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GoldHamster

Id Subject Object Predicate Lexical cue
T1 20-28 D020100 denotes hydrogel
T2 20-28 D020100 denotes hydrogel
T3 44-50 9913 denotes bovine
T6 51-70 UBERON:0001066 denotes intervertebral disc
T4 51-70 C535531 denotes intervertebral disc
T5 51-70 C535531 denotes intervertebral disc
T7 71-77 UBERON:0000479 denotes tissue
T8 196-205 32630 denotes synthetic
T11 206-214 1314219 denotes Laponite
T9 206-214 C524813 denotes Laponite
T10 206-214 C524813 denotes Laponite
T12 228-234 C052970 denotes pNIPAM
T13 228-234 CHEBI:53234 denotes pNIPAM
T14 228-234 CHEBI:60883 denotes pNIPAM
T15 246-252 C052970 denotes pNIPAM
T16 246-252 CHEBI:53234 denotes pNIPAM
T17 246-252 CHEBI:60883 denotes pNIPAM
T18 262-270 D020100 denotes hydrogel
T19 262-270 D020100 denotes hydrogel
T21 329-333 PR:000023297 denotes MSCs
T22 329-333 PR:P0C0S1 denotes MSCs
T20 329-333 GO:0043854 denotes MSCs
T25 338-345 GO:0005634 denotes nucleus
T23 338-345 CHEBI:33252 denotes nucleus
T26 338-354 UBERON:0002242 denotes nucleus pulposus
T27 385-399 D036341 denotes growth factors
T28 385-399 D036341 denotes growth factors
T29 430-438 D020100 denotes hydrogel
T30 430-438 D020100 denotes hydrogel
T31 485-491 UBERON:0000479 denotes tissue
T33 607-611 PR:000023297 denotes MSCs
T34 607-611 PR:P0C0S1 denotes MSCs
T32 607-611 GO:0043854 denotes MSCs
T35 613-619 9913 denotes Bovine
T36 623-629 UBERON:0000479 denotes tissue
T37 675-680 D006801 denotes human
T39 681-685 PR:000023297 denotes MSCs
T40 681-685 PR:P0C0S1 denotes MSCs
T38 681-685 GO:0043854 denotes MSCs
T41 713-719 C052970 denotes pNIPAM
T42 713-719 CHEBI:53234 denotes pNIPAM
T43 713-719 CHEBI:60883 denotes pNIPAM
T44 728-736 D020100 denotes hydrogel
T45 728-736 D020100 denotes hydrogel
T46 772-778 C052970 denotes pNIPAM
T47 772-778 CHEBI:53234 denotes pNIPAM
T48 772-778 CHEBI:60883 denotes pNIPAM
T49 787-795 D020100 denotes hydrogel
T50 787-795 D020100 denotes hydrogel
T56 875-879 PR:000023297 denotes MSCs
T57 875-879 PR:P0C0S1 denotes MSCs
T55 875-879 GO:0043854 denotes MSCs
T58 934-940 C052970 denotes pNIPAM
T59 934-940 CHEBI:53234 denotes pNIPAM
T60 934-940 CHEBI:60883 denotes pNIPAM
T61 949-957 D020100 denotes hydrogel
T62 949-957 D020100 denotes hydrogel
T63 989-995 UBERON:0027368 denotes matrix
T64 1008-1016 D053674 denotes aggrecan
T65 1008-1016 D053674 denotes aggrecan
T67 1018-1026 2714 denotes collagen
T66 1018-1026 GO:0005202 denotes collagen
T70 1018-1034 D024043 denotes collagen type II
T74 1039-1059 CHEBI:37397 denotes chondroitin sulphate
T76 1085-1093 D020100 denotes hydrogel
T77 1085-1093 D020100 denotes hydrogel
T78 1109-1115 UBERON:0000479 denotes tissue
T79 1131-1137 C052970 denotes pNIPAM
T80 1131-1137 CHEBI:53234 denotes pNIPAM
T81 1131-1137 CHEBI:60883 denotes pNIPAM
T82 1146-1154 D020100 denotes hydrogel
T83 1146-1154 D020100 denotes hydrogel
T84 1169-1180 P08897 denotes collagenase
T86 1169-1180 P33437 denotes collagenase
T87 1169-1180 P59916 denotes collagenase
T85 1169-1180 58939 denotes collagenase
T88 1169-1180 D017364 denotes collagenase
T89 1169-1180 CHEBI:3823 denotes collagenase
T90 1190-1196 9913 denotes bovine
T91 1296-1299 Q9FS87 denotes IVD
T92 1296-1299 Q9SWG0 denotes IVD
T93 1296-1299 P12007 denotes IVD
T94 1296-1299 P26440 denotes IVD
T95 1296-1299 Q3SZI8 denotes IVD
T96 1296-1299 PR:P12007 denotes IVD
T97 1296-1299 P34275 denotes IVD
T98 1296-1299 Q9JHI5 denotes IVD
T99 1296-1299 PR:Q9SWG0 denotes IVD
T100 1296-1299 Q75IM9 denotes IVD
T101 1296-1299 PR:P26440 denotes IVD
T102 1296-1299 Q5RBD5 denotes IVD
T103 1296-1299 PR:000009166 denotes IVD
T104 1296-1299 PR:Q9JHI5 denotes IVD
T105 1343-1349 C052970 denotes pNIPAM
T106 1343-1349 CHEBI:53234 denotes pNIPAM
T107 1343-1349 CHEBI:60883 denotes pNIPAM
T108 1358-1366 D020100 denotes hydrogel
T109 1358-1366 D020100 denotes hydrogel
T110 1428-1432 PR:Q9W0Y6 denotes pain
T112 1464-1468 PR:000023297 denotes MSCs
T113 1464-1468 PR:P0C0S1 denotes MSCs
T111 1464-1468 GO:0043854 denotes MSCs
T115 1498-1518 GO:0031012 denotes extracellular matrix
T116 1512-1518 UBERON:0027368 denotes matrix
T117 1531-1537 C052970 denotes pNIPAM
T118 1531-1537 CHEBI:53234 denotes pNIPAM
T119 1531-1537 CHEBI:60883 denotes pNIPAM
T120 1546-1554 D020100 denotes hydrogel
T121 1546-1554 D020100 denotes hydrogel
T122 1648-1661 D017116 denotes Low back pain
T123 1648-1661 D017116 denotes Low back pain
T126 1657-1661 PR:Q9W0Y6 denotes pain
T127 1663-1666 PR:Q61805 denotes LBP
T128 1663-1666 PR:000035701 denotes LBP
T129 1663-1666 P18428 denotes LBP
T130 1663-1666 Q61805 denotes LBP
T131 1663-1666 P29822 denotes LBP
T132 1663-1666 PR:Q63313 denotes LBP
T133 1663-1666 Q63313 denotes LBP
T134 1663-1666 P17454 denotes LBP
T135 1663-1666 PR:000001773 denotes LBP
T136 1663-1666 PR:P18428 denotes LBP
T137 1663-1666 P05938 denotes LBP
T138 1663-1666 Q2TBI0 denotes LBP
T141 1707-1726 UBERON:0001066 denotes intervertebral disc
T139 1707-1726 C535531 denotes intervertebral disc
T140 1707-1726 C535531 denotes intervertebral disc
T142 1728-1731 Q9FS87 denotes IVD
T143 1728-1731 Q9SWG0 denotes IVD
T144 1728-1731 P12007 denotes IVD
T145 1728-1731 P26440 denotes IVD
T146 1728-1731 Q3SZI8 denotes IVD
T147 1728-1731 PR:P12007 denotes IVD
T148 1728-1731 P34275 denotes IVD
T149 1728-1731 Q9JHI5 denotes IVD
T150 1728-1731 PR:Q9SWG0 denotes IVD
T151 1728-1731 Q75IM9 denotes IVD
T152 1728-1731 PR:P26440 denotes IVD
T153 1728-1731 Q5RBD5 denotes IVD
T154 1728-1731 PR:000009166 denotes IVD
T155 1728-1731 PR:Q9JHI5 denotes IVD
T156 1803-1811 D020100 denotes hydrogel
T157 1803-1811 D020100 denotes hydrogel
T158 1848-1853 UBERON:0007023 denotes adult
T159 1886-1889 Q9FS87 denotes IVD
T160 1886-1889 Q9SWG0 denotes IVD
T161 1886-1889 P12007 denotes IVD
T162 1886-1889 P26440 denotes IVD
T163 1886-1889 Q3SZI8 denotes IVD
T164 1886-1889 PR:P12007 denotes IVD
T165 1886-1889 P34275 denotes IVD
T166 1886-1889 Q9JHI5 denotes IVD
T167 1886-1889 PR:Q9SWG0 denotes IVD
T168 1886-1889 Q75IM9 denotes IVD
T169 1886-1889 PR:P26440 denotes IVD
T170 1886-1889 Q5RBD5 denotes IVD
T171 1886-1889 PR:000009166 denotes IVD
T172 1886-1889 PR:Q9JHI5 denotes IVD
T175 1904-1911 GO:0005634 denotes nucleus
T173 1904-1911 CHEBI:33252 denotes nucleus
T176 1904-1920 UBERON:0002242 denotes nucleus pulposus
T177 1959-1964 UBERON:0007023 denotes adult
T178 2090-2098 D020100 denotes hydrogel
T179 2090-2098 D020100 denotes hydrogel
T180 2130-2136 UBERON:0000479 denotes tissue
T181 2209-2212 Q9FS87 denotes IVD
T182 2209-2212 Q9SWG0 denotes IVD
T183 2209-2212 P12007 denotes IVD
T184 2209-2212 P26440 denotes IVD
T185 2209-2212 Q3SZI8 denotes IVD
T186 2209-2212 PR:P12007 denotes IVD
T187 2209-2212 P34275 denotes IVD
T188 2209-2212 Q9JHI5 denotes IVD
T189 2209-2212 PR:Q9SWG0 denotes IVD
T190 2209-2212 Q75IM9 denotes IVD
T191 2209-2212 PR:P26440 denotes IVD
T192 2209-2212 Q5RBD5 denotes IVD
T193 2209-2212 PR:000009166 denotes IVD
T194 2209-2212 PR:Q9JHI5 denotes IVD
T195 2238-2246 D020100 denotes hydrogel
T196 2238-2246 D020100 denotes hydrogel
T197 2299-2302 Q9FS87 denotes IVD
T198 2299-2302 Q9SWG0 denotes IVD
T199 2299-2302 P12007 denotes IVD
T200 2299-2302 P26440 denotes IVD
T201 2299-2302 Q3SZI8 denotes IVD
T202 2299-2302 PR:P12007 denotes IVD
T203 2299-2302 P34275 denotes IVD
T204 2299-2302 Q9JHI5 denotes IVD
T205 2299-2302 PR:Q9SWG0 denotes IVD
T206 2299-2302 Q75IM9 denotes IVD
T207 2299-2302 PR:P26440 denotes IVD
T208 2299-2302 Q5RBD5 denotes IVD
T209 2299-2302 PR:000009166 denotes IVD
T210 2299-2302 PR:Q9JHI5 denotes IVD
T211 2332-2344 GO:0031099 denotes regeneration
T212 2395-2398 PR:Q61805 denotes LBP
T213 2395-2398 PR:000035701 denotes LBP
T214 2395-2398 P18428 denotes LBP
T215 2395-2398 Q61805 denotes LBP
T216 2395-2398 P29822 denotes LBP
T217 2395-2398 PR:Q63313 denotes LBP
T218 2395-2398 Q63313 denotes LBP
T219 2395-2398 P17454 denotes LBP
T220 2395-2398 PR:000001773 denotes LBP
T221 2395-2398 PR:P18428 denotes LBP
T222 2395-2398 P05938 denotes LBP
T223 2395-2398 Q2TBI0 denotes LBP

PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 171-1620 None denotes We previously reported a synthetic Laponite® crosslinked pNIPAM-co-DMAc (L-pNIPAM-co-DMAc) hydrogel which promotes differentiation of mesenchymal stem cells (MSCs) to nucleus pulposus (NP) cells without additional growth factors. The clinical success of this hydrogel is dependent on: integration with surrounding tissue; the capacity to restore mechanical function; as well as supporting the viability and differentiation of delivered MSCs. Bovine NP tissue explants were injected with media (control), human MSCs (hMSCs) alone, acellular L-pNIPAM-co-DMAc hydrogel or hMSCs incorporated within the L-pNIPAM-co-DMAc hydrogel and maintained at 5% O2 for 6weeks. Viability of native NP cells and delivered MSCs was maintained. Furthermore hMSCs delivered via the L-pNIPAM-co-DMAc hydrogel differentiated and produced NP matrix components: aggrecan, collagen type II and chondroitin sulphate, with integration of the hydrogel with native NP tissue. In addition L-pNIPAM-co-DMAc hydrogel injected into collagenase digested bovine discs filled micro and macro fissures, were maintained within the disc during loading and restored IVD stiffness. The mechanical support of the L-pNIPAM-co-DMAc hydrogel, to restore disc height, could provide immediate symptomatic pain relief, whilst the delivery of MSCs over time regenerates the NP extracellular matrix; thus the L-pNIPAM-co-DMAc hydrogel could provide a combined cellular and mechanical repair approach.
T2 1648-2399 STATEMENT OF SIGNIFICANCE denotes Low back pain (LBP) is associated with degeneration of the intervertebral disc (IVD). We have previously described development of a jelly delivery system (hydrogel). This has the potential to deliver adult stem cells to the centre of the IVD, known as the nucleus pulposus (NP). Here, we have demonstrated that adult stem cells can be safely injected into the NP using small bore needles, reducing damage to the disc. Following injection the hydrogel integrates with surrounding NP tissue, promotes differentiation of stem cells towards disc cells and restores IVD mechanical function. The hydrogel could be used to restore mechanical function to the IVD and deliver cells to promote regeneration of the disc as a minimally invasive treatment for LBP.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 171-173 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes We
T2 194-195 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T3 235-237 CVCL_J653|Cancer_cell_line|Homo sapiens denotes co
T4 253-255 CVCL_J653|Cancer_cell_line|Homo sapiens denotes co
T5 720-722 CVCL_J653|Cancer_cell_line|Homo sapiens denotes co
T6 779-781 CVCL_J653|Cancer_cell_line|Homo sapiens denotes co
T7 811-815 CVCL_Y661|Cancer_cell_line|Rattus norvegicus denotes at 5
T8 941-943 CVCL_J653|Cancer_cell_line|Homo sapiens denotes co
T9 1138-1140 CVCL_J653|Cancer_cell_line|Homo sapiens denotes co
T10 1350-1352 CVCL_J653|Cancer_cell_line|Homo sapiens denotes co
T11 1474-1478 CVCL_0047|Telomerase_immortalized_cell_line|Homo sapiens denotes time
T12 1538-1540 CVCL_J653|Cancer_cell_line|Homo sapiens denotes co
T13 1569-1570 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T14 1734-1736 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes We
T15 1778-1779 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T16 1819-1822 CVCL_6758|Undefined_cell_line_type|Cricetulus griseus denotes has
T17 1819-1822 CVCL_E689|Transformed_cell_line|Homo sapiens denotes has
T18 1933-1935 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes we
T19 2360-2361 CVCL_6479|Finite_cell_line|Mus musculus denotes a