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PubMed:28255168 JSONTXT

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mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 17-31 Disease denotes herpes simplex http://purl.obolibrary.org/obo/MONDO_0004609
T2 144-158 Disease denotes herpes simplex http://purl.obolibrary.org/obo/MONDO_0004609
T3 850-863 Disease denotes neuroblastoma http://purl.obolibrary.org/obo/MONDO_0005072
T4 1219-1222 Disease denotes PFD http://purl.obolibrary.org/obo/MONDO_0010713|http://purl.obolibrary.org/obo/MONDO_0018919
T6 1342-1345 Disease denotes PFD http://purl.obolibrary.org/obo/MONDO_0010713|http://purl.obolibrary.org/obo/MONDO_0018919

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 431-434 Glycan denotes GD2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G02657AK
T2 881-884 Glycan denotes GD2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G02657AK

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 850-863 Phenotype denotes neuroblastoma HP:0003006

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 431-434 Glycan denotes GD2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G02657AK
T2 881-884 Glycan denotes GD2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G02657AK

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 850-863 Phenotype denotes neuroblastoma HP:0003006

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 24-31 Body_part denotes simplex http://purl.obolibrary.org/obo/UBERON_0005350
T2 151-158 Body_part denotes simplex http://purl.obolibrary.org/obo/UBERON_0005350

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 17-31 Disease denotes herpes simplex MONDO:0004609
T2 144-158 Disease denotes herpes simplex MONDO:0004609
T3 850-863 Disease denotes neuroblastoma MONDO:0005072

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 24-37 Organism denotes simplex virus 10294
T2 151-164 Organism denotes simplex virus 10294

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-120 Sentence denotes Mapping sites of herpes simplex virus type 1 glycoprotein D that permit insertions and impact gD and gB receptors usage.
T2 121-249 Sentence denotes Glycoprotein D (gD) of herpes simplex virus type 1 (HSV-1) is one of four glycoproteins essential for HSV entry and cell fusion.
T3 250-461 Sentence denotes The purpose of this study was to determine the plasticity of gD to tolerate insertion or deletion mutations and to construct an oncolytic HSV-1 that utilizes the disialoganglioside GD2 as a HSV-1 entry receptor.
T4 462-669 Sentence denotes We found that the N-terminus of gD tolerates long insertions, whereas residues adjacent to the gD Ig-like V-type core tolerated shorter insertions (up to 15 amino acids), but not greater than 60 amino acids.
T5 670-885 Sentence denotes Recombinant HSV-1 containing the ch14.18 single chain variable fragment (scFv) at the N-terminus of gD failed to mediate entry, even though the ch14.18 scFv-gD chimera Fc bound to neuroblastoma cells expressing GD2.
T6 886-1094 Sentence denotes Finally, we found that hyperfusogenic gB mutants enhanced fusion to a greater degree with the gB receptor the paired immunoglobulin-like type 2 receptor alpha (PILRα) than with gD receptors HVEM and nectin-1.
T7 1095-1346 Sentence denotes Hyperfusogenic gB could restore the fusion function with PILRα when a gD constructed contained only the "profusion domain" (PFD), suggesting the hyperfusogenic form of gB may regulate fusion of PILRα via a novel mechanism through gH/gL and the gD PFD.

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 24-37 OrganismTaxon denotes simplex virus 10294
T2 151-164 OrganismTaxon denotes simplex virus 10294

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 24-31 Body_part denotes simplex http://purl.obolibrary.org/obo/UBERON_0005350
T2 151-158 Body_part denotes simplex http://purl.obolibrary.org/obo/UBERON_0005350