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PubMed:28151486 JSONTXT

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LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
12230 0-8 GeneOrGeneProduct denotes Star-PAP NCBIGene:64852
12231 12-30 GeneOrGeneProduct denotes poly(A) polymerase NCBIGene:64852
12232 47-52 DiseaseOrPhenotypicFeature denotes tumor MESH:D009369
12233 81-86 OrganismTaxon denotes human NCBITaxon:9606
12234 87-100 DiseaseOrPhenotypicFeature denotes breast cancer MESH:D001943
12235 108-116 GeneOrGeneProduct denotes Star-PAP NCBIGene:64852
12236 135-153 GeneOrGeneProduct denotes poly(A) polymerase NCBIGene:64852
12237 246-254 GeneOrGeneProduct denotes Star-PAP NCBIGene:64852
12238 258-264 DiseaseOrPhenotypicFeature denotes cancer MESH:D009369
12239 341-349 GeneOrGeneProduct denotes Star-PAP NCBIGene:64852
12240 353-366 DiseaseOrPhenotypicFeature denotes breast cancer MESH:D001943
12241 399-407 GeneOrGeneProduct denotes Star-PAP NCBIGene:64852
12242 480-493 DiseaseOrPhenotypicFeature denotes breast cancer MESH:D001943
12243 504-517 DiseaseOrPhenotypicFeature denotes breast cancer MESH:D001943
12244 518-526 OrganismTaxon denotes patients NCBITaxon:9606
12245 543-551 GeneOrGeneProduct denotes Star-PAP NCBIGene:64852
12246 633-636 GeneOrGeneProduct denotes BIK NCBIGene:638
12247 638-661 GeneOrGeneProduct denotes BCL2-interacting killer NCBIGene:638
12248 664-672 GeneOrGeneProduct denotes Star-PAP NCBIGene:64852
12249 694-707 DiseaseOrPhenotypicFeature denotes breast cancer MESH:D001943
12250 763-776 DiseaseOrPhenotypicFeature denotes breast cancer MESH:D001943
12251 795-799 DiseaseOrPhenotypicFeature denotes SCID MESH:D016511
12252 800-804 OrganismTaxon denotes mice NCBITaxon:10090
12253 831-842 ChemicalEntity denotes doxycycline MESH:D004318
12254 851-859 GeneOrGeneProduct denotes Star-PAP NCBIGene:64852
12255 889-897 GeneOrGeneProduct denotes Star-PAP NCBIGene:64852
12256 909-922 DiseaseOrPhenotypicFeature denotes breast cancer MESH:D001943
12257 1007-1015 GeneOrGeneProduct denotes Star-PAP NCBIGene:64852
12258 1159-1167 GeneOrGeneProduct denotes Star-PAP NCBIGene:64852
12259 1178-1183 DiseaseOrPhenotypicFeature denotes tumor MESH:D009369
12260 1253-1259 DiseaseOrPhenotypicFeature denotes cancer MESH:D009369

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 81-86 OrganismTaxon denotes human NCBItxid:9606
T2 800-804 OrganismTaxon denotes mice NCBItxid:10095|NCBItxid:10088

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-107 Sentence denotes Star-PAP, a poly(A) polymerase, functions as a tumor suppressor in an orthotopic human breast cancer model.
T2 108-211 Sentence denotes Star-PAP is a noncanonical poly(A) polymerase and required for the expression of a select set of mRNAs.
T3 212-289 Sentence denotes However, the pathological role of Star-PAP in cancer largely remains unknown.
T4 290-390 Sentence denotes In this study, we observed decreased expression of Star-PAP in breast cancer cell lines and tissues.
T5 391-500 Sentence denotes Ectopic Star-PAP expression inhibited proliferation as well as colony-forming ability of breast cancer cells.
T6 501-590 Sentence denotes In breast cancer patients, high levels of Star-PAP correlated with an improved prognosis.
T7 591-748 Sentence denotes Moreover, by regulating the expression of BIK (BCL2-interacting killer), Star-PAP induced apoptosis of breast cancer cells through the mitochondrial pathway.
T8 749-875 Sentence denotes The growth of breast cancer xenografts in NOD/SCID mice was also inhibited by the doxycycline-induced Star-PAP overexpression.
T9 876-977 Sentence denotes Furthermore, Star-PAP sensitized breast cancer cells to chemotherapy drugs both in vitro and in vivo.
T10 978-1128 Sentence denotes In mammary epithelial cells, Star-PAP knockdown partially transformed these cells and induced them to undergo epithelial-mesenchymal transition (EMT).
T11 1129-1283 Sentence denotes These findings suggested that Star-PAP possesses tumor-suppressing activity and can be a valuable target for developing new cancer therapeutic strategies.

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 87-100 DiseaseOrPhenotypicFeature denotes breast cancer 0007254
T2 94-100 DiseaseOrPhenotypicFeature denotes cancer 0004992
T3 258-264 DiseaseOrPhenotypicFeature denotes cancer 0004992
T4 353-366 DiseaseOrPhenotypicFeature denotes breast cancer 0007254
T5 360-366 DiseaseOrPhenotypicFeature denotes cancer 0004992
T6 480-493 DiseaseOrPhenotypicFeature denotes breast cancer 0007254
T7 487-493 DiseaseOrPhenotypicFeature denotes cancer 0004992
T8 504-517 DiseaseOrPhenotypicFeature denotes breast cancer 0007254
T9 511-517 DiseaseOrPhenotypicFeature denotes cancer 0004992
T10 694-707 DiseaseOrPhenotypicFeature denotes breast cancer 0007254
T11 701-707 DiseaseOrPhenotypicFeature denotes cancer 0004992
T12 763-776 DiseaseOrPhenotypicFeature denotes breast cancer 0007254
T13 770-776 DiseaseOrPhenotypicFeature denotes cancer 0004992
T14 909-922 DiseaseOrPhenotypicFeature denotes breast cancer 0007254
T15 916-922 DiseaseOrPhenotypicFeature denotes cancer 0004992
T16 1253-1259 DiseaseOrPhenotypicFeature denotes cancer 0004992

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 0-8 GeneOrGeneProduct denotes Star-PAP
T2 12-30 GeneOrGeneProduct denotes poly(A) polymerase
T3 47-63 GeneOrGeneProduct denotes tumor suppressor
T4 108-116 GeneOrGeneProduct denotes Star-PAP
T5 135-153 GeneOrGeneProduct denotes poly(A) polymerase
T6 246-254 GeneOrGeneProduct denotes Star-PAP
T7 265-272 GeneOrGeneProduct denotes largely
T8 281-288 GeneOrGeneProduct denotes unknown
T9 341-349 GeneOrGeneProduct denotes Star-PAP
T10 367-371 GeneOrGeneProduct denotes cell
T11 372-377 GeneOrGeneProduct denotes lines
T12 399-407 GeneOrGeneProduct denotes Star-PAP
T13 494-499 GeneOrGeneProduct denotes cells
T14 528-532 GeneOrGeneProduct denotes high
T15 543-551 GeneOrGeneProduct denotes Star-PAP
T16 604-614 GeneOrGeneProduct denotes regulating
T17 638-661 GeneOrGeneProduct denotes BCL2-interacting killer
T18 664-672 GeneOrGeneProduct denotes Star-PAP
T19 673-680 GeneOrGeneProduct denotes induced
T20 681-690 GeneOrGeneProduct denotes apoptosis
T21 708-713 GeneOrGeneProduct denotes cells
T22 726-739 GeneOrGeneProduct denotes mitochondrial
T23 753-759 GeneOrGeneProduct denotes growth
T24 788-794 GeneOrGeneProduct denotes in NOD
T25 795-799 GeneOrGeneProduct denotes SCID
T26 800-804 GeneOrGeneProduct denotes mice
T27 843-850 GeneOrGeneProduct denotes induced
T28 851-859 GeneOrGeneProduct denotes Star-PAP
T29 889-897 GeneOrGeneProduct denotes Star-PAP
T30 923-928 GeneOrGeneProduct denotes cells
T31 1000-1005 GeneOrGeneProduct denotes cells
T32 1007-1015 GeneOrGeneProduct denotes Star-PAP
T33 1016-1025 GeneOrGeneProduct denotes knockdown
T34 1036-1047 GeneOrGeneProduct denotes transformed
T35 1054-1059 GeneOrGeneProduct denotes cells
T36 1064-1071 GeneOrGeneProduct denotes induced
T37 1072-1076 GeneOrGeneProduct denotes them
T38 1135-1143 GeneOrGeneProduct denotes findings
T39 1159-1167 GeneOrGeneProduct denotes Star-PAP
T40 1178-1183 GeneOrGeneProduct denotes tumor
T41 1196-1204 GeneOrGeneProduct denotes activity
T42 1209-1217 GeneOrGeneProduct denotes can be a

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 0-8 GeneOrGeneProduct denotes Star-PAP
T2 12-30 GeneOrGeneProduct denotes poly(A) polymerase
T3 47-63 GeneOrGeneProduct denotes tumor suppressor
T4 108-116 GeneOrGeneProduct denotes Star-PAP
T5 135-153 GeneOrGeneProduct denotes poly(A) polymerase
T6 246-254 GeneOrGeneProduct denotes Star-PAP
T7 281-288 GeneOrGeneProduct denotes unknown
T8 341-349 GeneOrGeneProduct denotes Star-PAP
T9 367-371 GeneOrGeneProduct denotes cell
T10 372-377 GeneOrGeneProduct denotes lines
T11 399-407 GeneOrGeneProduct denotes Star-PAP
T12 528-532 GeneOrGeneProduct denotes high
T13 543-551 GeneOrGeneProduct denotes Star-PAP
T14 638-661 GeneOrGeneProduct denotes BCL2-interacting killer
T15 664-672 GeneOrGeneProduct denotes Star-PAP
T16 681-690 GeneOrGeneProduct denotes apoptosis
T17 726-739 GeneOrGeneProduct denotes mitochondrial
T18 753-759 GeneOrGeneProduct denotes growth
T19 851-859 GeneOrGeneProduct denotes Star-PAP
T20 889-897 GeneOrGeneProduct denotes Star-PAP
T21 1007-1015 GeneOrGeneProduct denotes Star-PAP
T22 1016-1025 GeneOrGeneProduct denotes knockdown
T23 1159-1167 GeneOrGeneProduct denotes Star-PAP

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 47-52 DiseaseOrPhenotypicFeature denotes tumor D009369
T2 87-100 DiseaseOrPhenotypicFeature denotes breast cancer D001943
T3 258-264 DiseaseOrPhenotypicFeature denotes cancer D009369
T4 353-366 DiseaseOrPhenotypicFeature denotes breast cancer D001943
T5 480-493 DiseaseOrPhenotypicFeature denotes breast cancer D001943
T6 504-517 DiseaseOrPhenotypicFeature denotes breast cancer D001943
T7 694-707 DiseaseOrPhenotypicFeature denotes breast cancer D001943
T8 763-776 DiseaseOrPhenotypicFeature denotes breast cancer D001943
T9 909-922 DiseaseOrPhenotypicFeature denotes breast cancer D001943
T10 1178-1183 DiseaseOrPhenotypicFeature denotes tumor D009369
T11 1253-1259 DiseaseOrPhenotypicFeature denotes cancer D009369

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 0-8 GeneOrGeneProduct denotes Star-PAP
T2 12-30 GeneOrGeneProduct denotes poly(A) polymerase
T3 53-63 GeneOrGeneProduct denotes suppressor
T4 108-116 GeneOrGeneProduct denotes Star-PAP
T5 135-153 GeneOrGeneProduct denotes poly(A) polymerase
T6 246-254 GeneOrGeneProduct denotes Star-PAP
T7 341-349 GeneOrGeneProduct denotes Star-PAP
T8 399-407 GeneOrGeneProduct denotes Star-PAP
T9 543-551 GeneOrGeneProduct denotes Star-PAP
T10 638-661 GeneOrGeneProduct denotes BCL2-interacting killer
T11 664-672 GeneOrGeneProduct denotes Star-PAP
T12 851-859 GeneOrGeneProduct denotes Star-PAP
T13 889-897 GeneOrGeneProduct denotes Star-PAP
T14 1007-1015 GeneOrGeneProduct denotes Star-PAP
T15 1159-1167 GeneOrGeneProduct denotes Star-PAP

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 5-8 DiseaseOrPhenotypicFeature denotes PAP 0012579|0001437
T3 47-52 DiseaseOrPhenotypicFeature denotes tumor 0005070
T4 87-100 DiseaseOrPhenotypicFeature denotes breast cancer 0007254|0004989
T6 113-116 DiseaseOrPhenotypicFeature denotes PAP 0012579|0001437
T8 251-254 DiseaseOrPhenotypicFeature denotes PAP 0012579|0001437
T10 346-349 DiseaseOrPhenotypicFeature denotes PAP 0012579|0001437
T12 353-366 DiseaseOrPhenotypicFeature denotes breast cancer 0007254|0004989
T14 404-407 DiseaseOrPhenotypicFeature denotes PAP 0012579|0001437
T16 480-493 DiseaseOrPhenotypicFeature denotes breast cancer 0007254|0004989
T18 504-517 DiseaseOrPhenotypicFeature denotes breast cancer 0007254|0004989
T20 548-551 DiseaseOrPhenotypicFeature denotes PAP 0012579|0001437
T22 669-672 DiseaseOrPhenotypicFeature denotes PAP 0012579|0001437
T24 694-707 DiseaseOrPhenotypicFeature denotes breast cancer 0007254|0004989
T26 763-776 DiseaseOrPhenotypicFeature denotes breast cancer 0007254|0004989
T28 791-794 DiseaseOrPhenotypicFeature denotes NOD 0007435
T29 795-799 DiseaseOrPhenotypicFeature denotes SCID 0015974
T30 856-859 DiseaseOrPhenotypicFeature denotes PAP 0012579|0001437
T32 894-897 DiseaseOrPhenotypicFeature denotes PAP 0012579|0001437
T34 909-922 DiseaseOrPhenotypicFeature denotes breast cancer 0007254|0004989
T36 1012-1015 DiseaseOrPhenotypicFeature denotes PAP 0012579|0001437
T38 1164-1167 DiseaseOrPhenotypicFeature denotes PAP 0012579|0001437
T40 1178-1183 DiseaseOrPhenotypicFeature denotes tumor 0005070
T41 1209-1212 DiseaseOrPhenotypicFeature denotes can 0012833

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 47-52 DiseaseOrPhenotypicFeature denotes tumor D009369
T2 87-100 DiseaseOrPhenotypicFeature denotes breast cancer D001943
T3 258-264 DiseaseOrPhenotypicFeature denotes cancer D009369
T4 353-366 DiseaseOrPhenotypicFeature denotes breast cancer D001943
T5 480-493 DiseaseOrPhenotypicFeature denotes breast cancer D001943
T6 504-517 DiseaseOrPhenotypicFeature denotes breast cancer D001943
T7 694-707 DiseaseOrPhenotypicFeature denotes breast cancer D001943
T8 763-776 DiseaseOrPhenotypicFeature denotes breast cancer D001943
T9 795-799 DiseaseOrPhenotypicFeature denotes SCID DISEASE
T10 909-922 DiseaseOrPhenotypicFeature denotes breast cancer D001943
T11 1178-1183 DiseaseOrPhenotypicFeature denotes tumor D009369
T12 1253-1259 DiseaseOrPhenotypicFeature denotes cancer D009369

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 47-52 DiseaseOrPhenotypicFeature denotes tumor D009369
T2 87-100 DiseaseOrPhenotypicFeature denotes breast cancer D001943
T3 258-264 DiseaseOrPhenotypicFeature denotes cancer D009369
T4 353-366 DiseaseOrPhenotypicFeature denotes breast cancer D001943
T5 480-493 DiseaseOrPhenotypicFeature denotes breast cancer D001943
T6 504-517 DiseaseOrPhenotypicFeature denotes breast cancer D001943
T7 694-707 DiseaseOrPhenotypicFeature denotes breast cancer D001943
T8 763-776 DiseaseOrPhenotypicFeature denotes breast cancer D001943
T9 795-799 DiseaseOrPhenotypicFeature denotes SCID DISEASE
T10 909-922 DiseaseOrPhenotypicFeature denotes breast cancer D001943
T11 1178-1183 DiseaseOrPhenotypicFeature denotes tumor D009369
T12 1253-1259 DiseaseOrPhenotypicFeature denotes cancer D009369

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 5-8 ChemicalEntity denotes PAP http://purl.obolibrary.org/obo/CHEBI_53758|http://purl.obolibrary.org/obo/CHEBI_17985
T3 12-30 ChemicalEntity denotes poly(A) polymerase D011062
T4 113-116 ChemicalEntity denotes PAP http://purl.obolibrary.org/obo/CHEBI_53758|http://purl.obolibrary.org/obo/CHEBI_17985
T6 135-153 ChemicalEntity denotes poly(A) polymerase D011062
T7 251-254 ChemicalEntity denotes PAP http://purl.obolibrary.org/obo/CHEBI_53758|http://purl.obolibrary.org/obo/CHEBI_17985
T9 346-349 ChemicalEntity denotes PAP http://purl.obolibrary.org/obo/CHEBI_53758|http://purl.obolibrary.org/obo/CHEBI_17985
T11 404-407 ChemicalEntity denotes PAP http://purl.obolibrary.org/obo/CHEBI_53758|http://purl.obolibrary.org/obo/CHEBI_17985
T13 548-551 ChemicalEntity denotes PAP http://purl.obolibrary.org/obo/CHEBI_53758|http://purl.obolibrary.org/obo/CHEBI_17985
T15 669-672 ChemicalEntity denotes PAP http://purl.obolibrary.org/obo/CHEBI_53758|http://purl.obolibrary.org/obo/CHEBI_17985
T17 831-842 ChemicalEntity denotes doxycycline D004318|http://purl.obolibrary.org/obo/CHEBI_60648|http://purl.obolibrary.org/obo/CHEBI_50845
T20 856-859 ChemicalEntity denotes PAP http://purl.obolibrary.org/obo/CHEBI_53758|http://purl.obolibrary.org/obo/CHEBI_17985
T22 894-897 ChemicalEntity denotes PAP http://purl.obolibrary.org/obo/CHEBI_53758|http://purl.obolibrary.org/obo/CHEBI_17985
T24 1012-1015 ChemicalEntity denotes PAP http://purl.obolibrary.org/obo/CHEBI_53758|http://purl.obolibrary.org/obo/CHEBI_17985
T26 1164-1167 ChemicalEntity denotes PAP http://purl.obolibrary.org/obo/CHEBI_53758|http://purl.obolibrary.org/obo/CHEBI_17985

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 81-86 OrganismTaxon denotes human
T2 518-526 OrganismTaxon denotes patients
T3 800-804 OrganismTaxon denotes mice

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T26 1164-1167 ChemicalEntity denotes PAP http://purl.obolibrary.org/obo/CHEBI_17985|http://purl.obolibrary.org/obo/CHEBI_53758
T24 1012-1015 ChemicalEntity denotes PAP http://purl.obolibrary.org/obo/CHEBI_17985|http://purl.obolibrary.org/obo/CHEBI_53758
T22 894-897 ChemicalEntity denotes PAP http://purl.obolibrary.org/obo/CHEBI_17985|http://purl.obolibrary.org/obo/CHEBI_53758
T20 856-859 ChemicalEntity denotes PAP http://purl.obolibrary.org/obo/CHEBI_17985|http://purl.obolibrary.org/obo/CHEBI_53758
T17 831-842 ChemicalEntity denotes doxycycline http://purl.obolibrary.org/obo/CHEBI_50845|http://purl.obolibrary.org/obo/CHEBI_60648|D004318
T15 669-672 ChemicalEntity denotes PAP http://purl.obolibrary.org/obo/CHEBI_17985|http://purl.obolibrary.org/obo/CHEBI_53758
T13 548-551 ChemicalEntity denotes PAP http://purl.obolibrary.org/obo/CHEBI_17985|http://purl.obolibrary.org/obo/CHEBI_53758
T11 404-407 ChemicalEntity denotes PAP http://purl.obolibrary.org/obo/CHEBI_17985|http://purl.obolibrary.org/obo/CHEBI_53758
T9 346-349 ChemicalEntity denotes PAP http://purl.obolibrary.org/obo/CHEBI_17985|http://purl.obolibrary.org/obo/CHEBI_53758
T7 251-254 ChemicalEntity denotes PAP http://purl.obolibrary.org/obo/CHEBI_17985|http://purl.obolibrary.org/obo/CHEBI_53758
T6 135-153 ChemicalEntity denotes poly(A) polymerase D011062
T4 113-116 ChemicalEntity denotes PAP http://purl.obolibrary.org/obo/CHEBI_17985|http://purl.obolibrary.org/obo/CHEBI_53758
T3 12-30 ChemicalEntity denotes poly(A) polymerase D011062
T1 5-8 ChemicalEntity denotes PAP http://purl.obolibrary.org/obo/CHEBI_17985|http://purl.obolibrary.org/obo/CHEBI_53758
T37782 1159-1167 GeneOrGeneProduct denotes Star-PAP
T14 1007-1015 GeneOrGeneProduct denotes Star-PAP
T3322 889-897 GeneOrGeneProduct denotes Star-PAP
T12 851-859 GeneOrGeneProduct denotes Star-PAP
T81941 664-672 GeneOrGeneProduct denotes Star-PAP
T10 638-661 GeneOrGeneProduct denotes BCL2-interacting killer
T29152 543-551 GeneOrGeneProduct denotes Star-PAP
T8 399-407 GeneOrGeneProduct denotes Star-PAP
T33533 341-349 GeneOrGeneProduct denotes Star-PAP
T72509 246-254 GeneOrGeneProduct denotes Star-PAP
T5 135-153 GeneOrGeneProduct denotes poly(A) polymerase
T84307 108-116 GeneOrGeneProduct denotes Star-PAP
T34539 53-63 GeneOrGeneProduct denotes suppressor
T2 12-30 GeneOrGeneProduct denotes poly(A) polymerase
T36213 0-8 GeneOrGeneProduct denotes Star-PAP
T12815 1253-1259 DiseaseOrPhenotypicFeature denotes cancer D009369
T75141 1178-1183 DiseaseOrPhenotypicFeature denotes tumor D009369
T59275 909-922 DiseaseOrPhenotypicFeature denotes breast cancer D001943
T58243 795-799 DiseaseOrPhenotypicFeature denotes SCID DISEASE
T32118 763-776 DiseaseOrPhenotypicFeature denotes breast cancer D001943
T27168 694-707 DiseaseOrPhenotypicFeature denotes breast cancer D001943
T4714 504-517 DiseaseOrPhenotypicFeature denotes breast cancer D001943
T2836 480-493 DiseaseOrPhenotypicFeature denotes breast cancer D001943
T13146 353-366 DiseaseOrPhenotypicFeature denotes breast cancer D001943
T82551 258-264 DiseaseOrPhenotypicFeature denotes cancer D009369
T13803 87-100 DiseaseOrPhenotypicFeature denotes breast cancer D001943
T55978 47-52 DiseaseOrPhenotypicFeature denotes tumor D009369
T27975 800-804 OrganismTaxon denotes mice
T39101 518-526 OrganismTaxon denotes patients
T47324 81-86 OrganismTaxon denotes human