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GoldHamster

Id Subject Object Predicate Lexical cue
T2 0-21 D013211 denotes Staphylococcus aureus
T3 0-21 1280 denotes Staphylococcus aureus
T4 36-40 PR:O75594 denotes PGRP
T5 36-40 PR:Q9JLN4 denotes PGRP
T6 36-40 PR:O88593 denotes PGRP
T7 36-40 PR:000012610 denotes PGRP
T8 48-53 PR:Q071E0 denotes setd8
T9 48-53 PR:Q9NQR1 denotes setd8
T10 48-53 PR:000014723 denotes setd8
T11 48-53 PR:Q2YDW7 denotes setd8
T12 74-84 GO:0023052 denotes Signalling
T13 88-97 D010932 denotes Planarian
T14 161-170 D007239 denotes infection
T15 161-170 D007239 denotes infection
T16 298-308 D010932 denotes planarians
T17 356-365 D007239 denotes infection
T18 356-365 D007239 denotes infection
T20 369-390 D013211 denotes Staphylococcus aureus
T21 369-390 1280 denotes Staphylococcus aureus
T22 457-466 D007239 denotes infection
T23 457-466 D007239 denotes infection
T24 518-527 D007239 denotes infection
T25 518-527 D007239 denotes infection
T26 563-572 CL:0000034 denotes stem cell
T30 654-657 SO:0000356 denotes RNA
T27 654-657 CHEBI:33697 denotes RNA
T28 654-657 D012313 denotes RNA
T29 654-657 GO:0005562 denotes RNA
T31 654-670 GO:0016246 denotes RNA-interference
T32 699-705 UBERON:0000479 denotes tissue
T33 724-728 SO:0001742 denotes gain
T34 765-774 D007239 denotes infection
T35 765-774 D007239 denotes infection
T36 802-815 GO:0009274 denotes peptidoglycan
T40 802-824 C051223 denotes peptidoglycan receptor
T41 830-834 PR:O75594 denotes PGRP
T42 830-834 PR:Q9JLN4 denotes PGRP
T43 830-834 PR:O88593 denotes PGRP
T44 830-834 PR:000012610 denotes PGRP
T45 866-871 PR:Q071E0 denotes setd8
T46 866-871 PR:Q9NQR1 denotes setd8
T47 866-871 PR:000014723 denotes setd8
T48 866-871 PR:Q2YDW7 denotes setd8
T50 874-881 PR:000041244 denotes histone
T52 874-899 D000076983 denotes histone methyltransferase
T56 935-941 6536 denotes lysine
T53 935-941 SO:0001450 denotes lysine
T54 935-941 CHEBI:25094 denotes lysine
T55 935-941 D008239 denotes lysine
T57 935-941 D008239 denotes lysine
T58 935-941 CHEBI:18019 denotes lysine
T60 942-953 GO:0032259 denotes methylation
T59 942-953 MOP:0000364 denotes methylation
T61 1035-1044 D007239 denotes infection
T62 1035-1044 D007239 denotes infection
T63 1056-1065 D007239 denotes infection
T64 1056-1065 D007239 denotes infection
T65 1133-1137 PR:O75594 denotes PGRP
T66 1133-1137 PR:Q9JLN4 denotes PGRP
T67 1133-1137 PR:O88593 denotes PGRP
T68 1133-1137 PR:000012610 denotes PGRP
T69 1149-1154 PR:Q071E0 denotes setd8
T70 1149-1154 PR:Q9NQR1 denotes setd8
T71 1149-1154 PR:000014723 denotes setd8
T72 1149-1154 PR:Q2YDW7 denotes setd8
T73 1174-1178 PR:O75594 denotes PGRP
T74 1174-1178 PR:Q9JLN4 denotes PGRP
T75 1174-1178 PR:O88593 denotes PGRP
T76 1174-1178 PR:000012610 denotes PGRP
T77 1190-1195 PR:Q071E0 denotes setd8
T78 1190-1195 PR:Q9NQR1 denotes setd8
T79 1190-1195 PR:000014723 denotes setd8
T80 1190-1195 PR:Q2YDW7 denotes setd8
T109 1249-1257 O62618 denotes p38 MAPK
T108 1249-1257 D048051 denotes p38 MAPK
T114 1253-1257 GO:0004707 denotes MAPK
T117 1267-1272 PR:Q6UL01 denotes morn2
T118 1267-1272 PR:000031381 denotes morn2
T119 1267-1272 PR:Q502X0 denotes morn2
T120 1284-1294 SO:0001633 denotes downstream
T121 1384-1399 GO:0045087 denotes innate immunity
T122 1531-1540 D007239 denotes infection
T123 1531-1540 D007239 denotes infection

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 172-276 DRI_Challenge denotes Little is known about how organisms exposed to recurrent infections adapt their innate immune responses.
T2 277-528 DRI_Outcome denotes Here, we report that planarians display a form of instructed immunity to primo-infection by Staphylococcus aureus that consists of a transient state of heightened resistance to re-infection that persists for approximately 30days after primo-infection.
T3 529-567 DRI_Approach denotes We established the involvement of stem
T4 588-741 DRI_Approach denotes in this instructed immunity using the complementary approaches of RNA-interference-mediated cell depletion and tissue grafting-mediated gain of function.
T5 742-967 DRI_Background denotes Mechanistically, primo-infection leads to expression of the peptidoglycan receptor Smed-PGRP-2, which in turn promotes Smed-setd8-1 histone methyltransferase expression and increases levels of lysine methylation in neoblasts.
T6 968-1168 DRI_Outcome denotes Depletion of neoblasts did not affect S. aureus clearance in primo-infection but, in re-infection, abrogated the heightened elimination of bacteria and reduced Smed-PGRP-2 and Smed-setd8-1 expression.
T7 1169-1334 DRI_Background denotes Smed-PGRP-2 and Smed-setd8-1 sensitize animals to heightened expression of Smed-p38 MAPK and Smed-morn2, which are downstream components of anti-bacterial responses.
T8 1335-1541 DRI_Outcome denotes Our study reveals a central role of neoblasts in innate immunity against S. aureus to establish a resistance state facilitating Smed-sted8-1-dependent expression of anti-bacterial genes during re-infection.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 158-160 CVCL_U263|Spontaneously_immortalized_cell_line|Labeo rohita denotes Re
T2 283-285 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes we
T3 317-318 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T4 408-409 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T5 454-456 CVCL_U263|Spontaneously_immortalized_cell_line|Labeo rohita denotes re
T6 529-531 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes We
T7 1053-1055 CVCL_U263|Spontaneously_immortalized_cell_line|Labeo rohita denotes re
T8 1353-1354 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T9 1431-1432 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T10 1528-1530 CVCL_U263|Spontaneously_immortalized_cell_line|Labeo rohita denotes re