PubMed:28285645 JSONTXT

{"project":"Zierdiyeerkenaili_800","denotations":[{"id":"T1","span":{"begin":13,"end":34},"obj":"DP"},{"id":"T2","span":{"begin":227,"end":248},"obj":"DP"},{"id":"T3","span":{"begin":250,"end":252},"obj":"DP"},{"id":"T4","span":{"begin":511,"end":513},"obj":"DP"},{"id":"T5","span":{"begin":559,"end":561},"obj":"DP"},{"id":"T6","span":{"begin":1011,"end":1013},"obj":"DP"},{"id":"T7","span":{"begin":1255,"end":1257},"obj":"DP"},{"id":"T8","span":{"begin":1972,"end":1974},"obj":"DP"},{"id":"T9","span":{"begin":2052,"end":2054},"obj":"DP"}],"text":"Treatment of reactive hypoglycemia with the macrobiotic Ma-pi 2 diet as assessed by continuous glucose monitoring: The MAHYP randomized crossover trial.\nBACKGROUND AND AIMS: Nutritional therapy is recommended for management of reactive hypoglycemia (RH), a condition characterized by hypoglycemia that occurs within four hours after a meal. The macrobiotic Ma-Pi 2 diet improves glycemic control in subjects with type 2 diabetes. We explored the effect of this diet on outcomes in non-diabetic individuals with RH.\nMATERIALS AND METHODS: Twelve subjects with RH were randomized to the Ma-Pi 2 diet for three days and a control diet for three days in a randomized crossover design. Subjects received snacks on two days out of each three-day period only, and were monitored using continuous glucose monitoring. The 24-h period was divided into daytime (08:00-22:30h [subdivided into 'daytime without snacks' and 'daytime with snacks']) and night-time (22:31-07:59h). The effects of the two diets on the number of RH events (blood glucose \u003c70mg/dL [3.9mmol/L]) and the percentage distribution of glucose readings within each of 16 glycemic intervals from \u003c40mg/dL (2.2mmol/L) to \u003e180mg/dL (4.4mmol/L) were determined.\nRESULTS: There were significantly fewer RH events on the Ma-Pi 2 diet than the control diet during daytime without snacks (-2.5 events; 95% CI: -7.5, 0.0; P=0.022) and daytime with snacks (-4.25 events; 95% CI: -7.5; -2.0; P=0.013) but no difference at night. The percentage of glucose readings in the interval 71-80mg/dL (3.9-4.4mmol/L) was significantly higher on the control diet during daytime with and without snacks (P=0.03 for both), while the percentage of glucose readings in the interval 91-100mg/dL (5.1-5.6mmol/L) was significantly higher on the Ma-Pi 2 diet during daytime without snacks (P=0.02).\nCONCLUSIONS: The macrobiotic Ma-Pi 2 diet reduced blood glucose excursions during the day, thereby facilitating glycemic control in subjects with RH. The Ma-Pi 2 diet represents an effective nutritional tool for management of RH."}