PubMed:28260056
Annnotations
LitCoin-entities
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
12343 | 0-37 | GeneOrGeneProduct | denotes | Insulin-like growth factor 1 receptor | NCBIGene:16001 |
12344 | 64-71 | DiseaseOrPhenotypicFeature | denotes | hypoxia | MESH:D000860 |
12345 | 133-137 | GeneOrGeneProduct | denotes | PI3K | NCBIGene:18706 |
12346 | 138-141 | GeneOrGeneProduct | denotes | Akt | NCBIGene:11651 |
12347 | 142-146 | GeneOrGeneProduct | denotes | mTOR | NCBIGene:56717 |
12348 | 166-173 | DiseaseOrPhenotypicFeature | denotes | Hypoxia | MESH:D000860 |
12349 | 325-353 | GeneOrGeneProduct | denotes | Insulin-like growth factor‑1 | NCBIGene:16000 |
12350 | 355-360 | GeneOrGeneProduct | denotes | IGF‑1 | NCBIGene:16000 |
12351 | 455-462 | DiseaseOrPhenotypicFeature | denotes | Hypoxia | MESH:D000860 |
12352 | 493-496 | GeneOrGeneProduct | denotes | IGF | NCBIGene:16000 |
12353 | 529-543 | GeneOrGeneProduct | denotes | IGF-1 receptor | NCBIGene:16001 |
12354 | 545-551 | GeneOrGeneProduct | denotes | IGF‑1R | NCBIGene:16001 |
12355 | 556-563 | DiseaseOrPhenotypicFeature | denotes | hypoxia | MESH:D000860 |
12356 | 671-677 | GeneOrGeneProduct | denotes | IGF‑1R | NCBIGene:16001 |
12357 | 705-712 | DiseaseOrPhenotypicFeature | denotes | hypoxic | MESH:D000860 |
12358 | 725-730 | OrganismTaxon | denotes | Mouse | NCBITaxon:10090 |
12359 | 796-802 | GeneOrGeneProduct | denotes | IGF‑1R | NCBIGene:16001 |
12360 | 901-924 | ChemicalEntity | denotes | reactive oxygen species | MESH:D017382 |
12361 | 926-929 | ChemicalEntity | denotes | ROS | MESH:D017382 |
12362 | 956-971 | ChemicalEntity | denotes | 3‑methyladenine | MESH:C025946 |
12363 | 1018-1021 | ChemicalEntity | denotes | ROS | MESH:D017382 |
12364 | 1053-1060 | DiseaseOrPhenotypicFeature | denotes | hypoxic | MESH:D000860 |
12365 | 1124-1153 | GeneOrGeneProduct | denotes | phosphatidylinositol 3-kinase | NCBIGene:18706 |
12366 | 1155-1159 | GeneOrGeneProduct | denotes | PI3K | NCBIGene:18706 |
12367 | 1161-1187 | GeneOrGeneProduct | denotes | threonine protein kinase B | NCBIGene:11651 |
12368 | 1189-1192 | GeneOrGeneProduct | denotes | Akt | NCBIGene:11651 |
12369 | 1194-1223 | GeneOrGeneProduct | denotes | mammalian target of rapamycin | NCBIGene:56717 |
12370 | 1225-1229 | GeneOrGeneProduct | denotes | mTOR | NCBIGene:56717 |
12371 | 1301-1308 | DiseaseOrPhenotypicFeature | denotes | hypoxia | MESH:D000860 |
12372 | 1338-1341 | ChemicalEntity | denotes | ROS | MESH:D017382 |
12373 | 1510-1513 | ChemicalEntity | denotes | ROS | MESH:D017382 |
12374 | 1646-1649 | ChemicalEntity | denotes | ROS | MESH:D017382 |
12375 | 1740-1746 | GeneOrGeneProduct | denotes | IGF‑1R | NCBIGene:16001 |
12376 | 1763-1767 | GeneOrGeneProduct | denotes | PI3K | NCBIGene:18706 |
12377 | 1768-1771 | GeneOrGeneProduct | denotes | Akt | NCBIGene:11651 |
12378 | 1772-1776 | GeneOrGeneProduct | denotes | mTOR | NCBIGene:56717 |
12379 | 1897-1901 | GeneOrGeneProduct | denotes | PI3K | NCBIGene:18706 |
12380 | 1912-1920 | ChemicalEntity | denotes | LY294002 | MESH:C085911 |
12381 | 1951-1957 | GeneOrGeneProduct | denotes | IGF‑1R | NCBIGene:16001 |
12382 | 1992-1999 | DiseaseOrPhenotypicFeature | denotes | hypoxic | MESH:D000860 |
12383 | 2049-2052 | ChemicalEntity | denotes | ROS | MESH:D017382 |
12384 | 2086-2090 | GeneOrGeneProduct | denotes | PI3K | NCBIGene:18706 |
12385 | 2091-2094 | GeneOrGeneProduct | denotes | Akt | NCBIGene:11651 |
12386 | 2095-2099 | GeneOrGeneProduct | denotes | mTOR | NCBIGene:56717 |
LitCoin-entities-OrganismTaxon-PD
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 725-730 | OrganismTaxon | denotes | Mouse | NCBItxid:10090|NCBItxid:10088 |
LitCoin-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T6 | 725-931 | Sentence | denotes | Mouse embryonic fibroblasts exhibiting disruption or overexpression of IGF‑1R (R‑ cells and R+ cells) were used to examine the level of apoptosis, autophagy, and production of reactive oxygen species (ROS). |
T7 | 932-1072 | Sentence | denotes | The autophagy inhibitor 3‑methyladenine was used to assess the effect of autophagy on ROS production and apoptosis under hypoxic conditions. |
T8 | 1073-1270 | Sentence | denotes | A potential downstream signaling pathway involving phosphatidylinositol 3-kinase (PI3K)/threonine protein kinase B (Akt)/mammalian target of rapamycin (mTOR) was identifiedby western blot analysis. |
T1 | 0-165 | Sentence | denotes | Insulin-like growth factor 1 receptor-mediated cell survival in hypoxia depends on the promotion of autophagy via suppression of the PI3K/Akt/mTOR signaling pathway. |
T2 | 166-324 | Sentence | denotes | Hypoxia is widely accepted as a fundamental biological phenomenon, which is strongly associated with tissue damage and cell viability under stress conditions. |
T3 | 325-454 | Sentence | denotes | Insulin-like growth factor‑1 (IGF‑1) is known to protect tissues from multiple types of damage, and protect cells from apoptosis. |
T4 | 455-598 | Sentence | denotes | Hypoxia is a regulatory factor of the IGF system, however the role of the IGF-1 receptor (IGF‑1R) in hypoxia‑induced apoptosis remains unclear. |
T5 | 599-724 | Sentence | denotes | The present study investigated the potential mechanisms associated with IGF‑1R‑associated apoptosis under hypoxic conditions. |
T9 | 1271-1445 | Sentence | denotes | The results demonstrated that hypoxia induced apoptosis, increased ROS production, and promoted autophagy in a time‑dependent manner relative to that observed under normoxia. |
T12 | 1727-1921 | Sentence | denotes | Furthermore, IGF‑1R is related with PI3K/Akt/mTOR signaling pathway and enhanced autophagy-associated protein expression, which was verified following treatment with the PI3K inhibitor LY294002. |
T10 | 1446-1591 | Sentence | denotes | R+ cells exhibited a lower percentage of apoptotic cells, lower ROS production, and higher levels of autophagy when compared to that of R- cells. |
T11 | 1592-1726 | Sentence | denotes | In addition, inhibition of autophagy led to increased ROS production and a higher percentage of apoptotic cells in the two cell types. |
T13 | 1922-2118 | Sentence | denotes | These results indicated that IGF‑1R may increase cell viability under hypoxic conditions by promoting autophagy and scavenging ROS production, which is closed with PI3K/Akt/mTOR signaling pathway. |
LitCoin-GeneOrGeneProduct-v0
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-37 | GeneOrGeneProduct | denotes | Insulin-like growth factor 1 receptor |
T2 | 38-46 | GeneOrGeneProduct | denotes | mediated |
T3 | 47-51 | GeneOrGeneProduct | denotes | cell |
T4 | 100-109 | GeneOrGeneProduct | denotes | autophagy |
T5 | 133-137 | GeneOrGeneProduct | denotes | PI3K |
T6 | 142-146 | GeneOrGeneProduct | denotes | mTOR |
T7 | 274-280 | GeneOrGeneProduct | denotes | damage |
T8 | 285-289 | GeneOrGeneProduct | denotes | cell |
T9 | 290-299 | GeneOrGeneProduct | denotes | viability |
T10 | 325-337 | GeneOrGeneProduct | denotes | Insulin-like |
T11 | 338-351 | GeneOrGeneProduct | denotes | growth factor |
T12 | 355-360 | GeneOrGeneProduct | denotes | IGF‑1 |
T13 | 395-403 | GeneOrGeneProduct | denotes | multiple |
T14 | 413-419 | GeneOrGeneProduct | denotes | damage |
T15 | 433-438 | GeneOrGeneProduct | denotes | cells |
T16 | 444-453 | GeneOrGeneProduct | denotes | apoptosis |
T17 | 468-485 | GeneOrGeneProduct | denotes | regulatory factor |
T18 | 529-543 | GeneOrGeneProduct | denotes | IGF-1 receptor |
T19 | 545-551 | GeneOrGeneProduct | denotes | IGF‑1R |
T20 | 556-571 | GeneOrGeneProduct | denotes | hypoxia‑induced |
T21 | 572-581 | GeneOrGeneProduct | denotes | apoptosis |
T22 | 590-597 | GeneOrGeneProduct | denotes | unclear |
T23 | 671-677 | GeneOrGeneProduct | denotes | IGF‑1R |
T24 | 689-698 | GeneOrGeneProduct | denotes | apoptosis |
T25 | 764-774 | GeneOrGeneProduct | denotes | disruption |
T26 | 796-802 | GeneOrGeneProduct | denotes | IGF‑1R |
T27 | 807-812 | GeneOrGeneProduct | denotes | cells |
T28 | 820-825 | GeneOrGeneProduct | denotes | cells |
T29 | 861-870 | GeneOrGeneProduct | denotes | apoptosis |
T30 | 872-881 | GeneOrGeneProduct | denotes | autophagy |
T31 | 887-897 | GeneOrGeneProduct | denotes | production |
T32 | 936-945 | GeneOrGeneProduct | denotes | autophagy |
T33 | 946-955 | GeneOrGeneProduct | denotes | inhibitor |
T34 | 1005-1014 | GeneOrGeneProduct | denotes | autophagy |
T35 | 1022-1032 | GeneOrGeneProduct | denotes | production |
T36 | 1037-1046 | GeneOrGeneProduct | denotes | apoptosis |
T37 | 1124-1153 | GeneOrGeneProduct | denotes | phosphatidylinositol 3-kinase |
T38 | 1155-1159 | GeneOrGeneProduct | denotes | PI3K |
T39 | 1161-1185 | GeneOrGeneProduct | denotes | threonine protein kinase |
T40 | 1194-1223 | GeneOrGeneProduct | denotes | mammalian target of rapamycin |
T41 | 1225-1229 | GeneOrGeneProduct | denotes | mTOR |
T42 | 1256-1260 | GeneOrGeneProduct | denotes | blot |
T43 | 1301-1316 | GeneOrGeneProduct | denotes | hypoxia induced |
T44 | 1317-1326 | GeneOrGeneProduct | denotes | apoptosis |
T45 | 1342-1352 | GeneOrGeneProduct | denotes | production |
T46 | 1367-1376 | GeneOrGeneProduct | denotes | autophagy |
T47 | 1382-1386 | GeneOrGeneProduct | denotes | time |
T48 | 1449-1454 | GeneOrGeneProduct | denotes | cells |
T49 | 1497-1502 | GeneOrGeneProduct | denotes | cells |
T50 | 1514-1524 | GeneOrGeneProduct | denotes | production |
T51 | 1547-1556 | GeneOrGeneProduct | denotes | autophagy |
T52 | 1585-1590 | GeneOrGeneProduct | denotes | cells |
T53 | 1619-1628 | GeneOrGeneProduct | denotes | autophagy |
T54 | 1650-1660 | GeneOrGeneProduct | denotes | production |
T55 | 1698-1703 | GeneOrGeneProduct | denotes | cells |
T56 | 1715-1719 | GeneOrGeneProduct | denotes | cell |
T57 | 1740-1746 | GeneOrGeneProduct | denotes | IGF‑1R |
T58 | 1763-1767 | GeneOrGeneProduct | denotes | PI3K |
T59 | 1772-1776 | GeneOrGeneProduct | denotes | mTOR |
T60 | 1808-1817 | GeneOrGeneProduct | denotes | autophagy |
T61 | 1829-1836 | GeneOrGeneProduct | denotes | protein |
T62 | 1897-1901 | GeneOrGeneProduct | denotes | PI3K |
T63 | 1902-1911 | GeneOrGeneProduct | denotes | inhibitor |
T64 | 1951-1957 | GeneOrGeneProduct | denotes | IGF‑1R |
T65 | 1971-1975 | GeneOrGeneProduct | denotes | cell |
T66 | 1976-1985 | GeneOrGeneProduct | denotes | viability |
T67 | 2024-2033 | GeneOrGeneProduct | denotes | autophagy |
T68 | 2053-2063 | GeneOrGeneProduct | denotes | production |
T69 | 2086-2090 | GeneOrGeneProduct | denotes | PI3K |
T70 | 2095-2099 | GeneOrGeneProduct | denotes | mTOR |
LitCoin-GeneOrGeneProduct-v2
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-37 | GeneOrGeneProduct | denotes | Insulin-like growth factor 1 receptor |
T2 | 47-51 | GeneOrGeneProduct | denotes | cell |
T3 | 100-109 | GeneOrGeneProduct | denotes | autophagy |
T4 | 133-137 | GeneOrGeneProduct | denotes | PI3K |
T5 | 142-146 | GeneOrGeneProduct | denotes | mTOR |
T6 | 285-289 | GeneOrGeneProduct | denotes | cell |
T7 | 290-299 | GeneOrGeneProduct | denotes | viability |
T8 | 325-337 | GeneOrGeneProduct | denotes | Insulin-like |
T9 | 338-351 | GeneOrGeneProduct | denotes | growth factor |
T10 | 355-360 | GeneOrGeneProduct | denotes | IGF‑1 |
T11 | 395-403 | GeneOrGeneProduct | denotes | multiple |
T12 | 444-453 | GeneOrGeneProduct | denotes | apoptosis |
T13 | 468-485 | GeneOrGeneProduct | denotes | regulatory factor |
T14 | 529-543 | GeneOrGeneProduct | denotes | IGF-1 receptor |
T15 | 545-551 | GeneOrGeneProduct | denotes | IGF‑1R |
T16 | 556-571 | GeneOrGeneProduct | denotes | hypoxia‑induced |
T17 | 572-581 | GeneOrGeneProduct | denotes | apoptosis |
T18 | 590-597 | GeneOrGeneProduct | denotes | unclear |
T19 | 671-677 | GeneOrGeneProduct | denotes | IGF‑1R |
T20 | 689-698 | GeneOrGeneProduct | denotes | apoptosis |
T21 | 796-802 | GeneOrGeneProduct | denotes | IGF‑1R |
T22 | 861-870 | GeneOrGeneProduct | denotes | apoptosis |
T23 | 872-881 | GeneOrGeneProduct | denotes | autophagy |
T24 | 936-945 | GeneOrGeneProduct | denotes | autophagy |
T25 | 946-955 | GeneOrGeneProduct | denotes | inhibitor |
T26 | 1005-1014 | GeneOrGeneProduct | denotes | autophagy |
T27 | 1037-1046 | GeneOrGeneProduct | denotes | apoptosis |
T28 | 1124-1153 | GeneOrGeneProduct | denotes | phosphatidylinositol 3-kinase |
T29 | 1155-1159 | GeneOrGeneProduct | denotes | PI3K |
T30 | 1161-1185 | GeneOrGeneProduct | denotes | threonine protein kinase |
T31 | 1194-1223 | GeneOrGeneProduct | denotes | mammalian target of rapamycin |
T32 | 1225-1229 | GeneOrGeneProduct | denotes | mTOR |
T33 | 1256-1260 | GeneOrGeneProduct | denotes | blot |
T34 | 1301-1316 | GeneOrGeneProduct | denotes | hypoxia induced |
T35 | 1317-1326 | GeneOrGeneProduct | denotes | apoptosis |
T36 | 1367-1376 | GeneOrGeneProduct | denotes | autophagy |
T37 | 1547-1556 | GeneOrGeneProduct | denotes | autophagy |
T38 | 1619-1628 | GeneOrGeneProduct | denotes | autophagy |
T39 | 1715-1719 | GeneOrGeneProduct | denotes | cell |
T40 | 1740-1746 | GeneOrGeneProduct | denotes | IGF‑1R |
T41 | 1763-1767 | GeneOrGeneProduct | denotes | PI3K |
T42 | 1772-1776 | GeneOrGeneProduct | denotes | mTOR |
T43 | 1808-1817 | GeneOrGeneProduct | denotes | autophagy |
T44 | 1829-1836 | GeneOrGeneProduct | denotes | protein |
T45 | 1897-1901 | GeneOrGeneProduct | denotes | PI3K |
T46 | 1902-1911 | GeneOrGeneProduct | denotes | inhibitor |
T47 | 1951-1957 | GeneOrGeneProduct | denotes | IGF‑1R |
T48 | 1971-1975 | GeneOrGeneProduct | denotes | cell |
T49 | 1976-1985 | GeneOrGeneProduct | denotes | viability |
T50 | 2024-2033 | GeneOrGeneProduct | denotes | autophagy |
T51 | 2086-2090 | GeneOrGeneProduct | denotes | PI3K |
T52 | 2095-2099 | GeneOrGeneProduct | denotes | mTOR |
LitCoin-Disease-MeSH
Id | Subject | Object | Predicate | Lexical cue | originalLabel |
---|---|---|---|---|---|
T1 | 64-71 | DiseaseOrPhenotypicFeature | denotes | hypoxia | D000860 |
T2 | 166-173 | DiseaseOrPhenotypicFeature | denotes | Hypoxia | D000860 |
T3 | 455-462 | DiseaseOrPhenotypicFeature | denotes | Hypoxia | D000860 |
T4 | 556-563 | DiseaseOrPhenotypicFeature | denotes | hypoxia | D000860 |
T5 | 705-712 | DiseaseOrPhenotypicFeature | denotes | hypoxic | DISEASE |
T6 | 1053-1060 | DiseaseOrPhenotypicFeature | denotes | hypoxic | DISEASE |
T7 | 1301-1308 | DiseaseOrPhenotypicFeature | denotes | hypoxia | D000860 |
T8 | 1992-1999 | DiseaseOrPhenotypicFeature | denotes | hypoxic | DISEASE |
LitCoin-GeneOrGeneProduct-v3
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-37 | GeneOrGeneProduct | denotes | Insulin-like growth factor 1 receptor |
T2 | 133-137 | GeneOrGeneProduct | denotes | PI3K |
T3 | 138-141 | GeneOrGeneProduct | denotes | Akt |
T4 | 142-146 | GeneOrGeneProduct | denotes | mTOR |
T5 | 325-337 | GeneOrGeneProduct | denotes | Insulin-like |
T6 | 338-351 | GeneOrGeneProduct | denotes | growth factor |
T7 | 355-360 | GeneOrGeneProduct | denotes | IGF‑1 |
T8 | 468-485 | GeneOrGeneProduct | denotes | regulatory factor |
T9 | 529-543 | GeneOrGeneProduct | denotes | IGF-1 receptor |
T10 | 545-551 | GeneOrGeneProduct | denotes | IGF‑1R |
T11 | 556-571 | GeneOrGeneProduct | denotes | hypoxia‑induced |
T12 | 671-677 | GeneOrGeneProduct | denotes | IGF‑1R |
T13 | 796-802 | GeneOrGeneProduct | denotes | IGF‑1R |
T14 | 946-957 | GeneOrGeneProduct | denotes | inhibitor 3 |
T15 | 1124-1153 | GeneOrGeneProduct | denotes | phosphatidylinositol 3-kinase |
T16 | 1155-1159 | GeneOrGeneProduct | denotes | PI3K |
T17 | 1161-1185 | GeneOrGeneProduct | denotes | threonine protein kinase |
T18 | 1189-1192 | GeneOrGeneProduct | denotes | Akt |
T19 | 1194-1223 | GeneOrGeneProduct | denotes | mammalian target of rapamycin |
T20 | 1225-1229 | GeneOrGeneProduct | denotes | mTOR |
T21 | 1301-1316 | GeneOrGeneProduct | denotes | hypoxia induced |
T22 | 1740-1746 | GeneOrGeneProduct | denotes | IGF‑1R |
T23 | 1763-1767 | GeneOrGeneProduct | denotes | PI3K |
T24 | 1768-1771 | GeneOrGeneProduct | denotes | Akt |
T25 | 1772-1776 | GeneOrGeneProduct | denotes | mTOR |
T26 | 1808-1836 | GeneOrGeneProduct | denotes | autophagy-associated protein |
T27 | 1897-1901 | GeneOrGeneProduct | denotes | PI3K |
T28 | 1951-1957 | GeneOrGeneProduct | denotes | IGF‑1R |
T29 | 2086-2090 | GeneOrGeneProduct | denotes | PI3K |
T30 | 2091-2094 | GeneOrGeneProduct | denotes | Akt |
T31 | 2095-2099 | GeneOrGeneProduct | denotes | mTOR |
LitCoin-NCBITaxon-2
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 725-730 | OrganismTaxon | denotes | Mouse |
LitCoin-MeSH-Disease-2
Id | Subject | Object | Predicate | Lexical cue | ID: |
---|---|---|---|---|---|
T1 | 64-71 | DiseaseOrPhenotypicFeature | denotes | hypoxia | D000860 |
T2 | 166-173 | DiseaseOrPhenotypicFeature | denotes | Hypoxia | D000860 |
T3 | 455-462 | DiseaseOrPhenotypicFeature | denotes | Hypoxia | D000860 |
T4 | 556-563 | DiseaseOrPhenotypicFeature | denotes | hypoxia | D000860 |
T5 | 705-712 | DiseaseOrPhenotypicFeature | denotes | hypoxic | DISEASE |
T6 | 1053-1060 | DiseaseOrPhenotypicFeature | denotes | hypoxic | DISEASE |
T7 | 1301-1308 | DiseaseOrPhenotypicFeature | denotes | hypoxia | D000860 |
T8 | 1992-1999 | DiseaseOrPhenotypicFeature | denotes | hypoxic | DISEASE |
LitCoin-MONDO_bioort2019
Id | Subject | Object | Predicate | Lexical cue | #label |
---|---|---|---|---|---|
T1 | 64-71 | DiseaseOrPhenotypicFeature | denotes | hypoxia | D000860 |
T2 | 166-173 | DiseaseOrPhenotypicFeature | denotes | Hypoxia | D000860 |
T3 | 455-462 | DiseaseOrPhenotypicFeature | denotes | Hypoxia | D000860 |
T4 | 556-563 | DiseaseOrPhenotypicFeature | denotes | hypoxia | D000860 |
T5 | 705-712 | DiseaseOrPhenotypicFeature | denotes | hypoxic | DISEASE |
T6 | 1053-1060 | DiseaseOrPhenotypicFeature | denotes | hypoxic | DISEASE |
T7 | 1301-1308 | DiseaseOrPhenotypicFeature | denotes | hypoxia | D000860 |
T8 | 1992-1999 | DiseaseOrPhenotypicFeature | denotes | hypoxic | DISEASE |
LitCoin-Chemical-MeSH-CHEBI
Id | Subject | Object | Predicate | Lexical cue | ID: |
---|---|---|---|---|---|
T1 | 901-924 | ChemicalEntity | denotes | reactive oxygen species | D017382|http://purl.obolibrary.org/obo/CHEBI_26523 |
T3 | 926-929 | ChemicalEntity | denotes | ROS | http://purl.obolibrary.org/obo/CHEBI_26523 |
T4 | 956-971 | ChemicalEntity | denotes | 3‑methyladenine | C025946|http://purl.obolibrary.org/obo/CHEBI_38635 |
T6 | 1018-1021 | ChemicalEntity | denotes | ROS | http://purl.obolibrary.org/obo/CHEBI_26523 |
T7 | 1124-1144 | ChemicalEntity | denotes | phosphatidylinositol | D010716|http://purl.obolibrary.org/obo/CHEBI_28874 |
T9 | 1161-1170 | ChemicalEntity | denotes | threonine | http://purl.obolibrary.org/obo/CHEBI_26986 |
T10 | 1214-1223 | ChemicalEntity | denotes | rapamycin | D020123|http://purl.obolibrary.org/obo/CHEBI_9168 |
T12 | 1338-1341 | ChemicalEntity | denotes | ROS | http://purl.obolibrary.org/obo/CHEBI_26523 |
T13 | 1510-1513 | ChemicalEntity | denotes | ROS | http://purl.obolibrary.org/obo/CHEBI_26523 |
T14 | 1646-1649 | ChemicalEntity | denotes | ROS | http://purl.obolibrary.org/obo/CHEBI_26523 |
T15 | 1912-1920 | ChemicalEntity | denotes | LY294002 | C085911|http://purl.obolibrary.org/obo/CHEBI_65329 |
T17 | 2049-2052 | ChemicalEntity | denotes | ROS | http://purl.obolibrary.org/obo/CHEBI_26523 |
LitCoin-training-merged
Id | Subject | Object | Predicate | Lexical cue | #label | ID: |
---|---|---|---|---|---|---|
T17 | 2049-2052 | ChemicalEntity | denotes | ROS | http://purl.obolibrary.org/obo/CHEBI_26523 | |
T15 | 1912-1920 | ChemicalEntity | denotes | LY294002 | http://purl.obolibrary.org/obo/CHEBI_65329|C085911 | |
T14 | 1646-1649 | ChemicalEntity | denotes | ROS | http://purl.obolibrary.org/obo/CHEBI_26523 | |
T13 | 1510-1513 | ChemicalEntity | denotes | ROS | http://purl.obolibrary.org/obo/CHEBI_26523 | |
T12 | 1338-1341 | ChemicalEntity | denotes | ROS | http://purl.obolibrary.org/obo/CHEBI_26523 | |
T10 | 1214-1223 | ChemicalEntity | denotes | rapamycin | http://purl.obolibrary.org/obo/CHEBI_9168|D020123 | |
T9 | 1161-1170 | ChemicalEntity | denotes | threonine | http://purl.obolibrary.org/obo/CHEBI_26986 | |
T7 | 1124-1144 | ChemicalEntity | denotes | phosphatidylinositol | http://purl.obolibrary.org/obo/CHEBI_28874|D010716 | |
T6 | 1018-1021 | ChemicalEntity | denotes | ROS | http://purl.obolibrary.org/obo/CHEBI_26523 | |
T4 | 956-971 | ChemicalEntity | denotes | 3‑methyladenine | http://purl.obolibrary.org/obo/CHEBI_38635|C025946 | |
T3 | 926-929 | ChemicalEntity | denotes | ROS | http://purl.obolibrary.org/obo/CHEBI_26523 | |
T1 | 901-924 | ChemicalEntity | denotes | reactive oxygen species | http://purl.obolibrary.org/obo/CHEBI_26523|D017382 | |
T31 | 2095-2099 | GeneOrGeneProduct | denotes | mTOR | ||
T30 | 2091-2094 | GeneOrGeneProduct | denotes | Akt | ||
T29 | 2086-2090 | GeneOrGeneProduct | denotes | PI3K | ||
T28 | 1951-1957 | GeneOrGeneProduct | denotes | IGF‑1R | ||
T27 | 1897-1901 | GeneOrGeneProduct | denotes | PI3K | ||
T26 | 1808-1836 | GeneOrGeneProduct | denotes | autophagy-associated protein | ||
T25 | 1772-1776 | GeneOrGeneProduct | denotes | mTOR | ||
T24 | 1768-1771 | GeneOrGeneProduct | denotes | Akt | ||
T23 | 1763-1767 | GeneOrGeneProduct | denotes | PI3K | ||
T22 | 1740-1746 | GeneOrGeneProduct | denotes | IGF‑1R | ||
T21 | 1301-1316 | GeneOrGeneProduct | denotes | hypoxia induced | ||
T20 | 1225-1229 | GeneOrGeneProduct | denotes | mTOR | ||
T19 | 1194-1223 | GeneOrGeneProduct | denotes | mammalian target of rapamycin | ||
T18 | 1189-1192 | GeneOrGeneProduct | denotes | Akt | ||
T23059 | 1161-1185 | GeneOrGeneProduct | denotes | threonine protein kinase | ||
T16 | 1155-1159 | GeneOrGeneProduct | denotes | PI3K | ||
T35191 | 1124-1153 | GeneOrGeneProduct | denotes | phosphatidylinositol 3-kinase | ||
T11390 | 946-957 | GeneOrGeneProduct | denotes | inhibitor 3 | ||
T31633 | 796-802 | GeneOrGeneProduct | denotes | IGF‑1R | ||
T90276 | 671-677 | GeneOrGeneProduct | denotes | IGF‑1R | ||
T11 | 556-571 | GeneOrGeneProduct | denotes | hypoxia‑induced | ||
T84934 | 545-551 | GeneOrGeneProduct | denotes | IGF‑1R | ||
T91605 | 529-543 | GeneOrGeneProduct | denotes | IGF-1 receptor | ||
T8 | 468-485 | GeneOrGeneProduct | denotes | regulatory factor | ||
T82609 | 355-360 | GeneOrGeneProduct | denotes | IGF‑1 | ||
T36166 | 338-351 | GeneOrGeneProduct | denotes | growth factor | ||
T5 | 325-337 | GeneOrGeneProduct | denotes | Insulin-like | ||
T81203 | 142-146 | GeneOrGeneProduct | denotes | mTOR | ||
T83544 | 138-141 | GeneOrGeneProduct | denotes | Akt | ||
T2 | 133-137 | GeneOrGeneProduct | denotes | PI3K | ||
T87997 | 0-37 | GeneOrGeneProduct | denotes | Insulin-like growth factor 1 receptor | ||
T21810 | 1992-1999 | DiseaseOrPhenotypicFeature | denotes | hypoxic | DISEASE | |
T61548 | 1301-1308 | DiseaseOrPhenotypicFeature | denotes | hypoxia | D000860 | |
T78713 | 1053-1060 | DiseaseOrPhenotypicFeature | denotes | hypoxic | DISEASE | |
T45998 | 705-712 | DiseaseOrPhenotypicFeature | denotes | hypoxic | DISEASE | |
T31757 | 556-563 | DiseaseOrPhenotypicFeature | denotes | hypoxia | D000860 | |
T57278 | 455-462 | DiseaseOrPhenotypicFeature | denotes | Hypoxia | D000860 | |
T46454 | 166-173 | DiseaseOrPhenotypicFeature | denotes | Hypoxia | D000860 | |
T91804 | 64-71 | DiseaseOrPhenotypicFeature | denotes | hypoxia | D000860 | |
T3347 | 725-730 | OrganismTaxon | denotes | Mouse |