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PubMed:28260110 JSONTXT

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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 94-237 DRI_Background denotes Fatty acid synthase (FASN) is a key anabolic enzyme for de novo fatty acid synthesis, which is important in the development of colon carcinoma.
T2 238-334 DRI_Challenge denotes The high expression of FASN is considered a promising molecular target for colon cancer therapy.
T3 335-532 DRI_Challenge denotes Emodin, a naturally occurring anthraquinone, exhibits an anticancer effect in various types of human cancer, including colon cancer; however, the molecular mechanisms remain to be fully elucidated.
T4 533-596 DRI_Approach denotes Cell viability was evaluated using a Cell Counting Kit‑8 assay.
T5 597-705 DRI_Background denotes The apoptosis rate of cells was quantified via flow cytometry following Annexin V/propidium iodide staining.
T6 706-929 DRI_Background denotes FASN activity was measured by monitoring oxidation of nicotinamide adenine dinucleotide phosphate at a wavelength of 340 nm, and intracellular free fatty acid levels were detected using a Free Fatty Acid Quantification kit.
T7 930-1059 DRI_Background denotes Western blot analysis and reverse transcription‑polymerase chain reaction were used to detect target gene and protein expression.
T8 1060-1228 DRI_Background denotes The present study was performed to investigate whether the gene expression of FASN and its enzymatic activity are regulated by emodin in a human colon cancer cell line.
T9 1229-1392 DRI_Background denotes Emodin markedly inhibited the proliferation of HCT116 cells and a higher protein level of FASN was expressed, compared with that in SW480, SNU-C2A or SNU‑C5 cells.
T10 1393-1555 DRI_Background denotes Emodin significantly downregulated the protein expression of FASN in HCT116 cells, which was caused by protein degradation due to elevated protein ubiquitination.
T11 1556-1673 DRI_Background denotes Emodin also inhibited intracellular FASN enzymatic activity and reduced the levels of intracellular free fatty acids.
T12 1674-1759 DRI_Background denotes Emodin enhanced antiproliferation and apoptosis in a dose‑ and time‑dependent manner.
T13 1760-1880 DRI_Background denotes The combined treatment of emodin and cerulenin, a commercial FASN inhibitor, had an additive effect on these activities.
T14 1881-1979 DRI_Approach denotes Palmitate, the final product of the FASN reaction, rescued emodin‑induced viability and apoptosis.
T15 1980-2115 DRI_Background denotes In addition, emodin altered FASN‑involved signaling pathways, including phosphatidylinositol 3-kinase/Akt and mitogen‑activated protein
T16 2155-2167 DRI_Background denotes kinases 1/2.
T17 2168-2328 DRI_Background denotes These results suggested that emodin-regulated cell growth and apoptosis were mediated by inhibiting FASN and provide a molecular basis for colon cancer therapy.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
12437 21-27 ChemicalEntity denotes emodin MESH:D004642
12438 31-50 GeneOrGeneProduct denotes fatty acid synthase NCBIGene:2194
12439 52-64 DiseaseOrPhenotypicFeature denotes colon cancer MESH:D015179
12440 94-113 GeneOrGeneProduct denotes Fatty acid synthase NCBIGene:2194
12441 115-119 GeneOrGeneProduct denotes FASN NCBIGene:2194
12442 158-168 ChemicalEntity denotes fatty acid MESH:D005227
12443 221-236 DiseaseOrPhenotypicFeature denotes colon carcinoma MESH:D015179
12444 261-265 GeneOrGeneProduct denotes FASN NCBIGene:2194
12445 313-325 DiseaseOrPhenotypicFeature denotes colon cancer MESH:D015179
12446 335-341 ChemicalEntity denotes Emodin MESH:D004642
12447 365-378 ChemicalEntity denotes anthraquinone MESH:D000880
12448 430-435 OrganismTaxon denotes human NCBITaxon:9606
12449 436-442 DiseaseOrPhenotypicFeature denotes cancer MESH:D009369
12450 454-466 DiseaseOrPhenotypicFeature denotes colon cancer MESH:D015179
12451 669-678 GeneOrGeneProduct denotes Annexin V NCBIGene:308
12452 679-695 ChemicalEntity denotes propidium iodide MESH:D011419
12453 706-710 GeneOrGeneProduct denotes FASN NCBIGene:2194
12454 760-803 ChemicalEntity denotes nicotinamide adenine dinucleotide phosphate MESH:D009249
12455 849-864 ChemicalEntity denotes free fatty acid MESH:D005230
12456 894-909 ChemicalEntity denotes Free Fatty Acid MESH:D005230
12457 1138-1142 GeneOrGeneProduct denotes FASN NCBIGene:2194
12458 1187-1193 ChemicalEntity denotes emodin MESH:D004642
12459 1199-1204 OrganismTaxon denotes human NCBITaxon:9606
12460 1205-1217 DiseaseOrPhenotypicFeature denotes colon cancer MESH:D015179
12461 1229-1235 ChemicalEntity denotes Emodin MESH:D004642
12462 1276-1282 CellLine denotes HCT116 NCBITaxon:9606
12463 1319-1323 GeneOrGeneProduct denotes FASN NCBIGene:2194
12464 1361-1366 CellLine denotes SW480 NCBITaxon:9606
12465 1368-1375 CellLine denotes SNU-C2A NCBITaxon:9606
12466 1379-1385 CellLine denotes SNU‑C5 NCBITaxon:9606
12467 1393-1399 ChemicalEntity denotes Emodin MESH:D004642
12468 1454-1458 GeneOrGeneProduct denotes FASN NCBIGene:2194
12469 1462-1468 CellLine denotes HCT116 NCBITaxon:9606
12470 1556-1562 ChemicalEntity denotes Emodin MESH:D004642
12471 1592-1596 GeneOrGeneProduct denotes FASN NCBIGene:2194
12472 1656-1672 ChemicalEntity denotes free fatty acids MESH:D005230
12473 1674-1680 ChemicalEntity denotes Emodin MESH:D004642
12474 1786-1792 ChemicalEntity denotes emodin MESH:D004642
12475 1797-1806 ChemicalEntity denotes cerulenin MESH:D002569
12476 1821-1825 GeneOrGeneProduct denotes FASN NCBIGene:2194
12477 1881-1890 ChemicalEntity denotes Palmitate MESH:D010168
12478 1917-1921 GeneOrGeneProduct denotes FASN NCBIGene:2194
12479 1940-1946 ChemicalEntity denotes emodin MESH:D004642
12480 1993-1999 ChemicalEntity denotes emodin MESH:D004642
12481 2008-2012 GeneOrGeneProduct denotes FASN NCBIGene:2194
12482 2052-2081 GeneOrGeneProduct denotes phosphatidylinositol 3-kinase NCBIGene:5291
12483 2082-2085 GeneOrGeneProduct denotes Akt NCBIGene:207
12484 2090-2166 GeneOrGeneProduct denotes mitogen‑activated protein kinases/extracellular signal-regulated kinases 1/2 NCBIGene:5594|NCBIGene:5595
12485 2197-2203 ChemicalEntity denotes emodin MESH:D004642
12486 2268-2272 GeneOrGeneProduct denotes FASN NCBIGene:2194
12487 2307-2319 DiseaseOrPhenotypicFeature denotes colon cancer MESH:D015179

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 430-435 OrganismTaxon denotes human NCBItxid:9606
T2 1199-1204 OrganismTaxon denotes human NCBItxid:9606

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-93 Sentence denotes Inhibitory effect of emodin on fatty acid synthase, colon cancer proliferation and apoptosis.
T2 94-237 Sentence denotes Fatty acid synthase (FASN) is a key anabolic enzyme for de novo fatty acid synthesis, which is important in the development of colon carcinoma.
T3 238-334 Sentence denotes The high expression of FASN is considered a promising molecular target for colon cancer therapy.
T4 335-532 Sentence denotes Emodin, a naturally occurring anthraquinone, exhibits an anticancer effect in various types of human cancer, including colon cancer; however, the molecular mechanisms remain to be fully elucidated.
T5 533-596 Sentence denotes Cell viability was evaluated using a Cell Counting Kit‑8 assay.
T6 597-705 Sentence denotes The apoptosis rate of cells was quantified via flow cytometry following Annexin V/propidium iodide staining.
T7 706-929 Sentence denotes FASN activity was measured by monitoring oxidation of nicotinamide adenine dinucleotide phosphate at a wavelength of 340 nm, and intracellular free fatty acid levels were detected using a Free Fatty Acid Quantification kit.
T8 930-1059 Sentence denotes Western blot analysis and reverse transcription‑polymerase chain reaction were used to detect target gene and protein expression.
T9 1060-1228 Sentence denotes The present study was performed to investigate whether the gene expression of FASN and its enzymatic activity are regulated by emodin in a human colon cancer cell line.
T10 1229-1392 Sentence denotes Emodin markedly inhibited the proliferation of HCT116 cells and a higher protein level of FASN was expressed, compared with that in SW480, SNU-C2A or SNU‑C5 cells.
T11 1393-1555 Sentence denotes Emodin significantly downregulated the protein expression of FASN in HCT116 cells, which was caused by protein degradation due to elevated protein ubiquitination.
T12 1556-1673 Sentence denotes Emodin also inhibited intracellular FASN enzymatic activity and reduced the levels of intracellular free fatty acids.
T13 1674-1759 Sentence denotes Emodin enhanced antiproliferation and apoptosis in a dose‑ and time‑dependent manner.
T14 1760-1880 Sentence denotes The combined treatment of emodin and cerulenin, a commercial FASN inhibitor, had an additive effect on these activities.
T15 1881-1979 Sentence denotes Palmitate, the final product of the FASN reaction, rescued emodin‑induced viability and apoptosis.
T16 1980-2167 Sentence denotes In addition, emodin altered FASN‑involved signaling pathways, including phosphatidylinositol 3-kinase/Akt and mitogen‑activated protein kinases/extracellular signal-regulated kinases 1/2.
T17 2168-2328 Sentence denotes These results suggested that emodin-regulated cell growth and apoptosis were mediated by inhibiting FASN and provide a molecular basis for colon cancer therapy.

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 58-64 DiseaseOrPhenotypicFeature denotes cancer 0004992
T2 221-236 DiseaseOrPhenotypicFeature denotes colon carcinoma 0002032
T3 227-236 DiseaseOrPhenotypicFeature denotes carcinoma 0004993
T4 319-325 DiseaseOrPhenotypicFeature denotes cancer 0004992
T5 436-442 DiseaseOrPhenotypicFeature denotes cancer 0004992
T6 460-466 DiseaseOrPhenotypicFeature denotes cancer 0004992
T7 1211-1217 DiseaseOrPhenotypicFeature denotes cancer 0004992
T8 2313-2319 DiseaseOrPhenotypicFeature denotes cancer 0004992

LitCoin-SeqVar

Id Subject Object Predicate Lexical cue
T1 1372-1375 SequenceVariant denotes C2A

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 31-50 GeneOrGeneProduct denotes fatty acid synthase
T2 83-92 GeneOrGeneProduct denotes apoptosis
T3 94-113 GeneOrGeneProduct denotes Fatty acid synthase
T4 115-119 GeneOrGeneProduct denotes FASN
T5 139-145 GeneOrGeneProduct denotes enzyme
T6 158-163 GeneOrGeneProduct denotes fatty
T7 164-168 GeneOrGeneProduct denotes acid
T8 242-246 GeneOrGeneProduct denotes high
T9 261-265 GeneOrGeneProduct denotes FASN
T10 533-537 GeneOrGeneProduct denotes Cell
T11 538-547 GeneOrGeneProduct denotes viability
T12 570-574 GeneOrGeneProduct denotes Cell
T13 601-610 GeneOrGeneProduct denotes apoptosis
T14 619-624 GeneOrGeneProduct denotes cells
T15 669-676 GeneOrGeneProduct denotes Annexin
T16 706-710 GeneOrGeneProduct denotes FASN
T17 711-719 GeneOrGeneProduct denotes activity
T18 747-803 GeneOrGeneProduct denotes oxidation of nicotinamide adenine dinucleotide phosphate
T19 854-859 GeneOrGeneProduct denotes fatty
T20 860-864 GeneOrGeneProduct denotes acid
T21 899-904 GeneOrGeneProduct denotes Fatty
T22 905-909 GeneOrGeneProduct denotes Acid
T23 938-942 GeneOrGeneProduct denotes blot
T24 964-977 GeneOrGeneProduct denotes transcription
T25 978-988 GeneOrGeneProduct denotes polymerase
T26 989-994 GeneOrGeneProduct denotes chain
T27 1040-1047 GeneOrGeneProduct denotes protein
T28 1138-1142 GeneOrGeneProduct denotes FASN
T29 1161-1169 GeneOrGeneProduct denotes activity
T30 1174-1183 GeneOrGeneProduct denotes regulated
T31 1194-1198 GeneOrGeneProduct denotes in a
T32 1218-1222 GeneOrGeneProduct denotes cell
T33 1223-1227 GeneOrGeneProduct denotes line
T34 1236-1244 GeneOrGeneProduct denotes markedly
T35 1283-1288 GeneOrGeneProduct denotes cells
T36 1302-1309 GeneOrGeneProduct denotes protein
T37 1319-1323 GeneOrGeneProduct denotes FASN
T38 1386-1391 GeneOrGeneProduct denotes cells
T39 1432-1439 GeneOrGeneProduct denotes protein
T40 1454-1458 GeneOrGeneProduct denotes FASN
T41 1469-1474 GeneOrGeneProduct denotes cells
T42 1496-1503 GeneOrGeneProduct denotes protein
T43 1532-1539 GeneOrGeneProduct denotes protein
T44 1540-1554 GeneOrGeneProduct denotes ubiquitination
T45 1592-1596 GeneOrGeneProduct denotes FASN
T46 1607-1615 GeneOrGeneProduct denotes activity
T47 1620-1627 GeneOrGeneProduct denotes reduced
T48 1661-1666 GeneOrGeneProduct denotes fatty
T49 1667-1672 GeneOrGeneProduct denotes acids
T50 1712-1721 GeneOrGeneProduct denotes apoptosis
T51 1737-1741 GeneOrGeneProduct denotes time
T52 1821-1825 GeneOrGeneProduct denotes FASN
T53 1826-1835 GeneOrGeneProduct denotes inhibitor
T54 1869-1879 GeneOrGeneProduct denotes activities
T55 1902-1909 GeneOrGeneProduct denotes product
T56 1917-1921 GeneOrGeneProduct denotes FASN
T57 1947-1954 GeneOrGeneProduct denotes induced
T58 1955-1964 GeneOrGeneProduct denotes viability
T59 1969-1978 GeneOrGeneProduct denotes apoptosis
T60 2008-2012 GeneOrGeneProduct denotes FASN
T61 2052-2072 GeneOrGeneProduct denotes phosphatidylinositol
T62 2075-2081 GeneOrGeneProduct denotes kinase
T63 2090-2097 GeneOrGeneProduct denotes mitogen
T64 2098-2107 GeneOrGeneProduct denotes activated
T65 2108-2115 GeneOrGeneProduct denotes protein
T66 2116-2123 GeneOrGeneProduct denotes kinases
T67 2124-2137 GeneOrGeneProduct denotes extracellular
T68 2155-2162 GeneOrGeneProduct denotes kinases
T69 2204-2213 GeneOrGeneProduct denotes regulated
T70 2214-2218 GeneOrGeneProduct denotes cell
T71 2219-2225 GeneOrGeneProduct denotes growth
T72 2230-2239 GeneOrGeneProduct denotes apoptosis
T73 2245-2253 GeneOrGeneProduct denotes mediated
T74 2268-2272 GeneOrGeneProduct denotes FASN
T75 2297-2302 GeneOrGeneProduct denotes basis

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 31-50 GeneOrGeneProduct denotes fatty acid synthase
T2 83-92 GeneOrGeneProduct denotes apoptosis
T3 94-113 GeneOrGeneProduct denotes Fatty acid synthase
T4 115-119 GeneOrGeneProduct denotes FASN
T5 139-145 GeneOrGeneProduct denotes enzyme
T6 164-168 GeneOrGeneProduct denotes acid
T7 242-246 GeneOrGeneProduct denotes high
T8 261-265 GeneOrGeneProduct denotes FASN
T9 538-547 GeneOrGeneProduct denotes viability
T10 601-610 GeneOrGeneProduct denotes apoptosis
T11 669-676 GeneOrGeneProduct denotes Annexin
T12 706-710 GeneOrGeneProduct denotes FASN
T13 860-864 GeneOrGeneProduct denotes acid
T14 938-942 GeneOrGeneProduct denotes blot
T15 964-977 GeneOrGeneProduct denotes transcription
T16 978-988 GeneOrGeneProduct denotes polymerase
T17 989-994 GeneOrGeneProduct denotes chain
T18 1040-1047 GeneOrGeneProduct denotes protein
T19 1138-1142 GeneOrGeneProduct denotes FASN
T20 1218-1222 GeneOrGeneProduct denotes cell
T21 1302-1309 GeneOrGeneProduct denotes protein
T22 1319-1323 GeneOrGeneProduct denotes FASN
T23 1432-1439 GeneOrGeneProduct denotes protein
T24 1454-1458 GeneOrGeneProduct denotes FASN
T25 1496-1503 GeneOrGeneProduct denotes protein
T26 1532-1539 GeneOrGeneProduct denotes protein
T27 1592-1596 GeneOrGeneProduct denotes FASN
T28 1620-1627 GeneOrGeneProduct denotes reduced
T29 1712-1721 GeneOrGeneProduct denotes apoptosis
T30 1821-1825 GeneOrGeneProduct denotes FASN
T31 1826-1835 GeneOrGeneProduct denotes inhibitor
T32 1902-1909 GeneOrGeneProduct denotes product
T33 1917-1921 GeneOrGeneProduct denotes FASN
T34 1955-1964 GeneOrGeneProduct denotes viability
T35 1969-1978 GeneOrGeneProduct denotes apoptosis
T36 2008-2012 GeneOrGeneProduct denotes FASN
T37 2052-2072 GeneOrGeneProduct denotes phosphatidylinositol
T38 2075-2081 GeneOrGeneProduct denotes kinase
T39 2090-2097 GeneOrGeneProduct denotes mitogen
T40 2108-2115 GeneOrGeneProduct denotes protein
T41 2124-2137 GeneOrGeneProduct denotes extracellular
T42 2214-2218 GeneOrGeneProduct denotes cell
T43 2219-2225 GeneOrGeneProduct denotes growth
T44 2230-2239 GeneOrGeneProduct denotes apoptosis
T45 2268-2272 GeneOrGeneProduct denotes FASN

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 52-64 DiseaseOrPhenotypicFeature denotes colon cancer D003110
T2 227-236 DiseaseOrPhenotypicFeature denotes carcinoma D002277
T3 313-325 DiseaseOrPhenotypicFeature denotes colon cancer D003110
T4 436-442 DiseaseOrPhenotypicFeature denotes cancer D009369
T5 454-466 DiseaseOrPhenotypicFeature denotes colon cancer D003110
T6 1205-1217 DiseaseOrPhenotypicFeature denotes colon cancer D003110
T7 2307-2319 DiseaseOrPhenotypicFeature denotes colon cancer D003110

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 31-50 GeneOrGeneProduct denotes fatty acid synthase
T2 94-113 GeneOrGeneProduct denotes Fatty acid synthase
T3 115-119 GeneOrGeneProduct denotes FASN
T4 261-265 GeneOrGeneProduct denotes FASN
T5 669-676 GeneOrGeneProduct denotes Annexin
T6 706-710 GeneOrGeneProduct denotes FASN
T7 1040-1058 GeneOrGeneProduct denotes protein expression
T8 1138-1142 GeneOrGeneProduct denotes FASN
T9 1319-1323 GeneOrGeneProduct denotes FASN
T10 1432-1450 GeneOrGeneProduct denotes protein expression
T11 1454-1458 GeneOrGeneProduct denotes FASN
T12 1592-1596 GeneOrGeneProduct denotes FASN
T13 1821-1825 GeneOrGeneProduct denotes FASN
T14 1917-1921 GeneOrGeneProduct denotes FASN
T15 2008-2012 GeneOrGeneProduct denotes FASN
T16 2052-2072 GeneOrGeneProduct denotes phosphatidylinositol
T17 2082-2085 GeneOrGeneProduct denotes Akt
T18 2090-2115 GeneOrGeneProduct denotes mitogen‑activated protein
T19 2124-2162 GeneOrGeneProduct denotes extracellular signal-regulated kinases
T20 2268-2272 GeneOrGeneProduct denotes FASN

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 52-64 DiseaseOrPhenotypicFeature denotes colon cancer 0021063|0005575|0002032
T4 221-236 DiseaseOrPhenotypicFeature denotes colon carcinoma 0002032
T5 313-325 DiseaseOrPhenotypicFeature denotes colon cancer 0021063|0005575|0002032
T8 454-466 DiseaseOrPhenotypicFeature denotes colon cancer 0021063|0005575|0002032
T11 1205-1217 DiseaseOrPhenotypicFeature denotes colon cancer 0021063|0005575|0002032
T14 2307-2319 DiseaseOrPhenotypicFeature denotes colon cancer 0021063|0005575|0002032

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 52-64 DiseaseOrPhenotypicFeature denotes colon cancer D003110
T2 227-236 DiseaseOrPhenotypicFeature denotes carcinoma D002277
T3 313-325 DiseaseOrPhenotypicFeature denotes colon cancer D003110
T4 436-442 DiseaseOrPhenotypicFeature denotes cancer D009369
T5 454-466 DiseaseOrPhenotypicFeature denotes colon cancer D003110
T6 1205-1217 DiseaseOrPhenotypicFeature denotes colon cancer D003110
T7 2307-2319 DiseaseOrPhenotypicFeature denotes colon cancer D003110

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 52-64 DiseaseOrPhenotypicFeature denotes colon cancer D003110
T2 227-236 DiseaseOrPhenotypicFeature denotes carcinoma D002277
T3 313-325 DiseaseOrPhenotypicFeature denotes colon cancer D003110
T4 436-442 DiseaseOrPhenotypicFeature denotes cancer D009369
T5 454-466 DiseaseOrPhenotypicFeature denotes colon cancer D003110
T6 1205-1217 DiseaseOrPhenotypicFeature denotes colon cancer D003110
T7 2307-2319 DiseaseOrPhenotypicFeature denotes colon cancer D003110

LitCoin_CellLine

Id Subject Object Predicate Lexical cue cellosaurus_accession_id
T1 1276-1282 CellLine denotes HCT116 CVCL_0291
T2 1361-1366 CellLine denotes SW480 CVCL_0546
T3 1368-1375 CellLine denotes SNU-C2A CVCL_1709
T4 1379-1385 CellLine denotes SNU‑C5 AddedByYayamamo
T5 1462-1468 CellLine denotes HCT116 CVCL_0291

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 21-27 ChemicalEntity denotes emodin D004642|http://purl.obolibrary.org/obo/CHEBI_77659|http://purl.obolibrary.org/obo/CHEBI_42223
T4 31-50 ChemicalEntity denotes fatty acid synthase D064429
T5 94-113 ChemicalEntity denotes Fatty acid synthase D064429
T6 115-119 ChemicalEntity denotes FASN D064429
T7 261-265 ChemicalEntity denotes FASN D064429
T8 335-341 ChemicalEntity denotes Emodin http://purl.obolibrary.org/obo/CHEBI_42223
T9 365-378 ChemicalEntity denotes anthraquinone D000880|http://purl.obolibrary.org/obo/CHEBI_40448|http://purl.obolibrary.org/obo/CHEBI_22580
T12 679-695 ChemicalEntity denotes propidium iodide D011419|http://purl.obolibrary.org/obo/CHEBI_51240
T14 706-710 ChemicalEntity denotes FASN D064429
T15 760-772 ChemicalEntity denotes nicotinamide D009536|http://purl.obolibrary.org/obo/CHEBI_17154
T17 773-780 ChemicalEntity denotes adenine D000225|http://purl.obolibrary.org/obo/CHEBI_16708
T19 794-803 ChemicalEntity denotes phosphate D010710|http://purl.obolibrary.org/obo/CHEBI_43474|http://purl.obolibrary.org/obo/CHEBI_35780|http://purl.obolibrary.org/obo/CHEBI_26020|http://purl.obolibrary.org/obo/CHEBI_18367
T24 849-864 ChemicalEntity denotes free fatty acid D005230
T25 1138-1142 ChemicalEntity denotes FASN D064429
T26 1187-1193 ChemicalEntity denotes emodin D004642|http://purl.obolibrary.org/obo/CHEBI_77659|http://purl.obolibrary.org/obo/CHEBI_42223
T29 1229-1235 ChemicalEntity denotes Emodin http://purl.obolibrary.org/obo/CHEBI_42223
T30 1319-1323 ChemicalEntity denotes FASN D064429
T31 1393-1399 ChemicalEntity denotes Emodin http://purl.obolibrary.org/obo/CHEBI_42223
T32 1454-1458 ChemicalEntity denotes FASN D064429
T33 1556-1562 ChemicalEntity denotes Emodin http://purl.obolibrary.org/obo/CHEBI_42223
T34 1592-1596 ChemicalEntity denotes FASN D064429
T35 1656-1672 ChemicalEntity denotes free fatty acids D005230
T36 1674-1680 ChemicalEntity denotes Emodin http://purl.obolibrary.org/obo/CHEBI_42223
T37 1786-1792 ChemicalEntity denotes emodin D004642|http://purl.obolibrary.org/obo/CHEBI_77659|http://purl.obolibrary.org/obo/CHEBI_42223
T40 1797-1806 ChemicalEntity denotes cerulenin D002569|http://purl.obolibrary.org/obo/CHEBI_171741
T42 1821-1825 ChemicalEntity denotes FASN D064429
T43 1881-1890 ChemicalEntity denotes Palmitate http://purl.obolibrary.org/obo/CHEBI_15756
T44 1917-1921 ChemicalEntity denotes FASN D064429
T45 1940-1946 ChemicalEntity denotes emodin D004642|http://purl.obolibrary.org/obo/CHEBI_77659|http://purl.obolibrary.org/obo/CHEBI_42223
T48 1993-1999 ChemicalEntity denotes emodin D004642|http://purl.obolibrary.org/obo/CHEBI_77659|http://purl.obolibrary.org/obo/CHEBI_42223
T51 2008-2012 ChemicalEntity denotes FASN D064429
T52 2052-2072 ChemicalEntity denotes phosphatidylinositol D010716|http://purl.obolibrary.org/obo/CHEBI_28874
T54 2197-2203 ChemicalEntity denotes emodin D004642|http://purl.obolibrary.org/obo/CHEBI_77659|http://purl.obolibrary.org/obo/CHEBI_42223
T57 2268-2272 ChemicalEntity denotes FASN D064429

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 430-435 OrganismTaxon denotes human
T2 1199-1204 OrganismTaxon denotes human

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID: cellosaurus_accession_id
T5 1462-1468 CellLine denotes HCT116 CVCL_0291
T4 1379-1385 CellLine denotes SNU‑C5 AddedByYayamamo
T3 1368-1375 CellLine denotes SNU-C2A CVCL_1709
T2 1361-1366 CellLine denotes SW480 CVCL_0546
T1 1276-1282 CellLine denotes HCT116 CVCL_0291
T57 2268-2272 ChemicalEntity denotes FASN D064429
T54 2197-2203 ChemicalEntity denotes emodin http://purl.obolibrary.org/obo/CHEBI_42223|http://purl.obolibrary.org/obo/CHEBI_77659|D004642
T52 2052-2072 ChemicalEntity denotes phosphatidylinositol http://purl.obolibrary.org/obo/CHEBI_28874|D010716
T51 2008-2012 ChemicalEntity denotes FASN D064429
T48 1993-1999 ChemicalEntity denotes emodin http://purl.obolibrary.org/obo/CHEBI_42223|http://purl.obolibrary.org/obo/CHEBI_77659|D004642
T45 1940-1946 ChemicalEntity denotes emodin http://purl.obolibrary.org/obo/CHEBI_42223|http://purl.obolibrary.org/obo/CHEBI_77659|D004642
T44 1917-1921 ChemicalEntity denotes FASN D064429
T43 1881-1890 ChemicalEntity denotes Palmitate http://purl.obolibrary.org/obo/CHEBI_15756
T42 1821-1825 ChemicalEntity denotes FASN D064429
T40 1797-1806 ChemicalEntity denotes cerulenin http://purl.obolibrary.org/obo/CHEBI_171741|D002569
T37 1786-1792 ChemicalEntity denotes emodin http://purl.obolibrary.org/obo/CHEBI_42223|http://purl.obolibrary.org/obo/CHEBI_77659|D004642
T36 1674-1680 ChemicalEntity denotes Emodin http://purl.obolibrary.org/obo/CHEBI_42223
T35 1656-1672 ChemicalEntity denotes free fatty acids D005230
T34 1592-1596 ChemicalEntity denotes FASN D064429
T33 1556-1562 ChemicalEntity denotes Emodin http://purl.obolibrary.org/obo/CHEBI_42223
T32 1454-1458 ChemicalEntity denotes FASN D064429
T31 1393-1399 ChemicalEntity denotes Emodin http://purl.obolibrary.org/obo/CHEBI_42223
T30 1319-1323 ChemicalEntity denotes FASN D064429
T29 1229-1235 ChemicalEntity denotes Emodin http://purl.obolibrary.org/obo/CHEBI_42223
T26 1187-1193 ChemicalEntity denotes emodin http://purl.obolibrary.org/obo/CHEBI_42223|http://purl.obolibrary.org/obo/CHEBI_77659|D004642
T25 1138-1142 ChemicalEntity denotes FASN D064429
T24 849-864 ChemicalEntity denotes free fatty acid D005230
T19 794-803 ChemicalEntity denotes phosphate http://purl.obolibrary.org/obo/CHEBI_18367|http://purl.obolibrary.org/obo/CHEBI_26020|http://purl.obolibrary.org/obo/CHEBI_35780|http://purl.obolibrary.org/obo/CHEBI_43474|D010710
T17 773-780 ChemicalEntity denotes adenine http://purl.obolibrary.org/obo/CHEBI_16708|D000225
T15 760-772 ChemicalEntity denotes nicotinamide http://purl.obolibrary.org/obo/CHEBI_17154|D009536
T14 706-710 ChemicalEntity denotes FASN D064429
T12 679-695 ChemicalEntity denotes propidium iodide http://purl.obolibrary.org/obo/CHEBI_51240|D011419
T9 365-378 ChemicalEntity denotes anthraquinone http://purl.obolibrary.org/obo/CHEBI_22580|http://purl.obolibrary.org/obo/CHEBI_40448|D000880
T8 335-341 ChemicalEntity denotes Emodin http://purl.obolibrary.org/obo/CHEBI_42223
T7 261-265 ChemicalEntity denotes FASN D064429
T6 115-119 ChemicalEntity denotes FASN D064429
T7016 94-113 ChemicalEntity denotes Fatty acid synthase D064429
T97086 31-50 ChemicalEntity denotes fatty acid synthase D064429
T51024 21-27 ChemicalEntity denotes emodin http://purl.obolibrary.org/obo/CHEBI_42223|http://purl.obolibrary.org/obo/CHEBI_77659|D004642
T20 2268-2272 GeneOrGeneProduct denotes FASN
T29821 2124-2162 GeneOrGeneProduct denotes extracellular signal-regulated kinases
T18 2090-2115 GeneOrGeneProduct denotes mitogen‑activated protein
T47650 2082-2085 GeneOrGeneProduct denotes Akt
T16 2052-2072 GeneOrGeneProduct denotes phosphatidylinositol
T21861 2008-2012 GeneOrGeneProduct denotes FASN
T70263 1917-1921 GeneOrGeneProduct denotes FASN
T13 1821-1825 GeneOrGeneProduct denotes FASN
T71948 1592-1596 GeneOrGeneProduct denotes FASN
T11 1454-1458 GeneOrGeneProduct denotes FASN
T10 1432-1450 GeneOrGeneProduct denotes protein expression
T23743 1319-1323 GeneOrGeneProduct denotes FASN
T91394 1138-1142 GeneOrGeneProduct denotes FASN
T12620 1040-1058 GeneOrGeneProduct denotes protein expression
T1379 706-710 GeneOrGeneProduct denotes FASN
T42077 669-676 GeneOrGeneProduct denotes Annexin
T21268 261-265 GeneOrGeneProduct denotes FASN
T91919 115-119 GeneOrGeneProduct denotes FASN
T78138 94-113 GeneOrGeneProduct denotes Fatty acid synthase
T53366 31-50 GeneOrGeneProduct denotes fatty acid synthase
T58761 2307-2319 DiseaseOrPhenotypicFeature denotes colon cancer D003110
T82499 1205-1217 DiseaseOrPhenotypicFeature denotes colon cancer D003110
T14873 454-466 DiseaseOrPhenotypicFeature denotes colon cancer D003110
T7220 436-442 DiseaseOrPhenotypicFeature denotes cancer D009369
T57405 313-325 DiseaseOrPhenotypicFeature denotes colon cancer D003110
T96359 227-236 DiseaseOrPhenotypicFeature denotes carcinoma D002277
T1507 52-64 DiseaseOrPhenotypicFeature denotes colon cancer D003110
T27039 1199-1204 OrganismTaxon denotes human
T39537 430-435 OrganismTaxon denotes human
T33050 1372-1375 SequenceVariant denotes C2A