T598","span":{"begin":654,"end":661},"obj":"C0HJU0"},{"id":"T599","span":{"begin":654,"end":661},"obj":"P68992"},{"id":"T600","span":{"begin":654,"end":661},"obj":"P67970"},{"id":"T601","span":{"begin":654,"end":661},"obj":"P18109"},{"id":"T602","span":{"begin":654,"end":661},"obj":"Q9TQY7"},{"id":"T603","span":{"begin":654,"end":661},"obj":"O73727"},{"id":"T604","span":{"begin":654,"end":661},"obj":"P01329"},{"id":"T605","span":{"begin":654,"end":661},"obj":"P01324"},{"id":"T607","span":{"begin":654,"end":661},"obj":"P01335"},{"id":"T608","span":{"begin":654,"end":661},"obj":"P68243"},{"id":"T609","span":{"begin":654,"end":661},"obj":"P67972"},{"id":"T610","span":{"begin":654,"end":661},"obj":"P29335"},{"id":"T611","span":{"begin":654,"end":661},"obj":"P01342"},{"id":"T612","span":{"begin":654,"end":661},"obj":"P69048"},{"id":"T613","span":{"begin":654,"end":661},"obj":"P01313"},{"id":"T614","span":{"begin":654,"end":661},"obj":"P01316"},{"id":"T615","span":{"begin":654,"end":661},"obj":"P17715"},{"id":"T616","span":{"begin":654,"end":661},"obj":"P30407"},{"id":"T617","span":{"begin":654,"end":661},"obj":"P01339"},{"id":"T619","span":{"begin":654,"end":661},"obj":"P81025"},{"id":"T620","span":{"begin":654,"end":661},"obj":"P69045"},{"id":"T621","span":{"begin":654,"end":661},"obj":"P01317"},{"id":"T622","span":{"begin":654,"end":661},"obj":"P01310"},{"id":"T623","span":{"begin":654,"end":661},"obj":"Q98TA8"},{"id":"T624","span":{"begin":654,"end":661},"obj":"P67969"},{"id":"T625","span":{"begin":654,"end":661},"obj":"P0C236"},{"id":"T548","span":{"begin":654,"end":661},"obj":"CHEBI:5931"},{"id":"T554","span":{"begin":654,"end":661},"obj":"D007328"},{"id":"T586","span":{"begin":654,"end":661},"obj":"CHEBI:145810"},{"id":"T606","span":{"begin":654,"end":661},"obj":"D007328"},{"id":"T618","span":{"begin":654,"end":661},"obj":"GO:0016088"},{"id":"T626","span":{"begin":677,"end":684},"obj":"SO:0100018"},{"id":"T627","span":{"begin":677,"end":684},"obj":"SO:0001091"},{"id":"T628","span":{"begin":677,"end":684},"obj":"GO:0005488"},{"id":"T630","span":{"begin":690,"end":694},"obj":"PR:Q54DF9"},{"id":"T634","span":{"begin":690,"end":694},"obj":"PR:Q2FXA3"},{"id":"T635","span":{"begin":690,"end":694},"obj":"PR:P29680"},{"id":"T629","span":{"begin":690,"end":694},"obj":"CHEBI:17627"},{"id":"T631","span":{"begin":690,"end":694},"obj":"CHEBI:30413"},{"id":"T632","span":{"begin":690,"end":694},"obj":"D006418"},{"id":"T633","span":{"begin":690,"end":694},"obj":"CHEBI:26355"},{"id":"T636","span":{"begin":690,"end":694},"obj":"D006418"},{"id":"T637","span":{"begin":756,"end":764},"obj":"CHEBI:25367"},{"id":"T642","span":{"begin":788,"end":797},"obj":"5340"},{"id":"T641","span":{"begin":788,"end":797},"obj":"SO:0001452"},{"id":"T638","span":{"begin":788,"end":797},"obj":"D006639"},{"id":"T639","span":{"begin":788,"end":797},"obj":"CHEBI:15971"},{"id":"T640","span":{"begin":788,"end":797},"obj":"D006639"},{"id":"T643","span":{"begin":788,"end":797},"obj":"CHEBI:27570"},{"id":"T644","span":{"begin":804,"end":811},"obj":"P51463"},{"id":"T645","span":{"begin":804,"end":811},"obj":"Q91XI3"},{"id":"T646","span":{"begin":804,"end":811},"obj":"P01308"},{"id":"T647","span":{"begin":804,"end":811},"obj":"P01340"},{"id":"T648","span":{"begin":804,"end":811},"obj":"P07453"},{"id":"T649","span":{"begin":804,"end":811},"obj":"P68988"},{"id":"T650","span":{"begin":804,"end":811},"obj":"P21563"},{"id":"T651","span":{"begin":804,"end":811},"obj":"P68245"},{"id":"T652","span":{"begin":804,"end":811},"obj":"P68990"},{"id":"T654","span":{"begin":804,"end":811},"obj":"P09476"},{"id":"T655","span":{"begin":804,"end":811},"obj":"P69047"},{"id":"T656","span":{"begin":804,"end":811},"obj":"Q8HXV2"},{"id":"T657","span":{"begin":804,"end":811},"obj":"P12705"},{"id":"T658","span":{"begin":804,"end":811},"obj":"P68987"},{"id":"T660","span":{"begin":804,"end":811},"obj":"Q9NDE7"},{"id":"T661","span":{"begin":804,"end":811},"obj":"P13190"},{"id":"T662","span":{"begin":804,"end":811},"obj":"P01321"},{"id":"T663","span":{"begin":804,"end":811},"obj":"C0HJT9"},{"id":"T664","span":{"begin":804,"end":811},"obj":"P81423"},{"id":"T665","span":{"begin":804,"end":811},"obj":"P01327"},{"id":"T666","span":{"begin":804,"end":811},"obj":"P41522"},{"id":"T667","span":{"begin":804,"end":811},"obj":"C0HJI1"},{"id":"T668","span":{"begin":804,"end":811},"obj":"P01336"},{"id":"T669","span":{"begin":804,"end":811},"obj":"P67974"},{"id":"T670","span":{"begin":804,"end":811},"obj":"P69046"},{"id":"T671","span":{"begin":804,"end":811},"obj":"P12704"},{"id":"T672","span":{"begin":804,"end":811},"obj":"P42633"},{"id":"T673","span":{"begin":804,"end":811},"obj":"P67968"},{"id":"T674","span":{"begin":804,"end":811},"obj":"P01334"},{"id":"T675","span":{"begin":804,"end":811},"obj":"P67973"},{"id":"T676","span":{"begin":804,"end":811},"obj":"P01328"},{"id":"T677","span":{"begin":804,"end":811},"obj":"P81881"},{"id":"T678","span":{"begin":804,"end":811},"obj":"P01330"},{"id":"T679","span":{"begin":804,"end":811},"obj":"Q9W7R2"},{"id":"T680","span":{"begin":804,"end":811},"obj":"P09477"},{"id":"T681","span":{"begin":804,"end":811},"obj":"P01311"},{"id":"T682","span":{"begin":804,"end":811},"obj":"P01315"},{"id":"T683","span":{"begin":804,"end":811},"obj":"P06306"},{"id":"T684","span":{"begin":804,"end":811},"obj":"P01319"},{"id":"T685","span":{"begin":804,"end":811},"obj":"Q6YK33"},{"id":"T686","span":{"begin":804,"end":811},"obj":"P67971"},{"id":"T687","span":{"begin":804,"end":811},"obj":"Q62587"},{"id":"T688","span":{"begin":804,"end":811},"obj":"P68991"},{"id":"T689","span":{"begin":804,"end":811},"obj":"P12708"},{"id":"T690","span":{"begin":804,"end":811},"obj":"P04667"},{"id":"T692","span":{"begin":804,"end":811},"obj":"P68989"},{"id":"T693","span":{"begin":804,"end":811},"obj":"P01333"},{"id":"T694","span":{"begin":804,"end":811},"obj":"PR:000009054"},{"id":"T695","span":{"begin":804,"end":811},"obj":"P30410"},{"id":"T696","span":{"begin":804,"end":811},"obj":"P01331"},{"id":"T697","span":{"begin":804,"end":811},"obj":"P01314"},{"id":"T698","span":{"begin":804,"end":811},"obj":"P01320"},{"id":"T699","span":{"begin":804,"end":811},"obj":"P01318"},{"id":"T700","span":{"begin":804,"end":811},"obj":"P12703"},{"id":"T701","span":{"begin":804,"end":811},"obj":"C0HJI4"},{"id":"T702","span":{"begin":804,"end":811},"obj":"P30406"},{"id":"T703","span":{"begin":804,"end":811},"obj":"C0HJU0"},{"id":"T704","span":{"begin":804,"end":811},"obj":"P68992"},{"id":"T705","span":{"begin":804,"end":811},"obj":"P67970"},{"id":"T706","span":{"begin":804,"end":811},"obj":"P18109"},{"id":"T707","span":{"begin":804,"end":811},"obj":"Q9TQY7"},{"id":"T708","span":{"begin":804,"end":811},"obj":"O73727"},{"id":"T709","span":{"begin":804,"end":811},"obj":"P01329"},{"id":"T710","span":{"begin":804,"end":811},"obj":"P01324"},{"id":"T712","span":{"begin":804,"end":811},"obj":"P01335"},{"id":"T713","span":{"begin":804,"end":811},"obj":"P68243"},{"id":"T714","span":{"begin":804,"end":811},"obj":"P67972"},{"id":"T715","span":{"begin":804,"end":811},"obj":"P29335"},{"id":"T716","span":{"begin":804,"end":811},"obj":"P01342"},{"id":"T717","span":{"begin":804,"end":811},"obj":"P69048"},{"id":"T718","span":{"begin":804,"end":811},"obj":"P01313"},{"id":"T719","span":{"begin":804,"end":811},"obj":"P01316"},{"id":"T720","span":{"begin":804,"end":811},"obj":"P17715"},{"id":"T721","span":{"begin":804,"end":811},"obj":"P30407"},{"id":"T722","span":{"begin":804,"end":811},"obj":"P01339"},{"id":"T724","span":{"begin":804,"end":811},"obj":"P81025"},{"id":"T725","span":{"begin":804,"end":811},"obj":"P69045"},{"id":"T726","span":{"begin":804,"end":811},"obj":"P01317"},{"id":"T727","span":{"begin":804,"end":811},"obj":"P01310"},{"id":"T728","span":{"begin":804,"end":811},"obj":"Q98TA8"},{"id":"T729","span":{"begin":804,"end":811},"obj":"P67969"},{"id":"T730","span":{"begin":804,"end":811},"obj":"P0C236"},{"id":"T653","span":{"begin":804,"end":811},"obj":"CHEBI:5931"},{"id":"T659","span":{"begin":804,"end":811},"obj":"D007328"},{"id":"T691","span":{"begin":804,"end":811},"obj":"CHEBI:145810"},{"id":"T711","span":{"begin":804,"end":811},"obj":"D007328"},{"id":"T723","span":{"begin":804,"end":811},"obj":"GO:0016088"},{"id":"T732","span":{"begin":823,"end":827},"obj":"PR:Q54DF9"},{"id":"T736","span":{"begin":823,"end":827},"obj":"PR:Q2FXA3"},{"id":"T737","span":{"begin":823,"end":827},"obj":"PR:P29680"},{"id":"T731","span":{"begin":823,"end":827},"obj":"CHEBI:17627"},{"id":"T733","span":{"begin":823,"end":827},"obj":"CHEBI:30413"},{"id":"T734","span":{"begin":823,"end":827},"obj":"D006418"},{"id":"T735","span":{"begin":823,"end":827},"obj":"CHEBI:26355"},{"id":"T738","span":{"begin":823,"end":827},"obj":"D006418"},{"id":"T740","span":{"begin":853,"end":861},"obj":"10962"},{"id":"T744","span":{"begin":853,"end":861},"obj":"SO:0001446"},{"id":"T739","span":{"begin":853,"end":861},"obj":"D014443"},{"id":"T741","span":{"begin":853,"end":861},"obj":"CHEBI:18186"},{"id":"T742","span":{"begin":853,"end":861},"obj":"CHEBI:32783"},{"id":"T743","span":{"begin":853,"end":861},"obj":"CHEBI:17895"},{"id":"T745","span":{"begin":853,"end":861},"obj":"D014443"},{"id":"T746","span":{"begin":867,"end":880},"obj":"8156"},{"id":"T747","span":{"begin":867,"end":880},"obj":"SO:0001441"},{"id":"T748","span":{"begin":867,"end":880},"obj":"CHEBI:17295"},{"id":"T749","span":{"begin":867,"end":880},"obj":"D010649"},{"id":"T750","span":{"begin":867,"end":880},"obj":"D010649"},{"id":"T751","span":{"begin":867,"end":880},"obj":"CHEBI:58095"},{"id":"T752","span":{"begin":867,"end":880},"obj":"CHEBI:28044"},{"id":"T758","span":{"begin":888,"end":894},"obj":"11115"},{"id":"T757","span":{"begin":888,"end":894},"obj":"SO:0001436"},{"id":"T753","span":{"begin":888,"end":894},"obj":"CHEBI:16414"},{"id":"T754","span":{"begin":888,"end":894},"obj":"D014633"},{"id":"T755","span":{"begin":888,"end":894},"obj":"D014633"},{"id":"T756","span":{"begin":888,"end":894},"obj":"CHEBI:27266"},{"id":"T759","span":{"begin":922,"end":929},"obj":"SO:0100018"},{"id":"T760","span":{"begin":922,"end":929},"obj":"SO:0001091"},{"id":"T761","span":{"begin":922,"end":929},"obj":"GO:0005488"},{"id":"T763","span":{"begin":930,"end":934},"obj":"PR:Q54DF9"},{"id":"T767","span":{"begin":930,"end":934},"obj":"PR:Q2FXA3"},{"id":"T768","span":{"begin":930,"end":934},"obj":"PR:P29680"},{"id":"T762","span":{"begin":930,"end":934},"obj":"CHEBI:17627"},{"id":"T764","span":{"begin":930,"end":934},"obj":"CHEBI:30413"},{"id":"T765","span":{"begin":930,"end":934},"obj":"D006418"},{"id":"T766","span":{"begin":930,"end":934},"obj":"CHEBI:26355"},{"id":"T769","span":{"begin":930,"end":934},"obj":"D006418"},{"id":"T770","span":{"begin":940,"end":947},"obj":"SO:0100018"},{"id":"T771","span":{"begin":940,"end":947},"obj":"SO:0001091"},{"id":"T772","span":{"begin":940,"end":947},"obj":"GO:0005488"},{"id":"T773","span":{"begin":962,"end":972},"obj":"P15984"},{"id":"T774","span":{"begin":962,"end":972},"obj":"Q9SCX8"},{"id":"T775","span":{"begin":962,"end":972},"obj":"P85957"},{"id":"T776","span":{"begin":962,"end":972},"obj":"Q01603"},{"id":"T777","span":{"begin":962,"end":972},"obj":"Q55080"},{"id":"T778","span":{"begin":962,"end":972},"obj":"P85317"},{"id":"T779","span":{"begin":962,"end":972},"obj":"Q05855"},{"id":"T780","span":{"begin":962,"end":972},"obj":"A8NK72"},{"id":"T781","span":{"begin":962,"end":972},"obj":"P84714"},{"id":"T784","span":{"begin":962,"end":972},"obj":"P28313"},{"id":"T785","span":{"begin":962,"end":972},"obj":"P28314"},{"id":"T786","span":{"begin":962,"end":972},"obj":"P16147"},{"id":"T788","span":{"begin":962,"end":972},"obj":"B3EWG7"},{"id":"T782","span":{"begin":962,"end":972},"obj":"D009195"},{"id":"T783","span":{"begin":962,"end":972},"obj":"CHEBI:8027"},{"id":"T787","span":{"begin":962,"end":972},"obj":"1600930"},{"id":"T789","span":{"begin":962,"end":981},"obj":"GO:0004601"},{"id":"T791","span":{"begin":985,"end":989},"obj":"PR:Q54DF9"},{"id":"T795","span":{"begin":985,"end":989},"obj":"PR:Q2FXA3"},{"id":"T796","span":{"begin":985,"end":989},"obj":"PR:P29680"},{"id":"T790","span":{"begin":985,"end":989},"obj":"CHEBI:17627"},{"id":"T792","span":{"begin":985,"end":989},"obj":"CHEBI:30413"},{"id":"T793","span":{"begin":985,"end":989},"obj":"D006418"},{"id":"T794","span":{"begin":985,"end":989},"obj":"CHEBI:26355"},{"id":"T797","span":{"begin":985,"end":989},"obj":"D006418"},{"id":"T798","span":{"begin":1047,"end":1059},"obj":"GO:0009405"},{"id":"T799","span":{"begin":1100,"end":1107},"obj":"P51463"},{"id":"T800","span":{"begin":1100,"end":1107},"obj":"Q91XI3"},{"id":"T801","span":{"begin":1100,"end":1107},"obj":"P01308"},{"id":"T802","span":{"begin":1100,"end":1107},"obj":"P01340"},{"id":"T803","span":{"begin":1100,"end":1107},"obj":"P07453"},{"id":"T804","span":{"begin":1100,"end":1107},"obj":"P68988"},{"id":"T805","span":{"begin":1100,"end":1107},"obj":"P21563"},{"id":"T806","span":{"begin":1100,"end":1107},"obj":"P68245"},{"id":"T807","span":{"begin":1100,"end":1107},"obj":"P68990"},{"id":"T809","span":{"begin":1100,"end":1107},"obj":"P09476"},{"id":"T810","span":{"begin":1100,"end":1107},"obj":"P69047"},{"id":"T811","span":{"begin":1100,"end":1107},"obj":"Q8HXV2"},{"id":"T812","span":{"begin":1100,"end":1107},"obj":"P12705"},{"id":"T813","span":{"begin":1100,"end":1107},"obj":"P68987"},{"id":"T815","span":{"begin":1100,"end":1107},"obj":"Q9NDE7"},{"id":"T816","span":{"begin":1100,"end":1107},"obj":"P13190"},{"id":"T817","span":{"begin":1100,"end":1107},"obj":"P01321"},{"id":"T818","span":{"begin":1100,"end":1107},"obj":"C0HJT9"},{"id":"T819","span":{"begin":1100,"end":1107},"obj":"P81423"},{"id":"T820","span":{"begin":1100,"end":1107},"obj":"P01327"},{"id":"T821","span":{"begin":1100,"end":1107},"obj":"P41522"},{"id":"T822","span":{"begin":1100,"end":1107},"obj":"C0HJI1"},{"id":"T823","span":{"begin":1100,"end":1107},"obj":"P01336"},{"id":"T824","span":{"begin":1100,"end":1107},"obj":"P67974"},{"id":"T825","span":{"begin":1100,"end":1107},"obj":"P69046"},{"id":"T826","span":{"begin":1100,"end":1107},"obj":"P12704"},{"id":"T827","span":{"begin":1100,"end":1107},"obj":"P42633"},{"id":"T828","span":{"begin":1100,"end":1107},"obj":"P67968"},{"id":"T829","span":{"begin":1100,"end":1107},"obj":"P01334"},{"id":"T830","span":{"begin":1100,"end":1107},"obj":"P67973"},{"id":"T831","span":{"begin":1100,"end":1107},"obj":"P01328"},{"id":"T832","span":{"begin":1100,"end":1107},"obj":"P81881"},{"id":"T833","span":{"begin":1100,"end":1107},"obj":"P01330"},{"id":"T834","span":{"begin":1100,"end":1107},"obj":"Q9W7R2"},{"id":"T835","span":{"begin":1100,"end":1107},"obj":"P09477"},{"id":"T836","span":{"begin":1100,"end":1107},"obj":"P01311"},{"id":"T837","span":{"begin":1100,"end":1107},"obj":"P01315"},{"id":"T838","span":{"begin":1100,"end":1107},"obj":"P06306"},{"id":"T839","span":{"begin":1100,"end":1107},"obj":"P01319"},{"id":"T840","span":{"begin":1100,"end":1107},"obj":"Q6YK33"},{"id":"T841","span":{"begin":1100,"end":1107},"obj":"P67971"},{"id":"T842","span":{"begin":1100,"end":1107},"obj":"Q62587"},{"id":"T843","span":{"begin":1100,"end":1107},"obj":"P68991"},{"id":"T844","span":{"begin":1100,"end":1107},"obj":"P12708"},{"id":"T845","span":{"begin":1100,"end":1107},"obj":"P04667"},{"id":"T847","span":{"begin":1100,"end":1107},"obj":"P68989"},{"id":"T848","span":{"begin":1100,"end":1107},"obj":"P01333"},{"id":"T849","span":{"begin":1100,"end":1107},"obj":"PR:000009054"},{"id":"T850","span":{"begin":1100,"end":1107},"obj":"P30410"},{"id":"T851","span":{"begin":1100,"end":1107},"obj":"P01331"},{"id":"T852","span":{"begin":1100,"end":1107},"obj":"P01314"},{"id":"T853","span":{"begin":1100,"end":1107},"obj":"P01320"},{"id":"T854","span":{"begin":1100,"end":1107},"obj":"P01318"},{"id":"T855","span":{"begin":1100,"end":1107},"obj":"P12703"},{"id":"T856","span":{"begin":1100,"end":1107},"obj":"C0HJI4"},{"id":"T857","span":{"begin":1100,"end":1107},"obj":"P30406"},{"id":"T858","span":{"begin":1100,"end":1107},"obj":"C0HJU0"},{"id":"T859","span":{"begin":1100,"end":1107},"obj":"P68992"},{"id":"T860","span":{"begin":1100,"end":1107},"obj":"P67970"},{"id":"T861","span":{"begin":1100,"end":1107},"obj":"P18109"},{"id":"T862","span":{"begin":1100,"end":1107},"obj":"Q9TQY7"},{"id":"T863","span":{"begin":1100,"end":1107},"obj":"O73727"},{"id":"T864","span":{"begin":1100,"end":1107},"obj":"P01329"},{"id":"T865","span":{"begin":1100,"end":1107},"obj":"P01324"},{"id":"T867","span":{"begin":1100,"end":1107},"obj":"P01335"},{"id":"T868","span":{"begin":1100,"end":1107},"obj":"P68243"},{"id":"T869","span":{"begin":1100,"end":1107},"obj":"P67972"},{"id":"T870","span":{"begin":1100,"end":1107},"obj":"P29335"},{"id":"T871","span":{"begin":1100,"end":1107},"obj":"P01342"},{"id":"T872","span":{"begin":1100,"end":1107},"obj":"P69048"},{"id":"T873","span":{"begin":1100,"end":1107},"obj":"P01313"},{"id":"T874","span":{"begin":1100,"end":1107},"obj":"P01316"},{"id":"T875","span":{"begin":1100,"end":1107},"obj":"P17715"},{"id":"T876","span":{"begin":1100,"end":1107},"obj":"P30407"},{"id":"T877","span":{"begin":1100,"end":1107},"obj":"P01339"},{"id":"T879","span":{"begin":1100,"end":1107},"obj":"P81025"},{"id":"T880","span":{"begin":1100,"end":1107},"obj":"P69045"},{"id":"T881","span":{"begin":1100,"end":1107},"obj":"P01317"},{"id":"T882","span":{"begin":1100,"end":1107},"obj":"P01310"},{"id":"T883","span":{"begin":1100,"end":1107},"obj":"Q98TA8"},{"id":"T884","span":{"begin":1100,"end":1107},"obj":"P67969"},{"id":"T885","span":{"begin":1100,"end":1107},"obj":"P0C236"},{"id":"T808","span":{"begin":1100,"end":1107},"obj":"CHEBI:5931"},{"id":"T814","span":{"begin":1100,"end":1107},"obj":"D007328"},{"id":"T846","span":{"begin":1100,"end":1107},"obj":"CHEBI:145810"},{"id":"T866","span":{"begin":1100,"end":1107},"obj":"D007328"},{"id":"T878","span":{"begin":1100,"end":1107},"obj":"GO:0016088"},{"id":"T886","span":{"begin":1154,"end":1161},"obj":"P51463"},{"id":"T887","span":{"begin":1154,"end":1161},"obj":"Q91XI3"},{"id":"T888","span":{"begin":1154,"end":1161},"obj":"P01308"},{"id":"T889","span":{"begin":1154,"end":1161},"obj":"P01340"},{"id":"T890","span":{"begin":1154,"end":1161},"obj":"P07453"},{"id":"T891","span":{"begin":1154,"end":1161},"obj":"P68988"},{"id":"T892","span":{"begin":1154,"end":1161},"obj":"P21563"},{"id":"T893","span":{"begin":1154,"end":1161},"obj":"P68245"},{"id":"T894","span":{"begin":1154,"end":1161},"obj":"P68990"},{"id":"T896","span":{"begin":1154,"end":1161},"obj":"P09476"},{"id":"T897","span":{"begin":1154,"end":1161},"obj":"P69047"},{"id":"T898","span":{"begin":1154,"end":1161},"obj":"Q8HXV2"},{"id":"T899","span":{"begin":1154,"end":1161},"obj":"P12705"},{"id":"T900","span":{"begin":1154,"end":1161},"obj":"P68987"},{"id":"T902","span":{"begin":1154,"end":1161},"obj":"Q9NDE7"},{"id":"T903","span":{"begin":1154,"end":1161},"obj":"P13190"},{"id":"T904","span":{"begin":1154,"end":1161},"obj":"P01321"},{"id":"T905","span":{"begin":1154,"end":1161},"obj":"C0HJT9"},{"id":"T906","span":{"begin":1154,"end":1161},"obj":"P81423"},{"id":"T907","span":{"begin":1154,"end":1161},"obj":"P01327"},{"id":"T908","span":{"begin":1154,"end":1161},"obj":"P41522"},{"id":"T909","span":{"begin":1154,"end":1161},"obj":"C0HJI1"},{"id":"T910","span":{"begin":1154,"end":1161},"obj":"P01336"},{"id":"T911","span":{"begin":1154,"end":1161},"obj":"P67974"},{"id":"T912","span":{"begin":1154,"end":1161},"obj":"P69046"},{"id":"T913","span":{"begin":1154,"end":1161},"obj":"P12704"},{"id":"T914","span":{"begin":1154,"end":1161},"obj":"P42633"},{"id":"T915","span":{"begin":1154,"end":1161},"obj":"P67968"},{"id":"T916","span":{"begin":1154,"end":1161},"obj":"P01334"},{"id":"T917","span":{"begin":1154,"end":1161},"obj":"P67973"},{"id":"T918","span":{"begin":1154,"end":1161},"obj":"P01328"},{"id":"T919","span":{"begin":1154,"end":1161},"obj":"P81881"},{"id":"T920","span":{"begin":1154,"end":1161},"obj":"P01330"},{"id":"T921","span":{"begin":1154,"end":1161},"obj":"Q9W7R2"},{"id":"T922","span":{"begin":1154,"end":1161},"obj":"P09477"},{"id":"T923","span":{"begin":1154,"end":1161},"obj":"P01311"},{"id":"T924","span":{"begin":1154,"end":1161},"obj":"P01315"},{"id":"T925","span":{"begin":1154,"end":1161},"obj":"P06306"},{"id":"T926","span":{"begin":1154,"end":1161},"obj":"P01319"},{"id":"T927","span":{"begin":1154,"end":1161},"obj":"Q6YK33"},{"id":"T928","span":{"begin":1154,"end":1161},"obj":"P67971"},{"id":"T929","span":{"begin":1154,"end":1161},"obj":"Q62587"},{"id":"T930","span":{"begin":1154,"end":1161},"obj":"P68991"},{"id":"T931","span":{"begin":1154,"end":1161},"obj":"P12708"},{"id":"T932","span":{"begin":1154,"end":1161},"obj":"P04667"},{"id":"T934","span":{"begin":1154,"end":1161},"obj":"P68989"},{"id":"T935","span":{"begin":1154,"end":1161},"obj":"P01333"},{"id":"T936","span":{"begin":1154,"end":1161},"obj":"PR:000009054"},{"id":"T937","span":{"begin":1154,"end":1161},"obj":"P30410"},{"id":"T938","span":{"begin":1154,"end":1161},"obj":"P01331"},{"id":"T939","span":{"begin":1154,"end":1161},"obj":"P01314"},{"id":"T940","span":{"begin":1154,"end":1161},"obj":"P01320"},{"id":"T941","span":{"begin":1154,"end":1161},"obj":"P01318"},{"id":"T942","span":{"begin":1154,"end":1161},"obj":"P12703"},{"id":"T943","span":{"begin":1154,"end":1161},"obj":"C0HJI4"},{"id":"T944","span":{"begin":1154,"end":1161},"obj":"P30406"},{"id":"T945","span":{"begin":1154,"end":1161},"obj":"C0HJU0"},{"id":"T946","span":{"begin":1154,"end":1161},"obj":"P68992"},{"id":"T947","span":{"begin":1154,"end":1161},"obj":"P67970"},{"id":"T948","span":{"begin":1154,"end":1161},"obj":"P18109"},{"id":"T949","span":{"begin":1154,"end":1161},"obj":"Q9TQY7"},{"id":"T950","span":{"begin":1154,"end":1161},"obj":"O73727"},{"id":"T951","span":{"begin":1154,"end":1161},"obj":"P01329"},{"id":"T952","span":{"begin":1154,"end":1161},"obj":"P01324"},{"id":"T954","span":{"begin":1154,"end":1161},"obj":"P01335"},{"id":"T955","span":{"begin":1154,"end":1161},"obj":"P68243"},{"id":"T956","span":{"begin":1154,"end":1161},"obj":"P67972"},{"id":"T957","span":{"begin":1154,"end":1161},"obj":"P29335"},{"id":"T958","span":{"begin":1154,"end":1161},"obj":"P01342"},{"id":"T959","span":{"begin":1154,"end":1161},"obj":"P69048"},{"id":"T960","span":{"begin":1154,"end":1161},"obj":"P01313"},{"id":"T961","span":{"begin":1154,"end":1161},"obj":"P01316"},{"id":"T962","span":{"begin":1154,"end":1161},"obj":"P17715"},{"id":"T963","span":{"begin":1154,"end":1161},"obj":"P30407"},{"id":"T964","span":{"begin":1154,"end":1161},"obj":"P01339"},{"id":"T966","span":{"begin":1154,"end":1161},"obj":"P81025"},{"id":"T967","span":{"begin":1154,"end":1161},"obj":"P69045"},{"id":"T968","span":{"begin":1154,"end":1161},"obj":"P01317"},{"id":"T969","span":{"begin":1154,"end":1161},"obj":"P01310"},{"id":"T970","span":{"begin":1154,"end":1161},"obj":"Q98TA8"},{"id":"T971","span":{"begin":1154,"end":1161},"obj":"P67969"},{"id":"T972","span":{"begin":1154,"end":1161},"obj":"P0C236"},{"id":"T895","span":{"begin":1154,"end":1161},"obj":"CHEBI:5931"},{"id":"T901","span":{"begin":1154,"end":1161},"obj":"D007328"},{"id":"T933","span":{"begin":1154,"end":1161},"obj":"CHEBI:145810"},{"id":"T953","span":{"begin":1154,"end":1161},"obj":"D007328"},{"id":"T965","span":{"begin":1154,"end":1161},"obj":"GO:0016088"},{"id":"T977","span":{"begin":1203,"end":1210},"obj":"SO:0000104"},{"id":"T976","span":{"begin":1203,"end":1210},"obj":"PR:000000001"},{"id":"T973","span":{"begin":1203,"end":1210},"obj":"GO:0003675"},{"id":"T978","span":{"begin":1203,"end":1219},"obj":"CHEBI:16484"},{"id":"T980","span":{"begin":1211,"end":1219},"obj":"10962"},{"id":"T984","span":{"begin":1211,"end":1219},"obj":"SO:0001446"},{"id":"T986","span":{"begin":1220,"end":1229},"obj":"MOP:0000556"},{"id":"T987","span":{"begin":1265,"end":1273},"obj":"CHEBI:36080"},{"id":"T1002","span":{"begin":1357,"end":1367},"obj":"1600930"},{"id":"T988","span":{"begin":1357,"end":1367},"obj":"P15984"},{"id":"T989","span":{"begin":1357,"end":1367},"obj":"Q9SCX8"},{"id":"T990","span":{"begin":1357,"end":1367},"obj":"P85957"},{"id":"T991","span":{"begin":1357,"end":1367},"obj":"Q01603"},{"id":"T992","span":{"begin":1357,"end":1367},"obj":"Q55080"},{"id":"T993","span":{"begin":1357,"end":1367},"obj":"P85317"},{"id":"T994","span":{"begin":1357,"end":1367},"obj":"Q05855"},{"id":"T995","span":{"begin":1357,"end":1367},"obj":"A8NK72"},{"id":"T996","span":{"begin":1357,"end":1367},"obj":"P84714"},{"id":"T999","span":{"begin":1357,"end":1367},"obj":"P28313"},{"id":"T1000","span":{"begin":1357,"end":1367},"obj":"P28314"},{"id":"T1001","span":{"begin":1357,"end":1367},"obj":"P16147"},{"id":"T1003","span":{"begin":1357,"end":1367},"obj":"B3EWG7"},{"id":"T997","span":{"begin":1357,"end":1367},"obj":"D009195"},{"id":"T998","span":{"begin":1357,"end":1367},"obj":"CHEBI:8027"},{"id":"T1004","span":{"begin":1357,"end":1376},"obj":"GO:0004601"},{"id":"T1006","span":{"begin":1380,"end":1384},"obj":"PR:Q54DF9"},{"id":"T1010","span":{"begin":1380,"end":1384},"obj":"PR:Q2FXA3"},{"id":"T1011","span":{"begin":1380,"end":1384},"obj":"PR:P29680"},{"id":"T1005","span":{"begin":1380,"end":1384},"obj":"CHEBI:17627"},{"id":"T1007","span":{"begin":1380,"end":1384},"obj":"CHEBI:30413"},{"id":"T1008","span":{"begin":1380,"end":1384},"obj":"D006418"},{"id":"T1009","span":{"begin":1380,"end":1384},"obj":"CHEBI:26355"},{"id":"T1012","span":{"begin":1380,"end":1384},"obj":"D006418"},{"id":"T1013","span":{"begin":1393,"end":1400},"obj":"SO:0100018"},{"id":"T1014","span":{"begin":1393,"end":1400},"obj":"SO:0001091"},{"id":"T1015","span":{"begin":1393,"end":1400},"obj":"GO:0005488"},{"id":"T1016","span":{"begin":1406,"end":1413},"obj":"P51463"},{"id":"T1017","span":{"begin":1406,"end":1413},"obj":"Q91XI3"},{"id":"T1018","span":{"begin":1406,"end":1413},"obj":"P01308"},{"id":"T1019","span":{"begin":1406,"end":1413},"obj":"P01340"},{"id":"T1020","span":{"begin":1406,"end":1413},"obj":"P07453"},{"id":"T1021","span":{"begin":1406,"end":1413},"obj":"P68988"},{"id":"T1022","span":{"begin":1406,"end":1413},"obj":"P21563"},{"id":"T1023","span":{"begin":1406,"end":1413},"obj":"P68245"},{"id":"T1024","span":{"begin":1406,"end":1413},"obj":"P68990"},{"id":"T1026","span":{"begin":1406,"end":1413},"obj":"P09476"},{"id":"T1027","span":{"begin":1406,"end":1413},"obj":"P69047"},{"id":"T1028","span":{"begin":1406,"end":1413},"obj":"Q8HXV2"},{"id":"T1029","span":{"begin":1406,"end":1413},"obj":"P12705"},{"id":"T1030","span":{"begin":1406,"end":1413},"obj":"P68987"},{"id":"T1032","span":{"begin":1406,"end":1413},"obj":"Q9NDE7"},{"id":"T1033","span":{"begin":1406,"end":1413},"obj":"P13190"},{"id":"T1034","span":{"begin":1406,"end":1413},"obj":"P01321"},{"id":"T1035","span":{"begin":1406,"end":1413},"obj":"C0HJT9"},{"id":"T1036","span":{"begin":1406,"end":1413},"obj":"P81423"},{"id":"T1037","span":{"begin":1406,"end":1413},"obj":"P01327"},{"id":"T1038","span":{"begin":1406,"end":1413},"obj":"P41522"},{"id":"T1039","span":{"begin":1406,"end":1413},"obj":"C0HJI1"},{"id":"T1040","span":{"begin":1406,"end":1413},"obj":"P01336"},{"id":"T1041","span":{"begin":1406,"end":1413},"obj":"P67974"},{"id":"T1042","span":{"begin":1406,"end":1413},"obj":"P69046"},{"id":"T1043","span":{"begin":1406,"end":1413},"obj":"P12704"},{"id":"T1044","span":{"begin":1406,"end":1413},"obj":"P42633"},{"id":"T1045","span":{"begin":1406,"end":1413},"obj":"P67968"},{"id":"T1046","span":{"begin":1406,"end":1413},"obj":"P01334"},{"id":"T1047","span":{"begin":1406,"end":1413},"obj":"P67973"},{"id":"T1048","span":{"begin":1406,"end":1413},"obj":"P01328"},{"id":"T1049","span":{"begin":1406,"end":1413},"obj":"P81881"},{"id":"T1050","span":{"begin":1406,"end":1413},"obj":"P01330"},{"id":"T1051","span":{"begin":1406,"end":1413},"obj":"Q9W7R2"},{"id":"T1052","span":{"begin":1406,"end":1413},"obj":"P09477"},{"id":"T1053","span":{"begin":1406,"end":1413},"obj":"P01311"},{"id":"T1054","span":{"begin":1406,"end":1413},"obj":"P01315"},{"id":"T1055","span":{"begin":1406,"end":1413},"obj":"P06306"},{"id":"T1056","span":{"begin":1406,"end":1413},"obj":"P01319"},{"id":"T1057","span":{"begin":1406,"end":1413},"obj":"Q6YK33"},{"id":"T1058","span":{"begin":1406,"end":1413},"obj":"P67971"},{"id":"T1059","span":{"begin":1406,"end":1413},"obj":"Q62587"},{"id":"T1060","span":{"begin":1406,"end":1413},"obj":"P68991"},{"id":"T1061","span":{"begin":1406,"end":1413},"obj":"P12708"},{"id":"T1062","span":{"begin":1406,"end":1413},"obj":"P04667"},{"id":"T1064","span":{"begin":1406,"end":1413},"obj":"P68989"},{"id":"T1065","span":{"begin":1406,"end":1413},"obj":"P01333"},{"id":"T1066","span":{"begin":1406,"end":1413},"obj":"PR:000009054"},{"id":"T1067","span":{"begin":1406,"end":1413},"obj":"P30410"},{"id":"T1068","span":{"begin":1406,"end":1413},"obj":"P01331"},{"id":"T1069","span":{"begin":1406,"end":1413},"obj":"P01314"},{"id":"T1070","span":{"begin":1406,"end":1413},"obj":"P01320"},{"id":"T1071","span":{"begin":1406,"end":1413},"obj":"P01318"},{"id":"T1072","span":{"begin":1406,"end":1413},"obj":"P12703"},{"id":"T1073","span":{"begin":1406,"end":1413},"obj":"C0HJI4"},{"id":"T1074","span":{"begin":1406,"end":1413},"obj":"P30406"},{"id":"T1075","span":{"begin":1406,"end":1413},"obj":"C0HJU0"},{"id":"T1076","span":{"begin":1406,"end":1413},"obj":"P68992"},{"id":"T1077","span":{"begin":1406,"end":1413},"obj":"P67970"},{"id":"T1078","span":{"begin":1406,"end":1413},"obj":"P18109"},{"id":"T1079","span":{"begin":1406,"end":1413},"obj":"Q9TQY7"},{"id":"T1080","span":{"begin":1406,"end":1413},"obj":"O73727"},{"id":"T1081","span":{"begin":1406,"end":1413},"obj":"P01329"},{"id":"T1082","span":{"begin":1406,"end":1413},"obj":"P01324"},{"id":"T1084","span":{"begin":1406,"end":1413},"obj":"P01335"},{"id":"T1085","span":{"begin":1406,"end":1413},"obj":"P68243"},{"id":"T1086","span":{"begin":1406,"end":1413},"obj":"P67972"},{"id":"T1087","span":{"begin":1406,"end":1413},"obj":"P29335"},{"id":"T1088","span":{"begin":1406,"end":1413},"obj":"P01342"},{"id":"T1089","span":{"begin":1406,"end":1413},"obj":"P69048"},{"id":"T1090","span":{"begin":1406,"end":1413},"obj":"P01313"},{"id":"T1091","span":{"begin":1406,"end":1413},"obj":"P01316"},{"id":"T1092","span":{"begin":1406,"end":1413},"obj":"P17715"},{"id":"T1093","span":{"begin":1406,"end":1413},"obj":"P30407"},{"id":"T1094","span":{"begin":1406,"end":1413},"obj":"P01339"},{"id":"T1096","span":{"begin":1406,"end":1413},"obj":"P81025"},{"id":"T1097","span":{"begin":1406,"end":1413},"obj":"P69045"},{"id":"T1098","span":{"begin":1406,"end":1413},"obj":"P01317"},{"id":"T1099","span":{"begin":1406,"end":1413},"obj":"P01310"},{"id":"T1100","span":{"begin":1406,"end":1413},"obj":"Q98TA8"},{"id":"T1101","span":{"begin":1406,"end":1413},"obj":"P67969"},{"id":"T1102","span":{"begin":1406,"end":1413},"obj":"P0C236"},{"id":"T1025","span":{"begin":1406,"end":1413},"obj":"CHEBI:5931"},{"id":"T1031","span":{"begin":1406,"end":1413},"obj":"D007328"},{"id":"T1063","span":{"begin":1406,"end":1413},"obj":"CHEBI:145810"},{"id":"T1083","span":{"begin":1406,"end":1413},"obj":"D007328"},{"id":"T1095","span":{"begin":1406,"end":1413},"obj":"GO:0016088"},{"id":"T1103","span":{"begin":1468,"end":1480},"obj":"GO:0009405"},{"id":"T1105","span":{"begin":1497,"end":1501},"obj":"PR:Q54DF9"},{"id":"T1109","span":{"begin":1497,"end":1501},"obj":"PR:Q2FXA3"},{"id":"T1110","span":{"begin":1497,"end":1501},"obj":"PR:P29680"},{"id":"T1104","span":{"begin":1497,"end":1501},"obj":"CHEBI:17627"},{"id":"T1106","span":{"begin":1497,"end":1501},"obj":"CHEBI:30413"},{"id":"T1107","span":{"begin":1497,"end":1501},"obj":"D006418"},{"id":"T1108","span":{"begin":1497,"end":1501},"obj":"CHEBI:26355"},{"id":"T1111","span":{"begin":1497,"end":1501},"obj":"D006418"}],"text":"Insulin enhances the peroxidase activity of heme by forming heme-insulin complex: Relevance to type 2 diabetes mellitus.\nEvidences have implicated the involvement of heme in the type 2 diabetes mellitus (T2Dm) pathogenesis, but possible mediators linking between heme and diabetes are still poorly understood. Here, we explored a potential mechanism that linked heme, insulin and diabetes. Our results demonstrated the formation of heme-insulin complex by two classical methods, i.e. UV-vis and capillary electrophoresis-frontal analysis (CE-FA). UV-vis results implied heme binding insulin via bis-histidine sites, and CE-FA further revealed that, when insulin uses two sites binding with heme, this interaction occurs at high affinity (Kd=3.13×10(-6)M). Molecule docking supported that histidine-B5 of insulin binds with heme-Fe. In addition to that, tyrosine-B26, phenylalanine-B1 and valine-B2 are also contributed to binding heme. The binding amplified the peroxidase activity of heme itself. Under oxidative and nitrative stress, it affects pathogenesis of diabetes from two aspects: promoting insulin cross-linking that leads to permanent loss of insulin functionality on one hand, and enhancing protein tyrosine nitration that may result in inactivation of proteins associated with diabetes on the other hand. This study suggested that the enhanced peroxidase activity of heme through binding with insulin might be a previously unrecognized contributor to the pathogenesis of T2Dm in some heme-associated disorders."}

{"project":"PubMed_ArguminSci","denotations":[{"id":"T1","span":{"begin":121,"end":309},"obj":"DRI_Background"},{"id":"T2","span":{"begin":310,"end":389},"obj":"DRI_Challenge"},{"id":"T3","span":{"begin":390,"end":483},"obj":"DRI_Outcome"},{"id":"T4","span":{"begin":547,"end":755},"obj":"DRI_Background"},{"id":"T5","span":{"begin":756,"end":831},"obj":"DRI_Approach"},{"id":"T6","span":{"begin":832,"end":935},"obj":"DRI_Background"},{"id":"T7","span":{"begin":936,"end":997},"obj":"DRI_Approach"},{"id":"T8","span":{"begin":998,"end":1317},"obj":"DRI_Background"},{"id":"T9","span":{"begin":1318,"end":1523},"obj":"DRI_Challenge"}],"text":"Insulin enhances the peroxidase activity of heme by forming heme-insulin complex: Relevance to type 2 diabetes mellitus.\nEvidences have implicated the involvement of heme in the type 2 diabetes mellitus (T2Dm) pathogenesis, but possible mediators linking between heme and diabetes are still poorly understood. Here, we explored a potential mechanism that linked heme, insulin and diabetes. Our results demonstrated the formation of heme-insulin complex by two classical methods, i.e. UV-vis and capillary electrophoresis-frontal analysis (CE-FA). UV-vis results implied heme binding insulin via bis-histidine sites, and CE-FA further revealed that, when insulin uses two sites binding with heme, this interaction occurs at high affinity (Kd=3.13×10(-6)M). Molecule docking supported that histidine-B5 of insulin binds with heme-Fe. In addition to that, tyrosine-B26, phenylalanine-B1 and valine-B2 are also contributed to binding heme. The binding amplified the peroxidase activity of heme itself. Under oxidative and nitrative stress, it affects pathogenesis of diabetes from two aspects: promoting insulin cross-linking that leads to permanent loss of insulin functionality on one hand, and enhancing protein tyrosine nitration that may result in inactivation of proteins associated with diabetes on the other hand. This study suggested that the enhanced peroxidase activity of heme through binding with insulin might be a previously unrecognized contributor to the pathogenesis of T2Dm in some heme-associated disorders."}

{"project":"Goldhamster2_Cellosaurus","denotations":[{"id":"T1","span":{"begin":32,"end":40},"obj":"CVCL_C410|Hybridoma|Mus musculus"},{"id":"T2","span":{"begin":316,"end":318},"obj":"CVCL_5M23|Cancer_cell_line|Mesocricetus auratus"},{"id":"T3","span":{"begin":328,"end":329},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"},{"id":"T4","span":{"begin":539,"end":541},"obj":"CVCL_6D96|Spontaneously_immortalized_cell_line|Oryzias celebensis"},{"id":"T5","span":{"begin":620,"end":622},"obj":"CVCL_6D96|Spontaneously_immortalized_cell_line|Oryzias celebensis"},{"id":"T6","span":{"begin":798,"end":800},"obj":"CVCL_J748|Hybridoma|Mus musculus"},{"id":"T7","span":{"begin":798,"end":800},"obj":"CVCL_J979|Hybridoma|Mus musculus"},{"id":"T8","span":{"begin":881,"end":883},"obj":"CVCL_J977|Hybridoma|Mus musculus"},{"id":"T9","span":{"begin":881,"end":883},"obj":"CVCL_U437|Spontaneously_immortalized_cell_line|Cricetulus griseus"},{"id":"T10","span":{"begin":895,"end":897},"obj":"CVCL_5352|Spontaneously_immortalized_cell_line|Rattus norvegicus"},{"id":"T11","span":{"begin":895,"end":897},"obj":"CVCL_U440|Spontaneously_immortalized_cell_line|Cricetulus griseus"},{"id":"T12","span":{"begin":973,"end":981},"obj":"CVCL_C410|Hybridoma|Mus musculus"},{"id":"T13","span":{"begin":1179,"end":1182},"obj":"CVCL_Z424|Spontaneously_immortalized_cell_line|Ostrinia nubilalis"},{"id":"T14","span":{"begin":1235,"end":1238},"obj":"CVCL_E773|Transformed_cell_line|Homo sapiens"},{"id":"T15","span":{"begin":1368,"end":1376},"obj":"CVCL_C410|Hybridoma|Mus musculus"},{"id":"T16","span":{"begin":1423,"end":1424},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"}],"text":"Insulin enhances the peroxidase activity of heme by forming heme-insulin complex: Relevance to type 2 diabetes mellitus.\nEvidences have implicated the involvement of heme in the type 2 diabetes mellitus (T2Dm) pathogenesis, but possible mediators linking between heme and diabetes are still poorly understood. Here, we explored a potential mechanism that linked heme, insulin and diabetes. Our results demonstrated the formation of heme-insulin complex by two classical methods, i.e. UV-vis and capillary electrophoresis-frontal analysis (CE-FA). UV-vis results implied heme binding insulin via bis-histidine sites, and CE-FA further revealed that, when insulin uses two sites binding with heme, this interaction occurs at high affinity (Kd=3.13×10(-6)M). Molecule docking supported that histidine-B5 of insulin binds with heme-Fe. In addition to that, tyrosine-B26, phenylalanine-B1 and valine-B2 are also contributed to binding heme. The binding amplified the peroxidase activity of heme itself. Under oxidative and nitrative stress, it affects pathogenesis of diabetes from two aspects: promoting insulin cross-linking that leads to permanent loss of insulin functionality on one hand, and enhancing protein tyrosine nitration that may result in inactivation of proteins associated with diabetes on the other hand. This study suggested that the enhanced peroxidase activity of heme through binding with insulin might be a previously unrecognized contributor to the pathogenesis of T2Dm in some heme-associated disorders."}