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LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 775-780 OrganismTaxon denotes mouse NCBItxid:10090|NCBItxid:10088

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-215 Sentence denotes Aberrant caveolin-1-mediated Smad signaling and proliferation identified by analysis of adenine 474 deletion mutation (c.474delA) in patient fibroblasts: a new perspective on the mechanism of pulmonary hypertension.
T2 216-346 Sentence denotes A heterozygous caveolin-1 c.474delA mutation has been identified in a family with heritable pulmonary arterial hypertension (PAH).
T3 347-513 Sentence denotes This frameshift mutation leads to a caveolin-1 protein that contains all known functional domains but has a change in only the final 20 amino acids of the C-terminus.
T4 514-610 Sentence denotes Here we studied how this mutation alters caveolin-1 function, using patient-derived fibroblasts.
T5 611-722 Sentence denotes Transmission electron microscopy showed that fibroblasts carrying the c.474delA mutation form typical caveolae.
T6 723-901 Sentence denotes Expression of mutated caveolin-1 in caveolin-1-null mouse fibroblasts failed to induce formation of caveolae due to retention of the mutated protein in the endoplasmic reticulum.
T7 902-1010 Sentence denotes However, coexpression of wild-type caveolin-1 with mutated caveolin-1 restored the ability to form caveolae.
T8 1011-1154 Sentence denotes Importantly, fibroblasts carrying the mutation showed twofold increase in proliferation rate associated with hyperphosphorylation of Smad1/5/8.
T9 1155-1223 Sentence denotes This mutation impaired the antiproliferative function of caveolin-1.
T10 1224-1377 Sentence denotes Inhibition of type I TGFβ receptors ALK1/2/3/6 responsible for phosphorylation of Smad1/5/8 reduced the hyperproliferation seen in c.474delA fibroblasts.
T11 1378-1706 Sentence denotes These results demonstrate the critical role of the final 20 amino acids of caveolin-1 in modulating fibroblast proliferation by dampening Smad signaling and suggest that augmented Smad signaling and fibroblast hyperproliferation are contributing factors in the pathogenesis of PAH in patients with caveolin-1 c.474delA mutation.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
12808 9-19 GeneOrGeneProduct denotes caveolin-1 NCBIGene:857
12809 29-33 GeneOrGeneProduct denotes Smad NCBIGene:4086|NCBIGene:4090|NCBIGene:4093
12810 88-108 SequenceVariant denotes adenine 474 deletion DBSNP:rs587777017
12811 119-128 SequenceVariant denotes c.474delA DBSNP:rs587777017
12812 133-140 OrganismTaxon denotes patient NCBITaxon:9606
12813 192-214 DiseaseOrPhenotypicFeature denotes pulmonary hypertension MESH:D006976
12814 231-241 GeneOrGeneProduct denotes caveolin-1 NCBIGene:857
12815 242-251 SequenceVariant denotes c.474delA DBSNP:rs587777017
12816 308-339 DiseaseOrPhenotypicFeature denotes pulmonary arterial hypertension MESH:D000081029
12817 341-344 DiseaseOrPhenotypicFeature denotes PAH MESH:D000081029
12818 383-393 GeneOrGeneProduct denotes caveolin-1 NCBIGene:857
12819 555-565 GeneOrGeneProduct denotes caveolin-1 NCBIGene:857
12820 582-589 OrganismTaxon denotes patient NCBITaxon:9606
12821 681-690 SequenceVariant denotes c.474delA DBSNP:rs587777017
12822 745-755 GeneOrGeneProduct denotes caveolin-1 NCBIGene:857
12823 759-769 GeneOrGeneProduct denotes caveolin-1 NCBIGene:12389
12824 775-780 OrganismTaxon denotes mouse NCBITaxon:10090
12825 937-947 GeneOrGeneProduct denotes caveolin-1 NCBIGene:857
12826 961-971 GeneOrGeneProduct denotes caveolin-1 NCBIGene:857
12827 1144-1153 GeneOrGeneProduct denotes Smad1/5/8 NCBIGene:4086|NCBIGene:4090|NCBIGene:4093
12828 1212-1222 GeneOrGeneProduct denotes caveolin-1 NCBIGene:857
12829 1238-1259 GeneOrGeneProduct denotes type I TGFβ receptors NCBIGene:657|NCBIGene:658|NCBIGene:90|NCBIGene:94
12830 1260-1270 GeneOrGeneProduct denotes ALK1/2/3/6 NCBIGene:657|NCBIGene:658|NCBIGene:90|NCBIGene:94
12831 1306-1315 GeneOrGeneProduct denotes Smad1/5/8 NCBIGene:4086|NCBIGene:4090|NCBIGene:4093
12832 1355-1364 SequenceVariant denotes c.474delA DBSNP:rs587777017
12833 1453-1463 GeneOrGeneProduct denotes caveolin-1 NCBIGene:857
12834 1516-1520 GeneOrGeneProduct denotes Smad NCBIGene:4086|NCBIGene:4090|NCBIGene:4093
12835 1558-1562 GeneOrGeneProduct denotes Smad NCBIGene:4086|NCBIGene:4090|NCBIGene:4093
12836 1655-1658 DiseaseOrPhenotypicFeature denotes PAH MESH:D000081029
12837 1662-1670 OrganismTaxon denotes patients NCBITaxon:9606
12838 1676-1686 GeneOrGeneProduct denotes caveolin-1 NCBIGene:857
12839 1687-1696 SequenceVariant denotes c.474delA DBSNP:rs587777017

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 192-214 DiseaseOrPhenotypicFeature denotes pulmonary hypertension 0005149
T2 298-339 DiseaseOrPhenotypicFeature denotes heritable pulmonary arterial hypertension 0017148
T3 308-339 DiseaseOrPhenotypicFeature denotes pulmonary arterial hypertension 0015924

LitCoin-SeqVar

Id Subject Object Predicate Lexical cue
T1 119-128 SequenceVariant denotes c.474delA
T2 242-251 SequenceVariant denotes c.474delA
T3 681-690 SequenceVariant denotes c.474delA
T4 1355-1364 SequenceVariant denotes c.474delA
T5 1687-1696 SequenceVariant denotes c.474delA

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 9-19 GeneOrGeneProduct denotes caveolin-1
T2 20-28 GeneOrGeneProduct denotes mediated
T3 29-33 GeneOrGeneProduct denotes Smad
T4 109-117 GeneOrGeneProduct denotes mutation
T5 202-214 GeneOrGeneProduct denotes hypertension
T6 231-241 GeneOrGeneProduct denotes caveolin-1
T7 252-260 GeneOrGeneProduct denotes mutation
T8 281-285 GeneOrGeneProduct denotes in a
T9 327-339 GeneOrGeneProduct denotes hypertension
T10 363-371 GeneOrGeneProduct denotes mutation
T11 383-401 GeneOrGeneProduct denotes caveolin-1 protein
T12 416-419 GeneOrGeneProduct denotes all
T13 449-454 GeneOrGeneProduct denotes has a
T14 483-494 GeneOrGeneProduct denotes amino acids
T15 504-512 GeneOrGeneProduct denotes terminus
T16 539-547 GeneOrGeneProduct denotes mutation
T17 555-565 GeneOrGeneProduct denotes caveolin-1
T18 691-699 GeneOrGeneProduct denotes mutation
T19 737-744 GeneOrGeneProduct denotes mutated
T20 745-755 GeneOrGeneProduct denotes caveolin-1
T21 759-769 GeneOrGeneProduct denotes caveolin-1
T22 770-774 GeneOrGeneProduct denotes null
T23 803-809 GeneOrGeneProduct denotes induce
T24 810-819 GeneOrGeneProduct denotes formation
T25 856-863 GeneOrGeneProduct denotes mutated
T26 864-871 GeneOrGeneProduct denotes protein
T27 879-900 GeneOrGeneProduct denotes endoplasmic reticulum
T28 937-947 GeneOrGeneProduct denotes caveolin-1
T29 953-960 GeneOrGeneProduct denotes mutated
T30 961-971 GeneOrGeneProduct denotes caveolin-1
T31 1049-1057 GeneOrGeneProduct denotes mutation
T32 1144-1151 GeneOrGeneProduct denotes Smad1/5
T33 1160-1168 GeneOrGeneProduct denotes mutation
T34 1212-1222 GeneOrGeneProduct denotes caveolin-1
T35 1238-1244 GeneOrGeneProduct denotes type I
T36 1250-1259 GeneOrGeneProduct denotes receptors
T37 1260-1264 GeneOrGeneProduct denotes ALK1
T38 1306-1313 GeneOrGeneProduct denotes Smad1/5
T39 1316-1323 GeneOrGeneProduct denotes reduced
T40 1438-1449 GeneOrGeneProduct denotes amino acids
T41 1453-1463 GeneOrGeneProduct denotes caveolin-1
T42 1506-1515 GeneOrGeneProduct denotes dampening
T43 1516-1520 GeneOrGeneProduct denotes Smad
T44 1558-1562 GeneOrGeneProduct denotes Smad
T45 1624-1631 GeneOrGeneProduct denotes factors
T46 1676-1686 GeneOrGeneProduct denotes caveolin-1
T47 1697-1705 GeneOrGeneProduct denotes mutation

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 9-19 GeneOrGeneProduct denotes caveolin-1
T2 29-33 GeneOrGeneProduct denotes Smad
T3 202-214 GeneOrGeneProduct denotes hypertension
T4 231-241 GeneOrGeneProduct denotes caveolin-1
T5 327-339 GeneOrGeneProduct denotes hypertension
T6 383-401 GeneOrGeneProduct denotes caveolin-1 protein
T7 483-494 GeneOrGeneProduct denotes amino acids
T8 504-512 GeneOrGeneProduct denotes terminus
T9 555-565 GeneOrGeneProduct denotes caveolin-1
T10 745-755 GeneOrGeneProduct denotes caveolin-1
T11 759-769 GeneOrGeneProduct denotes caveolin-1
T12 770-774 GeneOrGeneProduct denotes null
T13 864-871 GeneOrGeneProduct denotes protein
T14 879-900 GeneOrGeneProduct denotes endoplasmic reticulum
T15 937-947 GeneOrGeneProduct denotes caveolin-1
T16 961-971 GeneOrGeneProduct denotes caveolin-1
T17 1144-1151 GeneOrGeneProduct denotes Smad1/5
T18 1212-1222 GeneOrGeneProduct denotes caveolin-1
T19 1238-1244 GeneOrGeneProduct denotes type I
T20 1260-1264 GeneOrGeneProduct denotes ALK1
T21 1306-1313 GeneOrGeneProduct denotes Smad1/5
T22 1316-1323 GeneOrGeneProduct denotes reduced
T23 1438-1449 GeneOrGeneProduct denotes amino acids
T24 1453-1463 GeneOrGeneProduct denotes caveolin-1
T25 1516-1520 GeneOrGeneProduct denotes Smad
T26 1558-1562 GeneOrGeneProduct denotes Smad
T27 1676-1686 GeneOrGeneProduct denotes caveolin-1

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 192-214 DiseaseOrPhenotypicFeature denotes pulmonary hypertension D006976
T2 298-339 DiseaseOrPhenotypicFeature denotes heritable pulmonary arterial hypertension D065627
T3 341-344 DiseaseOrPhenotypicFeature denotes PAH D000081029
T4 1655-1658 DiseaseOrPhenotypicFeature denotes PAH D000081029

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 9-19 GeneOrGeneProduct denotes caveolin-1
T2 29-33 GeneOrGeneProduct denotes Smad
T3 231-241 GeneOrGeneProduct denotes caveolin-1
T4 383-401 GeneOrGeneProduct denotes caveolin-1 protein
T5 555-565 GeneOrGeneProduct denotes caveolin-1
T6 745-755 GeneOrGeneProduct denotes caveolin-1
T7 759-769 GeneOrGeneProduct denotes caveolin-1
T8 937-947 GeneOrGeneProduct denotes caveolin-1
T9 961-971 GeneOrGeneProduct denotes caveolin-1
T10 1144-1151 GeneOrGeneProduct denotes Smad1/5
T11 1212-1222 GeneOrGeneProduct denotes caveolin-1
T12 1260-1264 GeneOrGeneProduct denotes ALK1
T13 1306-1313 GeneOrGeneProduct denotes Smad1/5
T14 1453-1463 GeneOrGeneProduct denotes caveolin-1
T15 1516-1520 GeneOrGeneProduct denotes Smad
T16 1558-1562 GeneOrGeneProduct denotes Smad
T17 1676-1686 GeneOrGeneProduct denotes caveolin-1

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 192-214 DiseaseOrPhenotypicFeature denotes pulmonary hypertension 0005149
T2 298-339 DiseaseOrPhenotypicFeature denotes heritable pulmonary arterial hypertension 0017148
T3 341-344 DiseaseOrPhenotypicFeature denotes PAH 0015924|0024533
T5 1655-1658 DiseaseOrPhenotypicFeature denotes PAH 0015924|0024533

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 192-214 DiseaseOrPhenotypicFeature denotes pulmonary hypertension D006976
T2 298-339 DiseaseOrPhenotypicFeature denotes heritable pulmonary arterial hypertension D065627
T3 341-344 DiseaseOrPhenotypicFeature denotes PAH D000081029
T4 1655-1658 DiseaseOrPhenotypicFeature denotes PAH D000081029

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 192-214 DiseaseOrPhenotypicFeature denotes pulmonary hypertension D006976
T2 298-339 DiseaseOrPhenotypicFeature denotes heritable pulmonary arterial hypertension D065627
T3 341-344 DiseaseOrPhenotypicFeature denotes PAH D000081029
T4 1655-1658 DiseaseOrPhenotypicFeature denotes PAH D000081029

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 88-95 ChemicalEntity denotes adenine D000225|http://purl.obolibrary.org/obo/CHEBI_16708
T3 341-344 ChemicalEntity denotes PAH http://purl.obolibrary.org/obo/CHEBI_53305|http://purl.obolibrary.org/obo/CHEBI_33848|http://purl.obolibrary.org/obo/CHEBI_31204|http://purl.obolibrary.org/obo/CHEBI_104011
T7 1655-1658 ChemicalEntity denotes PAH http://purl.obolibrary.org/obo/CHEBI_53305|http://purl.obolibrary.org/obo/CHEBI_33848|http://purl.obolibrary.org/obo/CHEBI_31204|http://purl.obolibrary.org/obo/CHEBI_104011

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 133-140 OrganismTaxon denotes patient
T2 582-589 OrganismTaxon denotes patient
T3 775-780 OrganismTaxon denotes mouse
T4 1662-1670 OrganismTaxon denotes patients

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T7 1655-1658 ChemicalEntity denotes PAH http://purl.obolibrary.org/obo/CHEBI_104011|http://purl.obolibrary.org/obo/CHEBI_31204|http://purl.obolibrary.org/obo/CHEBI_33848|http://purl.obolibrary.org/obo/CHEBI_53305
T3 341-344 ChemicalEntity denotes PAH http://purl.obolibrary.org/obo/CHEBI_104011|http://purl.obolibrary.org/obo/CHEBI_31204|http://purl.obolibrary.org/obo/CHEBI_33848|http://purl.obolibrary.org/obo/CHEBI_53305
T1 88-95 ChemicalEntity denotes adenine http://purl.obolibrary.org/obo/CHEBI_16708|D000225
T17 1676-1686 GeneOrGeneProduct denotes caveolin-1
T16 1558-1562 GeneOrGeneProduct denotes Smad
T15 1516-1520 GeneOrGeneProduct denotes Smad
T14 1453-1463 GeneOrGeneProduct denotes caveolin-1
T13 1306-1313 GeneOrGeneProduct denotes Smad1/5
T12 1260-1264 GeneOrGeneProduct denotes ALK1
T11 1212-1222 GeneOrGeneProduct denotes caveolin-1
T10 1144-1151 GeneOrGeneProduct denotes Smad1/5
T9 961-971 GeneOrGeneProduct denotes caveolin-1
T8 937-947 GeneOrGeneProduct denotes caveolin-1
T96878 759-769 GeneOrGeneProduct denotes caveolin-1
T6 745-755 GeneOrGeneProduct denotes caveolin-1
T5 555-565 GeneOrGeneProduct denotes caveolin-1
T4 383-401 GeneOrGeneProduct denotes caveolin-1 protein
T95750 231-241 GeneOrGeneProduct denotes caveolin-1
T2 29-33 GeneOrGeneProduct denotes Smad
T74967 9-19 GeneOrGeneProduct denotes caveolin-1
T70693 1655-1658 DiseaseOrPhenotypicFeature denotes PAH D000081029
T56048 341-344 DiseaseOrPhenotypicFeature denotes PAH D000081029
T9384 298-339 DiseaseOrPhenotypicFeature denotes heritable pulmonary arterial hypertension D065627
T25700 192-214 DiseaseOrPhenotypicFeature denotes pulmonary hypertension D006976
T92895 1662-1670 OrganismTaxon denotes patients
T2973 775-780 OrganismTaxon denotes mouse
T12946 582-589 OrganismTaxon denotes patient
T15543 133-140 OrganismTaxon denotes patient
T22226 1687-1696 SequenceVariant denotes c.474delA
T3689 1355-1364 SequenceVariant denotes c.474delA
T2837 681-690 SequenceVariant denotes c.474delA
T65793 242-251 SequenceVariant denotes c.474delA
T48410 119-128 SequenceVariant denotes c.474delA