PubMed:28416580
Annnotations
LitCoin-entities-OrganismTaxon-PD
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 524-529 | OrganismTaxon | denotes | mouse | NCBItxid:10090|NCBItxid:10088 |
| T3 | 653-657 | OrganismTaxon | denotes | mice | NCBItxid:10095|NCBItxid:10088 |
| T5 | 875-879 | OrganismTaxon | denotes | mice | NCBItxid:10095|NCBItxid:10088 |
| T7 | 1157-1161 | OrganismTaxon | denotes | mice | NCBItxid:10095|NCBItxid:10088 |
LitCoin-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-69 | Sentence | denotes | A TSPO ligand attenuates brain injury after intracerebral hemorrhage. |
| T2 | 70-154 | Sentence | denotes | Intracerebral hemorrhage (ICH) is a devastating disease without effective treatment. |
| T3 | 155-318 | Sentence | denotes | After ICH, the immediate infiltration of leukocytes and activation of microglia are accompanied by a rapid up-regulation of the 18-kDa translocator protein (TSPO). |
| T4 | 319-416 | Sentence | denotes | TSPO ligands have shown anti-inflammatory and neuroprotective properties in models of CNS injury. |
| T5 | 417-544 | Sentence | denotes | In this study, we determined the impact of a TSPO ligand, etifoxine, on brain injury and inflammation in 2 mouse models of ICH. |
| T8 | 848-1019 | Sentence | denotes | In collagenase-induced ICH mice, the protection of etifoxine was associated with reduced leukocyte infiltration into the brain and microglial production of IL-6 and TNF-α. |
| T6 | 545-695 | Sentence | denotes | TSPO was up-regulated in Iba1(+) cells from brains of patients with ICH and in CD11b(+)CD45(int) cells from mice subjected to collagenase-induced ICH. |
| T7 | 696-847 | Sentence | denotes | Etifoxine significantly reduced neurodeficits and perihematomal brain edema after ICH induction by injection of either autologous blood or collagenase. |
| T9 | 1020-1095 | Sentence | denotes | Etifoxine improved blood-brain barrier integrity and diminished cell death. |
| T10 | 1096-1242 | Sentence | denotes | Notably, the protective effect of etifoxine was abolished in mice depleted of microglia by using a colony-stimulating factor 1 receptor inhibitor. |
| T11 | 1243-1348 | Sentence | denotes | These results indicate that the TSPO ligand etifoxine attenuates brain injury and inflammation after ICH. |
| T12 | 1349-1460 | Sentence | denotes | TSPO may be a viable therapeutic target that requires further investigations in ICH.-Li, M., Ren, H., Sheth, K. |
| T13 | 1461-1484 | Sentence | denotes | N., Shi, F.-D., Liu, Q. |
| T14 | 1485-1554 | Sentence | denotes | A TSPO ligand attenuates brain injury after intracerebral hemorrhage. |
LitCoin-entities
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| 12714 | 2-6 | GeneOrGeneProduct | denotes | TSPO | NCBIGene:12257 |
| 12715 | 25-37 | DiseaseOrPhenotypicFeature | denotes | brain injury | MESH:D001927 |
| 12716 | 44-68 | DiseaseOrPhenotypicFeature | denotes | intracerebral hemorrhage | MESH:D002543 |
| 12717 | 70-94 | DiseaseOrPhenotypicFeature | denotes | Intracerebral hemorrhage | MESH:D002543 |
| 12718 | 96-99 | DiseaseOrPhenotypicFeature | denotes | ICH | MESH:D002543 |
| 12719 | 161-164 | DiseaseOrPhenotypicFeature | denotes | ICH | MESH:D002543 |
| 12720 | 290-310 | GeneOrGeneProduct | denotes | translocator protein | NCBIGene:12257 |
| 12721 | 312-316 | GeneOrGeneProduct | denotes | TSPO | NCBIGene:12257 |
| 12722 | 319-323 | GeneOrGeneProduct | denotes | TSPO | NCBIGene:12257 |
| 12723 | 348-360 | DiseaseOrPhenotypicFeature | denotes | inflammatory | MESH:D007249 |
| 12724 | 405-415 | DiseaseOrPhenotypicFeature | denotes | CNS injury | MESH:D002493 |
| 12725 | 462-466 | GeneOrGeneProduct | denotes | TSPO | NCBIGene:12257 |
| 12726 | 475-484 | ChemicalEntity | denotes | etifoxine | MESH:C002125 |
| 12727 | 489-501 | DiseaseOrPhenotypicFeature | denotes | brain injury | MESH:D001927 |
| 12728 | 506-518 | DiseaseOrPhenotypicFeature | denotes | inflammation | MESH:D007249 |
| 12729 | 524-529 | OrganismTaxon | denotes | mouse | NCBITaxon:10090 |
| 12730 | 540-543 | DiseaseOrPhenotypicFeature | denotes | ICH | MESH:D002543 |
| 12731 | 545-549 | GeneOrGeneProduct | denotes | TSPO | NCBIGene:706 |
| 12732 | 570-574 | GeneOrGeneProduct | denotes | Iba1 | NCBIGene:199 |
| 12733 | 599-607 | OrganismTaxon | denotes | patients | NCBITaxon:9606 |
| 12734 | 613-616 | DiseaseOrPhenotypicFeature | denotes | ICH | MESH:D002543 |
| 12735 | 624-629 | GeneOrGeneProduct | denotes | CD11b | NCBIGene:16409 |
| 12736 | 632-636 | GeneOrGeneProduct | denotes | CD45 | NCBIGene:19264 |
| 12737 | 653-657 | OrganismTaxon | denotes | mice | NCBITaxon:10090 |
| 12738 | 671-682 | ChemicalEntity | denotes | collagenase | MESH:D017364 |
| 12739 | 691-694 | DiseaseOrPhenotypicFeature | denotes | ICH | MESH:D002543 |
| 12740 | 696-705 | ChemicalEntity | denotes | Etifoxine | MESH:C002125 |
| 12741 | 728-741 | DiseaseOrPhenotypicFeature | denotes | neurodeficits | MESH:D001927 |
| 12742 | 760-771 | DiseaseOrPhenotypicFeature | denotes | brain edema | MESH:D001929 |
| 12743 | 778-781 | DiseaseOrPhenotypicFeature | denotes | ICH | MESH:D002543 |
| 12744 | 835-846 | ChemicalEntity | denotes | collagenase | MESH:D017364 |
| 12745 | 851-862 | ChemicalEntity | denotes | collagenase | MESH:D017364 |
| 12746 | 871-874 | DiseaseOrPhenotypicFeature | denotes | ICH | MESH:D002543 |
| 12747 | 875-879 | OrganismTaxon | denotes | mice | NCBITaxon:10090 |
| 12748 | 899-908 | ChemicalEntity | denotes | etifoxine | MESH:C002125 |
| 12749 | 1004-1008 | GeneOrGeneProduct | denotes | IL-6 | NCBIGene:16193 |
| 12750 | 1013-1018 | GeneOrGeneProduct | denotes | TNF-α | NCBIGene:21926 |
| 12751 | 1020-1029 | ChemicalEntity | denotes | Etifoxine | MESH:C002125 |
| 12752 | 1130-1139 | ChemicalEntity | denotes | etifoxine | MESH:C002125 |
| 12753 | 1157-1161 | OrganismTaxon | denotes | mice | NCBITaxon:10090 |
| 12754 | 1195-1231 | GeneOrGeneProduct | denotes | colony-stimulating factor 1 receptor | NCBIGene:12978 |
| 12755 | 1275-1279 | GeneOrGeneProduct | denotes | TSPO | NCBIGene:12257 |
| 12756 | 1287-1296 | ChemicalEntity | denotes | etifoxine | MESH:C002125 |
| 12757 | 1308-1320 | DiseaseOrPhenotypicFeature | denotes | brain injury | MESH:D001927 |
| 12758 | 1325-1337 | DiseaseOrPhenotypicFeature | denotes | inflammation | MESH:D007249 |
| 12759 | 1344-1347 | DiseaseOrPhenotypicFeature | denotes | ICH | MESH:D002543 |
| 12760 | 1349-1353 | GeneOrGeneProduct | denotes | TSPO | NCBIGene:12257 |
| 12761 | 1429-1432 | DiseaseOrPhenotypicFeature | denotes | ICH | MESH:D002543 |
| 12762 | 1487-1491 | GeneOrGeneProduct | denotes | TSPO | NCBIGene:12257 |
| 12763 | 1510-1522 | DiseaseOrPhenotypicFeature | denotes | brain injury | MESH:D001927 |
| 12764 | 1529-1553 | DiseaseOrPhenotypicFeature | denotes | intracerebral hemorrhage | MESH:D002543 |
LitCoin_Mondo
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 25-37 | DiseaseOrPhenotypicFeature | denotes | brain injury | 0043510 |
| T2 | 31-37 | DiseaseOrPhenotypicFeature | denotes | injury | 0021178 |
| T3 | 44-68 | DiseaseOrPhenotypicFeature | denotes | intracerebral hemorrhage | 0013792 |
| T4 | 70-94 | DiseaseOrPhenotypicFeature | denotes | Intracerebral hemorrhage | 0013792 |
| T5 | 409-415 | DiseaseOrPhenotypicFeature | denotes | injury | 0021178 |
| T6 | 489-501 | DiseaseOrPhenotypicFeature | denotes | brain injury | 0043510 |
| T7 | 495-501 | DiseaseOrPhenotypicFeature | denotes | injury | 0021178 |
| T8 | 760-771 | DiseaseOrPhenotypicFeature | denotes | brain edema | 0006684 |
| T9 | 1308-1320 | DiseaseOrPhenotypicFeature | denotes | brain injury | 0043510 |
| T10 | 1314-1320 | DiseaseOrPhenotypicFeature | denotes | injury | 0021178 |
| T11 | 1510-1522 | DiseaseOrPhenotypicFeature | denotes | brain injury | 0043510 |
| T12 | 1516-1522 | DiseaseOrPhenotypicFeature | denotes | injury | 0021178 |
| T13 | 1529-1553 | DiseaseOrPhenotypicFeature | denotes | intracerebral hemorrhage | 0013792 |
LitCoin-GeneOrGeneProduct-v0
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 2-6 | GeneOrGeneProduct | denotes | TSPO |
| T2 | 14-24 | GeneOrGeneProduct | denotes | attenuates |
| T3 | 25-30 | GeneOrGeneProduct | denotes | brain |
| T4 | 95-103 | GeneOrGeneProduct | denotes | (ICH) is |
| T5 | 211-221 | GeneOrGeneProduct | denotes | activation |
| T6 | 265-275 | GeneOrGeneProduct | denotes | regulation |
| T7 | 283-289 | GeneOrGeneProduct | denotes | 18-kDa |
| T8 | 290-310 | GeneOrGeneProduct | denotes | translocator protein |
| T9 | 312-316 | GeneOrGeneProduct | denotes | TSPO |
| T10 | 319-323 | GeneOrGeneProduct | denotes | TSPO |
| T11 | 435-445 | GeneOrGeneProduct | denotes | determined |
| T12 | 450-456 | GeneOrGeneProduct | denotes | impact |
| T13 | 462-466 | GeneOrGeneProduct | denotes | TSPO |
| T14 | 489-494 | GeneOrGeneProduct | denotes | brain |
| T15 | 519-523 | GeneOrGeneProduct | denotes | in 2 |
| T16 | 545-549 | GeneOrGeneProduct | denotes | TSPO |
| T17 | 557-566 | GeneOrGeneProduct | denotes | regulated |
| T18 | 570-574 | GeneOrGeneProduct | denotes | Iba1 |
| T19 | 578-583 | GeneOrGeneProduct | denotes | cells |
| T20 | 589-595 | GeneOrGeneProduct | denotes | brains |
| T21 | 624-629 | GeneOrGeneProduct | denotes | CD11b |
| T22 | 632-636 | GeneOrGeneProduct | denotes | CD45 |
| T23 | 637-640 | GeneOrGeneProduct | denotes | int |
| T24 | 642-647 | GeneOrGeneProduct | denotes | cells |
| T25 | 653-657 | GeneOrGeneProduct | denotes | mice |
| T26 | 671-682 | GeneOrGeneProduct | denotes | collagenase |
| T27 | 683-690 | GeneOrGeneProduct | denotes | induced |
| T28 | 720-727 | GeneOrGeneProduct | denotes | reduced |
| T29 | 760-765 | GeneOrGeneProduct | denotes | brain |
| T30 | 835-846 | GeneOrGeneProduct | denotes | collagenase |
| T31 | 851-862 | GeneOrGeneProduct | denotes | collagenase |
| T32 | 863-870 | GeneOrGeneProduct | denotes | induced |
| T33 | 875-879 | GeneOrGeneProduct | denotes | mice |
| T34 | 929-936 | GeneOrGeneProduct | denotes | reduced |
| T35 | 969-974 | GeneOrGeneProduct | denotes | brain |
| T36 | 990-1000 | GeneOrGeneProduct | denotes | production |
| T37 | 1004-1008 | GeneOrGeneProduct | denotes | IL-6 |
| T38 | 1045-1050 | GeneOrGeneProduct | denotes | brain |
| T39 | 1084-1088 | GeneOrGeneProduct | denotes | cell |
| T40 | 1157-1161 | GeneOrGeneProduct | denotes | mice |
| T41 | 1162-1170 | GeneOrGeneProduct | denotes | depleted |
| T42 | 1195-1220 | GeneOrGeneProduct | denotes | colony-stimulating factor |
| T43 | 1223-1231 | GeneOrGeneProduct | denotes | receptor |
| T44 | 1232-1241 | GeneOrGeneProduct | denotes | inhibitor |
| T45 | 1275-1279 | GeneOrGeneProduct | denotes | TSPO |
| T46 | 1297-1307 | GeneOrGeneProduct | denotes | attenuates |
| T47 | 1308-1313 | GeneOrGeneProduct | denotes | brain |
| T48 | 1349-1353 | GeneOrGeneProduct | denotes | TSPO |
| T49 | 1354-1362 | GeneOrGeneProduct | denotes | may be a |
| T50 | 1465-1471 | GeneOrGeneProduct | denotes | Shi, F |
| T51 | 1487-1491 | GeneOrGeneProduct | denotes | TSPO |
| T52 | 1499-1509 | GeneOrGeneProduct | denotes | attenuates |
| T53 | 1510-1515 | GeneOrGeneProduct | denotes | brain |
LitCoin-GeneOrGeneProduct-v2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 2-6 | GeneOrGeneProduct | denotes | TSPO |
| T2 | 25-30 | GeneOrGeneProduct | denotes | brain |
| T3 | 283-289 | GeneOrGeneProduct | denotes | 18-kDa |
| T4 | 290-310 | GeneOrGeneProduct | denotes | translocator protein |
| T5 | 312-316 | GeneOrGeneProduct | denotes | TSPO |
| T6 | 319-323 | GeneOrGeneProduct | denotes | TSPO |
| T7 | 450-456 | GeneOrGeneProduct | denotes | impact |
| T8 | 462-466 | GeneOrGeneProduct | denotes | TSPO |
| T9 | 489-494 | GeneOrGeneProduct | denotes | brain |
| T10 | 545-549 | GeneOrGeneProduct | denotes | TSPO |
| T11 | 570-574 | GeneOrGeneProduct | denotes | Iba1 |
| T12 | 624-629 | GeneOrGeneProduct | denotes | CD11b |
| T13 | 632-636 | GeneOrGeneProduct | denotes | CD45 |
| T14 | 671-682 | GeneOrGeneProduct | denotes | collagenase |
| T15 | 720-727 | GeneOrGeneProduct | denotes | reduced |
| T16 | 760-765 | GeneOrGeneProduct | denotes | brain |
| T17 | 835-846 | GeneOrGeneProduct | denotes | collagenase |
| T18 | 851-862 | GeneOrGeneProduct | denotes | collagenase |
| T19 | 929-936 | GeneOrGeneProduct | denotes | reduced |
| T20 | 969-974 | GeneOrGeneProduct | denotes | brain |
| T21 | 1004-1008 | GeneOrGeneProduct | denotes | IL-6 |
| T22 | 1045-1050 | GeneOrGeneProduct | denotes | brain |
| T23 | 1084-1088 | GeneOrGeneProduct | denotes | cell |
| T24 | 1162-1170 | GeneOrGeneProduct | denotes | depleted |
| T25 | 1195-1220 | GeneOrGeneProduct | denotes | colony-stimulating factor |
| T26 | 1223-1231 | GeneOrGeneProduct | denotes | receptor |
| T27 | 1232-1241 | GeneOrGeneProduct | denotes | inhibitor |
| T28 | 1275-1279 | GeneOrGeneProduct | denotes | TSPO |
| T29 | 1308-1313 | GeneOrGeneProduct | denotes | brain |
| T30 | 1349-1353 | GeneOrGeneProduct | denotes | TSPO |
| T31 | 1487-1491 | GeneOrGeneProduct | denotes | TSPO |
| T32 | 1510-1515 | GeneOrGeneProduct | denotes | brain |
LitCoin-Disease-MeSH
| Id | Subject | Object | Predicate | Lexical cue | originalLabel |
|---|---|---|---|---|---|
| T1 | 25-37 | DiseaseOrPhenotypicFeature | denotes | brain injury | D001930 |
| T2 | 44-68 | DiseaseOrPhenotypicFeature | denotes | intracerebral hemorrhage | D002543 |
| T3 | 70-94 | DiseaseOrPhenotypicFeature | denotes | Intracerebral hemorrhage | D002543 |
| T4 | 96-99 | DiseaseOrPhenotypicFeature | denotes | ICH | D002543 |
| T5 | 118-125 | DiseaseOrPhenotypicFeature | denotes | disease | D004194 |
| T6 | 161-164 | DiseaseOrPhenotypicFeature | denotes | ICH | D002543 |
| T7 | 348-360 | DiseaseOrPhenotypicFeature | denotes | inflammatory | DISEASE |
| T8 | 409-415 | DiseaseOrPhenotypicFeature | denotes | injury | D014947 |
| T9 | 489-501 | DiseaseOrPhenotypicFeature | denotes | brain injury | D001930 |
| T10 | 506-518 | DiseaseOrPhenotypicFeature | denotes | inflammation | D007249 |
| T11 | 540-543 | DiseaseOrPhenotypicFeature | denotes | ICH | D002543 |
| T12 | 613-616 | DiseaseOrPhenotypicFeature | denotes | ICH | D002543 |
| T13 | 691-694 | DiseaseOrPhenotypicFeature | denotes | ICH | D002543 |
| T14 | 760-771 | DiseaseOrPhenotypicFeature | denotes | brain edema | D001929 |
| T15 | 778-781 | DiseaseOrPhenotypicFeature | denotes | ICH | D002543 |
| T16 | 871-874 | DiseaseOrPhenotypicFeature | denotes | ICH | D002543 |
| T17 | 1089-1094 | DiseaseOrPhenotypicFeature | denotes | death | D003643 |
| T18 | 1308-1320 | DiseaseOrPhenotypicFeature | denotes | brain injury | D001930 |
| T19 | 1325-1337 | DiseaseOrPhenotypicFeature | denotes | inflammation | D007249 |
| T20 | 1344-1347 | DiseaseOrPhenotypicFeature | denotes | ICH | D002543 |
| T21 | 1429-1432 | DiseaseOrPhenotypicFeature | denotes | ICH | D002543 |
| T22 | 1510-1522 | DiseaseOrPhenotypicFeature | denotes | brain injury | D001930 |
| T23 | 1529-1553 | DiseaseOrPhenotypicFeature | denotes | intracerebral hemorrhage | D002543 |
LitCoin-GeneOrGeneProduct-v3
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 2-6 | GeneOrGeneProduct | denotes | TSPO |
| T2 | 283-289 | GeneOrGeneProduct | denotes | 18-kDa |
| T3 | 290-310 | GeneOrGeneProduct | denotes | translocator protein |
| T4 | 312-316 | GeneOrGeneProduct | denotes | TSPO |
| T5 | 319-323 | GeneOrGeneProduct | denotes | TSPO |
| T6 | 462-466 | GeneOrGeneProduct | denotes | TSPO |
| T7 | 545-549 | GeneOrGeneProduct | denotes | TSPO |
| T8 | 570-574 | GeneOrGeneProduct | denotes | Iba1 |
| T9 | 624-629 | GeneOrGeneProduct | denotes | CD11b |
| T10 | 632-636 | GeneOrGeneProduct | denotes | CD45 |
| T11 | 1004-1008 | GeneOrGeneProduct | denotes | IL-6 |
| T12 | 1195-1220 | GeneOrGeneProduct | denotes | colony-stimulating factor |
| T13 | 1275-1279 | GeneOrGeneProduct | denotes | TSPO |
| T14 | 1349-1353 | GeneOrGeneProduct | denotes | TSPO |
| T15 | 1487-1491 | GeneOrGeneProduct | denotes | TSPO |
LitCoin_Mondo_095
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 25-37 | DiseaseOrPhenotypicFeature | denotes | brain injury | 0043510 |
| T2 | 44-68 | DiseaseOrPhenotypicFeature | denotes | intracerebral hemorrhage | 0013792 |
| T3 | 70-94 | DiseaseOrPhenotypicFeature | denotes | Intracerebral hemorrhage | 0013792 |
| T4 | 96-99 | DiseaseOrPhenotypicFeature | denotes | ICH | 0013792 |
| T5 | 161-164 | DiseaseOrPhenotypicFeature | denotes | ICH | 0013792 |
| T6 | 409-415 | DiseaseOrPhenotypicFeature | denotes | injury | 0021178 |
| T7 | 489-501 | DiseaseOrPhenotypicFeature | denotes | brain injury | 0043510 |
| T8 | 540-543 | DiseaseOrPhenotypicFeature | denotes | ICH | 0013792 |
| T9 | 613-616 | DiseaseOrPhenotypicFeature | denotes | ICH | 0013792 |
| T10 | 691-694 | DiseaseOrPhenotypicFeature | denotes | ICH | 0013792 |
| T11 | 760-771 | DiseaseOrPhenotypicFeature | denotes | brain edema | 0006684 |
| T12 | 778-781 | DiseaseOrPhenotypicFeature | denotes | ICH | 0013792 |
| T13 | 871-874 | DiseaseOrPhenotypicFeature | denotes | ICH | 0013792 |
| T14 | 1308-1320 | DiseaseOrPhenotypicFeature | denotes | brain injury | 0043510 |
| T15 | 1344-1347 | DiseaseOrPhenotypicFeature | denotes | ICH | 0013792 |
| T16 | 1429-1432 | DiseaseOrPhenotypicFeature | denotes | ICH | 0013792 |
| T17 | 1510-1522 | DiseaseOrPhenotypicFeature | denotes | brain injury | 0043510 |
| T18 | 1529-1553 | DiseaseOrPhenotypicFeature | denotes | intracerebral hemorrhage | 0013792 |
LitCoin-MeSH-Disease-2
| Id | Subject | Object | Predicate | Lexical cue | ID: |
|---|---|---|---|---|---|
| T1 | 25-37 | DiseaseOrPhenotypicFeature | denotes | brain injury | D001930 |
| T2 | 44-68 | DiseaseOrPhenotypicFeature | denotes | intracerebral hemorrhage | D002543 |
| T3 | 70-94 | DiseaseOrPhenotypicFeature | denotes | Intracerebral hemorrhage | D002543 |
| T4 | 96-99 | DiseaseOrPhenotypicFeature | denotes | ICH | DISEASE|D002543 |
| T6 | 118-125 | DiseaseOrPhenotypicFeature | denotes | disease | D004194 |
| T7 | 161-164 | DiseaseOrPhenotypicFeature | denotes | ICH | DISEASE|D002543 |
| T9 | 348-360 | DiseaseOrPhenotypicFeature | denotes | inflammatory | DISEASE |
| T10 | 409-415 | DiseaseOrPhenotypicFeature | denotes | injury | D014947 |
| T11 | 489-501 | DiseaseOrPhenotypicFeature | denotes | brain injury | D001930 |
| T12 | 506-518 | DiseaseOrPhenotypicFeature | denotes | inflammation | DISEASE|D007249 |
| T14 | 540-543 | DiseaseOrPhenotypicFeature | denotes | ICH | DISEASE|D002543 |
| T16 | 613-616 | DiseaseOrPhenotypicFeature | denotes | ICH | DISEASE|D002543 |
| T18 | 691-694 | DiseaseOrPhenotypicFeature | denotes | ICH | DISEASE|D002543 |
| T20 | 728-741 | DiseaseOrPhenotypicFeature | denotes | neurodeficits | DISEASE |
| T21 | 760-771 | DiseaseOrPhenotypicFeature | denotes | brain edema | D001929 |
| T22 | 778-781 | DiseaseOrPhenotypicFeature | denotes | ICH | DISEASE|D002543 |
| T24 | 871-874 | DiseaseOrPhenotypicFeature | denotes | ICH | DISEASE|D002543 |
| T26 | 1089-1094 | DiseaseOrPhenotypicFeature | denotes | death | D003643 |
| T27 | 1308-1320 | DiseaseOrPhenotypicFeature | denotes | brain injury | D001930 |
| T28 | 1325-1337 | DiseaseOrPhenotypicFeature | denotes | inflammation | DISEASE|D007249 |
| T30 | 1344-1347 | DiseaseOrPhenotypicFeature | denotes | ICH | DISEASE|D002543 |
| T32 | 1429-1432 | DiseaseOrPhenotypicFeature | denotes | ICH | DISEASE|D002543 |
| T34 | 1510-1522 | DiseaseOrPhenotypicFeature | denotes | brain injury | D001930 |
| T35 | 1529-1553 | DiseaseOrPhenotypicFeature | denotes | intracerebral hemorrhage | D002543 |
LitCoin-MONDO_bioort2019
| Id | Subject | Object | Predicate | Lexical cue | #label |
|---|---|---|---|---|---|
| T1 | 25-37 | DiseaseOrPhenotypicFeature | denotes | brain injury | D001930 |
| T2 | 44-68 | DiseaseOrPhenotypicFeature | denotes | intracerebral hemorrhage | D002543 |
| T3 | 70-94 | DiseaseOrPhenotypicFeature | denotes | Intracerebral hemorrhage | D002543 |
| T4 | 96-99 | DiseaseOrPhenotypicFeature | denotes | ICH | DISEASE|D002543 |
| T6 | 161-164 | DiseaseOrPhenotypicFeature | denotes | ICH | DISEASE|D002543 |
| T8 | 489-501 | DiseaseOrPhenotypicFeature | denotes | brain injury | D001930 |
| T9 | 506-518 | DiseaseOrPhenotypicFeature | denotes | inflammation | D007249 |
| T10 | 540-543 | DiseaseOrPhenotypicFeature | denotes | ICH | DISEASE|D002543 |
| T12 | 613-616 | DiseaseOrPhenotypicFeature | denotes | ICH | DISEASE|D002543 |
| T14 | 691-694 | DiseaseOrPhenotypicFeature | denotes | ICH | DISEASE|D002543 |
| T16 | 728-741 | DiseaseOrPhenotypicFeature | denotes | neurodeficits | DISEASE |
| T17 | 760-771 | DiseaseOrPhenotypicFeature | denotes | brain edema | D001929 |
| T18 | 778-781 | DiseaseOrPhenotypicFeature | denotes | ICH | DISEASE|D002543 |
| T20 | 871-874 | DiseaseOrPhenotypicFeature | denotes | ICH | DISEASE|D002543 |
| T22 | 1308-1320 | DiseaseOrPhenotypicFeature | denotes | brain injury | D001930 |
| T23 | 1325-1337 | DiseaseOrPhenotypicFeature | denotes | inflammation | D007249 |
| T24 | 1344-1347 | DiseaseOrPhenotypicFeature | denotes | ICH | DISEASE|D002543 |
| T26 | 1429-1432 | DiseaseOrPhenotypicFeature | denotes | ICH | DISEASE|D002543 |
| T28 | 1510-1522 | DiseaseOrPhenotypicFeature | denotes | brain injury | D001930 |
| T29 | 1529-1553 | DiseaseOrPhenotypicFeature | denotes | intracerebral hemorrhage | D002543 |
LitCoin_CellLine
| Id | Subject | Object | Predicate | Lexical cue | cellosaurus_accession_id |
|---|---|---|---|---|---|
| T1 | 1442-1445 | CellLine | denotes | Ren | CVCL_M202 |
LitCoin-NCBITaxon-2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 524-529 | OrganismTaxon | denotes | mouse |
| T2 | 599-607 | OrganismTaxon | denotes | patients |
| T3 | 653-657 | OrganismTaxon | denotes | mice |
| T4 | 875-879 | OrganismTaxon | denotes | mice |
| T5 | 1157-1161 | OrganismTaxon | denotes | mice |
LitCoin-Chemical-MeSH-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | ID: |
|---|---|---|---|---|---|
| T1 | 475-484 | ChemicalEntity | denotes | etifoxine | C002125|http://purl.obolibrary.org/obo/CHEBI_135272 |
| T3 | 671-682 | ChemicalEntity | denotes | collagenase | D017364|ChemicalEntity |
| T5 | 696-705 | ChemicalEntity | denotes | Etifoxine | C002125|http://purl.obolibrary.org/obo/CHEBI_135272 |
| T7 | 835-846 | ChemicalEntity | denotes | collagenase | D017364|ChemicalEntity |
| T9 | 851-862 | ChemicalEntity | denotes | collagenase | D017364|ChemicalEntity |
| T11 | 899-908 | ChemicalEntity | denotes | etifoxine | C002125|http://purl.obolibrary.org/obo/CHEBI_135272 |
| T13 | 1020-1029 | ChemicalEntity | denotes | Etifoxine | C002125|http://purl.obolibrary.org/obo/CHEBI_135272 |
| T15 | 1130-1139 | ChemicalEntity | denotes | etifoxine | C002125|http://purl.obolibrary.org/obo/CHEBI_135272 |
| T17 | 1287-1296 | ChemicalEntity | denotes | etifoxine | C002125|http://purl.obolibrary.org/obo/CHEBI_135272 |
LitCoin-training-merged
| Id | Subject | Object | Predicate | Lexical cue | #label | ID: | cellosaurus_accession_id |
|---|---|---|---|---|---|---|---|
| T1 | 1442-1445 | CellLine | denotes | Ren | CVCL_M202 | ||
| T17 | 1287-1296 | ChemicalEntity | denotes | etifoxine | http://purl.obolibrary.org/obo/CHEBI_135272|C002125 | ||
| T15 | 1130-1139 | ChemicalEntity | denotes | etifoxine | http://purl.obolibrary.org/obo/CHEBI_135272|C002125 | ||
| T13 | 1020-1029 | ChemicalEntity | denotes | Etifoxine | http://purl.obolibrary.org/obo/CHEBI_135272|C002125 | ||
| T11 | 899-908 | ChemicalEntity | denotes | etifoxine | http://purl.obolibrary.org/obo/CHEBI_135272|C002125 | ||
| T9 | 851-862 | ChemicalEntity | denotes | collagenase | ChemicalEntity|D017364 | ||
| T7 | 835-846 | ChemicalEntity | denotes | collagenase | ChemicalEntity|D017364 | ||
| T5 | 696-705 | ChemicalEntity | denotes | Etifoxine | http://purl.obolibrary.org/obo/CHEBI_135272|C002125 | ||
| T3 | 671-682 | ChemicalEntity | denotes | collagenase | ChemicalEntity|D017364 | ||
| T31766 | 475-484 | ChemicalEntity | denotes | etifoxine | http://purl.obolibrary.org/obo/CHEBI_135272|C002125 | ||
| T77960 | 1487-1491 | GeneOrGeneProduct | denotes | TSPO | |||
| T14 | 1349-1353 | GeneOrGeneProduct | denotes | TSPO | |||
| T25542 | 1275-1279 | GeneOrGeneProduct | denotes | TSPO | |||
| T12 | 1195-1220 | GeneOrGeneProduct | denotes | colony-stimulating factor | |||
| T30240 | 1004-1008 | GeneOrGeneProduct | denotes | IL-6 | |||
| T10 | 632-636 | GeneOrGeneProduct | denotes | CD45 | |||
| T38251 | 624-629 | GeneOrGeneProduct | denotes | CD11b | |||
| T8 | 570-574 | GeneOrGeneProduct | denotes | Iba1 | |||
| T45034 | 545-549 | GeneOrGeneProduct | denotes | TSPO | |||
| T6 | 462-466 | GeneOrGeneProduct | denotes | TSPO | |||
| T81983 | 319-323 | GeneOrGeneProduct | denotes | TSPO | |||
| T4 | 312-316 | GeneOrGeneProduct | denotes | TSPO | |||
| T95994 | 290-310 | GeneOrGeneProduct | denotes | translocator protein | |||
| T2 | 283-289 | GeneOrGeneProduct | denotes | 18-kDa | |||
| T96893 | 2-6 | GeneOrGeneProduct | denotes | TSPO | |||
| T29 | 1529-1553 | DiseaseOrPhenotypicFeature | denotes | intracerebral hemorrhage | D002543 | ||
| T28 | 1510-1522 | DiseaseOrPhenotypicFeature | denotes | brain injury | D001930 | ||
| T26 | 1429-1432 | DiseaseOrPhenotypicFeature | denotes | ICH | D002543|DISEASE | ||
| T24 | 1344-1347 | DiseaseOrPhenotypicFeature | denotes | ICH | D002543|DISEASE | ||
| T23 | 1325-1337 | DiseaseOrPhenotypicFeature | denotes | inflammation | D007249 | ||
| T22 | 1308-1320 | DiseaseOrPhenotypicFeature | denotes | brain injury | D001930 | ||
| T20 | 871-874 | DiseaseOrPhenotypicFeature | denotes | ICH | D002543|DISEASE | ||
| T18 | 778-781 | DiseaseOrPhenotypicFeature | denotes | ICH | D002543|DISEASE | ||
| T47955 | 760-771 | DiseaseOrPhenotypicFeature | denotes | brain edema | D001929 | ||
| T16 | 728-741 | DiseaseOrPhenotypicFeature | denotes | neurodeficits | DISEASE | ||
| T18936 | 691-694 | DiseaseOrPhenotypicFeature | denotes | ICH | D002543|DISEASE | ||
| T93591 | 613-616 | DiseaseOrPhenotypicFeature | denotes | ICH | D002543|DISEASE | ||
| T13798 | 540-543 | DiseaseOrPhenotypicFeature | denotes | ICH | D002543|DISEASE | ||
| T59856 | 506-518 | DiseaseOrPhenotypicFeature | denotes | inflammation | D007249 | ||
| T14406 | 489-501 | DiseaseOrPhenotypicFeature | denotes | brain injury | D001930 | ||
| T98817 | 161-164 | DiseaseOrPhenotypicFeature | denotes | ICH | D002543|DISEASE | ||
| T39415 | 96-99 | DiseaseOrPhenotypicFeature | denotes | ICH | D002543|DISEASE | ||
| T5677 | 70-94 | DiseaseOrPhenotypicFeature | denotes | Intracerebral hemorrhage | D002543 | ||
| T97959 | 44-68 | DiseaseOrPhenotypicFeature | denotes | intracerebral hemorrhage | D002543 | ||
| T50667 | 25-37 | DiseaseOrPhenotypicFeature | denotes | brain injury | D001930 | ||
| T16659 | 1157-1161 | OrganismTaxon | denotes | mice | |||
| T20298 | 875-879 | OrganismTaxon | denotes | mice | |||
| T60109 | 653-657 | OrganismTaxon | denotes | mice | |||
| T67953 | 599-607 | OrganismTaxon | denotes | patients | |||
| T1904 | 524-529 | OrganismTaxon | denotes | mouse |
Inflammaging
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-69 | Sentence | denotes | A TSPO ligand attenuates brain injury after intracerebral hemorrhage. |
| T2 | 70-154 | Sentence | denotes | Intracerebral hemorrhage (ICH) is a devastating disease without effective treatment. |
| T3 | 155-318 | Sentence | denotes | After ICH, the immediate infiltration of leukocytes and activation of microglia are accompanied by a rapid up-regulation of the 18-kDa translocator protein (TSPO). |
| T4 | 319-416 | Sentence | denotes | TSPO ligands have shown anti-inflammatory and neuroprotective properties in models of CNS injury. |
| T5 | 417-544 | Sentence | denotes | In this study, we determined the impact of a TSPO ligand, etifoxine, on brain injury and inflammation in 2 mouse models of ICH. |
| T6 | 545-695 | Sentence | denotes | TSPO was up-regulated in Iba1(+) cells from brains of patients with ICH and in CD11b(+)CD45(int) cells from mice subjected to collagenase-induced ICH. |
| T7 | 696-847 | Sentence | denotes | Etifoxine significantly reduced neurodeficits and perihematomal brain edema after ICH induction by injection of either autologous blood or collagenase. |
| T8 | 848-1019 | Sentence | denotes | In collagenase-induced ICH mice, the protection of etifoxine was associated with reduced leukocyte infiltration into the brain and microglial production of IL-6 and TNF-α. |
| T9 | 1020-1095 | Sentence | denotes | Etifoxine improved blood-brain barrier integrity and diminished cell death. |
| T10 | 1096-1242 | Sentence | denotes | Notably, the protective effect of etifoxine was abolished in mice depleted of microglia by using a colony-stimulating factor 1 receptor inhibitor. |
| T11 | 1243-1348 | Sentence | denotes | These results indicate that the TSPO ligand etifoxine attenuates brain injury and inflammation after ICH. |
| T12 | 1349-1460 | Sentence | denotes | TSPO may be a viable therapeutic target that requires further investigations in ICH.-Li, M., Ren, H., Sheth, K. |
| T13 | 1461-1484 | Sentence | denotes | N., Shi, F.-D., Liu, Q. |
| T14 | 1485-1554 | Sentence | denotes | A TSPO ligand attenuates brain injury after intracerebral hemorrhage. |
| T1 | 0-69 | Sentence | denotes | A TSPO ligand attenuates brain injury after intracerebral hemorrhage. |
| T2 | 70-154 | Sentence | denotes | Intracerebral hemorrhage (ICH) is a devastating disease without effective treatment. |
| T3 | 155-318 | Sentence | denotes | After ICH, the immediate infiltration of leukocytes and activation of microglia are accompanied by a rapid up-regulation of the 18-kDa translocator protein (TSPO). |
| T4 | 319-416 | Sentence | denotes | TSPO ligands have shown anti-inflammatory and neuroprotective properties in models of CNS injury. |
| T5 | 417-544 | Sentence | denotes | In this study, we determined the impact of a TSPO ligand, etifoxine, on brain injury and inflammation in 2 mouse models of ICH. |
| T6 | 545-695 | Sentence | denotes | TSPO was up-regulated in Iba1(+) cells from brains of patients with ICH and in CD11b(+)CD45(int) cells from mice subjected to collagenase-induced ICH. |
| T7 | 696-847 | Sentence | denotes | Etifoxine significantly reduced neurodeficits and perihematomal brain edema after ICH induction by injection of either autologous blood or collagenase. |
| T8 | 848-1019 | Sentence | denotes | In collagenase-induced ICH mice, the protection of etifoxine was associated with reduced leukocyte infiltration into the brain and microglial production of IL-6 and TNF-α. |
| T9 | 1020-1095 | Sentence | denotes | Etifoxine improved blood-brain barrier integrity and diminished cell death. |
| T10 | 1096-1242 | Sentence | denotes | Notably, the protective effect of etifoxine was abolished in mice depleted of microglia by using a colony-stimulating factor 1 receptor inhibitor. |
| T11 | 1243-1348 | Sentence | denotes | These results indicate that the TSPO ligand etifoxine attenuates brain injury and inflammation after ICH. |
| T12 | 1349-1460 | Sentence | denotes | TSPO may be a viable therapeutic target that requires further investigations in ICH.-Li, M., Ren, H., Sheth, K. |
| T13 | 1461-1484 | Sentence | denotes | N., Shi, F.-D., Liu, Q. |
| T14 | 1485-1554 | Sentence | denotes | A TSPO ligand attenuates brain injury after intracerebral hemorrhage. |