PubMed:28200119 JSONTXT

{"project":"Zoonoses","denotations":[{"id":"T5","span":{"begin":583,"end":602},"obj":"Species"},{"id":"T1","span":{"begin":24,"end":35},"obj":"Species"},{"id":"T10","span":{"begin":710,"end":717},"obj":"Species"},{"id":"T100","span":{"begin":1078,"end":1085},"obj":"Type"},{"id":"T101","span":{"begin":1217,"end":1227},"obj":"Phenomena"},{"id":"T102","span":{"begin":199,"end":222},"obj":"Method"},{"id":"T103","span":{"begin":188,"end":198},"obj":"Type"},{"id":"T12","span":{"begin":77,"end":90},"obj":"Species"},{"id":"T13","span":{"begin":687,"end":700},"obj":"Species"},{"id":"T14","span":{"begin":163,"end":170},"obj":"Species"},{"id":"T15","span":{"begin":290,"end":297},"obj":"Species"},{"id":"T16","span":{"begin":462,"end":469},"obj":"Species"},{"id":"T17","span":{"begin":397,"end":399},"obj":"Number"},{"id":"T18","span":{"begin":400,"end":409},"obj":"Type"},{"id":"T19","span":{"begin":410,"end":419},"obj":"Variation"},{"id":"T2","span":{"begin":264,"end":275},"obj":"Species"},{"id":"T20","span":{"begin":238,"end":247},"obj":"Variation"},{"id":"T21","span":{"begin":620,"end":629},"obj":"Variation"},{"id":"T22","span":{"begin":731,"end":740},"obj":"Variation"},{"id":"T23","span":{"begin":788,"end":797},"obj":"Variation"},{"id":"T24","span":{"begin":957,"end":966},"obj":"Variation"},{"id":"T25","span":{"begin":1058,"end":1067},"obj":"Variation"},{"id":"T26","span":{"begin":1086,"end":1095},"obj":"Variation"},{"id":"T27","span":{"begin":1275,"end":1284},"obj":"Variation"},{"id":"T28","span":{"begin":1305,"end":1310},"obj":"Species"},{"id":"T29","span":{"begin":1181,"end":1186},"obj":"Species"},{"id":"T3","span":{"begin":345,"end":356},"obj":"Species"},{"id":"T30","span":{"begin":1177,"end":1180},"obj":"Without"},{"id":"T31","span":{"begin":1231,"end":1235},"obj":"Species"},{"id":"T32","span":{"begin":1239,"end":1243},"obj":"Area"},{"id":"T33","span":{"begin":783,"end":787},"obj":"Gene"},{"id":"T34","span":{"begin":497,"end":501},"obj":"Gene"},{"id":"T35","span":{"begin":517,"end":521},"obj":"Gene"},{"id":"T36","span":{"begin":862,"end":866},"obj":"Gene"},{"id":"T37","span":{"begin":952,"end":956},"obj":"Gene"},{"id":"T38","span":{"begin":1099,"end":1103},"obj":"Gene"},{"id":"T39","span":{"begin":506,"end":510},"obj":"Gene"},{"id":"T4","span":{"begin":436,"end":447},"obj":"Species"},{"id":"T40","span":{"begin":486,"end":488},"obj":"Gene"},{"id":"T41","span":{"begin":523,"end":525},"obj":"Gene"},{"id":"T42","span":{"begin":744,"end":746},"obj":"Gene"},{"id":"T43","span":{"begin":568,"end":574},"obj":"Species"},{"id":"T44","span":{"begin":1154,"end":1166},"obj":"Species"},{"id":"T45","span":{"begin":938,"end":951},"obj":"Number"},{"id":"T46","span":{"begin":1322,"end":1334},"obj":"Species"},{"id":"T47","span":{"begin":1198,"end":1216},"obj":"Species"},{"id":"T48","span":{"begin":777,"end":782},"obj":"Number"},{"id":"T49","span":{"begin":331,"end":344},"obj":"Type"},{"id":"T50","span":{"begin":490,"end":492},"obj":"Gene"},{"id":"T51","span":{"begin":530,"end":532},"obj":"Gene"},{"id":"T52","span":{"begin":751,"end":753},"obj":"Gene"},{"id":"T53","span":{"begin":604,"end":619},"obj":"Number"},{"id":"T54","span":{"begin":36,"end":46},"obj":"Phenomena"},{"id":"T55","span":{"begin":276,"end":286},"obj":"Phenomena"},{"id":"T56","span":{"begin":448,"end":458},"obj":"Phenomena"},{"id":"T57","span":{"begin":673,"end":683},"obj":"Phenomena"},{"id":"T58","span":{"begin":1123,"end":1133},"obj":"Phenomena"},{"id":"T59","span":{"begin":0,"end":7},"obj":"Phenomena"},{"id":"T6","span":{"begin":1111,"end":1122},"obj":"Species"},{"id":"T60","span":{"begin":99,"end":109},"obj":"Phenomena"},{"id":"T61","span":{"begin":1187,"end":1197},"obj":"Phenomena"},{"id":"T62","span":{"begin":1311,"end":1321},"obj":"Phenomena"},{"id":"T63","span":{"begin":95,"end":98},"obj":"Without"},{"id":"T64","span":{"begin":757,"end":760},"obj":"Without"},{"id":"T65","span":{"begin":152,"end":159},"obj":"Disease"},{"id":"T66","span":{"begin":132,"end":141},"obj":"Phenomena"},{"id":"T67","span":{"begin":77,"end":90},"obj":"Species"},{"id":"T68","span":{"begin":121,"end":128},"obj":"Phenomena"},{"id":"T69","span":{"begin":575,"end":582},"obj":"Phenomena"},{"id":"T7","span":{"begin":50,"end":55},"obj":"Type"},{"id":"T70","span":{"begin":163,"end":170},"obj":"Species"},{"id":"T71","span":{"begin":357,"end":370},"obj":"Phenomena"},{"id":"T72","span":{"begin":494,"end":495},"obj":"Gene"},{"id":"T74","span":{"begin":633,"end":644},"obj":"Gene"},{"id":"T75","span":{"begin":633,"end":644},"obj":"Gene"},{"id":"T76","span":{"begin":633,"end":644},"obj":"Gene"},{"id":"T78","span":{"begin":557,"end":564},"obj":"Variation"},{"id":"T79","span":{"begin":538,"end":550},"obj":"Type"},{"id":"T8","span":{"begin":1299,"end":1304},"obj":"Type"},{"id":"T80","span":{"begin":706,"end":709},"obj":"Type"},{"id":"T81","span":{"begin":1137,"end":1140},"obj":"Type"},{"id":"T82","span":{"begin":836,"end":850},"obj":"Gene"},{"id":"T83","span":{"begin":821,"end":830},"obj":"Phenomena"},{"id":"T85","span":{"begin":878,"end":890},"obj":"Gene"},{"id":"T86","span":{"begin":917,"end":936},"obj":"Phenomena"},{"id":"T87","span":{"begin":912,"end":916},"obj":"Species"},{"id":"T88","span":{"begin":687,"end":700},"obj":"Species"},{"id":"T9","span":{"begin":56,"end":63},"obj":"Species"},{"id":"T90","span":{"begin":813,"end":820},"obj":"Gene"},{"id":"T91","span":{"begin":870,"end":877},"obj":"Inhibition"},{"id":"T92","span":{"begin":1054,"end":1057},"obj":"Number"},{"id":"T93","span":{"begin":1141,"end":1146},"obj":"Species"},{"id":"T94","span":{"begin":1271,"end":1274},"obj":"Number"},{"id":"T95","span":{"begin":1172,"end":1176},"obj":"Type"},{"id":"T96","span":{"begin":974,"end":990},"obj":"Phenomena"},{"id":"T97","span":{"begin":1000,"end":1014},"obj":"Structure"},{"id":"T98","span":{"begin":967,"end":973},"obj":"NegativeRegulation"},{"id":"T99","span":{"begin":1015,"end":1022},"obj":"NegativeRegulation"},{"id":"T104","span":{"begin":761,"end":766},"obj":"Condition"}],"relations":[{"id":"R46","pred":"is_a","subj":"T13","obj":"T57"},{"id":"R47","pred":"of_a","subj":"T57","obj":"T10"},{"id":"R1","pred":"of_a","subj":"T7","obj":"T9"},{"id":"R10","pred":"has_a","subj":"T70","obj":"T65"},{"id":"R100","pred":"in","subj":"T32","obj":"T31"},{"id":"R101","pred":"is_a","subj":"T46","obj":"T62"},{"id":"R102","pred":"to","subj":"T62","obj":"T28"},{"id":"R103","pred":"cause_of","subj":"T27","obj":"T46"},{"id":"R104","pred":"of_a","subj":"T8","obj":"T46"},{"id":"R105","pred":"of_a","subj":"T103","obj":"T102"},{"id":"R106","pred":"of_a","subj":"T40","obj":"T19"},{"id":"R107","pred":"of_a","subj":"T50","obj":"T19"},{"id":"R108","pred":"of_a","subj":"T72","obj":"T19"},{"id":"R109","pred":"of_a","subj":"T39","obj":"T19"},{"id":"R11","pred":"is_a","subj":"T67","obj":"T66"},{"id":"R110","pred":"of_a","subj":"T34","obj":"T19"},{"id":"R111","pred":"of_a","subj":"T51","obj":"T78"},{"id":"R112","pred":"of_a","subj":"T41","obj":"T78"},{"id":"R113","pred":"of_a","subj":"T35","obj":"T78"},{"id":"R114","pred":"of_a","subj":"T74","obj":"T21"},{"id":"R115","pred":"of_a","subj":"T75","obj":"T21"},{"id":"R116","pred":"of_a","subj":"T76","obj":"T21"},{"id":"R117","pred":"of_a","subj":"T52","obj":"T22"},{"id":"R118","pred":"of_a","subj":"T42","obj":"T22"},{"id":"R119","pred":"of_a","subj":"T33","obj":"T23"},{"id":"R12","pred":"in","subj":"T70","obj":"T66"},{"id":"R120","pred":"of_a","subj":"T37","obj":"T24"},{"id":"R121","pred":"of_a","subj":"T38","obj":"T26"},{"id":"R122","pred":"of_a","subj":"T38","obj":"T25"},{"id":"R13","pred":"of_a","subj":"T2","obj":"T55"},{"id":"R14","pred":"to","subj":"T55","obj":"T15"},{"id":"R15","pred":"cause_of","subj":"T20","obj":"T55"},{"id":"R16","pred":"is_a","subj":"T3","obj":"T71"},{"id":"R17","pred":"of_a","subj":"T49","obj":"T71"},{"id":"R18","pred":"is_a","subj":"T4","obj":"T56"},{"id":"R19","pred":"to","subj":"T56","obj":"T16"},{"id":"R2","pred":"is_a","subj":"T1","obj":"T54"},{"id":"R20","pred":"associate_with","subj":"T17","obj":"T19"},{"id":"R21","pred":"of_a","subj":"T18","obj":"T19"},{"id":"R22","pred":"cause_of","subj":"T19","obj":"T56"},{"id":"R23","pred":"of_a","subj":"T4","obj":"T40"},{"id":"R24","pred":"of_a","subj":"T4","obj":"T50"},{"id":"R25","pred":"of_a","subj":"T4","obj":"T39"},{"id":"R26","pred":"of_a","subj":"T4","obj":"T34"},{"id":"R27","pred":"of_a","subj":"T4","obj":"T72"},{"id":"R28","pred":"is_a","subj":"T5","obj":"T69"},{"id":"R29","pred":"to","subj":"T69","obj":"T43"},{"id":"R3","pred":"to","subj":"T54","obj":"T9"},{"id":"R30","pred":"of_a","subj":"T5","obj":"T51"},{"id":"R31","pred":"of_a","subj":"T5","obj":"T41"},{"id":"R32","pred":"of_a","subj":"T5","obj":"T35"},{"id":"R36","pred":"of_a","subj":"T79","obj":"T78"},{"id":"R37","pred":"cause_of","subj":"T78","obj":"T69"},{"id":"R38","pred":"of_a","subj":"T80","obj":"T10"},{"id":"R39","pred":"associate_with","subj":"T53","obj":"T21"},{"id":"R4","pred":"is_a","subj":"T63","obj":"T60"},{"id":"R43","pred":"of_a","subj":"T13","obj":"T74"},{"id":"R44","pred":"of_a","subj":"T13","obj":"T75"},{"id":"R45","pred":"of_a","subj":"T13","obj":"T76"},{"id":"R48","pred":"cause_of","subj":"T21","obj":"T57"},{"id":"R49","pred":"coreference","subj":"T51","obj":"T76"},{"id":"R5","pred":"is_a","subj":"T12","obj":"T60"},{"id":"R50","pred":"coreference","subj":"T41","obj":"T75"},{"id":"R51","pred":"coreference","subj":"T35","obj":"T74"},{"id":"R6","pred":"to","subj":"T60","obj":"T14"},{"id":"R62","pred":"associate_with","subj":"T48","obj":"T23"},{"id":"R64","pred":"of_a","subj":"T88","obj":"T42"},{"id":"R65","pred":"of_a","subj":"T88","obj":"T52"},{"id":"R66","pred":"of_a","subj":"T88","obj":"T33"},{"id":"R67","pred":"of_a","subj":"T87","obj":"T82"},{"id":"R68","pred":"of_a","subj":"T88","obj":"T36"},{"id":"R69","pred":"coreference","subj":"T90","obj":"T33"},{"id":"R7","pred":"is_a","subj":"T67","obj":"T68"},{"id":"R70","pred":"is_a","subj":"T90","obj":"T83"},{"id":"R71","pred":"with","subj":"T83","obj":"T82"},{"id":"R72","pred":"has_role","subj":"T23","obj":"T91"},{"id":"R73","pred":"is_a","subj":"T91","obj":"T83"},{"id":"R74","pred":"is_a","subj":"T87","obj":"T86"},{"id":"R75","pred":"is_a","subj":"T91","obj":"T86"},{"id":"R76","pred":"associate_with","subj":"T45","obj":"T24"},{"id":"R78","pred":"is_a","subj":"T24","obj":"T98"},{"id":"R79","pred":"is_a","subj":"T24","obj":"T99"},{"id":"R8","pred":"to","subj":"T68","obj":"T70"},{"id":"R80","pred":"is_a","subj":"T99","obj":"T97"},{"id":"R81","pred":"is_a","subj":"T98","obj":"T96"},{"id":"R82","pred":"of_a","subj":"T100","obj":"T26"},{"id":"R84","pred":"of_a","subj":"T88","obj":"T37"},{"id":"R85","pred":"of_a","subj":"T6","obj":"T38"},{"id":"R86","pred":"associate_with","subj":"T92","obj":"T25"},{"id":"R87","pred":"associate_with","subj":"T92","obj":"T26"},{"id":"R88","pred":"is_a","subj":"T6","obj":"T58"},{"id":"R89","pred":"to","subj":"T58","obj":"T93"},{"id":"R9","pred":"cause_of","subj":"T67","obj":"T65"},{"id":"R90","pred":"of_a","subj":"T81","obj":"T93"},{"id":"R91","pred":"cause_of","subj":"T26","obj":"T58"},{"id":"R92","pred":"associate_with","subj":"T94","obj":"T27"},{"id":"R93","pred":"is_a","subj":"T44","obj":"T61"},{"id":"R94","pred":"is_a","subj":"T30","obj":"T61"},{"id":"R95","pred":"to","subj":"T61","obj":"T29"},{"id":"R96","pred":"of_a","subj":"T95","obj":"T61"},{"id":"R97","pred":"in","subj":"T47","obj":"T44"},{"id":"R98","pred":"is_a","subj":"T44","obj":"T101"},{"id":"R99","pred":"in","subj":"T31","obj":"T101"},{"id":"R123","pred":"is_a","subj":"T64","obj":"T104"},{"id":"R124","pred":"has_status","subj":"T22","obj":"T104"}],"attributes":[{"id":"A59","pred":"tao:has_database_id","subj":"T74","obj":"MESH:C446938"},{"id":"A68","pred":"tao:has_database_id","subj":"T96","obj":"MESH:D006860"},{"id":"A64","pred":"Memo","subj":"T85","obj":"MESH:C423142"},{"id":"A65","pred":"Memo","subj":"T86","obj":"MESH:D007372"},{"id":"A63","pred":"Memo","subj":"T82","obj":"MESH:C423142"},{"id":"A9","pred":"tao:has_database_id","subj":"T14","obj":"Tax:9989"},{"id":"A70","pred":"Memo","subj":"T72","obj":"Gene:911824"},{"id":"A71","pred":"Memo","subj":"T72","obj":"Zaire ebolavirus"},{"id":"A45","pred":"tao:has_database_id","subj":"T57","obj":"MESH:D000086967"},{"id":"A18","pred":"tao:has_database_id","subj":"T25","obj":"MESH:D009154"},{"id":"A42","pred":"tao:has_database_id","subj":"T54","obj":"MESH:D000086967"},{"id":"A41","pred":"tao:has_database_id","subj":"T52","obj":"MESH:C113190"},{"id":"A61","pred":"tao:has_database_id","subj":"T76","obj":"MESH:C113190"},{"id":"A29","pred":"tao:has_database_id","subj":"T37","obj":"MESH:C446938"},{"id":"A58","pred":"tao:has_database_id","subj":"T71","obj":"MESH:D014774"},{"id":"A13","pred":"tao:has_database_id","subj":"T20","obj":"MESH:D009154"},{"id":"A25","pred":"tao:has_database_id","subj":"T33","obj":"MESH:C446938"},{"id":"A39","pred":"tao:has_database_id","subj":"T50","obj":"MESH:C113190"},{"id":"A15","pred":"tao:has_database_id","subj":"T22","obj":"MESH:D009154"},{"id":"A40","pred":"tao:has_database_id","subj":"T51","obj":"MESH:C113190"},{"id":"A6","pred":"tao:has_database_id","subj":"T6","obj":"Tax:186536"},{"id":"A1","pred":"tao:has_database_id","subj":"T1","obj":"Tax:186536"},{"id":"A23","pred":"tao:has_database_id","subj":"T31","obj":"Tax:9823"},{"id":"A47","pred":"Memo","subj":"T59","obj":"MESH:D009154"},{"id":"A62","pred":"tao:has_database_id","subj":"T78","obj":"MESH:D009154"},{"id":"A60","pred":"tao:has_database_id","subj":"T75","obj":"MESH:C110614"},{"id":"A55","pred":"tao:has_database_id","subj":"T69","obj":"MESH:D000086967"},{"id":"A50","pred":"tao:has_database_id","subj":"T62","obj":"MESH:D014774"},{"id":"A28","pred":"tao:has_database_id","subj":"T36","obj":"MESH:C446938"},{"id":"A7","pred":"tao:has_database_id","subj":"T12","obj":"Tax:186536"},{"id":"A14","pred":"tao:has_database_id","subj":"T21","obj":"MESH:D009154"},{"id":"A52","pred":"Memo","subj":"T66","obj":"MESH:D050296"},{"id":"A67","pred":"tao:has_database_id","subj":"T90","obj":"MESH:C446938"},{"id":"A27","pred":"tao:has_database_id","subj":"T35","obj":"MESH:C446938"},{"id":"A53","pred":"tao:has_database_id","subj":"T67","obj":"Tax:186536"},{"id":"A31","pred":"tao:has_database_id","subj":"T39","obj":"MESH:C084818"},{"id":"A24","pred":"tao:has_database_id","subj":"T32","obj":"MESH:D001208"},{"id":"A44","pred":"tao:has_database_id","subj":"T56","obj":"MESH:D000086967"},{"id":"A20","pred":"tao:has_database_id","subj":"T27","obj":"MESH:D009154"},{"id":"A12","pred":"tao:has_database_id","subj":"T19","obj":"MESH:D009154"},{"id":"A16","pred":"tao:has_database_id","subj":"T23","obj":"MESH:D009154"},{"id":"A17","pred":"tao:has_database_id","subj":"T24","obj":"MESH:D009154"},{"id":"A3","pred":"tao:has_database_id","subj":"T3","obj":"Tax:186536"},{"id":"A33","pred":"tao:has_database_id","subj":"T41","obj":"MESH:C110614"},{"id":"A5","pred":"tao:has_database_id","subj":"T5","obj":"Tax:186536"},{"id":"A37","pred":"tao:has_database_id","subj":"T46","obj":"Tax:186536"},{"id":"A43","pred":"tao:has_database_id","subj":"T55","obj":"MESH:D000086967"},{"id":"A51","pred":"tao:has_database_id","subj":"T65","obj":"MESH:D019142"},{"id":"A34","pred":"tao:has_database_id","subj":"T42","obj":"MESH:C110614"},{"id":"A46","pred":"tao:has_database_id","subj":"T58","obj":"MESH:D000086967"},{"id":"A26","pred":"tao:has_database_id","subj":"T34","obj":"MESH:C446938"},{"id":"A4","pred":"tao:has_database_id","subj":"T4","obj":"Tax:186536"},{"id":"A38","pred":"tao:has_database_id","subj":"T47","obj":"Tax:186536"},{"id":"A54","pred":"tao:has_database_id","subj":"T68","obj":"MESH:D000086967"},{"id":"A11","pred":"tao:has_database_id","subj":"T16","obj":"Tax:9989"},{"id":"A35","pred":"tao:has_database_id","subj":"T43","obj":"Tax:9989"},{"id":"A10","pred":"tao:has_database_id","subj":"T15","obj":"Tax:9989"},{"id":"A49","pred":"tao:has_database_id","subj":"T61","obj":"MESH:D014774"},{"id":"A56","pred":"tao:has_database_id","subj":"T70","obj":"Tax:9989"},{"id":"A57","pred":"tao:has_database_id","subj":"T60","obj":"MESH:D014774"},{"id":"A2","pred":"tao:has_database_id","subj":"T2","obj":"Tax:186536"},{"id":"A32","pred":"tao:has_database_id","subj":"T40","obj":"MESH:C110614"},{"id":"A36","pred":"tao:has_database_id","subj":"T44","obj":"Tax:186539"},{"id":"A69","pred":"tao:has_database_id","subj":"T102","obj":"MESH:D019295"},{"id":"A8","pred":"tao:has_database_id","subj":"T13","obj":"Tax:186536"},{"id":"A19","pred":"tao:has_database_id","subj":"T26","obj":"MESH:D009154"},{"id":"A22","pred":"tao:has_database_id","subj":"T29","obj":"Tax:9606"},{"id":"A30","pred":"tao:has_database_id","subj":"T38","obj":"MESH:C446938"},{"id":"A66","pred":"tao:has_database_id","subj":"T88","obj":"Tax:186536"},{"id":"A21","pred":"tao:has_database_id","subj":"T28","obj":"Tax:9606"}],"text":"Changes associated with Ebola virus adaptation to novel species.\nMotivation: Ebola viruses are not pathogenic but can be adapted to replicate and cause disease in rodents. Here, we used a structural bioinformatics approach to analyze the mutations associated with Ebola virus adaptation to rodents to elucidate the determinants of host-specific Ebola virus pathogenicity.\nResults: : We identified 33 different mutations associated with Ebola virus adaptation to rodents in the proteins GP, NP, L, VP24 and VP35. Only VP24, GP and NP were consistently found mutated in rodent-adapted Ebola virus strains. Fewer than five mutations in these genes seem to be required for the adaptation of Ebola viruses to a new species. The role of mutations in GP and NP is not clear. However, three VP24 mutations located in the protein interface with karyopherin α5 may enable VP24 to inhibit karyopherins and subsequently the host interferon response. Three further VP24 mutations change hydrogen bonding or cause conformational changes. Hence, there is evidence that few mutations including crucial mutations in VP24 enable Ebola virus adaptation to new hosts. Since Reston virus, the only non-human pathogenic Ebolavirus species circulates in pigs in Asia, this raises concerns that few mutations may result in novel human pathogenic Ebolaviruses.\nContact: m.n.wass@kent.ac.uk , m.michaelis@kent.ac.uk or j.s.rossman@kent.ac.uk.\nSupplementary information: Supplementary data are available at Bioinformatics online."}