PubMed:28260056
Annnotations
LitCoin-entities
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| 12343 | 0-37 | GeneOrGeneProduct | denotes | Insulin-like growth factor 1 receptor | NCBIGene:16001 |
| 12344 | 64-71 | DiseaseOrPhenotypicFeature | denotes | hypoxia | MESH:D000860 |
| 12345 | 133-137 | GeneOrGeneProduct | denotes | PI3K | NCBIGene:18706 |
| 12346 | 138-141 | GeneOrGeneProduct | denotes | Akt | NCBIGene:11651 |
| 12347 | 142-146 | GeneOrGeneProduct | denotes | mTOR | NCBIGene:56717 |
| 12348 | 166-173 | DiseaseOrPhenotypicFeature | denotes | Hypoxia | MESH:D000860 |
| 12349 | 325-353 | GeneOrGeneProduct | denotes | Insulin-like growth factor‑1 | NCBIGene:16000 |
| 12350 | 355-360 | GeneOrGeneProduct | denotes | IGF‑1 | NCBIGene:16000 |
| 12351 | 455-462 | DiseaseOrPhenotypicFeature | denotes | Hypoxia | MESH:D000860 |
| 12352 | 493-496 | GeneOrGeneProduct | denotes | IGF | NCBIGene:16000 |
| 12353 | 529-543 | GeneOrGeneProduct | denotes | IGF-1 receptor | NCBIGene:16001 |
| 12354 | 545-551 | GeneOrGeneProduct | denotes | IGF‑1R | NCBIGene:16001 |
| 12355 | 556-563 | DiseaseOrPhenotypicFeature | denotes | hypoxia | MESH:D000860 |
| 12356 | 671-677 | GeneOrGeneProduct | denotes | IGF‑1R | NCBIGene:16001 |
| 12357 | 705-712 | DiseaseOrPhenotypicFeature | denotes | hypoxic | MESH:D000860 |
| 12358 | 725-730 | OrganismTaxon | denotes | Mouse | NCBITaxon:10090 |
| 12359 | 796-802 | GeneOrGeneProduct | denotes | IGF‑1R | NCBIGene:16001 |
| 12360 | 901-924 | ChemicalEntity | denotes | reactive oxygen species | MESH:D017382 |
| 12361 | 926-929 | ChemicalEntity | denotes | ROS | MESH:D017382 |
| 12362 | 956-971 | ChemicalEntity | denotes | 3‑methyladenine | MESH:C025946 |
| 12363 | 1018-1021 | ChemicalEntity | denotes | ROS | MESH:D017382 |
| 12364 | 1053-1060 | DiseaseOrPhenotypicFeature | denotes | hypoxic | MESH:D000860 |
| 12365 | 1124-1153 | GeneOrGeneProduct | denotes | phosphatidylinositol 3-kinase | NCBIGene:18706 |
| 12366 | 1155-1159 | GeneOrGeneProduct | denotes | PI3K | NCBIGene:18706 |
| 12367 | 1161-1187 | GeneOrGeneProduct | denotes | threonine protein kinase B | NCBIGene:11651 |
| 12368 | 1189-1192 | GeneOrGeneProduct | denotes | Akt | NCBIGene:11651 |
| 12369 | 1194-1223 | GeneOrGeneProduct | denotes | mammalian target of rapamycin | NCBIGene:56717 |
| 12370 | 1225-1229 | GeneOrGeneProduct | denotes | mTOR | NCBIGene:56717 |
| 12371 | 1301-1308 | DiseaseOrPhenotypicFeature | denotes | hypoxia | MESH:D000860 |
| 12372 | 1338-1341 | ChemicalEntity | denotes | ROS | MESH:D017382 |
| 12373 | 1510-1513 | ChemicalEntity | denotes | ROS | MESH:D017382 |
| 12374 | 1646-1649 | ChemicalEntity | denotes | ROS | MESH:D017382 |
| 12375 | 1740-1746 | GeneOrGeneProduct | denotes | IGF‑1R | NCBIGene:16001 |
| 12376 | 1763-1767 | GeneOrGeneProduct | denotes | PI3K | NCBIGene:18706 |
| 12377 | 1768-1771 | GeneOrGeneProduct | denotes | Akt | NCBIGene:11651 |
| 12378 | 1772-1776 | GeneOrGeneProduct | denotes | mTOR | NCBIGene:56717 |
| 12379 | 1897-1901 | GeneOrGeneProduct | denotes | PI3K | NCBIGene:18706 |
| 12380 | 1912-1920 | ChemicalEntity | denotes | LY294002 | MESH:C085911 |
| 12381 | 1951-1957 | GeneOrGeneProduct | denotes | IGF‑1R | NCBIGene:16001 |
| 12382 | 1992-1999 | DiseaseOrPhenotypicFeature | denotes | hypoxic | MESH:D000860 |
| 12383 | 2049-2052 | ChemicalEntity | denotes | ROS | MESH:D017382 |
| 12384 | 2086-2090 | GeneOrGeneProduct | denotes | PI3K | NCBIGene:18706 |
| 12385 | 2091-2094 | GeneOrGeneProduct | denotes | Akt | NCBIGene:11651 |
| 12386 | 2095-2099 | GeneOrGeneProduct | denotes | mTOR | NCBIGene:56717 |
LitCoin-entities-OrganismTaxon-PD
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 725-730 | OrganismTaxon | denotes | Mouse | NCBItxid:10090|NCBItxid:10088 |
LitCoin-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T6 | 725-931 | Sentence | denotes | Mouse embryonic fibroblasts exhibiting disruption or overexpression of IGF‑1R (R‑ cells and R+ cells) were used to examine the level of apoptosis, autophagy, and production of reactive oxygen species (ROS). |
| T7 | 932-1072 | Sentence | denotes | The autophagy inhibitor 3‑methyladenine was used to assess the effect of autophagy on ROS production and apoptosis under hypoxic conditions. |
| T8 | 1073-1270 | Sentence | denotes | A potential downstream signaling pathway involving phosphatidylinositol 3-kinase (PI3K)/threonine protein kinase B (Akt)/mammalian target of rapamycin (mTOR) was identifiedby western blot analysis. |
| T1 | 0-165 | Sentence | denotes | Insulin-like growth factor 1 receptor-mediated cell survival in hypoxia depends on the promotion of autophagy via suppression of the PI3K/Akt/mTOR signaling pathway. |
| T2 | 166-324 | Sentence | denotes | Hypoxia is widely accepted as a fundamental biological phenomenon, which is strongly associated with tissue damage and cell viability under stress conditions. |
| T3 | 325-454 | Sentence | denotes | Insulin-like growth factor‑1 (IGF‑1) is known to protect tissues from multiple types of damage, and protect cells from apoptosis. |
| T4 | 455-598 | Sentence | denotes | Hypoxia is a regulatory factor of the IGF system, however the role of the IGF-1 receptor (IGF‑1R) in hypoxia‑induced apoptosis remains unclear. |
| T5 | 599-724 | Sentence | denotes | The present study investigated the potential mechanisms associated with IGF‑1R‑associated apoptosis under hypoxic conditions. |
| T9 | 1271-1445 | Sentence | denotes | The results demonstrated that hypoxia induced apoptosis, increased ROS production, and promoted autophagy in a time‑dependent manner relative to that observed under normoxia. |
| T12 | 1727-1921 | Sentence | denotes | Furthermore, IGF‑1R is related with PI3K/Akt/mTOR signaling pathway and enhanced autophagy-associated protein expression, which was verified following treatment with the PI3K inhibitor LY294002. |
| T10 | 1446-1591 | Sentence | denotes | R+ cells exhibited a lower percentage of apoptotic cells, lower ROS production, and higher levels of autophagy when compared to that of R- cells. |
| T11 | 1592-1726 | Sentence | denotes | In addition, inhibition of autophagy led to increased ROS production and a higher percentage of apoptotic cells in the two cell types. |
| T13 | 1922-2118 | Sentence | denotes | These results indicated that IGF‑1R may increase cell viability under hypoxic conditions by promoting autophagy and scavenging ROS production, which is closed with PI3K/Akt/mTOR signaling pathway. |
LitCoin-GeneOrGeneProduct-v0
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-37 | GeneOrGeneProduct | denotes | Insulin-like growth factor 1 receptor |
| T2 | 38-46 | GeneOrGeneProduct | denotes | mediated |
| T3 | 47-51 | GeneOrGeneProduct | denotes | cell |
| T4 | 100-109 | GeneOrGeneProduct | denotes | autophagy |
| T5 | 133-137 | GeneOrGeneProduct | denotes | PI3K |
| T6 | 142-146 | GeneOrGeneProduct | denotes | mTOR |
| T7 | 274-280 | GeneOrGeneProduct | denotes | damage |
| T8 | 285-289 | GeneOrGeneProduct | denotes | cell |
| T9 | 290-299 | GeneOrGeneProduct | denotes | viability |
| T10 | 325-337 | GeneOrGeneProduct | denotes | Insulin-like |
| T11 | 338-351 | GeneOrGeneProduct | denotes | growth factor |
| T12 | 355-360 | GeneOrGeneProduct | denotes | IGF‑1 |
| T13 | 395-403 | GeneOrGeneProduct | denotes | multiple |
| T14 | 413-419 | GeneOrGeneProduct | denotes | damage |
| T15 | 433-438 | GeneOrGeneProduct | denotes | cells |
| T16 | 444-453 | GeneOrGeneProduct | denotes | apoptosis |
| T17 | 468-485 | GeneOrGeneProduct | denotes | regulatory factor |
| T18 | 529-543 | GeneOrGeneProduct | denotes | IGF-1 receptor |
| T19 | 545-551 | GeneOrGeneProduct | denotes | IGF‑1R |
| T20 | 556-571 | GeneOrGeneProduct | denotes | hypoxia‑induced |
| T21 | 572-581 | GeneOrGeneProduct | denotes | apoptosis |
| T22 | 590-597 | GeneOrGeneProduct | denotes | unclear |
| T23 | 671-677 | GeneOrGeneProduct | denotes | IGF‑1R |
| T24 | 689-698 | GeneOrGeneProduct | denotes | apoptosis |
| T25 | 764-774 | GeneOrGeneProduct | denotes | disruption |
| T26 | 796-802 | GeneOrGeneProduct | denotes | IGF‑1R |
| T27 | 807-812 | GeneOrGeneProduct | denotes | cells |
| T28 | 820-825 | GeneOrGeneProduct | denotes | cells |
| T29 | 861-870 | GeneOrGeneProduct | denotes | apoptosis |
| T30 | 872-881 | GeneOrGeneProduct | denotes | autophagy |
| T31 | 887-897 | GeneOrGeneProduct | denotes | production |
| T32 | 936-945 | GeneOrGeneProduct | denotes | autophagy |
| T33 | 946-955 | GeneOrGeneProduct | denotes | inhibitor |
| T34 | 1005-1014 | GeneOrGeneProduct | denotes | autophagy |
| T35 | 1022-1032 | GeneOrGeneProduct | denotes | production |
| T36 | 1037-1046 | GeneOrGeneProduct | denotes | apoptosis |
| T37 | 1124-1153 | GeneOrGeneProduct | denotes | phosphatidylinositol 3-kinase |
| T38 | 1155-1159 | GeneOrGeneProduct | denotes | PI3K |
| T39 | 1161-1185 | GeneOrGeneProduct | denotes | threonine protein kinase |
| T40 | 1194-1223 | GeneOrGeneProduct | denotes | mammalian target of rapamycin |
| T41 | 1225-1229 | GeneOrGeneProduct | denotes | mTOR |
| T42 | 1256-1260 | GeneOrGeneProduct | denotes | blot |
| T43 | 1301-1316 | GeneOrGeneProduct | denotes | hypoxia induced |
| T44 | 1317-1326 | GeneOrGeneProduct | denotes | apoptosis |
| T45 | 1342-1352 | GeneOrGeneProduct | denotes | production |
| T46 | 1367-1376 | GeneOrGeneProduct | denotes | autophagy |
| T47 | 1382-1386 | GeneOrGeneProduct | denotes | time |
| T48 | 1449-1454 | GeneOrGeneProduct | denotes | cells |
| T49 | 1497-1502 | GeneOrGeneProduct | denotes | cells |
| T50 | 1514-1524 | GeneOrGeneProduct | denotes | production |
| T51 | 1547-1556 | GeneOrGeneProduct | denotes | autophagy |
| T52 | 1585-1590 | GeneOrGeneProduct | denotes | cells |
| T53 | 1619-1628 | GeneOrGeneProduct | denotes | autophagy |
| T54 | 1650-1660 | GeneOrGeneProduct | denotes | production |
| T55 | 1698-1703 | GeneOrGeneProduct | denotes | cells |
| T56 | 1715-1719 | GeneOrGeneProduct | denotes | cell |
| T57 | 1740-1746 | GeneOrGeneProduct | denotes | IGF‑1R |
| T58 | 1763-1767 | GeneOrGeneProduct | denotes | PI3K |
| T59 | 1772-1776 | GeneOrGeneProduct | denotes | mTOR |
| T60 | 1808-1817 | GeneOrGeneProduct | denotes | autophagy |
| T61 | 1829-1836 | GeneOrGeneProduct | denotes | protein |
| T62 | 1897-1901 | GeneOrGeneProduct | denotes | PI3K |
| T63 | 1902-1911 | GeneOrGeneProduct | denotes | inhibitor |
| T64 | 1951-1957 | GeneOrGeneProduct | denotes | IGF‑1R |
| T65 | 1971-1975 | GeneOrGeneProduct | denotes | cell |
| T66 | 1976-1985 | GeneOrGeneProduct | denotes | viability |
| T67 | 2024-2033 | GeneOrGeneProduct | denotes | autophagy |
| T68 | 2053-2063 | GeneOrGeneProduct | denotes | production |
| T69 | 2086-2090 | GeneOrGeneProduct | denotes | PI3K |
| T70 | 2095-2099 | GeneOrGeneProduct | denotes | mTOR |
LitCoin-GeneOrGeneProduct-v2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-37 | GeneOrGeneProduct | denotes | Insulin-like growth factor 1 receptor |
| T2 | 47-51 | GeneOrGeneProduct | denotes | cell |
| T3 | 100-109 | GeneOrGeneProduct | denotes | autophagy |
| T4 | 133-137 | GeneOrGeneProduct | denotes | PI3K |
| T5 | 142-146 | GeneOrGeneProduct | denotes | mTOR |
| T6 | 285-289 | GeneOrGeneProduct | denotes | cell |
| T7 | 290-299 | GeneOrGeneProduct | denotes | viability |
| T8 | 325-337 | GeneOrGeneProduct | denotes | Insulin-like |
| T9 | 338-351 | GeneOrGeneProduct | denotes | growth factor |
| T10 | 355-360 | GeneOrGeneProduct | denotes | IGF‑1 |
| T11 | 395-403 | GeneOrGeneProduct | denotes | multiple |
| T12 | 444-453 | GeneOrGeneProduct | denotes | apoptosis |
| T13 | 468-485 | GeneOrGeneProduct | denotes | regulatory factor |
| T14 | 529-543 | GeneOrGeneProduct | denotes | IGF-1 receptor |
| T15 | 545-551 | GeneOrGeneProduct | denotes | IGF‑1R |
| T16 | 556-571 | GeneOrGeneProduct | denotes | hypoxia‑induced |
| T17 | 572-581 | GeneOrGeneProduct | denotes | apoptosis |
| T18 | 590-597 | GeneOrGeneProduct | denotes | unclear |
| T19 | 671-677 | GeneOrGeneProduct | denotes | IGF‑1R |
| T20 | 689-698 | GeneOrGeneProduct | denotes | apoptosis |
| T21 | 796-802 | GeneOrGeneProduct | denotes | IGF‑1R |
| T22 | 861-870 | GeneOrGeneProduct | denotes | apoptosis |
| T23 | 872-881 | GeneOrGeneProduct | denotes | autophagy |
| T24 | 936-945 | GeneOrGeneProduct | denotes | autophagy |
| T25 | 946-955 | GeneOrGeneProduct | denotes | inhibitor |
| T26 | 1005-1014 | GeneOrGeneProduct | denotes | autophagy |
| T27 | 1037-1046 | GeneOrGeneProduct | denotes | apoptosis |
| T28 | 1124-1153 | GeneOrGeneProduct | denotes | phosphatidylinositol 3-kinase |
| T29 | 1155-1159 | GeneOrGeneProduct | denotes | PI3K |
| T30 | 1161-1185 | GeneOrGeneProduct | denotes | threonine protein kinase |
| T31 | 1194-1223 | GeneOrGeneProduct | denotes | mammalian target of rapamycin |
| T32 | 1225-1229 | GeneOrGeneProduct | denotes | mTOR |
| T33 | 1256-1260 | GeneOrGeneProduct | denotes | blot |
| T34 | 1301-1316 | GeneOrGeneProduct | denotes | hypoxia induced |
| T35 | 1317-1326 | GeneOrGeneProduct | denotes | apoptosis |
| T36 | 1367-1376 | GeneOrGeneProduct | denotes | autophagy |
| T37 | 1547-1556 | GeneOrGeneProduct | denotes | autophagy |
| T38 | 1619-1628 | GeneOrGeneProduct | denotes | autophagy |
| T39 | 1715-1719 | GeneOrGeneProduct | denotes | cell |
| T40 | 1740-1746 | GeneOrGeneProduct | denotes | IGF‑1R |
| T41 | 1763-1767 | GeneOrGeneProduct | denotes | PI3K |
| T42 | 1772-1776 | GeneOrGeneProduct | denotes | mTOR |
| T43 | 1808-1817 | GeneOrGeneProduct | denotes | autophagy |
| T44 | 1829-1836 | GeneOrGeneProduct | denotes | protein |
| T45 | 1897-1901 | GeneOrGeneProduct | denotes | PI3K |
| T46 | 1902-1911 | GeneOrGeneProduct | denotes | inhibitor |
| T47 | 1951-1957 | GeneOrGeneProduct | denotes | IGF‑1R |
| T48 | 1971-1975 | GeneOrGeneProduct | denotes | cell |
| T49 | 1976-1985 | GeneOrGeneProduct | denotes | viability |
| T50 | 2024-2033 | GeneOrGeneProduct | denotes | autophagy |
| T51 | 2086-2090 | GeneOrGeneProduct | denotes | PI3K |
| T52 | 2095-2099 | GeneOrGeneProduct | denotes | mTOR |
LitCoin-Disease-MeSH
| Id | Subject | Object | Predicate | Lexical cue | originalLabel |
|---|---|---|---|---|---|
| T1 | 64-71 | DiseaseOrPhenotypicFeature | denotes | hypoxia | D000860 |
| T2 | 166-173 | DiseaseOrPhenotypicFeature | denotes | Hypoxia | D000860 |
| T3 | 455-462 | DiseaseOrPhenotypicFeature | denotes | Hypoxia | D000860 |
| T4 | 556-563 | DiseaseOrPhenotypicFeature | denotes | hypoxia | D000860 |
| T5 | 705-712 | DiseaseOrPhenotypicFeature | denotes | hypoxic | DISEASE |
| T6 | 1053-1060 | DiseaseOrPhenotypicFeature | denotes | hypoxic | DISEASE |
| T7 | 1301-1308 | DiseaseOrPhenotypicFeature | denotes | hypoxia | D000860 |
| T8 | 1992-1999 | DiseaseOrPhenotypicFeature | denotes | hypoxic | DISEASE |
LitCoin-GeneOrGeneProduct-v3
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-37 | GeneOrGeneProduct | denotes | Insulin-like growth factor 1 receptor |
| T2 | 133-137 | GeneOrGeneProduct | denotes | PI3K |
| T3 | 138-141 | GeneOrGeneProduct | denotes | Akt |
| T4 | 142-146 | GeneOrGeneProduct | denotes | mTOR |
| T5 | 325-337 | GeneOrGeneProduct | denotes | Insulin-like |
| T6 | 338-351 | GeneOrGeneProduct | denotes | growth factor |
| T7 | 355-360 | GeneOrGeneProduct | denotes | IGF‑1 |
| T8 | 468-485 | GeneOrGeneProduct | denotes | regulatory factor |
| T9 | 529-543 | GeneOrGeneProduct | denotes | IGF-1 receptor |
| T10 | 545-551 | GeneOrGeneProduct | denotes | IGF‑1R |
| T11 | 556-571 | GeneOrGeneProduct | denotes | hypoxia‑induced |
| T12 | 671-677 | GeneOrGeneProduct | denotes | IGF‑1R |
| T13 | 796-802 | GeneOrGeneProduct | denotes | IGF‑1R |
| T14 | 946-957 | GeneOrGeneProduct | denotes | inhibitor 3 |
| T15 | 1124-1153 | GeneOrGeneProduct | denotes | phosphatidylinositol 3-kinase |
| T16 | 1155-1159 | GeneOrGeneProduct | denotes | PI3K |
| T17 | 1161-1185 | GeneOrGeneProduct | denotes | threonine protein kinase |
| T18 | 1189-1192 | GeneOrGeneProduct | denotes | Akt |
| T19 | 1194-1223 | GeneOrGeneProduct | denotes | mammalian target of rapamycin |
| T20 | 1225-1229 | GeneOrGeneProduct | denotes | mTOR |
| T21 | 1301-1316 | GeneOrGeneProduct | denotes | hypoxia induced |
| T22 | 1740-1746 | GeneOrGeneProduct | denotes | IGF‑1R |
| T23 | 1763-1767 | GeneOrGeneProduct | denotes | PI3K |
| T24 | 1768-1771 | GeneOrGeneProduct | denotes | Akt |
| T25 | 1772-1776 | GeneOrGeneProduct | denotes | mTOR |
| T26 | 1808-1836 | GeneOrGeneProduct | denotes | autophagy-associated protein |
| T27 | 1897-1901 | GeneOrGeneProduct | denotes | PI3K |
| T28 | 1951-1957 | GeneOrGeneProduct | denotes | IGF‑1R |
| T29 | 2086-2090 | GeneOrGeneProduct | denotes | PI3K |
| T30 | 2091-2094 | GeneOrGeneProduct | denotes | Akt |
| T31 | 2095-2099 | GeneOrGeneProduct | denotes | mTOR |
LitCoin-NCBITaxon-2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 725-730 | OrganismTaxon | denotes | Mouse |
LitCoin-MeSH-Disease-2
| Id | Subject | Object | Predicate | Lexical cue | ID: |
|---|---|---|---|---|---|
| T1 | 64-71 | DiseaseOrPhenotypicFeature | denotes | hypoxia | D000860 |
| T2 | 166-173 | DiseaseOrPhenotypicFeature | denotes | Hypoxia | D000860 |
| T3 | 455-462 | DiseaseOrPhenotypicFeature | denotes | Hypoxia | D000860 |
| T4 | 556-563 | DiseaseOrPhenotypicFeature | denotes | hypoxia | D000860 |
| T5 | 705-712 | DiseaseOrPhenotypicFeature | denotes | hypoxic | DISEASE |
| T6 | 1053-1060 | DiseaseOrPhenotypicFeature | denotes | hypoxic | DISEASE |
| T7 | 1301-1308 | DiseaseOrPhenotypicFeature | denotes | hypoxia | D000860 |
| T8 | 1992-1999 | DiseaseOrPhenotypicFeature | denotes | hypoxic | DISEASE |
LitCoin-MONDO_bioort2019
| Id | Subject | Object | Predicate | Lexical cue | #label |
|---|---|---|---|---|---|
| T1 | 64-71 | DiseaseOrPhenotypicFeature | denotes | hypoxia | D000860 |
| T2 | 166-173 | DiseaseOrPhenotypicFeature | denotes | Hypoxia | D000860 |
| T3 | 455-462 | DiseaseOrPhenotypicFeature | denotes | Hypoxia | D000860 |
| T4 | 556-563 | DiseaseOrPhenotypicFeature | denotes | hypoxia | D000860 |
| T5 | 705-712 | DiseaseOrPhenotypicFeature | denotes | hypoxic | DISEASE |
| T6 | 1053-1060 | DiseaseOrPhenotypicFeature | denotes | hypoxic | DISEASE |
| T7 | 1301-1308 | DiseaseOrPhenotypicFeature | denotes | hypoxia | D000860 |
| T8 | 1992-1999 | DiseaseOrPhenotypicFeature | denotes | hypoxic | DISEASE |
LitCoin-Chemical-MeSH-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | ID: |
|---|---|---|---|---|---|
| T1 | 901-924 | ChemicalEntity | denotes | reactive oxygen species | D017382|http://purl.obolibrary.org/obo/CHEBI_26523 |
| T3 | 926-929 | ChemicalEntity | denotes | ROS | http://purl.obolibrary.org/obo/CHEBI_26523 |
| T4 | 956-971 | ChemicalEntity | denotes | 3‑methyladenine | C025946|http://purl.obolibrary.org/obo/CHEBI_38635 |
| T6 | 1018-1021 | ChemicalEntity | denotes | ROS | http://purl.obolibrary.org/obo/CHEBI_26523 |
| T7 | 1124-1144 | ChemicalEntity | denotes | phosphatidylinositol | D010716|http://purl.obolibrary.org/obo/CHEBI_28874 |
| T9 | 1161-1170 | ChemicalEntity | denotes | threonine | http://purl.obolibrary.org/obo/CHEBI_26986 |
| T10 | 1214-1223 | ChemicalEntity | denotes | rapamycin | D020123|http://purl.obolibrary.org/obo/CHEBI_9168 |
| T12 | 1338-1341 | ChemicalEntity | denotes | ROS | http://purl.obolibrary.org/obo/CHEBI_26523 |
| T13 | 1510-1513 | ChemicalEntity | denotes | ROS | http://purl.obolibrary.org/obo/CHEBI_26523 |
| T14 | 1646-1649 | ChemicalEntity | denotes | ROS | http://purl.obolibrary.org/obo/CHEBI_26523 |
| T15 | 1912-1920 | ChemicalEntity | denotes | LY294002 | C085911|http://purl.obolibrary.org/obo/CHEBI_65329 |
| T17 | 2049-2052 | ChemicalEntity | denotes | ROS | http://purl.obolibrary.org/obo/CHEBI_26523 |
LitCoin-training-merged
| Id | Subject | Object | Predicate | Lexical cue | #label | ID: |
|---|---|---|---|---|---|---|
| T17 | 2049-2052 | ChemicalEntity | denotes | ROS | http://purl.obolibrary.org/obo/CHEBI_26523 | |
| T15 | 1912-1920 | ChemicalEntity | denotes | LY294002 | http://purl.obolibrary.org/obo/CHEBI_65329|C085911 | |
| T14 | 1646-1649 | ChemicalEntity | denotes | ROS | http://purl.obolibrary.org/obo/CHEBI_26523 | |
| T13 | 1510-1513 | ChemicalEntity | denotes | ROS | http://purl.obolibrary.org/obo/CHEBI_26523 | |
| T12 | 1338-1341 | ChemicalEntity | denotes | ROS | http://purl.obolibrary.org/obo/CHEBI_26523 | |
| T10 | 1214-1223 | ChemicalEntity | denotes | rapamycin | http://purl.obolibrary.org/obo/CHEBI_9168|D020123 | |
| T9 | 1161-1170 | ChemicalEntity | denotes | threonine | http://purl.obolibrary.org/obo/CHEBI_26986 | |
| T7 | 1124-1144 | ChemicalEntity | denotes | phosphatidylinositol | http://purl.obolibrary.org/obo/CHEBI_28874|D010716 | |
| T6 | 1018-1021 | ChemicalEntity | denotes | ROS | http://purl.obolibrary.org/obo/CHEBI_26523 | |
| T4 | 956-971 | ChemicalEntity | denotes | 3‑methyladenine | http://purl.obolibrary.org/obo/CHEBI_38635|C025946 | |
| T3 | 926-929 | ChemicalEntity | denotes | ROS | http://purl.obolibrary.org/obo/CHEBI_26523 | |
| T1 | 901-924 | ChemicalEntity | denotes | reactive oxygen species | http://purl.obolibrary.org/obo/CHEBI_26523|D017382 | |
| T31 | 2095-2099 | GeneOrGeneProduct | denotes | mTOR | ||
| T30 | 2091-2094 | GeneOrGeneProduct | denotes | Akt | ||
| T29 | 2086-2090 | GeneOrGeneProduct | denotes | PI3K | ||
| T28 | 1951-1957 | GeneOrGeneProduct | denotes | IGF‑1R | ||
| T27 | 1897-1901 | GeneOrGeneProduct | denotes | PI3K | ||
| T26 | 1808-1836 | GeneOrGeneProduct | denotes | autophagy-associated protein | ||
| T25 | 1772-1776 | GeneOrGeneProduct | denotes | mTOR | ||
| T24 | 1768-1771 | GeneOrGeneProduct | denotes | Akt | ||
| T23 | 1763-1767 | GeneOrGeneProduct | denotes | PI3K | ||
| T22 | 1740-1746 | GeneOrGeneProduct | denotes | IGF‑1R | ||
| T21 | 1301-1316 | GeneOrGeneProduct | denotes | hypoxia induced | ||
| T20 | 1225-1229 | GeneOrGeneProduct | denotes | mTOR | ||
| T19 | 1194-1223 | GeneOrGeneProduct | denotes | mammalian target of rapamycin | ||
| T18 | 1189-1192 | GeneOrGeneProduct | denotes | Akt | ||
| T23059 | 1161-1185 | GeneOrGeneProduct | denotes | threonine protein kinase | ||
| T16 | 1155-1159 | GeneOrGeneProduct | denotes | PI3K | ||
| T35191 | 1124-1153 | GeneOrGeneProduct | denotes | phosphatidylinositol 3-kinase | ||
| T11390 | 946-957 | GeneOrGeneProduct | denotes | inhibitor 3 | ||
| T31633 | 796-802 | GeneOrGeneProduct | denotes | IGF‑1R | ||
| T90276 | 671-677 | GeneOrGeneProduct | denotes | IGF‑1R | ||
| T11 | 556-571 | GeneOrGeneProduct | denotes | hypoxia‑induced | ||
| T84934 | 545-551 | GeneOrGeneProduct | denotes | IGF‑1R | ||
| T91605 | 529-543 | GeneOrGeneProduct | denotes | IGF-1 receptor | ||
| T8 | 468-485 | GeneOrGeneProduct | denotes | regulatory factor | ||
| T82609 | 355-360 | GeneOrGeneProduct | denotes | IGF‑1 | ||
| T36166 | 338-351 | GeneOrGeneProduct | denotes | growth factor | ||
| T5 | 325-337 | GeneOrGeneProduct | denotes | Insulin-like | ||
| T81203 | 142-146 | GeneOrGeneProduct | denotes | mTOR | ||
| T83544 | 138-141 | GeneOrGeneProduct | denotes | Akt | ||
| T2 | 133-137 | GeneOrGeneProduct | denotes | PI3K | ||
| T87997 | 0-37 | GeneOrGeneProduct | denotes | Insulin-like growth factor 1 receptor | ||
| T21810 | 1992-1999 | DiseaseOrPhenotypicFeature | denotes | hypoxic | DISEASE | |
| T61548 | 1301-1308 | DiseaseOrPhenotypicFeature | denotes | hypoxia | D000860 | |
| T78713 | 1053-1060 | DiseaseOrPhenotypicFeature | denotes | hypoxic | DISEASE | |
| T45998 | 705-712 | DiseaseOrPhenotypicFeature | denotes | hypoxic | DISEASE | |
| T31757 | 556-563 | DiseaseOrPhenotypicFeature | denotes | hypoxia | D000860 | |
| T57278 | 455-462 | DiseaseOrPhenotypicFeature | denotes | Hypoxia | D000860 | |
| T46454 | 166-173 | DiseaseOrPhenotypicFeature | denotes | Hypoxia | D000860 | |
| T91804 | 64-71 | DiseaseOrPhenotypicFeature | denotes | hypoxia | D000860 | |
| T3347 | 725-730 | OrganismTaxon | denotes | Mouse |