PubMed:2839511
Annnotations
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 68-71 | Glycan_Motif | denotes | GM3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH |
| T3 | 81-84 | Glycan_Motif | denotes | GM3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH |
| T5 | 283-286 | Glycan_Motif | denotes | GM3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH |
| T7 | 518-521 | Glycan_Motif | denotes | GM3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH |
| T9 | 749-752 | Glycan_Motif | denotes | GM3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH |
| T11 | 849-852 | Glycan_Motif | denotes | GM3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH |
| T13 | 1017-1020 | Glycan_Motif | denotes | GM3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH |
| T15 | 1131-1134 | Glycan_Motif | denotes | GM3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH |
| T17 | 1282-1285 | Glycan_Motif | denotes | GM3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH |
| T19 | 1364-1367 | Glycan_Motif | denotes | GM3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH |
| T21 | 1466-1469 | Glycan_Motif | denotes | GM3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH |
| T23 | 1526-1529 | Glycan_Motif | denotes | GM3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH |
| T25 | 1695-1698 | Glycan_Motif | denotes | GM3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH |
| T27 | 1918-1921 | Glycan_Motif | denotes | GM3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-47 | Sentence | denotes | Ganglioside-mediated modulation of cell growth. |
| T2 | 48-153 | Sentence | denotes | Specific effects of GM3 and lyso-GM3 in tyrosine phosphorylation of the epidermal growth factor receptor. |
| T3 | 154-397 | Sentence | denotes | Epidermal growth factor- (EGF) dependent tyrosine phosphorylation of the EGF receptor was inhibited by the exogenous addition of GM3 to a membrane preparation and to purified EGF receptor adsorbed to antireceptor-antibody-Sepharose (Bremer, E. |
| T4 | 398-446 | Sentence | denotes | G., Schlessinger, J., and Hakomori, S. (1986) J. |
| T5 | 447-452 | Sentence | denotes | Biol. |
| T6 | 453-458 | Sentence | denotes | Chem. |
| T7 | 459-475 | Sentence | denotes | 261, 2434-2440). |
| T8 | 476-685 | Sentence | denotes | A specific functional correlation between GM3 and EGF receptor function has been further assessed in this study, employing two variant clones of A431 cells showing completely different growth responses to EGF. |
| T9 | 686-853 | Sentence | denotes | The A1S clone showed EGF cell growth stimulation and contained GM3 whereas the A5I clone, whose growth was completely inhibited by EGF addition, lacked detectable GM3. |
| T10 | 854-1021 | Sentence | denotes | Both the endogenous and EGF-dependent receptor tyrosine-kinase activities were low in the A1S clone and were only minimally inhibited by the exogenous addition of GM3. |
| T11 | 1022-1160 | Sentence | denotes | In contrast the EGF receptor kinase activity in A5I cells was much higher and was more strongly inhibited by GM3 than it was in A1S cells. |
| T12 | 1161-1368 | Sentence | denotes | The EGF receptor fraction prepared from A1S cells, eluted from an anti-EGF receptor antibody-Sepharose column, contained GM3, in contrast to the fraction prepared from A5I cells, which lacked detectable GM3. |
| T13 | 1369-1465 | Sentence | denotes | The receptor kinase activity in vitro was greatly influenced by detergent and ATP concentration. |
| T14 | 1466-1677 | Sentence | denotes | GM3 affected the receptor kinase in a biphasic manner, i.e. GM3 was inhibitory at a low concentration of detergent under a physiological concentration of ATP and stimulatory at a high concentration of detergent. |
| T15 | 1678-1787 | Sentence | denotes | In contrast lyso-GM3 displayed a monophasic inhibitory effect under a wide range of detergent concentrations. |
| T16 | 1788-1876 | Sentence | denotes | Lyso-CDH (lactosylsphingosine) had no detectable effect on the receptor kinase activity. |
| T17 | 1877-2077 | Sentence | denotes | The presence of a small quantity of lyso-GM3 in A431 cells was detected after DEAE-Sepharose chromatography followed by high performance liquid chromatography in a n-propanolyl alcohol-ammonia system. |
| T18 | 2078-2210 | Sentence | denotes | It is possible that de-N-fatty acylation of gangliosides could be an effective means to modulate EGF receptor function in membranes. |
| T1 | 0-47 | Sentence | denotes | Ganglioside-mediated modulation of cell growth. |
| T2 | 48-153 | Sentence | denotes | Specific effects of GM3 and lyso-GM3 in tyrosine phosphorylation of the epidermal growth factor receptor. |
| T3 | 154-397 | Sentence | denotes | Epidermal growth factor- (EGF) dependent tyrosine phosphorylation of the EGF receptor was inhibited by the exogenous addition of GM3 to a membrane preparation and to purified EGF receptor adsorbed to antireceptor-antibody-Sepharose (Bremer, E. |
| T4 | 398-446 | Sentence | denotes | G., Schlessinger, J., and Hakomori, S. (1986) J. |
| T5 | 447-452 | Sentence | denotes | Biol. |
| T6 | 453-458 | Sentence | denotes | Chem. |
| T7 | 459-475 | Sentence | denotes | 261, 2434-2440). |
| T8 | 476-685 | Sentence | denotes | A specific functional correlation between GM3 and EGF receptor function has been further assessed in this study, employing two variant clones of A431 cells showing completely different growth responses to EGF. |
| T9 | 686-853 | Sentence | denotes | The A1S clone showed EGF cell growth stimulation and contained GM3 whereas the A5I clone, whose growth was completely inhibited by EGF addition, lacked detectable GM3. |
| T10 | 854-1021 | Sentence | denotes | Both the endogenous and EGF-dependent receptor tyrosine-kinase activities were low in the A1S clone and were only minimally inhibited by the exogenous addition of GM3. |
| T11 | 1022-1160 | Sentence | denotes | In contrast the EGF receptor kinase activity in A5I cells was much higher and was more strongly inhibited by GM3 than it was in A1S cells. |
| T12 | 1161-1368 | Sentence | denotes | The EGF receptor fraction prepared from A1S cells, eluted from an anti-EGF receptor antibody-Sepharose column, contained GM3, in contrast to the fraction prepared from A5I cells, which lacked detectable GM3. |
| T13 | 1369-1465 | Sentence | denotes | The receptor kinase activity in vitro was greatly influenced by detergent and ATP concentration. |
| T14 | 1466-1677 | Sentence | denotes | GM3 affected the receptor kinase in a biphasic manner, i.e. GM3 was inhibitory at a low concentration of detergent under a physiological concentration of ATP and stimulatory at a high concentration of detergent. |
| T15 | 1678-1787 | Sentence | denotes | In contrast lyso-GM3 displayed a monophasic inhibitory effect under a wide range of detergent concentrations. |
| T16 | 1788-1876 | Sentence | denotes | Lyso-CDH (lactosylsphingosine) had no detectable effect on the receptor kinase activity. |
| T17 | 1877-2077 | Sentence | denotes | The presence of a small quantity of lyso-GM3 in A431 cells was detected after DEAE-Sepharose chromatography followed by high performance liquid chromatography in a n-propanolyl alcohol-ammonia system. |
| T18 | 2078-2210 | Sentence | denotes | It is possible that de-N-fatty acylation of gangliosides could be an effective means to modulate EGF receptor function in membranes. |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 68-71 | https://glytoucan.org/Structures/Glycans/G56516VH | denotes | GM3 |
| T2 | 68-71 | https://glytoucan.org/Structures/Glycans/G91237TK | denotes | GM3 |
| T3 | 81-84 | https://glytoucan.org/Structures/Glycans/G56516VH | denotes | GM3 |
| T4 | 81-84 | https://glytoucan.org/Structures/Glycans/G91237TK | denotes | GM3 |
| T5 | 283-286 | https://glytoucan.org/Structures/Glycans/G56516VH | denotes | GM3 |
| T6 | 283-286 | https://glytoucan.org/Structures/Glycans/G91237TK | denotes | GM3 |
| T7 | 518-521 | https://glytoucan.org/Structures/Glycans/G56516VH | denotes | GM3 |
| T8 | 518-521 | https://glytoucan.org/Structures/Glycans/G91237TK | denotes | GM3 |
| T9 | 749-752 | https://glytoucan.org/Structures/Glycans/G56516VH | denotes | GM3 |
| T10 | 749-752 | https://glytoucan.org/Structures/Glycans/G91237TK | denotes | GM3 |
| T11 | 849-852 | https://glytoucan.org/Structures/Glycans/G56516VH | denotes | GM3 |
| T12 | 849-852 | https://glytoucan.org/Structures/Glycans/G91237TK | denotes | GM3 |
| T13 | 1017-1020 | https://glytoucan.org/Structures/Glycans/G56516VH | denotes | GM3 |
| T14 | 1017-1020 | https://glytoucan.org/Structures/Glycans/G91237TK | denotes | GM3 |
| T15 | 1131-1134 | https://glytoucan.org/Structures/Glycans/G56516VH | denotes | GM3 |
| T16 | 1131-1134 | https://glytoucan.org/Structures/Glycans/G91237TK | denotes | GM3 |
| T17 | 1282-1285 | https://glytoucan.org/Structures/Glycans/G56516VH | denotes | GM3 |
| T18 | 1282-1285 | https://glytoucan.org/Structures/Glycans/G91237TK | denotes | GM3 |
| T19 | 1364-1367 | https://glytoucan.org/Structures/Glycans/G56516VH | denotes | GM3 |
| T20 | 1364-1367 | https://glytoucan.org/Structures/Glycans/G91237TK | denotes | GM3 |
| T21 | 1466-1469 | https://glytoucan.org/Structures/Glycans/G56516VH | denotes | GM3 |
| T22 | 1466-1469 | https://glytoucan.org/Structures/Glycans/G91237TK | denotes | GM3 |
| T23 | 1526-1529 | https://glytoucan.org/Structures/Glycans/G56516VH | denotes | GM3 |
| T24 | 1526-1529 | https://glytoucan.org/Structures/Glycans/G91237TK | denotes | GM3 |
| T25 | 1695-1698 | https://glytoucan.org/Structures/Glycans/G56516VH | denotes | GM3 |
| T26 | 1695-1698 | https://glytoucan.org/Structures/Glycans/G91237TK | denotes | GM3 |
| T27 | 1918-1921 | https://glytoucan.org/Structures/Glycans/G56516VH | denotes | GM3 |
| T28 | 1918-1921 | https://glytoucan.org/Structures/Glycans/G91237TK | denotes | GM3 |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1955-1959 | HP_0000365 | denotes | DEAE |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 1793-1796 | Disease | denotes | CDH | http://purl.obolibrary.org/obo/MONDO_0005711 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 68-71 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T2 | 81-84 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T3 | 283-286 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T4 | 518-521 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T5 | 749-752 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T6 | 849-852 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T7 | 1017-1020 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T8 | 1131-1134 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T9 | 1282-1285 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T10 | 1364-1367 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T11 | 1466-1469 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T12 | 1526-1529 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T13 | 1695-1698 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T14 | 1918-1921 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 1793-1796 | Disease | denotes | CDH | http://purl.obolibrary.org/obo/MONDO_0005711 |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 2062-2069 | OrganismTaxon | denotes | ammonia | 29189 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 120-136 | Body_part | denotes | epidermal growth | http://purl.obolibrary.org/obo/UBERON_0000021 |
| T2 | 154-170 | Body_part | denotes | Epidermal growth | http://purl.obolibrary.org/obo/UBERON_0000021 |
| T3 | 292-300 | Body_part | denotes | membrane | http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158 |
| T6 | 2200-2209 | Body_part | denotes | membranes | http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-47 | Sentence | denotes | Ganglioside-mediated modulation of cell growth. |
| T2 | 48-153 | Sentence | denotes | Specific effects of GM3 and lyso-GM3 in tyrosine phosphorylation of the epidermal growth factor receptor. |
| T3 | 154-397 | Sentence | denotes | Epidermal growth factor- (EGF) dependent tyrosine phosphorylation of the EGF receptor was inhibited by the exogenous addition of GM3 to a membrane preparation and to purified EGF receptor adsorbed to antireceptor-antibody-Sepharose (Bremer, E. |
| T4 | 398-446 | Sentence | denotes | G., Schlessinger, J., and Hakomori, S. (1986) J. |
| T5 | 447-452 | Sentence | denotes | Biol. |
| T6 | 453-458 | Sentence | denotes | Chem. |
| T7 | 459-475 | Sentence | denotes | 261, 2434-2440). |
| T8 | 476-685 | Sentence | denotes | A specific functional correlation between GM3 and EGF receptor function has been further assessed in this study, employing two variant clones of A431 cells showing completely different growth responses to EGF. |
| T9 | 686-853 | Sentence | denotes | The A1S clone showed EGF cell growth stimulation and contained GM3 whereas the A5I clone, whose growth was completely inhibited by EGF addition, lacked detectable GM3. |
| T10 | 854-1021 | Sentence | denotes | Both the endogenous and EGF-dependent receptor tyrosine-kinase activities were low in the A1S clone and were only minimally inhibited by the exogenous addition of GM3. |
| T11 | 1022-1160 | Sentence | denotes | In contrast the EGF receptor kinase activity in A5I cells was much higher and was more strongly inhibited by GM3 than it was in A1S cells. |
| T12 | 1161-1368 | Sentence | denotes | The EGF receptor fraction prepared from A1S cells, eluted from an anti-EGF receptor antibody-Sepharose column, contained GM3, in contrast to the fraction prepared from A5I cells, which lacked detectable GM3. |
| T13 | 1369-1465 | Sentence | denotes | The receptor kinase activity in vitro was greatly influenced by detergent and ATP concentration. |
| T14 | 1466-1677 | Sentence | denotes | GM3 affected the receptor kinase in a biphasic manner, i.e. GM3 was inhibitory at a low concentration of detergent under a physiological concentration of ATP and stimulatory at a high concentration of detergent. |
| T15 | 1678-1787 | Sentence | denotes | In contrast lyso-GM3 displayed a monophasic inhibitory effect under a wide range of detergent concentrations. |
| T16 | 1788-1876 | Sentence | denotes | Lyso-CDH (lactosylsphingosine) had no detectable effect on the receptor kinase activity. |
| T17 | 1877-2077 | Sentence | denotes | The presence of a small quantity of lyso-GM3 in A431 cells was detected after DEAE-Sepharose chromatography followed by high performance liquid chromatography in a n-propanolyl alcohol-ammonia system. |
| T18 | 2078-2210 | Sentence | denotes | It is possible that de-N-fatty acylation of gangliosides could be an effective means to modulate EGF receptor function in membranes. |
| T1 | 0-47 | Sentence | denotes | Ganglioside-mediated modulation of cell growth. |
| T2 | 48-153 | Sentence | denotes | Specific effects of GM3 and lyso-GM3 in tyrosine phosphorylation of the epidermal growth factor receptor. |
| T3 | 154-397 | Sentence | denotes | Epidermal growth factor- (EGF) dependent tyrosine phosphorylation of the EGF receptor was inhibited by the exogenous addition of GM3 to a membrane preparation and to purified EGF receptor adsorbed to antireceptor-antibody-Sepharose (Bremer, E. |
| T4 | 398-446 | Sentence | denotes | G., Schlessinger, J., and Hakomori, S. (1986) J. |
| T5 | 447-452 | Sentence | denotes | Biol. |
| T6 | 453-458 | Sentence | denotes | Chem. |
| T7 | 459-475 | Sentence | denotes | 261, 2434-2440). |
| T8 | 476-685 | Sentence | denotes | A specific functional correlation between GM3 and EGF receptor function has been further assessed in this study, employing two variant clones of A431 cells showing completely different growth responses to EGF. |
| T9 | 686-853 | Sentence | denotes | The A1S clone showed EGF cell growth stimulation and contained GM3 whereas the A5I clone, whose growth was completely inhibited by EGF addition, lacked detectable GM3. |
| T10 | 854-1021 | Sentence | denotes | Both the endogenous and EGF-dependent receptor tyrosine-kinase activities were low in the A1S clone and were only minimally inhibited by the exogenous addition of GM3. |
| T11 | 1022-1160 | Sentence | denotes | In contrast the EGF receptor kinase activity in A5I cells was much higher and was more strongly inhibited by GM3 than it was in A1S cells. |
| T12 | 1161-1368 | Sentence | denotes | The EGF receptor fraction prepared from A1S cells, eluted from an anti-EGF receptor antibody-Sepharose column, contained GM3, in contrast to the fraction prepared from A5I cells, which lacked detectable GM3. |
| T13 | 1369-1465 | Sentence | denotes | The receptor kinase activity in vitro was greatly influenced by detergent and ATP concentration. |
| T14 | 1466-1677 | Sentence | denotes | GM3 affected the receptor kinase in a biphasic manner, i.e. GM3 was inhibitory at a low concentration of detergent under a physiological concentration of ATP and stimulatory at a high concentration of detergent. |
| T15 | 1678-1787 | Sentence | denotes | In contrast lyso-GM3 displayed a monophasic inhibitory effect under a wide range of detergent concentrations. |
| T16 | 1788-1876 | Sentence | denotes | Lyso-CDH (lactosylsphingosine) had no detectable effect on the receptor kinase activity. |
| T17 | 1877-2077 | Sentence | denotes | The presence of a small quantity of lyso-GM3 in A431 cells was detected after DEAE-Sepharose chromatography followed by high performance liquid chromatography in a n-propanolyl alcohol-ammonia system. |
| T18 | 2078-2210 | Sentence | denotes | It is possible that de-N-fatty acylation of gangliosides could be an effective means to modulate EGF receptor function in membranes. |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-47 | Sentence | denotes | Ganglioside-mediated modulation of cell growth. |
| T2 | 48-153 | Sentence | denotes | Specific effects of GM3 and lyso-GM3 in tyrosine phosphorylation of the epidermal growth factor receptor. |
| T3 | 154-475 | Sentence | denotes | Epidermal growth factor- (EGF) dependent tyrosine phosphorylation of the EGF receptor was inhibited by the exogenous addition of GM3 to a membrane preparation and to purified EGF receptor adsorbed to antireceptor-antibody-Sepharose (Bremer, E. G., Schlessinger, J., and Hakomori, S. (1986) J. Biol. Chem. 261, 2434-2440). |
| T4 | 476-685 | Sentence | denotes | A specific functional correlation between GM3 and EGF receptor function has been further assessed in this study, employing two variant clones of A431 cells showing completely different growth responses to EGF. |
| T5 | 686-853 | Sentence | denotes | The A1S clone showed EGF cell growth stimulation and contained GM3 whereas the A5I clone, whose growth was completely inhibited by EGF addition, lacked detectable GM3. |
| T6 | 854-1021 | Sentence | denotes | Both the endogenous and EGF-dependent receptor tyrosine-kinase activities were low in the A1S clone and were only minimally inhibited by the exogenous addition of GM3. |
| T7 | 1022-1160 | Sentence | denotes | In contrast the EGF receptor kinase activity in A5I cells was much higher and was more strongly inhibited by GM3 than it was in A1S cells. |
| T8 | 1161-1368 | Sentence | denotes | The EGF receptor fraction prepared from A1S cells, eluted from an anti-EGF receptor antibody-Sepharose column, contained GM3, in contrast to the fraction prepared from A5I cells, which lacked detectable GM3. |
| T9 | 1369-1465 | Sentence | denotes | The receptor kinase activity in vitro was greatly influenced by detergent and ATP concentration. |
| T10 | 1466-1677 | Sentence | denotes | GM3 affected the receptor kinase in a biphasic manner, i.e. GM3 was inhibitory at a low concentration of detergent under a physiological concentration of ATP and stimulatory at a high concentration of detergent. |
| T11 | 1678-1787 | Sentence | denotes | In contrast lyso-GM3 displayed a monophasic inhibitory effect under a wide range of detergent concentrations. |
| T12 | 1788-1876 | Sentence | denotes | Lyso-CDH (lactosylsphingosine) had no detectable effect on the receptor kinase activity. |
| T13 | 1877-2077 | Sentence | denotes | The presence of a small quantity of lyso-GM3 in A431 cells was detected after DEAE-Sepharose chromatography followed by high performance liquid chromatography in a n-propanolyl alcohol-ammonia system. |
| T14 | 2078-2210 | Sentence | denotes | It is possible that de-N-fatty acylation of gangliosides could be an effective means to modulate EGF receptor function in membranes. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 68-71 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T2 | 81-84 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T3 | 283-286 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T4 | 518-521 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T5 | 749-752 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T6 | 849-852 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T7 | 1017-1020 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T8 | 1131-1134 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T9 | 1282-1285 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T10 | 1364-1367 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T11 | 1466-1469 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T12 | 1526-1529 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T13 | 1695-1698 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
| T14 | 1918-1921 | Glycan | denotes | GM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 2062-2069 | OrganismTaxon | denotes | ammonia | 29189 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 120-136 | Body_part | denotes | epidermal growth | http://purl.obolibrary.org/obo/UBERON_0000021 |
| T2 | 154-170 | Body_part | denotes | Epidermal growth | http://purl.obolibrary.org/obo/UBERON_0000021 |
| T3 | 292-300 | Body_part | denotes | membrane | http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158 |
| T6 | 2200-2209 | Body_part | denotes | membranes | http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158 |