PubMed:28390726
Annnotations
GoldHamster
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 22-30 | CHEBI:33284 | denotes | nutrient |
T2 | 76-82 | UBERON:0000479 | denotes | tissue |
T3 | 98-111 | UBERON:0001911 | denotes | mammary gland |
T4 | 98-111 | UBERON:0005200 | denotes | mammary gland |
T6 | 251-264 | UBERON:0001911 | denotes | mammary gland |
T7 | 251-264 | UBERON:0005200 | denotes | mammary gland |
T9 | 288-296 | CHEBI:33284 | denotes | nutrient |
T10 | 377-385 | CHEBI:33284 | denotes | nutrient |
T11 | 407-420 | UBERON:0001911 | denotes | mammary gland |
T12 | 407-420 | UBERON:0005200 | denotes | mammary gland |
T13 | 407-432 | GO:0030879 | denotes | mammary gland development |
T16 | 466-479 | UBERON:2000098 | denotes | proliferation |
T17 | 575-579 | UBERON:0001913 | denotes | milk |
T23 | 721-728 | SO:0000104 | denotes | protein |
T22 | 721-728 | PR:000000001 | denotes | protein |
T19 | 721-728 | GO:0003675 | denotes | protein |
T20 | 721-728 | CHEBI:36080 | denotes | protein |
T21 | 721-728 | CHEBI:11122 | denotes | protein |
T24 | 734-737 | UBERON:0001013 | denotes | fat |
T25 | 734-737 | CHEBI:24021 | denotes | fat |
T26 | 738-742 | UBERON:0001913 | denotes | milk |
T29 | 917-928 | D001835 | denotes | body weight |
T30 | 917-928 | D001835 | denotes | body weight |
T34 | 1048-1055 | PR:000000001 | denotes | protein |
T32 | 1048-1055 | CHEBI:36080 | denotes | protein |
T33 | 1048-1055 | CHEBI:11122 | denotes | protein |
T35 | 1048-1055 | SO:0000104 | denotes | protein |
T31 | 1048-1055 | GO:0003675 | denotes | protein |
T36 | 1067-1071 | UBERON:0003823 | denotes | calf |
T38 | 1177-1181 | UBERON:0003823 | denotes | calf |
T39 | 1194-1198 | UBERON:0003823 | denotes | calf |
T48 | 1277-1281 | UBERON:0003823 | denotes | calf |
T49 | 1294-1298 | UBERON:0003823 | denotes | calf |
T50 | 1351-1360 | CL:0000034 | denotes | stem cell |
T51 | 1351-1374 | GO:0072089 | denotes | stem cell proliferation |
T53 | 1361-1374 | UBERON:2000098 | denotes | proliferation |
T54 | 1376-1380 | CHEBI:472552 | denotes | BrdU |
T55 | 1376-1380 | D001973 | denotes | BrdU |
T56 | 1376-1380 | D001973 | denotes | BrdU |
T57 | 1382-1405 | CHEBI:472552 | denotes | 5-bromo-2'-deoxyuridine |
T58 | 1382-1405 | D001973 | denotes | 5-bromo-2'-deoxyuridine |
T59 | 1382-1405 | D001973 | denotes | 5-bromo-2'-deoxyuridine |
T66 | 1546-1557 | D001835 | denotes | body weight |
T67 | 1546-1557 | D001835 | denotes | body weight |
T68 | 1674-1679 | UBERON:0002107 | denotes | liver |
T69 | 1690-1698 | UBERON:3011040 | denotes | pancreas |
T70 | 1690-1698 | UBERON:0001264 | denotes | pancreas |
T71 | 1714-1727 | UBERON:0001911 | denotes | mammary gland |
T72 | 1714-1727 | UBERON:0005200 | denotes | mammary gland |
T74 | 1741-1751 | UBERON:0000353 | denotes | parenchyma |
T75 | 1791-1796 | UBERON:0000062 | denotes | organ |
T76 | 1791-1796 | UBERON:0003103 | denotes | organ |
T77 | 1878-1883 | UBERON:0000062 | denotes | organ |
T78 | 1878-1883 | UBERON:0003103 | denotes | organ |
T79 | 1910-1921 | D001835 | denotes | body weight |
T80 | 1910-1921 | D001835 | denotes | body weight |
T81 | 2078-2083 | CVCL_C076 | denotes | had 5 |
T82 | 2141-2154 | UBERON:0001911 | denotes | mammary gland |
T83 | 2141-2154 | UBERON:0005200 | denotes | mammary gland |
T85 | 2173-2181 | CHEBI:33284 | denotes | nutrient |
T86 | 2230-2243 | UBERON:0001911 | denotes | mammary gland |
T87 | 2230-2243 | UBERON:0005200 | denotes | mammary gland |
T89 | 2367-2371 | CHEBI:472552 | denotes | BrdU |
T90 | 2367-2371 | D001973 | denotes | BrdU |
T91 | 2367-2371 | D001973 | denotes | BrdU |
T92 | 2372-2377 | CHEBI:35209 | denotes | label |
T93 | 2424-2430 | UBERON:0000479 | denotes | tissue |
T94 | 2560-2565 | CHEBI:35209 | denotes | label |
T95 | 2733-2746 | UBERON:0001911 | denotes | mammary gland |
T96 | 2733-2746 | UBERON:0005200 | denotes | mammary gland |
PubMed_ArguminSci
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 84-210 | DRI_Background | denotes | Historically, mammary gland growth has been considered isometric the first 2 mo of life and then allometric until peripuberty. |
T2 | 211-315 | DRI_Background | denotes | However, recent work indicated that the mammary gland might be responsive to nutrient intake preweaning. |
T3 | 316-513 | DRI_Background | denotes | The objectives of this study were to describe the effects of nutrient intake preweaning on mammary gland development and to investigate cell specific proliferation during this phase of development. |
T4 | 514-663 | DRI_Approach | denotes | Twelve dairy heifer calves were fed either a fixed amount of milk replacer (MR; control, n = 6) or an amount of MR adjusted for BW (enhanced, n = 6). |
T5 | 664-991 | DRI_Outcome | denotes | Control calves received a constant amount of a 28% crude protein, 15% fat milk MR per day that was equivalent to 2.8 Mcal of metabolizable energy intake per day; enhanced calves received 0.3 Mcal of metabolizable energy intake per kilogram of metabolic body weight (from 4.2 to 8.4 Mcal of metabolizable energy intake per day). |
T6 | 992-1080 | DRI_Approach | denotes | All calves had constant access to water and a 22% crude protein commercial calf starter. |
T7 | 1081-1320 | DRI_Outcome | denotes | Calves were killed at 54 ± 2 d. Control calves consumed 32.6 ± 2.4 kg of MR and 6.7 ± 0.5 kg of calf starter per calf, whereas the enhanced calves consumed 69.5 ± 2.4 kg of MR and 1.9 ± 0.5 kg of calf starter per calf over the 54-d period. |
T8 | 1321-1527 | DRI_Approach | denotes | Further, to evaluate putative stem cell proliferation, BrdU (5-bromo-2'-deoxyuridine; 5 mg/kg) was injected intramuscularly once per day between 12 to 15 d and again once per day between 24 to 27 d of life. |
T9 | 1528-1647 | DRI_Background | denotes | Initial and final body weight for the control and enhanced treatments were 39.2, 61.0, 39.7, and 83.2 kg, respectively. |
T10 | 1648-1766 | DRI_Background | denotes | At euthanasia, weights of liver, kidneys, pancreas, whole skinned mammary gland, and mammary parenchyma were measured. |
T11 | 1767-1922 | DRI_Outcome | denotes | The growth rate of each organ was calculated using the concept of allometry as the difference in the change in organ weight as a percentage of body weight. |
T12 | 1923-2204 | DRI_Background | denotes | The mammary glands of calves fed the enhanced diet were significantly heavier at euthanasia; when mammary parenchymal weight was analyzed, enhanced calves had 5.9 times greater mammary parenchymal mass, indicating the mammary gland was responsive to nutrient intake before weaning. |
T13 | 2205-2310 | DRI_Approach | denotes | Allometric growth of the mammary gland was initiated preweaning in the calves fed the enhanced treatment. |
T14 | 2311-2747 | DRI_Approach | denotes | Further characterization of mammary cells that retained BrdU label revealed no significant differences among the tissue slices analyzed between treatments; however, as calves fed the enhanced diet had more mammary parenchymal mass, if the number of label-retaining cells per counted slide were similar between treatments then the enhanced calves had a larger total population of putative mammary stem cells present in the mammary gland. |
Goldhamster2_Cellosaurus
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 119-122 | CVCL_6758|Undefined_cell_line_type|Cricetulus griseus | denotes | has |
T2 | 119-122 | CVCL_E689|Transformed_cell_line|Homo sapiens | denotes | has |
T3 | 161-163 | CVCL_1439|Cancer_cell_line|Homo sapiens | denotes | mo |
T4 | 161-163 | CVCL_7019|Cancer_cell_line|Homo sapiens | denotes | mo |
T5 | 557-558 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
T6 | 603-608 | CVCL_D461|Transformed_cell_line|Mus musculus | denotes | n = 6 |
T7 | 613-615 | CVCL_8754|Cancer_cell_line|Homo sapiens | denotes | an |
T8 | 613-615 | CVCL_H241|Cancer_cell_line|Homo sapiens | denotes | an |
T9 | 656-661 | CVCL_D461|Transformed_cell_line|Mus musculus | denotes | n = 6 |
T10 | 688-689 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
T11 | 709-710 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
T12 | 1036-1037 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
T13 | 1038-1040 | CVCL_WT45|Hybridoma|Mus musculus | denotes | 22 |
T14 | 1103-1105 | CVCL_ZT26|Transformed_cell_line|Homo sapiens | denotes | 54 |
T15 | 1308-1310 | CVCL_ZT26|Transformed_cell_line|Homo sapiens | denotes | 54 |
T16 | 1514-1516 | CVCL_T366|Transformed_cell_line|Chlorocebus aethiops | denotes | 27 |
T17 | 1868-1874 | CVCL_0238|Cancer_cell_line|Homo sapiens | denotes | change |
T18 | 1894-1895 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
T19 | 2082-2085 | CVCL_J991|Hybridoma|Mus musculus | denotes | 5.9 |
T20 | 2086-2091 | CVCL_0047|Telomerase_immortalized_cell_line|Homo sapiens | denotes | times |
T21 | 2372-2377 | CVCL_3734|Finite_cell_line|Homo sapiens | denotes | label |
T22 | 2560-2565 | CVCL_3734|Finite_cell_line|Homo sapiens | denotes | label |
T23 | 2661-2662 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |