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PubMed:28259923 JSONTXT

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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 146-273 DRI_Background denotes Epithelial-mesenchymal transition (EMT) is a critical step in the acquisition of metastatic and invasive power for tumor cells.
T2 274-381 DRI_Background denotes Colorectal adenocarcinoma (CRC) is a common cancer where metastasis is directly linked to patient survival.
T3 382-552 DRI_Background denotes Recent studies show that pleomorphic adenoma gene like-2 (PLAGL2) could induce tumor EMT and is an independent predictive factor associated with poor prognosis in cancer.
T4 553-717 DRI_Outcome denotes In the present study, we confirmed the role of PLAGL2 in the prognosis of CRC patients and provide molecular evidence of PLAGL2 promoted EMT in CRC cell line SW480.
T5 718-844 DRI_Outcome denotes We found that PLAGL2 expression was upregulated in the paraffin-embedded CRC tissues compared to borderline or benign tissues.
T6 845-1151 DRI_Background denotes Experimental EMT induced by PLAGL2 plasmid transfection proved PLAGL2 protein overexpression could enhance the cell scratch wound-healing and transwell ability and significantly upregulated mesenchymal marker proteins, N-cadherin and vimentin and concurrently downregulated epithelial marker of E-cadherin.
T7 1152-1282 DRI_Approach denotes Subsequently, through western blot assay, we found that PLAGL2 could activate the wnt-signaling component β-catenin in the nuclei.
T8 1283-1475 DRI_Background denotes More CRC cell metastasis to the lungs was observed when the PLAGL2 overexpressing SW480 cells were injected into the tail vein of rats, compared with the cell control and PLAGL2 silence group.
T9 1476-1608 DRI_Outcome denotes Our findings indicated that PLAGL2 might be a very upstream key molecule regulating EMT involved in Wnt/β‑catenin signaling pathway.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
12302 0-31 GeneOrGeneProduct denotes Pleomorphic adenoma gene like-2 NCBIGene:5326
12303 78-81 GeneOrGeneProduct denotes Wnt NCBIGene:7474
12304 82-91 GeneOrGeneProduct denotes β-catenin NCBIGene:1499
12305 113-118 OrganismTaxon denotes human NCBITaxon:9606
12306 119-144 DiseaseOrPhenotypicFeature denotes colorectal adenocarcinoma MESH:D015179
12307 261-266 DiseaseOrPhenotypicFeature denotes tumor MESH:D009369
12308 274-299 DiseaseOrPhenotypicFeature denotes Colorectal adenocarcinoma MESH:D015179
12309 301-304 DiseaseOrPhenotypicFeature denotes CRC MESH:D015179
12310 318-324 DiseaseOrPhenotypicFeature denotes cancer MESH:D009369
12311 331-341 DiseaseOrPhenotypicFeature denotes metastasis MESH:D009362
12312 364-371 OrganismTaxon denotes patient NCBITaxon:9606
12313 407-438 GeneOrGeneProduct denotes pleomorphic adenoma gene like-2 NCBIGene:5326
12314 440-446 GeneOrGeneProduct denotes PLAGL2 NCBIGene:5326
12315 461-466 DiseaseOrPhenotypicFeature denotes tumor MESH:D009369
12316 545-551 DiseaseOrPhenotypicFeature denotes cancer MESH:D009369
12317 600-606 GeneOrGeneProduct denotes PLAGL2 NCBIGene:5326
12318 627-630 DiseaseOrPhenotypicFeature denotes CRC MESH:D015179
12319 631-639 OrganismTaxon denotes patients NCBITaxon:9606
12320 674-680 GeneOrGeneProduct denotes PLAGL2 NCBIGene:5326
12321 697-700 DiseaseOrPhenotypicFeature denotes CRC MESH:D015179
12322 711-716 CellLine denotes SW480 NCBITaxon:9606
12323 732-738 GeneOrGeneProduct denotes PLAGL2 NCBIGene:5326
12324 773-781 ChemicalEntity denotes paraffin MESH:D010232
12325 791-794 DiseaseOrPhenotypicFeature denotes CRC MESH:D015179
12326 873-879 GeneOrGeneProduct denotes PLAGL2 NCBIGene:5326
12327 908-914 GeneOrGeneProduct denotes PLAGL2 NCBIGene:5326
12328 1064-1074 GeneOrGeneProduct denotes N-cadherin NCBIGene:1000
12329 1079-1087 GeneOrGeneProduct denotes vimentin NCBIGene:7431
12330 1140-1150 GeneOrGeneProduct denotes E-cadherin NCBIGene:999
12331 1208-1214 GeneOrGeneProduct denotes PLAGL2 NCBIGene:5326
12332 1234-1237 GeneOrGeneProduct denotes wnt NCBIGene:7474
12333 1258-1267 GeneOrGeneProduct denotes β-catenin NCBIGene:1499
12334 1288-1291 DiseaseOrPhenotypicFeature denotes CRC MESH:D015179
12335 1297-1307 DiseaseOrPhenotypicFeature denotes metastasis MESH:D009362
12336 1343-1349 GeneOrGeneProduct denotes PLAGL2 NCBIGene:5326
12337 1365-1370 CellLine denotes SW480 NCBITaxon:9606
12338 1413-1417 OrganismTaxon denotes rats NCBITaxon:10116
12339 1454-1460 GeneOrGeneProduct denotes PLAGL2 NCBIGene:5326
12340 1504-1510 GeneOrGeneProduct denotes PLAGL2 NCBIGene:5326
12341 1576-1579 GeneOrGeneProduct denotes Wnt NCBIGene:7474
12342 1580-1589 GeneOrGeneProduct denotes β‑catenin NCBIGene:1499

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T10 1476-1608 Sentence denotes Our findings indicated that PLAGL2 might be a very upstream key molecule regulating EMT involved in Wnt/β‑catenin signaling pathway.
T1 0-145 Sentence denotes Pleomorphic adenoma gene like-2 induces epithelial-mesenchymal transition via Wnt/β-catenin signaling pathway in human colorectal adenocarcinoma.
T2 146-273 Sentence denotes Epithelial-mesenchymal transition (EMT) is a critical step in the acquisition of metastatic and invasive power for tumor cells.
T3 274-381 Sentence denotes Colorectal adenocarcinoma (CRC) is a common cancer where metastasis is directly linked to patient survival.
T4 382-552 Sentence denotes Recent studies show that pleomorphic adenoma gene like-2 (PLAGL2) could induce tumor EMT and is an independent predictive factor associated with poor prognosis in cancer.
T5 553-717 Sentence denotes In the present study, we confirmed the role of PLAGL2 in the prognosis of CRC patients and provide molecular evidence of PLAGL2 promoted EMT in CRC cell line SW480.
T6 718-844 Sentence denotes We found that PLAGL2 expression was upregulated in the paraffin-embedded CRC tissues compared to borderline or benign tissues.
T7 845-1151 Sentence denotes Experimental EMT induced by PLAGL2 plasmid transfection proved PLAGL2 protein overexpression could enhance the cell scratch wound-healing and transwell ability and significantly upregulated mesenchymal marker proteins, N-cadherin and vimentin and concurrently downregulated epithelial marker of E-cadherin.
T8 1152-1282 Sentence denotes Subsequently, through western blot assay, we found that PLAGL2 could activate the wnt-signaling component β-catenin in the nuclei.
T9 1283-1475 Sentence denotes More CRC cell metastasis to the lungs was observed when the PLAGL2 overexpressing SW480 cells were injected into the tail vein of rats, compared with the cell control and PLAGL2 silence group.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 113-118 OrganismTaxon denotes human NCBItxid:9606
T2 880-887 OrganismTaxon denotes plasmid NCBItxid:45202
T3 1413-1417 OrganismTaxon denotes rats NCBItxid:10118|NCBItxid:10116|NCBItxid:10114

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 0-19 DiseaseOrPhenotypicFeature denotes Pleomorphic adenoma 0008401
T2 12-19 DiseaseOrPhenotypicFeature denotes adenoma 0004972
T3 119-144 DiseaseOrPhenotypicFeature denotes colorectal adenocarcinoma 0005008
T4 130-144 DiseaseOrPhenotypicFeature denotes adenocarcinoma 0004970
T5 274-299 DiseaseOrPhenotypicFeature denotes Colorectal adenocarcinoma 0005008
T6 285-299 DiseaseOrPhenotypicFeature denotes adenocarcinoma 0004970
T7 318-324 DiseaseOrPhenotypicFeature denotes cancer 0004992
T8 407-426 DiseaseOrPhenotypicFeature denotes pleomorphic adenoma 0008401
T9 419-426 DiseaseOrPhenotypicFeature denotes adenoma 0004972
T10 545-551 DiseaseOrPhenotypicFeature denotes cancer 0004992

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 25-29 GeneOrGeneProduct denotes like
T2 32-39 GeneOrGeneProduct denotes induces
T3 84-91 GeneOrGeneProduct denotes catenin
T4 180-190 GeneOrGeneProduct denotes (EMT) is a
T5 200-204 GeneOrGeneProduct denotes step
T6 261-266 GeneOrGeneProduct denotes tumor
T7 267-272 GeneOrGeneProduct denotes cells
T8 301-304 GeneOrGeneProduct denotes CRC
T9 354-360 GeneOrGeneProduct denotes linked
T10 432-436 GeneOrGeneProduct denotes like
T11 440-446 GeneOrGeneProduct denotes PLAGL2
T12 454-460 GeneOrGeneProduct denotes induce
T13 461-466 GeneOrGeneProduct denotes tumor
T14 504-510 GeneOrGeneProduct denotes factor
T15 600-606 GeneOrGeneProduct denotes PLAGL2
T16 627-630 GeneOrGeneProduct denotes CRC
T17 674-680 GeneOrGeneProduct denotes PLAGL2
T18 697-700 GeneOrGeneProduct denotes CRC
T19 701-705 GeneOrGeneProduct denotes cell
T20 706-710 GeneOrGeneProduct denotes line
T21 732-738 GeneOrGeneProduct denotes PLAGL2
T22 791-794 GeneOrGeneProduct denotes CRC
T23 862-869 GeneOrGeneProduct denotes induced
T24 873-879 GeneOrGeneProduct denotes PLAGL2
T25 908-914 GeneOrGeneProduct denotes PLAGL2
T26 915-922 GeneOrGeneProduct denotes protein
T27 956-960 GeneOrGeneProduct denotes cell
T28 961-968 GeneOrGeneProduct denotes scratch
T29 1054-1062 GeneOrGeneProduct denotes proteins
T30 1064-1074 GeneOrGeneProduct denotes N-cadherin
T31 1079-1087 GeneOrGeneProduct denotes vimentin
T32 1140-1150 GeneOrGeneProduct denotes E-cadherin
T33 1182-1186 GeneOrGeneProduct denotes blot
T34 1208-1214 GeneOrGeneProduct denotes PLAGL2
T35 1221-1229 GeneOrGeneProduct denotes activate
T36 1260-1267 GeneOrGeneProduct denotes catenin
T37 1288-1291 GeneOrGeneProduct denotes CRC
T38 1292-1296 GeneOrGeneProduct denotes cell
T39 1315-1320 GeneOrGeneProduct denotes lungs
T40 1343-1349 GeneOrGeneProduct denotes PLAGL2
T41 1371-1376 GeneOrGeneProduct denotes cells
T42 1400-1404 GeneOrGeneProduct denotes tail
T43 1405-1409 GeneOrGeneProduct denotes vein
T44 1437-1441 GeneOrGeneProduct denotes cell
T45 1454-1460 GeneOrGeneProduct denotes PLAGL2
T46 1480-1488 GeneOrGeneProduct denotes findings
T47 1504-1510 GeneOrGeneProduct denotes PLAGL2
T48 1549-1559 GeneOrGeneProduct denotes regulating
T49 1582-1589 GeneOrGeneProduct denotes catenin

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 25-29 GeneOrGeneProduct denotes like
T2 84-91 GeneOrGeneProduct denotes catenin
T3 200-204 GeneOrGeneProduct denotes step
T4 432-436 GeneOrGeneProduct denotes like
T5 440-446 GeneOrGeneProduct denotes PLAGL2
T6 504-510 GeneOrGeneProduct denotes factor
T7 600-606 GeneOrGeneProduct denotes PLAGL2
T8 674-680 GeneOrGeneProduct denotes PLAGL2
T9 701-705 GeneOrGeneProduct denotes cell
T10 732-738 GeneOrGeneProduct denotes PLAGL2
T11 873-879 GeneOrGeneProduct denotes PLAGL2
T12 908-914 GeneOrGeneProduct denotes PLAGL2
T13 915-922 GeneOrGeneProduct denotes protein
T14 956-960 GeneOrGeneProduct denotes cell
T15 961-968 GeneOrGeneProduct denotes scratch
T16 1064-1074 GeneOrGeneProduct denotes N-cadherin
T17 1079-1087 GeneOrGeneProduct denotes vimentin
T18 1140-1150 GeneOrGeneProduct denotes E-cadherin
T19 1182-1186 GeneOrGeneProduct denotes blot
T20 1208-1214 GeneOrGeneProduct denotes PLAGL2
T21 1260-1267 GeneOrGeneProduct denotes catenin
T22 1292-1296 GeneOrGeneProduct denotes cell
T23 1343-1349 GeneOrGeneProduct denotes PLAGL2
T24 1400-1404 GeneOrGeneProduct denotes tail
T25 1405-1409 GeneOrGeneProduct denotes vein
T26 1437-1441 GeneOrGeneProduct denotes cell
T27 1454-1460 GeneOrGeneProduct denotes PLAGL2
T28 1504-1510 GeneOrGeneProduct denotes PLAGL2
T29 1582-1589 GeneOrGeneProduct denotes catenin

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 0-19 DiseaseOrPhenotypicFeature denotes Pleomorphic adenoma D008949
T2 130-144 DiseaseOrPhenotypicFeature denotes adenocarcinoma D000230
T3 261-266 DiseaseOrPhenotypicFeature denotes tumor D009369
T4 285-299 DiseaseOrPhenotypicFeature denotes adenocarcinoma D000230
T5 318-324 DiseaseOrPhenotypicFeature denotes cancer D009369
T6 331-341 DiseaseOrPhenotypicFeature denotes metastasis D009362
T7 407-426 DiseaseOrPhenotypicFeature denotes pleomorphic adenoma D008949
T8 461-466 DiseaseOrPhenotypicFeature denotes tumor D009369
T9 545-551 DiseaseOrPhenotypicFeature denotes cancer D009369
T10 969-974 DiseaseOrPhenotypicFeature denotes wound D014947
T11 1297-1307 DiseaseOrPhenotypicFeature denotes metastasis D009362

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 0-31 GeneOrGeneProduct denotes Pleomorphic adenoma gene like-2
T2 84-91 GeneOrGeneProduct denotes catenin
T3 407-438 GeneOrGeneProduct denotes pleomorphic adenoma gene like-2
T4 440-446 GeneOrGeneProduct denotes PLAGL2
T5 600-606 GeneOrGeneProduct denotes PLAGL2
T6 674-680 GeneOrGeneProduct denotes PLAGL2
T7 732-738 GeneOrGeneProduct denotes PLAGL2
T8 873-879 GeneOrGeneProduct denotes PLAGL2
T9 908-914 GeneOrGeneProduct denotes PLAGL2
T10 961-968 GeneOrGeneProduct denotes scratch
T11 1064-1074 GeneOrGeneProduct denotes N-cadherin
T12 1079-1087 GeneOrGeneProduct denotes vimentin
T13 1140-1150 GeneOrGeneProduct denotes E-cadherin
T14 1208-1214 GeneOrGeneProduct denotes PLAGL2
T15 1260-1267 GeneOrGeneProduct denotes catenin
T16 1343-1349 GeneOrGeneProduct denotes PLAGL2
T17 1454-1460 GeneOrGeneProduct denotes PLAGL2
T18 1504-1510 GeneOrGeneProduct denotes PLAGL2
T19 1582-1589 GeneOrGeneProduct denotes catenin

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 0-19 DiseaseOrPhenotypicFeature denotes Pleomorphic adenoma 0008401
T2 119-144 DiseaseOrPhenotypicFeature denotes colorectal adenocarcinoma 0005008
T3 261-266 DiseaseOrPhenotypicFeature denotes tumor 0005070
T4 274-299 DiseaseOrPhenotypicFeature denotes Colorectal adenocarcinoma 0005008
T5 301-304 DiseaseOrPhenotypicFeature denotes CRC 0024331|0005575|0005008
T8 407-426 DiseaseOrPhenotypicFeature denotes pleomorphic adenoma 0008401
T9 461-466 DiseaseOrPhenotypicFeature denotes tumor 0005070
T10 627-630 DiseaseOrPhenotypicFeature denotes CRC 0024331|0005575|0005008
T13 697-700 DiseaseOrPhenotypicFeature denotes CRC 0024331|0005575|0005008
T16 791-794 DiseaseOrPhenotypicFeature denotes CRC 0024331|0005575|0005008
T19 969-974 DiseaseOrPhenotypicFeature denotes wound 0021178
T20 1288-1291 DiseaseOrPhenotypicFeature denotes CRC 0024331|0005575|0005008

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 0-19 DiseaseOrPhenotypicFeature denotes Pleomorphic adenoma D008949
T2 130-144 DiseaseOrPhenotypicFeature denotes adenocarcinoma D000230
T3 261-266 DiseaseOrPhenotypicFeature denotes tumor D009369
T4 285-299 DiseaseOrPhenotypicFeature denotes adenocarcinoma D000230
T5 301-304 DiseaseOrPhenotypicFeature denotes CRC DISEASE
T6 318-324 DiseaseOrPhenotypicFeature denotes cancer D009369
T7 331-341 DiseaseOrPhenotypicFeature denotes metastasis D009362
T8 407-426 DiseaseOrPhenotypicFeature denotes pleomorphic adenoma D008949
T9 461-466 DiseaseOrPhenotypicFeature denotes tumor D009369
T10 545-551 DiseaseOrPhenotypicFeature denotes cancer D009369
T11 627-630 DiseaseOrPhenotypicFeature denotes CRC DISEASE
T12 697-700 DiseaseOrPhenotypicFeature denotes CRC DISEASE
T13 791-794 DiseaseOrPhenotypicFeature denotes CRC DISEASE
T14 969-974 DiseaseOrPhenotypicFeature denotes wound D014947
T15 1288-1291 DiseaseOrPhenotypicFeature denotes CRC DISEASE
T16 1297-1307 DiseaseOrPhenotypicFeature denotes metastasis D009362

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 0-19 DiseaseOrPhenotypicFeature denotes Pleomorphic adenoma D008949
T2 130-144 DiseaseOrPhenotypicFeature denotes adenocarcinoma D000230
T3 261-266 DiseaseOrPhenotypicFeature denotes tumor D009369
T4 285-299 DiseaseOrPhenotypicFeature denotes adenocarcinoma D000230
T5 301-304 DiseaseOrPhenotypicFeature denotes CRC DISEASE
T6 318-324 DiseaseOrPhenotypicFeature denotes cancer D009369
T7 407-426 DiseaseOrPhenotypicFeature denotes pleomorphic adenoma D008949
T8 461-466 DiseaseOrPhenotypicFeature denotes tumor D009369
T9 545-551 DiseaseOrPhenotypicFeature denotes cancer D009369
T10 627-630 DiseaseOrPhenotypicFeature denotes CRC DISEASE
T11 697-700 DiseaseOrPhenotypicFeature denotes CRC DISEASE
T12 791-794 DiseaseOrPhenotypicFeature denotes CRC DISEASE
T13 1288-1291 DiseaseOrPhenotypicFeature denotes CRC DISEASE

LitCoin_CellLine

Id Subject Object Predicate Lexical cue cellosaurus_accession_id
T1 711-716 CellLine denotes SW480 CVCL_0546
T2 1365-1370 CellLine denotes SW480 CVCL_0546

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 113-118 OrganismTaxon denotes human
T2 364-371 OrganismTaxon denotes patient
T3 631-639 OrganismTaxon denotes patients
T4 880-887 OrganismTaxon denotes plasmid
T5 1413-1417 OrganismTaxon denotes rats

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 773-781 ChemicalEntity denotes paraffin D010232|ChemicalEntity

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID: cellosaurus_accession_id
T2 1365-1370 CellLine denotes SW480 CVCL_0546
T1 711-716 CellLine denotes SW480 CVCL_0546
T80757 773-781 ChemicalEntity denotes paraffin ChemicalEntity|D010232
T19 1582-1589 GeneOrGeneProduct denotes catenin
T18 1504-1510 GeneOrGeneProduct denotes PLAGL2
T17 1454-1460 GeneOrGeneProduct denotes PLAGL2
T16 1343-1349 GeneOrGeneProduct denotes PLAGL2
T15 1260-1267 GeneOrGeneProduct denotes catenin
T14 1208-1214 GeneOrGeneProduct denotes PLAGL2
T13 1140-1150 GeneOrGeneProduct denotes E-cadherin
T12 1079-1087 GeneOrGeneProduct denotes vimentin
T11 1064-1074 GeneOrGeneProduct denotes N-cadherin
T10 961-968 GeneOrGeneProduct denotes scratch
T9 908-914 GeneOrGeneProduct denotes PLAGL2
T8 873-879 GeneOrGeneProduct denotes PLAGL2
T7 732-738 GeneOrGeneProduct denotes PLAGL2
T6 674-680 GeneOrGeneProduct denotes PLAGL2
T5 600-606 GeneOrGeneProduct denotes PLAGL2
T4 440-446 GeneOrGeneProduct denotes PLAGL2
T3 407-438 GeneOrGeneProduct denotes pleomorphic adenoma gene like-2
T2513 84-91 GeneOrGeneProduct denotes catenin
T86758 0-31 GeneOrGeneProduct denotes Pleomorphic adenoma gene like-2
T25596 1288-1291 DiseaseOrPhenotypicFeature denotes CRC DISEASE
T70214 791-794 DiseaseOrPhenotypicFeature denotes CRC DISEASE
T14313 697-700 DiseaseOrPhenotypicFeature denotes CRC DISEASE
T55522 627-630 DiseaseOrPhenotypicFeature denotes CRC DISEASE
T73680 545-551 DiseaseOrPhenotypicFeature denotes cancer D009369
T6091 461-466 DiseaseOrPhenotypicFeature denotes tumor D009369
T67961 407-426 DiseaseOrPhenotypicFeature denotes pleomorphic adenoma D008949
T43461 318-324 DiseaseOrPhenotypicFeature denotes cancer D009369
T78259 301-304 DiseaseOrPhenotypicFeature denotes CRC DISEASE
T82014 285-299 DiseaseOrPhenotypicFeature denotes adenocarcinoma D000230
T8355 261-266 DiseaseOrPhenotypicFeature denotes tumor D009369
T81062 130-144 DiseaseOrPhenotypicFeature denotes adenocarcinoma D000230
T85596 0-19 DiseaseOrPhenotypicFeature denotes Pleomorphic adenoma D008949
T43991 1413-1417 OrganismTaxon denotes rats
T3537 880-887 OrganismTaxon denotes plasmid
T94110 631-639 OrganismTaxon denotes patients
T23014 364-371 OrganismTaxon denotes patient
T66585 113-118 OrganismTaxon denotes human