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PubMed:28368423 JSONTXT

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LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
12536 0-3 GeneOrGeneProduct denotes Myc NCBIGene:17869
12537 13-28 GeneOrGeneProduct denotes B-cell receptor NCBIGene:16019
12538 42-54 DiseaseOrPhenotypicFeature denotes precancerous MESH:D011230
12539 89-92 GeneOrGeneProduct denotes Btk NCBIGene:12229
12540 157-160 GeneOrGeneProduct denotes MYC NCBIGene:17869
12541 211-238 DiseaseOrPhenotypicFeature denotes B-cell non-Hodgkin lymphoma MESH:D016393
12542 240-245 DiseaseOrPhenotypicFeature denotes B-NHL MESH:D016393
12543 248-251 GeneOrGeneProduct denotes MYC NCBIGene:17869
12544 270-275 DiseaseOrPhenotypicFeature denotes B-NHL MESH:D016393
12545 390-393 GeneOrGeneProduct denotes MYC NCBIGene:17869
12546 413-428 GeneOrGeneProduct denotes B-cell receptor NCBIGene:16019
12547 430-433 GeneOrGeneProduct denotes BCR NCBIGene:16019
12548 458-463 DiseaseOrPhenotypicFeature denotes B-NHL MESH:D016393
12549 497-500 GeneOrGeneProduct denotes Myc NCBIGene:17869
12550 653-656 GeneOrGeneProduct denotes Myc NCBIGene:17869
12551 661-664 GeneOrGeneProduct denotes BCR NCBIGene:16019
12552 718-721 GeneOrGeneProduct denotes myc NCBIGene:17869
12553 722-727 OrganismTaxon denotes mouse NCBITaxon:10090
12554 741-744 GeneOrGeneProduct denotes Myc NCBIGene:17869
12555 813-816 GeneOrGeneProduct denotes BCR NCBIGene:16019
12556 845-857 DiseaseOrPhenotypicFeature denotes precancerous MESH:D011230
12557 880-883 GeneOrGeneProduct denotes myc NCBIGene:17869
12558 884-888 OrganismTaxon denotes mice NCBITaxon:10090
12559 949-952 GeneOrGeneProduct denotes Myc NCBIGene:17869
12560 1005-1010 GeneOrGeneProduct denotes CD79α NCBIGene:12518
12561 1012-1015 GeneOrGeneProduct denotes Btk NCBIGene:12229
12562 1017-1022 GeneOrGeneProduct denotes Plcγ2 NCBIGene:234779
12563 1027-1033 GeneOrGeneProduct denotes Erk1/2 NCBIGene:26413|NCBIGene:26417
12564 1044-1047 GeneOrGeneProduct denotes Myc NCBIGene:17869
12565 1091-1094 GeneOrGeneProduct denotes BCR NCBIGene:16019
12566 1128-1137 ChemicalEntity denotes ibrutinib MESH:C551803
12567 1141-1165 GeneOrGeneProduct denotes Bruton's tyrosine kinase NCBIGene:695
12568 1190-1194 GeneOrGeneProduct denotes PI3K NCBIGene:18708
12569 1195-1198 GeneOrGeneProduct denotes Akt NCBIGene:11651
12570 1242-1245 GeneOrGeneProduct denotes myc NCBIGene:17869
12571 1303-1312 ChemicalEntity denotes ibrutinib MESH:C551803
12572 1344-1347 GeneOrGeneProduct denotes Btk NCBIGene:12229
12573 1392-1401 ChemicalEntity denotes ibrutinib MESH:C551803
12574 1405-1408 GeneOrGeneProduct denotes BCR NCBIGene:16019
12575 1465-1468 GeneOrGeneProduct denotes Myc NCBIGene:17869
12576 1510-1513 GeneOrGeneProduct denotes BCR NCBIGene:16019
12577 1518-1522 GeneOrGeneProduct denotes PI3K NCBIGene:18708
12578 1523-1526 GeneOrGeneProduct denotes Akt NCBIGene:11651
12579 1587-1590 GeneOrGeneProduct denotes BCR NCBIGene:16019
12580 1638-1650 DiseaseOrPhenotypicFeature denotes precancerous MESH:D011230
12581 1764-1767 GeneOrGeneProduct denotes MYC NCBIGene:17869
12582 1824-1827 GeneOrGeneProduct denotes BCR NCBIGene:16019
12583 1878-1883 DiseaseOrPhenotypicFeature denotes B-NHL MESH:D016393

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 722-727 OrganismTaxon denotes mouse NCBItxid:10090|NCBItxid:10088
T3 884-888 OrganismTaxon denotes mice NCBItxid:10095|NCBItxid:10088

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-104 Sentence denotes Myc enhances B-cell receptor signaling in precancerous B cells and confers resistance to Btk inhibition.
T2 105-247 Sentence denotes Dysregulation of the oncogenic transcription factor MYC induces B-cell transformation and is a driver for B-cell non-Hodgkin lymphoma (B-NHL).
T3 248-341 Sentence denotes MYC overexpression in B-NHL is associated with more aggressive phenotypes and poor prognosis.
T4 342-563 Sentence denotes Although genomic studies suggest a link between MYC overexpression and B-cell receptor (BCR) signaling molecules in B-NHL, signaling pathways essential to Myc-mediated B-cell transformation have not been fully elucidated.
T5 564-700 Sentence denotes We utilized intracellular phospho-flow cytometry to investigate the relationship between Myc and BCR signaling in pre-malignant B cells.
T6 701-925 Sentence denotes Utilizing the Eμ-myc mouse model, where Myc is overexpressed specifically in B cells, both basal and stimulated BCR signaling were increased in precancerous B lymphocytes from Eμ-myc mice compared with wild-type littermates.
T7 926-1034 Sentence denotes B cells overexpressing Myc displayed constitutively higher levels of activated CD79α, Btk, Plcγ2 and Erk1/2.
T8 1035-1176 Sentence denotes Notably, Myc-overexpressing B cells maintained elevated BCR signaling despite treatment with ibrutinib, a Bruton's tyrosine kinase inhibitor.
T9 1177-1313 Sentence denotes Furthermore, PI3K/Akt pathway signaling was also increased in Eμ-myc B cells, and this increase was partially suppressed with ibrutinib.
T10 1314-1419 Sentence denotes In addition, experiments with Btk-null B cells revealed off-target effects of ibrutinib on BCR signaling.
T11 1420-1600 Sentence denotes Our data show that in pre-malignant B cells, Myc overexpression is sufficient to activate BCR and PI3K/Akt signaling pathways and further enhances signaling following BCR ligation.
T12 1601-1894 Sentence denotes Therefore, our results indicate that precancerous B cells have already acquired enhanced survival and growth capabilities before transformation, and that elevated MYC levels confer resistance to pharmacologic inhibitors of BCR signaling, which has significant implications for B-NHL treatment.

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 211-238 DiseaseOrPhenotypicFeature denotes B-cell non-Hodgkin lymphoma 0015759
T2 218-238 DiseaseOrPhenotypicFeature denotes non-Hodgkin lymphoma 0018908
T3 230-238 DiseaseOrPhenotypicFeature denotes lymphoma 0005062
T4 1672-1680 DiseaseOrPhenotypicFeature denotes acquired 0021141

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 0-3 GeneOrGeneProduct denotes Myc
T2 15-19 GeneOrGeneProduct denotes cell
T3 20-28 GeneOrGeneProduct denotes receptor
T4 57-62 GeneOrGeneProduct denotes cells
T5 126-135 GeneOrGeneProduct denotes oncogenic
T6 136-156 GeneOrGeneProduct denotes transcription factor
T7 161-168 GeneOrGeneProduct denotes induces
T8 171-175 GeneOrGeneProduct denotes cell
T9 176-190 GeneOrGeneProduct denotes transformation
T10 213-217 GeneOrGeneProduct denotes cell
T11 377-381 GeneOrGeneProduct denotes link
T12 415-419 GeneOrGeneProduct denotes cell
T13 420-428 GeneOrGeneProduct denotes receptor
T14 435-454 GeneOrGeneProduct denotes signaling molecules
T15 497-500 GeneOrGeneProduct denotes Myc
T16 501-509 GeneOrGeneProduct denotes mediated
T17 512-516 GeneOrGeneProduct denotes cell
T18 517-531 GeneOrGeneProduct denotes transformation
T19 653-656 GeneOrGeneProduct denotes Myc
T20 694-699 GeneOrGeneProduct denotes cells
T21 741-747 GeneOrGeneProduct denotes Myc is
T22 780-785 GeneOrGeneProduct denotes cells
T23 860-871 GeneOrGeneProduct denotes lymphocytes
T24 884-888 GeneOrGeneProduct denotes mice
T25 928-933 GeneOrGeneProduct denotes cells
T26 949-952 GeneOrGeneProduct denotes Myc
T27 995-1004 GeneOrGeneProduct denotes activated
T28 1027-1033 GeneOrGeneProduct denotes Erk1/2
T29 1044-1047 GeneOrGeneProduct denotes Myc
T30 1065-1070 GeneOrGeneProduct denotes cells
T31 1141-1165 GeneOrGeneProduct denotes Bruton's tyrosine kinase
T32 1166-1175 GeneOrGeneProduct denotes inhibitor
T33 1190-1194 GeneOrGeneProduct denotes PI3K
T34 1242-1247 GeneOrGeneProduct denotes myc B
T35 1248-1253 GeneOrGeneProduct denotes cells
T36 1348-1352 GeneOrGeneProduct denotes null
T37 1355-1360 GeneOrGeneProduct denotes cells
T38 1458-1463 GeneOrGeneProduct denotes cells
T39 1465-1468 GeneOrGeneProduct denotes Myc
T40 1501-1509 GeneOrGeneProduct denotes activate
T41 1518-1522 GeneOrGeneProduct denotes PI3K
T42 1653-1658 GeneOrGeneProduct denotes cells
T43 1703-1709 GeneOrGeneProduct denotes growth
T44 1710-1722 GeneOrGeneProduct denotes capabilities
T45 1730-1744 GeneOrGeneProduct denotes transformation
T46 1810-1820 GeneOrGeneProduct denotes inhibitors

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 15-19 GeneOrGeneProduct denotes cell
T2 20-28 GeneOrGeneProduct denotes receptor
T3 136-156 GeneOrGeneProduct denotes transcription factor
T4 171-175 GeneOrGeneProduct denotes cell
T5 213-217 GeneOrGeneProduct denotes cell
T6 377-381 GeneOrGeneProduct denotes link
T7 415-419 GeneOrGeneProduct denotes cell
T8 420-428 GeneOrGeneProduct denotes receptor
T9 512-516 GeneOrGeneProduct denotes cell
T10 860-871 GeneOrGeneProduct denotes lymphocytes
T11 1027-1033 GeneOrGeneProduct denotes Erk1/2
T12 1141-1165 GeneOrGeneProduct denotes Bruton's tyrosine kinase
T13 1166-1175 GeneOrGeneProduct denotes inhibitor
T14 1190-1194 GeneOrGeneProduct denotes PI3K
T15 1242-1247 GeneOrGeneProduct denotes myc B
T16 1348-1352 GeneOrGeneProduct denotes null
T17 1518-1522 GeneOrGeneProduct denotes PI3K
T18 1703-1709 GeneOrGeneProduct denotes growth
T19 1810-1820 GeneOrGeneProduct denotes inhibitors

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 42-54 DiseaseOrPhenotypicFeature denotes precancerous DISEASE
T2 218-238 DiseaseOrPhenotypicFeature denotes non-Hodgkin lymphoma D008228
T3 682-691 DiseaseOrPhenotypicFeature denotes malignant D009369
T4 845-857 DiseaseOrPhenotypicFeature denotes precancerous DISEASE
T5 1446-1455 DiseaseOrPhenotypicFeature denotes malignant D009369
T6 1638-1650 DiseaseOrPhenotypicFeature denotes precancerous DISEASE

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 136-160 GeneOrGeneProduct denotes transcription factor MYC
T2 1027-1033 GeneOrGeneProduct denotes Erk1/2
T3 1141-1165 GeneOrGeneProduct denotes Bruton's tyrosine kinase
T4 1190-1194 GeneOrGeneProduct denotes PI3K
T5 1195-1198 GeneOrGeneProduct denotes Akt
T6 1242-1247 GeneOrGeneProduct denotes myc B
T7 1518-1522 GeneOrGeneProduct denotes PI3K
T8 1523-1526 GeneOrGeneProduct denotes Akt

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 211-238 DiseaseOrPhenotypicFeature denotes B-cell non-Hodgkin lymphoma 0015759
T2 242-245 DiseaseOrPhenotypicFeature denotes NHL 0018908
T3 272-275 DiseaseOrPhenotypicFeature denotes NHL 0018908
T4 460-463 DiseaseOrPhenotypicFeature denotes NHL 0018908
T5 1880-1883 DiseaseOrPhenotypicFeature denotes NHL 0018908

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 42-54 DiseaseOrPhenotypicFeature denotes precancerous DISEASE
T2 218-238 DiseaseOrPhenotypicFeature denotes non-Hodgkin lymphoma D008228
T3 240-245 DiseaseOrPhenotypicFeature denotes B-NHL DISEASE
T4 270-275 DiseaseOrPhenotypicFeature denotes B-NHL DISEASE
T5 458-463 DiseaseOrPhenotypicFeature denotes B-NHL DISEASE
T6 845-857 DiseaseOrPhenotypicFeature denotes precancerous DISEASE
T7 1638-1650 DiseaseOrPhenotypicFeature denotes precancerous DISEASE
T8 1878-1883 DiseaseOrPhenotypicFeature denotes B-NHL DISEASE

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 42-54 DiseaseOrPhenotypicFeature denotes precancerous DISEASE
T2 218-238 DiseaseOrPhenotypicFeature denotes non-Hodgkin lymphoma D008228
T3 240-245 DiseaseOrPhenotypicFeature denotes B-NHL DISEASE
T4 270-275 DiseaseOrPhenotypicFeature denotes B-NHL DISEASE
T5 458-463 DiseaseOrPhenotypicFeature denotes B-NHL DISEASE
T6 845-857 DiseaseOrPhenotypicFeature denotes precancerous DISEASE
T7 1638-1650 DiseaseOrPhenotypicFeature denotes precancerous DISEASE
T8 1878-1883 DiseaseOrPhenotypicFeature denotes B-NHL DISEASE

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 590-597 ChemicalEntity denotes phospho http://purl.obolibrary.org/obo/CHEBI_48108
T2 1128-1137 ChemicalEntity denotes ibrutinib C551803|http://purl.obolibrary.org/obo/CHEBI_76612
T4 1150-1158 ChemicalEntity denotes tyrosine http://purl.obolibrary.org/obo/CHEBI_18186
T5 1303-1312 ChemicalEntity denotes ibrutinib C551803|http://purl.obolibrary.org/obo/CHEBI_76612
T7 1392-1401 ChemicalEntity denotes ibrutinib C551803|http://purl.obolibrary.org/obo/CHEBI_76612

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 722-727 OrganismTaxon denotes mouse
T2 884-888 OrganismTaxon denotes mice

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T7 1392-1401 ChemicalEntity denotes ibrutinib http://purl.obolibrary.org/obo/CHEBI_76612|C551803
T5 1303-1312 ChemicalEntity denotes ibrutinib http://purl.obolibrary.org/obo/CHEBI_76612|C551803
T4 1150-1158 ChemicalEntity denotes tyrosine http://purl.obolibrary.org/obo/CHEBI_18186
T2 1128-1137 ChemicalEntity denotes ibrutinib http://purl.obolibrary.org/obo/CHEBI_76612|C551803
T1 590-597 ChemicalEntity denotes phospho http://purl.obolibrary.org/obo/CHEBI_48108
T8 1523-1526 GeneOrGeneProduct denotes Akt
T87658 1518-1522 GeneOrGeneProduct denotes PI3K
T6 1242-1247 GeneOrGeneProduct denotes myc B
T88858 1195-1198 GeneOrGeneProduct denotes Akt
T64334 1190-1194 GeneOrGeneProduct denotes PI3K
T3 1141-1165 GeneOrGeneProduct denotes Bruton's tyrosine kinase
T72754 1027-1033 GeneOrGeneProduct denotes Erk1/2
T6339 136-160 GeneOrGeneProduct denotes transcription factor MYC
T87397 1878-1883 DiseaseOrPhenotypicFeature denotes B-NHL DISEASE
T86326 1638-1650 DiseaseOrPhenotypicFeature denotes precancerous DISEASE
T32640 845-857 DiseaseOrPhenotypicFeature denotes precancerous DISEASE
T75054 458-463 DiseaseOrPhenotypicFeature denotes B-NHL DISEASE
T7701 270-275 DiseaseOrPhenotypicFeature denotes B-NHL DISEASE
T26501 240-245 DiseaseOrPhenotypicFeature denotes B-NHL DISEASE
T32756 218-238 DiseaseOrPhenotypicFeature denotes non-Hodgkin lymphoma D008228
T72170 42-54 DiseaseOrPhenotypicFeature denotes precancerous DISEASE
T84460 884-888 OrganismTaxon denotes mice
T18690 722-727 OrganismTaxon denotes mouse